膝骨关节炎生物标记物研究进展
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摘要
<正>膝骨关节炎(Knee Osteoarthritis,KOA)在中医属"痹症"范畴,其病理特征主要有软骨破坏、软骨下骨硬化和滑膜炎症改变等。所谓"上医治未病",早期诊断KOA对该病的治疗尤为重要。生物标记物是一类能够客观反映某一生理、病理过程或治疗效果的生理指标[1]。近年来科研工作者在探索KOA早期诊断、
引文
[1] ISSAQ,HALEEM J.Proteomic and metabolomic approaches to biomarker discovery[M].New York:Elsevier Academic Press,2013:245-258.
[2] BETTICA P,CLINE G,HART D J,et al.Evidence for increased bone resorption in patients with progressive knee osteoarthritis:longitudinal results from the Chingford study[J].Arthritis & Rheumatology,2002,46(12):3178-3184.
[3] CHENG H,HAO B,SUN J,et al.C-Terminal Cross-Linked telopeptides of type II collagen as biomarker for radiological knee osteoarthritis:a meta-analysis[J].Cartilage,2018:1947603518798884.
[4] 陈江涛,艾克拜尔·尤努斯,徐磊磊,等.血清NTx和TRACP5b在骨巨细胞瘤中的表达及临床意义[J].临床和实验医学杂志,2016,15(8):724-726.
[5] 张红,苏成海.Ⅰ型胶原交联氨基末端肽(NTX)在转移性骨肿瘤中的表达和临床价值[J].放射免疫学杂志,2011,24(2):150-153.
[6] 潘凌凌,金璐,李奕,等.尿NTx在多发性骨髓瘤骨病变监测及疗效判断中的临床意义[J].浙江实用医学,2017,24(2):95-98.
[7] TANISHI N,YAMAGIWA H,HAYAMI T,et al.Usefulness of urinary CTX-II and NTX-I in evaluating radiological knee osteoarthritis:the Matsudai knee osteoarthritis survey[J].Journal of Orthopaedic Science,2014,19(3):429-436.
[8] KALAA E BA,BOUZID K,LAADHAR L,et al.The role of type II collagen fragments and X-ray progression of knee osteoarthritis[J].Annales de Biologie Clinque,2014,72(6):715-721.
[9] XIN L,WU Z,QU Q,et al.Comparative study of CTX-II,Zn2+,and Ca2+ from the urine for knee osteoarthritis patients and healthy individuals[J].Medicine(Baltimore),2017,96(32):e7593.
[10] 邹信明,占卫兵,范乃人.血清CTX-Ⅱ、COMP在关节镜清理术治疗膝骨关节炎前后变化及临床意义[J].中国医学创新,2016,13(9):13-17.
[11] 常保磊,史冬泉,陈东阳,等.血清Ⅱ型胶原交联C-末端肽和软骨寡聚基质蛋白在老年膝关节炎中的表达及意义[J].中国临床医生杂志,2015,43(9):58-60.
[12] KLUZEK S,BAY-JENSEN AC,JUDGE A,et al.Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis:a community-based cohort of middle-aged women[J].Biomarkers,2015,20(8):557-564.
[13] GEORGIEV T,IVANOVA M,KOPCHEV A,et al.Cartilage oligomeric protein,matrix metalloproteinase-3,and Coll2-1 as serum biomarkers in knee osteoarthritis:a cross-sectional study[J].Rheumatology International,2018,38(5):821-830.
[14] PRIYANKA V,KRISHNA D.Serum cartilage oligomeric matrix protein(COMP)in knee osteoarthritis:a novel diagnostic and prognostic biomarker[J].Journal of Orthopaedic Research,2013,31(7):999-1006.
[15] V??N?NEN T,KOSKINEN A,PAUKKERI EL,et al.YKL-40 as a novel factor associated with inflammation and catabolic mechanisms in osteoarthritic Joints[J].Mediators of Inflammation,2014:215140.
[16] GUAN J,LIU Z,LI F,et al.Increased synovial fluid YKL-40 levels are linked with symptomatic severity in knee osteoarthritis patients[J].Clinical Laboratory,2015,61(8):991-997.
[17] 苏晓恩,孔志强,朱娟,等.膝关节骨关节炎软骨中YKL-40、IL-1β的表达及相关性探讨[J].重庆医学,2017,46(4):480-482.
[18] 陈宇.血浆白细胞介素1β基因多态性与原发性膝骨关节炎的相关性[J].中国老年学杂志,2012,32(16):3425-3426.
