以血液学改变为主要表现的HIV/AIDS患者52例临床分析
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摘要
目的探讨HIV/AIDS患者的血液学改变特点与临床表现。方法便利选择2016年9月—2017年9月期间该院收治的HIV/AIDS患者52例为研究对象,对其临床治疗资料进行回顾性分析。结果该组的52例患者中,22例皮肤瘀点瘀斑、30例发热、1例抽搐、3例皮疹、5例头痛、4例真菌感染、4例淋巴结肿大、5例乏力、6例慢性腹泻、11例气促、心悸以及头晕;血液学改变:①血常规。52例患者中,26例血色素低于正常范围,占50.00%,其中6例为轻度贫血,占11.54%,13例为中度贫血,占25.00%,7例重度贫血,占13.46%;18例血小板减少,占34.62%,34例白细胞减少,占65.38%,其中30例合并淋巴细胞百分比减少;②骨髓细胞数目及形态。52例患者中,13例骨髓细胞活力低下,占25.00%,其余39例活跃,占72.00%;26例粒系增生活跃,占50.00%,7例欠活跃,占13.46%,6例明显活跃,占11.54%;同时,患者治疗前后的外周血T淋巴细胞和VL变化比较差异有统计学意义(P<0.05)。结论艾滋病患者往往合并免疫功能低下,其骨髓和血液学改变存在着一定的特点。
Objective To investigate the characteristics and clinical manifestations of hematological changes in HIV/AIDS patients. Methods A total of 52 HIV/AIDS patients admitted to our hospital from September 2016 to September 2017 were random selected as subjects, and their clinical treatment data were retrospectively analyzed. Results Of the 52 patients in this group, 22 had ecchymosis, 30 had fever, 1 had convulsions, 3 had rash, 5 had headache, 4 had fungal infection, 4 had lymphadenopathy, and 5 had fatigue, 6 had chronic diarrhea, 11 cases of shortness of breath, palpitations and dizziness;hematological changes: 1.blood routine. Of the 52 patients, 26 had hypoglycemia below the normal range, accounting for50.00%, of which 6 were mild anemia, accounting for 11.54%, 13 were moderate anemia, accounting for 25.00%, and 7 were severe anemia, accounting for 13.46%; 18 cases of thrombocytopenia, accounting for 34.62%, 34 cases of leukopenia,accounting for 65.38%, of which 30 cases of combined lymphocyte percentage decreased; 2.bone marrow cell number and morphology. Of the 52 patients, 13 had lower bone marrow cell viability, accounting for 25.00%, and the remaining 39 were active, accounting for 72.00%; 26 cases were active in granulocyte hyperplasia, accounting for 50.00%, 7 cases were underactive, accounting for 13.46%, and 6 cases were significantly active of 11.54%; at the same time, the difference of peripheral blood T lymphocytes and VL before and after treatment was statistically significant(P<0.05). Conclusion AIDS patients often have low immune function, and their bone marrow and hematological changes have certain characteristics.
Objective To investigate the characteristics and clinical manifestations of hematological changes in HIV/AIDS patients. Methods A total of 52 HIV/AIDS patients admitted to our hospital from September 2016 to September 2017 were random selected as subjects, and their clinical treatment data were retrospectively analyzed. Results Of the 52 patients in this group, 22 had ecchymosis, 30 had fever, 1 had convulsions, 3 had rash, 5 had headache, 4 had fungal infection, 4 had lymphadenopathy, and 5 had fatigue, 6 had chronic diarrhea, 11 cases of shortness of breath, palpitations and dizziness;hematological changes: 1.blood routine. Of the 52 patients, 26 had hypoglycemia below the normal range, accounting for50.00%, of which 6 were mild anemia, accounting for 11.54%, 13 were moderate anemia, accounting for 25.00%, and 7 were severe anemia, accounting for 13.46%; 18 cases of thrombocytopenia, accounting for 34.62%, 34 cases of leukopenia,accounting for 65.38%, of which 30 cases of combined lymphocyte percentage decreased; 2.bone marrow cell number and morphology. Of the 52 patients, 13 had lower bone marrow cell viability, accounting for 25.00%, and the remaining 39 were active, accounting for 72.00%; 26 cases were active in granulocyte hyperplasia, accounting for 50.00%, 7 cases were underactive, accounting for 13.46%, and 6 cases were significantly active of 11.54%; at the same time, the difference of peripheral blood T lymphocytes and VL before and after treatment was statistically significant(P<0.05). Conclusion AIDS patients often have low immune function, and their bone marrow and hematological changes have certain characteristics.
引文
[1]王瑞兴.艾滋病患者进行的血液学检验异常分析[J].临床医药文献电子杂志,2016,3(42):8414.
[2]张庆团,覃善芳,吕青.艾滋病患者外周血象及骨髓象的临床研究[J].中国医学创新,2017,10(14):142-143.
[3]陈祖聪,李雯.以血液学改变为主要表现的HIV/AIDS患者52例临床分析[J].中国社区医师:医学专业,2018,12(5):80.
[4]陈红英,朱小丹.12例HIV感染与艾滋病人的血液学异常[J]新疆医学,2018,39(1):26-30.
[5]Garner Bryan R,Gotham Heather J,et al.Testing the effectiveness of a motivational interviewing-based brief intervention for substance use as an adjunct to usual care in community-based AIDS service organizations:study protocol for a multisite randomized controlled trial.[J].Addiction science&clinical practice,2017,12(1):223-225.
[6]赵勤,张会芬,李丽华,等.40例艾滋病患者外周血细胞及骨髓细胞异常改变[J].实用医技杂志,2017(34):4682-4684.
[7]杨克利,张弛,沈凤.AIDS并发肺结核的血液学改变与死亡[J].中国艾滋病性病,2014(3):193-194.
[8]王时书,陈琪,林榕,等.艾滋病患者15例血液改变观察[J]实用医学杂志,2017(12):1326-1328.
[9]向海平.吴昊.汪习成.等.HIV/AIDS患者血浆病毒载量及外周血T淋巴细胞亚群的变化对病情评估的探讨[J].中华实验与临床病毒学杂志,2017,19(2):145.
[2]张庆团,覃善芳,吕青.艾滋病患者外周血象及骨髓象的临床研究[J].中国医学创新,2017,10(14):142-143.
[3]陈祖聪,李雯.以血液学改变为主要表现的HIV/AIDS患者52例临床分析[J].中国社区医师:医学专业,2018,12(5):80.
[4]陈红英,朱小丹.12例HIV感染与艾滋病人的血液学异常[J]新疆医学,2018,39(1):26-30.
[5]Garner Bryan R,Gotham Heather J,et al.Testing the effectiveness of a motivational interviewing-based brief intervention for substance use as an adjunct to usual care in community-based AIDS service organizations:study protocol for a multisite randomized controlled trial.[J].Addiction science&clinical practice,2017,12(1):223-225.
[6]赵勤,张会芬,李丽华,等.40例艾滋病患者外周血细胞及骨髓细胞异常改变[J].实用医技杂志,2017(34):4682-4684.
[7]杨克利,张弛,沈凤.AIDS并发肺结核的血液学改变与死亡[J].中国艾滋病性病,2014(3):193-194.
[8]王时书,陈琪,林榕,等.艾滋病患者15例血液改变观察[J]实用医学杂志,2017(12):1326-1328.
[9]向海平.吴昊.汪习成.等.HIV/AIDS患者血浆病毒载量及外周血T淋巴细胞亚群的变化对病情评估的探讨[J].中华实验与临床病毒学杂志,2017,19(2):145.