奥洛他定联合氟米龙与奥洛他定单独治疗过敏性结膜炎疗效比较
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摘要
目的:比较盐酸奥洛他定滴眼液联合氟米龙滴眼液与单独应用奥洛他定滴眼液治疗过敏性结膜炎的疗效。方法:收治常年性和季节性过敏性结膜炎患者200例,分为两组。试验组用盐酸奥洛他定联合氟米龙滴眼液治疗,对照组单独使用盐酸奥洛他定滴眼液治疗,对比两组的总有效率。结果:试验组治疗总有效率97%,对照组91%,组间对比差异有统计学意义(P=0.036)。结论:盐酸奥洛他定滴眼液联合氟米龙滴眼液,能较快、有效消除常年性和季节性过敏性结膜炎患者的各项临床症状和体征,效果佳,短期内未见严重不良反应。
Objective:To decide the better treatment for allergic conjunctivitis between olopatadine combined with fluoromethane versus olopatadine alone.Methods:200 patients with perennial and seasonal allergic conjunctivitis were enrolled and divided into the two groups,the case group was treated with olopatadine hydrochloride eye drops combined with fluoromethane eye drops.The control group was treated with olopatadine hydrochloride eye drops alone at the same period,the total effective rate of the two groups was compared.Results:The total effective rate of the case group(97%)was significantly higher than that of the control group(91%),the difference between the two groups was statistically significant(P=0.036).Conclusion:Olopatadine hydrochloride eye drops combined with fluorometholone eye drops can effectively eliminate the clinical symptoms and signs of perennial and seasonal allergic conjunctivitis,with good results,no serious adverse reactions in the short term.
Objective:To decide the better treatment for allergic conjunctivitis between olopatadine combined with fluoromethane versus olopatadine alone.Methods:200 patients with perennial and seasonal allergic conjunctivitis were enrolled and divided into the two groups,the case group was treated with olopatadine hydrochloride eye drops combined with fluoromethane eye drops.The control group was treated with olopatadine hydrochloride eye drops alone at the same period,the total effective rate of the two groups was compared.Results:The total effective rate of the case group(97%)was significantly higher than that of the control group(91%),the difference between the two groups was statistically significant(P=0.036).Conclusion:Olopatadine hydrochloride eye drops combined with fluorometholone eye drops can effectively eliminate the clinical symptoms and signs of perennial and seasonal allergic conjunctivitis,with good results,no serious adverse reactions in the short term.
引文
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[6]中华医学会眼科学分会角膜病学组.过敏性结膜炎诊断和治疗专家共识(2018)[J].中华眼科杂志,2018,54(6):409-414.
[7]晏晓明,孙旭光,李海丽,等.过敏性结膜炎[M].北京:人民卫生出版社,2018:78-79.
[8]王振杰.奥洛他定滴眼液联合普拉洛芬滴眼液治疗过敏性结膜炎的临床疗效[J].中国医药科学,2012,14(2):40-41.
[2]Berdy GJ,Heqvist B.Ocular allergic disorders and dry eye disease:associations,diagnosticdilemmas,andmanagement[J].Acta Ophthalmol Scandinavica,2000,230(78):32-37.
[3]Leonard IA,Castegnaro A,Valerio ALG,et al.Epidemiology of allergic conjunctivitis:clinical,appearance and treatment patterns in apopulation-based study[J].CurrOpin Allergy ClinImmunol,2015,(15):482-488.
[4]Bilkhu PS,Wolffsohn JS,Naroo SA.A review of non-pharmacological and pharmacologica management of seasonal and perennial allergic conjunctivitis[J].Cont Lens Anterior Eye,2012,35(1):9-16.
[5]李淑敏,薛秋萍.奥洛他定联合萘敏维治疗过敏性结膜炎疗效研究[J].医药论坛杂志,2012,33(9):44-45.
[6]中华医学会眼科学分会角膜病学组.过敏性结膜炎诊断和治疗专家共识(2018)[J].中华眼科杂志,2018,54(6):409-414.
[7]晏晓明,孙旭光,李海丽,等.过敏性结膜炎[M].北京:人民卫生出版社,2018:78-79.
[8]王振杰.奥洛他定滴眼液联合普拉洛芬滴眼液治疗过敏性结膜炎的临床疗效[J].中国医药科学,2012,14(2):40-41.