[19] 查振刚,黄良任,姚平,等.膝骨关节炎患者血清TNF-α与IL-6水平及其临床意义[J].广东医学,2005,26(2):191-193.
[20] 俞叶军,骆幸才,毕丽娜.血清白介素-15水平与膝骨关节炎患者影像学改变程度的相关性[J].健康研究,2015,35(2):164-165.
[21] CAI L,YIN J,STAROVASNIK M,et al.,Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo[J].Cytokine,2001,16(1):10-21.
[22] 张海森,白玉明,刘畅,等.血清及滑液白介素-17水平与膝骨关节炎退变及膝痛程度的相关性研究[J].中国医药导报,2016,13(33):84-87.
[23] 任海亮,马剑雄,马信龙.膝骨关节炎时关节滑液中炎症相关物质的表达[J].中国组织工程研究,2015,19(15):2336-2340.
[24] 刘冰,高兆宾,赵亮亮.膝骨关节炎患者血清和关节滑液TWEAK水平与影像学严重程度的相关性[J].中国中医骨伤科杂志,2017,25(4):18-21.
[25] 贾成瑶,李萍.尿吡啶啉和脱氧吡啶啉是骨吸收特异性生化标志物[J].中国临床康复,2002,6(15):2256-2257.
[26] JORDAN K M,SYDDALL H E,GARNERO P,et al.Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men[J].Annals of the Rheumatic Diseases,2006,65(7):871-877.
[27] LOHMANDER L S,BRANDT K D,MAZZUCA S A,et al.Use of the plasma stromelysin(matrix metalloproteinase 3)concentration to predict joint space narrowing in knee osteoarthritis[J].Arthritis Rheum,2005,52(10):3160-3167.
[28] PEARLE A D,SCANZELLO CR,GEORGE S,et al.Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis[J].Osteoarthritis Cartilage,2007,15(5):516-523.
[29] 韩文萍.益气健脾活血通络方对膝骨关节炎患者超敏C反应蛋白的影响[J].中国中医药科技,2014,21(3):299-300.
[30] 廖伟雄,李众利,王杰,等.骨性关节炎患者关节滑液中结合珠蛋白水平与病情严重程度的相关性[J].解放军医学院学报,2013,34(8):820-822.
[31] HENROTIN Y,GHARBI M,MAZZUCCHELLI G,et al.Fibulin 3 peptides Fib3-1 and Fib3-2 are potential biomarkers of osteoarthritis[J].Arthritis & Rheumatism,2012,64(7):2260-2267.
[32] 周星彤,刘恒,孟志超,等.代表性生物标记物及MicroRNAs在骨关节炎诊断及病情评估中的意义[J].中国矫形外科杂志,2017,25(15):1409-1415.
[33] SASAKI E,TSUDA E,YAMAMOTO Y,et al.Serum hyaluronic acid concentration predicts the progression of joint space narrowing in normal knees and established knee osteoarthritis-a five-year prospective cohort study[J].Arthritis Research & Therapy,2015,17(1):283-288.
[34] SHARIF M,GEORGE E,SHEPSTONE L,et al.Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee[J].Arthritis & Rheumatology,2010,38(6):760-767.
[35] 韩煜,荆秦,李春日.湿注骨节膝骨关节炎关节液CS和KS分析及临床意义[J].辽宁中医药大学学报,2014,16(9):11-13.
[36] NAKAJIMA A,NAKAGAWA K,AOKI Y,et al.Changes in synovial fluid biochemical markers following arthroscopic surgery in patients with knee osteoarthritis[J].Rheumatology International,2013,33(1):209-214.
[37] WAKITANI S,NAWATA M,KAWAGUCHI A,et al.Serum keratan sulfate is a promising marker of early articular cartilage breakdown[J].Rheumatology,2007,46(11):1652-1656.
[38] MIYAKI S,ASAHARA H.Macro view of microRNA function in osteoarthritis[J].Nature Reviews Rheumatology,2012,8(9):543-552.
[39] KIM D,SONG J,AHN C,et al.Peroxisomal dysfunction is associated with up-regulation of apoptotic cell death via miR-223 induction in knee osteoarthritis patients with type 2 diabetes mellitus[J].Bone,2014,64(1):124-131.
[40] WAN L,ZHAO Q,NIU G,et al.Plasma miR-136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL-17[J].Experimental and Therapeutic Medicine,2018,16(4):3419-3424..
