羌归膝舒丸联合膝痛宁治疗慢性膝关节滑膜炎临床观察
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摘要
目的:观察羌归膝舒丸口服联合膝痛宁熏洗治疗风寒湿阻型膝关节滑膜炎的临床疗效。方法:将风寒湿阻型膝关节滑膜炎患者105例随机分为内服组、熏洗组及联合组各35例。内服组口服羌归膝舒丸;熏洗组应用膝痛宁熏洗;联合组口服羌归膝舒丸同时联合膝痛宁方熏洗。应用Lysholm评分及中医证候积分评价治疗效果。结果:总有效率联合组为94.12%,优于内服组的82.80%和熏洗组的85.29%,差异有统计学意义(P<0.05),熏洗组与内服组疗效相当。治疗后联合组功能评分优于熏洗组与内服组,差异有统计学意义(P<0.05)。联合组Lysholm总评分改善情况优于熏洗组与内服组,差异有统计学意义(P<0.05)。结论:羌归膝舒丸口服联合膝痛宁熏洗治疗风寒湿阻型慢性膝关节滑膜炎疗效优于单纯熏洗与内服治疗。
Objective: To observe clinical effects of oral administration of QiangGui Xi Shu pills combined with fumigation by Xi TongNing in the treatment for chronic synovitis of knee joint of wind-cold-damp blocking pattern.Methods: All 105 patients were randomized into internal administration group, fumigation group and the combination group, 35 cases each group. Internal administration group took QiangGui Xi Shu pills; fumigation group used Xi TongNing; the combination group accepted oral administration of QiangGui Xi Shu pills combined with fumigation by Xi TongNing. Therapeutic effects were assessed using Lysholm scores and TCM syndrome scores.Results: Total effective rate of the combination group was 94.12% superior to 82.80% of internal administration group and 82.29% of fumigation group, and the difference showed statistical meaning(P<0.05), fumigation group was equivalent to internal administration group in clinical effects, after treating, the combination group was superior to the fumigation group and internal administration group in functional scores after treating, and the difference showed statistical meaning(P <0.05). The combination group was superior to fumigation group and internal administration group in the improvements of Lysholm total scores, and the difference had statistical meaning(P<0.05).Conclusion: Oral administration of QiangGui Xi Shu pills combined with fumigation by Xi TongNing in the treatment for chronic synovitis of knee joint of wind-cold-damp blocking pattern are superior to fumigation group and internal administration group.
Objective: To observe clinical effects of oral administration of QiangGui Xi Shu pills combined with fumigation by Xi TongNing in the treatment for chronic synovitis of knee joint of wind-cold-damp blocking pattern.Methods: All 105 patients were randomized into internal administration group, fumigation group and the combination group, 35 cases each group. Internal administration group took QiangGui Xi Shu pills; fumigation group used Xi TongNing; the combination group accepted oral administration of QiangGui Xi Shu pills combined with fumigation by Xi TongNing. Therapeutic effects were assessed using Lysholm scores and TCM syndrome scores.Results: Total effective rate of the combination group was 94.12% superior to 82.80% of internal administration group and 82.29% of fumigation group, and the difference showed statistical meaning(P<0.05), fumigation group was equivalent to internal administration group in clinical effects, after treating, the combination group was superior to the fumigation group and internal administration group in functional scores after treating, and the difference showed statistical meaning(P <0.05). The combination group was superior to fumigation group and internal administration group in the improvements of Lysholm total scores, and the difference had statistical meaning(P<0.05).Conclusion: Oral administration of QiangGui Xi Shu pills combined with fumigation by Xi TongNing in the treatment for chronic synovitis of knee joint of wind-cold-damp blocking pattern are superior to fumigation group and internal administration group.
引文
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[15]吴一梦,高书图,刘又文,等.综合疗法治疗膝骨关节炎43例疗效观察[J].风湿病与关节炎,2014,3(11):36-38.
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[2]陈百成,王飞,孙然,等.滑膜炎颗粒治疗急、慢性膝关节滑膜炎的临床疗效观察[J].中国骨与关节外科杂志,2014,7(3):226-230.
[3]赵新杰,孙实,武爱玲.中医药治疗膝关节滑膜炎的研究进展[J].中医正骨,2015,17(8):65-66.
[4]陆小龙,黄保国,周彪,等.十味膝康颗粒治疗慢性膝关节滑膜炎的临床研究[J].湖南中医药大学学报,2015,35(11):42-44.
[5]张康乐,郭艳幸.中药外敷联合滑膜炎颗粒口服及功能锻炼对膝骨关节炎性滑膜炎临床观察[J].风湿病与关节炎,2016,5(6):18-20.
[6]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:206-207.
[7]Lysholm J,Gillquist J.Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale[J].American Journal of Sports Medicine,1982,10(3):150-154.
[8]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:349.
[9]王小鹏,谢水华.中西医结合治疗创伤性膝关节滑膜炎临床疗效观察[J].实用中西医结合临床,2012,12(4):38-40.
[10]蔡飞龙,邵强,黄秩峰.中西医结合治疗膝关节急性创伤性滑膜炎临床观察[J].中国中医急症,2015,24(10):1815-1816.
[11]高瞻鹏,乔卫平.中药热奄包外敷联合加减四妙散口服治疗膝骨关节炎性滑膜炎30例[J].中医研究,2017,30(5):25-27.
[12]郭维淮.平乐正骨[M].北京:中国中医药出版社,1996:56.
[13]韩宗昌,李无阴,王战朝,等.羌归膝舒丸联合双醋瑞因胶囊治疗膝骨关节炎50例临床观察[J].湖南中医杂志,2016,32(5):103-105.
[14]韩军涛,夏华玲,何广宏.羌归膝舒丸的质量标准研究[J].中医正骨,2005,17(10):77.
[15]吴一梦,高书图,刘又文,等.综合疗法治疗膝骨关节炎43例疗效观察[J].风湿病与关节炎,2014,3(11):36-38.
[16]高学敏.中药学[M].2版.北京:中国中医药出版社,2010:205.
[17]胡俊青,胡晓.黄柏化学成分和药理作用的现代研究[J].当代医学,2009,15(7):139-141.
[18]张冠英,董瑞娟,廉莲.川黄柏、关黄柏的化学成分及药理活性研究进展[J].沈阳药科大学学报,2012,29(10):812-821.