基于科学技术交叉的神经科学领域内新兴技术识别
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摘要
目的:识别神经科学新兴技术。方法:基于Web of Science数据库获取2013-2017近5年神经科学领域的ESI高被引论文,使用Lens.org构建专利-高被引论文引用映射关系,就科学技术交叉视角下探索神经科学领域内新兴技术识别。结果:基于高被引论文专利耦合分析得到22个、集合,涉及神经元活性的光遗传学探针研发、AD的特异性抗体研发、肌萎缩侧索硬化症的基因和药物治疗策略等,多数都涉及神经系统疾病的抗体靶向治疗。结论:基于科学与技术交叉模型,神经科学领域内的新兴技术可为新兴技术识别研究提供新视角,对抢占国际竞争的技术制高点具有重要意义。
Objective To identify the emerging technologies in neuroscience. Methods The ESI highly-cited papers in 2013-2017 were retrieved from Web of Science. The citation mapping relationship between patents and highly-cited papers was established using Lens.org. The identification of emerging technologies in neuroscience was studied in view of science and technology interface. Results Patent coupling analysis showed 22 sets of patents in highly-cited papers,involving the R & D of optogenetic probes for detecting neuron activity,specific antibodies to AD,gene and drug treatment of amyotrophic lateral sclerosis,and antibody-targeted therapy for nervous system diseases.Conclusion Science and technology interface model can provide reference for the identification of researches on emerging technologies in neuroscience and are of great importance in racing to control the commanding point of technologies in international competition.
Objective To identify the emerging technologies in neuroscience. Methods The ESI highly-cited papers in 2013-2017 were retrieved from Web of Science. The citation mapping relationship between patents and highly-cited papers was established using Lens.org. The identification of emerging technologies in neuroscience was studied in view of science and technology interface. Results Patent coupling analysis showed 22 sets of patents in highly-cited papers,involving the R & D of optogenetic probes for detecting neuron activity,specific antibodies to AD,gene and drug treatment of amyotrophic lateral sclerosis,and antibody-targeted therapy for nervous system diseases.Conclusion Science and technology interface model can provide reference for the identification of researches on emerging technologies in neuroscience and are of great importance in racing to control the commanding point of technologies in international competition.
引文
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[21]潘锋.中国脑计划开启临床神经科学研究新征程:访中国科学院院士、北京天坛医院赵继宗教授[J].中国医药导报,2018,15(22):1-3.
[2]Insel T R,Landis S C,Collins F S.The NIH BRAIN Initiative[J].Science,2013,340(6133):687-688.
[3]Amunts K,Ebell C,Muller J,et al.The Human Brain Project:Creating a European Research Infrastructure to Decode the Human Brain[J].Neuron,2016,92(3):574-581.
[4]Okano H,Miyawaki A,Kasai K.Brain/MINDS:brain-mapping project in Japan[J].Philosophical Transactions of the Royal Society B:Biological Sciences,2015,370(1668):20140310-20140310.
[5]OECD(2016.OECD Science,Technology and Innovation Outlook2016[EB/OL].(2016-12-08)[2018-09-21].https://doi.org/10.1787/sti_in_outlook-2016-en.
[6]National Research Council(US)Committee on Opportunities in Neuroscience for Future Army Applications.Opportunities in Neuroscience for Future Army Applications[M].Washington(DC):National Academies Press(US),2009.
[7]National Research Council(US)Committee on Military and Intelligence Methodology for Emergent Neruophysiological and Cognitive/Neural Research in the Next Two Decades.Emerging Cognitive Neuroscience and Related Technologies[M].Washington(DC):National Academies Press(US),2008.
[8]中华人民共和国科学技术部.国家中长期科学和技术发展规划纲要(2006-2020年)[EB/OL].[2018-09-23].http://www.most.gov.cn/kjgh/.
[9]中华人民共和国科学技术部.关于印发十二五生物技术发展规划的通知[EB/OL].(2011-11-14)[2018-09-23].http://www.most.gov.cn/fggw/zfwj/zfwj2011/201111/t20111128_91115.htm.
[10]国家自然科学基金委员会.国家自然科学基金“十三五”发展规划[EB/OL].[2018-09-21].http://www.nsfc.gov.cn/publish/portal0/tab405/info50064.htm.
[11]国务院.国务院关于印发“十三五”国家科技创新规划的通知[EB/OL].(2016-08-08)[2018-09-21].http://www.gov.cn/zhengce/content/2016-08/08/content_5098072.htm.
[12]邓亚玲.突破性创新与新兴技术的起源[J].现代商业,2007(17):237-238.
[13]国务院.国务院关于全面加强基础科学研究的若干意见国发[2018]4号[EB/OL].(2018-01-31)[2018-09-21].http://www.gov.cn/zhengce/content/2018-01/31/content_5262539.htm.
[14]杜建,孙轶楠,李永洁,等.从科学-技术交叉处识别创新前沿:方法与实证[EB/OL].(2018-09-03)[2018-12-03].http://kns.cnki.net/kns/ReadRedirectPage.aspx?flag=html&domain=%2fKXReader%2fDetail%3fdbcode%3dCJFQ%26filename%3dQBLL201901016.
[15]Jefferson O A,Jaffe A,Ashton D,et al.Mapping the global influence of published research on industry and innovation[J].Nature Biotechnology,2018,36:31.
[16]蒲慕明,徐波,谭铁牛.脑科学与类脑研究概述[J].中国科学院院刊,2016,31(7):725-736,714.
[17]杨雄里.中国脑计划:“一体两翼”[N].文汇报,2017-03-26(007).
[18]Boyden E S,Zhang F,Bamberg E,et al.Millisecond-timescale,genetically targeted optical control of neural activity[J].Nature Neuroscience,2005,8(9):1263-1268.
[19]PhRMA(2018).Alzheimer's Medicines:Setbacks and Stepping Stones[EB/OL].[2018-09-23].https://www.phrma.org/alzheimer-s-medicines-setbacks-and-stepping-stones.
[20]阮梅花,袁天蔚,王慧媛,等.神经科学和类脑人工智能发展:未来路径与中国布局:基于业界百位专家调研访谈[J].生命科学,2017,29(2):97-113.
[21]潘锋.中国脑计划开启临床神经科学研究新征程:访中国科学院院士、北京天坛医院赵继宗教授[J].中国医药导报,2018,15(22):1-3.