超宽带光源频谱域相干层析术的光谱标定方法
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摘要
基于超宽带光源频谱域相干层析术,提出一种适用于实际系统的多普勒频移标定方法。该方法先用光路模块整体运动替代传统的平面镜运动,使标定方法适用于实际情况,然后在运动中采集一系列随时间变化的光谱,最后通过傅里叶变换分析光谱分布范围。结果表明,相比于传统标定方法,所提标定方法拥有更高的精度,系统轴向分辨率提高了0.34μm,在实际生物组织成像中有更好的成像效果。
Based on spectral domain optical coherence tomography with ultra-wideband light source,one Doppler shift calibration method suitable for a practical system is proposed,in which the mirror motion in the traditional method is replaced by a moving optical-path module,thereby enabling its applications in actual situations.After acquiring a series of time-varying spectra in motion,the proposed method is used to analyze the spectral distribution range via Fourier transform.Compared with the traditional calibration method,the proposed method is more precise and the axial resolution of the system is improved by 0.34μm.Thus,this method improves the imaging effect in actual biological tissue imaging.
Based on spectral domain optical coherence tomography with ultra-wideband light source,one Doppler shift calibration method suitable for a practical system is proposed,in which the mirror motion in the traditional method is replaced by a moving optical-path module,thereby enabling its applications in actual situations.After acquiring a series of time-varying spectra in motion,the proposed method is used to analyze the spectral distribution range via Fourier transform.Compared with the traditional calibration method,the proposed method is more precise and the axial resolution of the system is improved by 0.34μm.Thus,this method improves the imaging effect in actual biological tissue imaging.
引文
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[6] Ha Usler G,Lindner M W.Coherence radar"andspectral radar"-new tools for dermatological diagnosis[J].Journal of Biomedical Optics,1998,3(1):21-31.
[7] Hu Z L, Rollins A M.Fourier domain optical coherence tomography with a linear-in-wavenumber spectrometer[J].Optics Letters,2007,32(24):3525-3527.
[8] Zhang N,Chen T Y,Wang C M,et al.Spectraldomain optical coherence tomography with a Fresnel spectrometer[J].Optics Letters,2012,37(8):1307-1309.
[9] Wang Z G,Yuan Z J,Wang H Y,et al.Increasing the imaging depth of spectral-domain OCT by using interpixel shift technique[J].Optics Express,2006,14(16):7014-7023.
[10] Ding C,Bu P,Wang X Z,et al.A new spectral calibration method for Fourier domain optical coherence tomography[J].Optik,2010,121(11):965-970.
[11] Fornaro G,Franceschetti G,Lanari R,et al.Robust phase-unwrapping techniques:a comparison[J].Journal of the Optical Society of America A,1996,13(12):2355-2366.
[12] Wang K,Ding Z H.Spectral calibration in spectral domain optical coherence tomography[J].Chinese Optics Letters,2008,6(12):902-904.
[13] Faber D J,van Leeuwen T G.Doppler calibration method for spectral domain OCT spectrometers[J].Journal of Biophotonics,2009,2(6/7):407-415.
[14] Liu L B,Gardecki J A,Nadkarni S K,et al.Imaging the subcellular structure of human coronary atherosclerosisusingmicro-opticalcoherence tomography[J].Nature Medicine,2011,17(8):1010-1014.
[15] Szkulmowski M, Tamborski S, Wojtkowski M.Wavelength to pixel calibration for FdOCT[J].Proceedings of SPIE,2015,9312:93123L.
[16] Szkulmowski M, Tamborski S, Wojtkowski M.Spectrometer calibration for spectroscopic Fourier domain optical coherence tomography[J].Biomedical Optics Express,2016,7(12):5042-5054.
[17] Leitgeb R A,Werkmeister R M,Blatter C,et al.Doppler optical coherence tomography[J].Progress in Retinal and Eye Research,2014,41(10):26-43.
[18] Szkulmowski M,Szkulmowska A,Bajraszewski T,et al.Flow velocity estimation using joint spectral and time domain optical coherence tomography[J].Optics Express,2008,16(9):6008-6025.
[19] Kim J H,Han J H,Jeong J.Accurate wavelength calibration method for spectrometer using low coherence interferometry[J].Journal of Lightwave Technology,2015,33(16):3413-3418.
[20] Makita S,Fabritius T,Yasuno Y.Full-range,highspeed,high-resolution 1 microm spectral-domain optical coherence tomography using BM-scan for volumetric imaging of the human posterior eye[J].Optics Express,2008,16(12):8406-8420.