[41] 吴寒松,黄世福,孙阔,等.microRNA-25促进骨关节炎软骨细胞外蛋白多糖和Ⅱ型胶原蛋白合成作用[J].科学技术与工程,2016,16(16):143-148.
[42] 陈蓟,雷鸣,刘弼,等.MicroRNA与骨关节炎[J].中国矫形外科杂志,2017,25(19):1783-1787.
[2] BETTICA P,CLINE G,HART D J,et al.Evidence for increased bone resorption in patients with progressive knee osteoarthritis:longitudinal results from the Chingford study[J].Arthritis & Rheumatology,2002,46(12):3178-3184.
[3] CHENG H,HAO B,SUN J,et al.C-Terminal Cross-Linked telopeptides of type II collagen as biomarker for radiological knee osteoarthritis:a meta-analysis[J].Cartilage,2018:1947603518798884.
[4] 陈江涛,艾克拜尔·尤努斯,徐磊磊,等.血清NTx和TRACP5b在骨巨细胞瘤中的表达及临床意义[J].临床和实验医学杂志,2016,15(8):724-726.
[5] 张红,苏成海.Ⅰ型胶原交联氨基末端肽(NTX)在转移性骨肿瘤中的表达和临床价值[J].放射免疫学杂志,2011,24(2):150-153.
[6] 潘凌凌,金璐,李奕,等.尿NTx在多发性骨髓瘤骨病变监测及疗效判断中的临床意义[J].浙江实用医学,2017,24(2):95-98.
[7] TANISHI N,YAMAGIWA H,HAYAMI T,et al.Usefulness of urinary CTX-II and NTX-I in evaluating radiological knee osteoarthritis:the Matsudai knee osteoarthritis survey[J].Journal of Orthopaedic Science,2014,19(3):429-436.
[8] KALAA E BA,BOUZID K,LAADHAR L,et al.The role of type II collagen fragments and X-ray progression of knee osteoarthritis[J].Annales de Biologie Clinque,2014,72(6):715-721.
[9] XIN L,WU Z,QU Q,et al.Comparative study of CTX-II,Zn2+,and Ca2+ from the urine for knee osteoarthritis patients and healthy individuals[J].Medicine(Baltimore),2017,96(32):e7593.
[10] 邹信明,占卫兵,范乃人.血清CTX-Ⅱ、COMP在关节镜清理术治疗膝骨关节炎前后变化及临床意义[J].中国医学创新,2016,13(9):13-17.
[11] 常保磊,史冬泉,陈东阳,等.血清Ⅱ型胶原交联C-末端肽和软骨寡聚基质蛋白在老年膝关节炎中的表达及意义[J].中国临床医生杂志,2015,43(9):58-60.
[12] KLUZEK S,BAY-JENSEN AC,JUDGE A,et al.Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis:a community-based cohort of middle-aged women[J].Biomarkers,2015,20(8):557-564.
[13] GEORGIEV T,IVANOVA M,KOPCHEV A,et al.Cartilage oligomeric protein,matrix metalloproteinase-3,and Coll2-1 as serum biomarkers in knee osteoarthritis:a cross-sectional study[J].Rheumatology International,2018,38(5):821-830.
[14] PRIYANKA V,KRISHNA D.Serum cartilage oligomeric matrix protein(COMP)in knee osteoarthritis:a novel diagnostic and prognostic biomarker[J].Journal of Orthopaedic Research,2013,31(7):999-1006.
[15] V??N?NEN T,KOSKINEN A,PAUKKERI EL,et al.YKL-40 as a novel factor associated with inflammation and catabolic mechanisms in osteoarthritic Joints[J].Mediators of Inflammation,2014:215140.
[16] GUAN J,LIU Z,LI F,et al.Increased synovial fluid YKL-40 levels are linked with symptomatic severity in knee osteoarthritis patients[J].Clinical Laboratory,2015,61(8):991-997.
[17] 苏晓恩,孔志强,朱娟,等.膝关节骨关节炎软骨中YKL-40、IL-1β的表达及相关性探讨[J].重庆医学,2017,46(4):480-482.
[18] 陈宇.血浆白细胞介素1β基因多态性与原发性膝骨关节炎的相关性[J].中国老年学杂志,2012,32(16):3425-3426.
[19] 查振刚,黄良任,姚平,等.膝骨关节炎患者血清TNF-α与IL-6水平及其临床意义[J].广东医学,2005,26(2):191-193.
[20] 俞叶军,骆幸才,毕丽娜.血清白介素-15水平与膝骨关节炎患者影像学改变程度的相关性[J].健康研究,2015,35(2):164-165.
[21] CAI L,YIN J,STAROVASNIK M,et al.,Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo[J].Cytokine,2001,16(1):10-21.
[22] 张海森,白玉明,刘畅,等.血清及滑液白介素-17水平与膝骨关节炎退变及膝痛程度的相关性研究[J].中国医药导报,2016,13(33):84-87.
[23] 任海亮,马剑雄,马信龙.膝骨关节炎时关节滑液中炎症相关物质的表达[J].中国组织工程研究,2015,19(15):2336-2340.
[24] 刘冰,高兆宾,赵亮亮.膝骨关节炎患者血清和关节滑液TWEAK水平与影像学严重程度的相关性[J].中国中医骨伤科杂志,2017,25(4):18-21.
[25] 贾成瑶,李萍.尿吡啶啉和脱氧吡啶啉是骨吸收特异性生化标志物[J].中国临床康复,2002,6(15):2256-2257.
[26] JORDAN K M,SYDDALL H E,GARNERO P,et al.Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men[J].Annals of the Rheumatic Diseases,2006,65(7):871-877.
[27] LOHMANDER L S,BRANDT K D,MAZZUCA S A,et al.Use of the plasma stromelysin(matrix metalloproteinase 3)concentration to predict joint space narrowing in knee osteoarthritis[J].Arthritis Rheum,2005,52(10):3160-3167.
[28] PEARLE A D,SCANZELLO CR,GEORGE S,et al.Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis[J].Osteoarthritis Cartilage,2007,15(5):516-523.
[29] 韩文萍.益气健脾活血通络方对膝骨关节炎患者超敏C反应蛋白的影响[J].中国中医药科技,2014,21(3):299-300.
[30] 廖伟雄,李众利,王杰,等.骨性关节炎患者关节滑液中结合珠蛋白水平与病情严重程度的相关性[J].解放军医学院学报,2013,34(8):820-822.
[31] HENROTIN Y,GHARBI M,MAZZUCCHELLI G,et al.Fibulin 3 peptides Fib3-1 and Fib3-2 are potential biomarkers of osteoarthritis[J].Arthritis & Rheumatism,2012,64(7):2260-2267.
[32] 周星彤,刘恒,孟志超,等.代表性生物标记物及MicroRNAs在骨关节炎诊断及病情评估中的意义[J].中国矫形外科杂志,2017,25(15):1409-1415.
[33] SASAKI E,TSUDA E,YAMAMOTO Y,et al.Serum hyaluronic acid concentration predicts the progression of joint space narrowing in normal knees and established knee osteoarthritis-a five-year prospective cohort study[J].Arthritis Research & Therapy,2015,17(1):283-288.
[34] SHARIF M,GEORGE E,SHEPSTONE L,et al.Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee[J].Arthritis & Rheumatology,2010,38(6):760-767.
[35] 韩煜,荆秦,李春日.湿注骨节膝骨关节炎关节液CS和KS分析及临床意义[J].辽宁中医药大学学报,2014,16(9):11-13.
[36] NAKAJIMA A,NAKAGAWA K,AOKI Y,et al.Changes in synovial fluid biochemical markers following arthroscopic surgery in patients with knee osteoarthritis[J].Rheumatology International,2013,33(1):209-214.
[37] WAKITANI S,NAWATA M,KAWAGUCHI A,et al.Serum keratan sulfate is a promising marker of early articular cartilage breakdown[J].Rheumatology,2007,46(11):1652-1656.
[38] MIYAKI S,ASAHARA H.Macro view of microRNA function in osteoarthritis[J].Nature Reviews Rheumatology,2012,8(9):543-552.
[39] KIM D,SONG J,AHN C,et al.Peroxisomal dysfunction is associated with up-regulation of apoptotic cell death via miR-223 induction in knee osteoarthritis patients with type 2 diabetes mellitus[J].Bone,2014,64(1):124-131.
[40] WAN L,ZHAO Q,NIU G,et al.Plasma miR-136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL-17[J].Experimental and Therapeutic Medicine,2018,16(4):3419-3424..
[41] 吴寒松,黄世福,孙阔,等.microRNA-25促进骨关节炎软骨细胞外蛋白多糖和Ⅱ型胶原蛋白合成作用[J].科学技术与工程,2016,16(16):143-148.
[42] 陈蓟,雷鸣,刘弼,等.MicroRNA与骨关节炎[J].中国矫形外科杂志,2017,25(19):1783-1787.