小儿咳喘灵颗粒联合丙酸氟替卡松治疗小儿咳嗽变异型哮喘的临床疗效观察
|
摘要
目的探讨小儿咳喘灵颗粒联合丙酸氟替卡松治疗小儿咳嗽变异型哮喘的临床疗效。方法选取2017年3月—2018年3月我院收治的84例咳嗽变异型哮喘患儿为研究对象,随机分为观察组与对照组,各42例。对照组患儿给予西医常规治疗联合丙酸氟替卡松治疗,观察组患儿在对照组的基础上给予小儿咳喘灵颗粒治疗,治疗结束后评价二组患儿临床疗效,对比治疗前后二组患儿嗜酸细胞阳离子蛋白(ECP)、嗜酸粒细胞(EOS)、白细胞介素-5 (IL-5)水平及肺功能指标变化情况,并观察二组患儿不良反应发生情况。结果观察组患儿的临床疗效显著高于对照组(P<0.05);治疗前,二组患儿ECP、EOS、IL-5水平及肺功能指标比较差异无统计学意义(P>0.05),治疗后,二组患儿的ECP、EOS、IL-5水平均较治疗前降低(P<0.05),且观察组患儿ECP、EOS、IL-5水平低于对照组(P<0.05);治疗后二组患儿FEV1、FVC及FEV1/FVC值均较治疗前明显升高,且观察组患儿的FEV1、FVC及FEV1/FVC值显著高于对照组(P<0.05)。结论小儿咳喘灵颗粒联合丙酸氟替卡松治疗小儿咳嗽变异型哮喘临床疗效显著,可有效改善患儿炎性因子水平、肺功能,安全性高,值得临床推广。
Objective To explore the clinical efficacy of Xiaoer Kechuanling Granule combined with fluticasone propionate in the treatment of children with cough variant asthma.Methods Eighty-four children with cough variant asthma admitted to Panzhihua Second People′s Hospital from March 2017 to March 2018 were selected and were randomly divided into study group and control group,42 cases in each group.The control group was treated with routine western medicine combined with fluticasone propionate,while the study group was treated with Xiaoer Kechuanling Granule on the basis of the control group.The clinical efficacy of the twogroups was evaluated after the treatment.Eosinophilic cationic protein(ECP),eosinophil(EOS) and leukocyte mediator were compared before and after the treatment.The levels of IL-5 and the changes of pulmonary function were observed,and the occurrence of adverse reactions in the two groups was also observed.Results The clinical effect of the study group was significantly higher than that of the control group(P<0.05).Before treatment,there was no statistically significant difference in ECP,EOS,IL-5 levels and pulmonary function index between the two groups(P>0.05).After treatment,the ECP,EOS,IL-5 levels of the two groups were lower than those before treatment(P<0.05),and the ECP,EOS levels of the study group were lower than those of the control group(P<0.05).The level of IL-5 was lower than that of control group(P<0.05).The values of FEV1,FVC and FEV1/FVC in the two groups were significantly higher than those before treatment,and the FEV1,FVC and FEV1/FVC in the study group were significantly higher than those of control group.Conclusion Xiaoer Kechuanling Granule combined with fluticasone propionate has significant clinical effect on treating children with cough variant asthma.It can effectively improve the level of inflammatory factors and pulmonary function of children with high safety,and is worthy of clinical promotion.
Objective To explore the clinical efficacy of Xiaoer Kechuanling Granule combined with fluticasone propionate in the treatment of children with cough variant asthma.Methods Eighty-four children with cough variant asthma admitted to Panzhihua Second People′s Hospital from March 2017 to March 2018 were selected and were randomly divided into study group and control group,42 cases in each group.The control group was treated with routine western medicine combined with fluticasone propionate,while the study group was treated with Xiaoer Kechuanling Granule on the basis of the control group.The clinical efficacy of the twogroups was evaluated after the treatment.Eosinophilic cationic protein(ECP),eosinophil(EOS) and leukocyte mediator were compared before and after the treatment.The levels of IL-5 and the changes of pulmonary function were observed,and the occurrence of adverse reactions in the two groups was also observed.Results The clinical effect of the study group was significantly higher than that of the control group(P<0.05).Before treatment,there was no statistically significant difference in ECP,EOS,IL-5 levels and pulmonary function index between the two groups(P>0.05).After treatment,the ECP,EOS,IL-5 levels of the two groups were lower than those before treatment(P<0.05),and the ECP,EOS levels of the study group were lower than those of the control group(P<0.05).The level of IL-5 was lower than that of control group(P<0.05).The values of FEV1,FVC and FEV1/FVC in the two groups were significantly higher than those before treatment,and the FEV1,FVC and FEV1/FVC in the study group were significantly higher than those of control group.Conclusion Xiaoer Kechuanling Granule combined with fluticasone propionate has significant clinical effect on treating children with cough variant asthma.It can effectively improve the level of inflammatory factors and pulmonary function of children with high safety,and is worthy of clinical promotion.
引文
[1] 余思捷,代继宏.儿童咳嗽变异性哮喘治疗进展[J].儿科药学杂志,2015,21(6):64
[2] 伍亚辉,杨晓鸥,刘翠梅,等.小儿咳嗽变异性哮喘与肺炎支原体感染相关性研究[J].中国医药导报,2013,8(21):54-56
[3] 贺务实,燕旭东,吴本清,等.孟鲁司特治疗小儿咳嗽变异性哮喘60 例疗效观察[J].中国中西医结合儿科学,2013,5 (3):235-236
[4] 吴贵员,周黎平,徐军,等.开瑞坦联合顺尔宁治疗小儿咳嗽变异性哮喘150例临床分析[J].海南医学,2013,21(4):41-42
[5] 中华医学会儿科学分会呼吸学组.儿童支气管哮喘诊断与防治指南(2016 年版)[J].中华儿科杂志,2016,54(3):167-181
[6] 国家中医药管理局.中药新药临床研究指导原则[S].南京:南京大学出版社,1994:30
[7] 吴艳.孟鲁司特钠联合麻杏石甘汤治疗小儿咳嗽变异性哮喘的疗效分析[J].海峡药学,2014,26(11):185-186
[8] 胡锦丽.养阴祛风法治疗小儿肺阴亏虚型咳嗽变异性哮喘临床疗效观察[J].世界中医药,2017,12(3):582-586
[9] 李胜红,蔡宝珍,胡汉楚,等.酮替芬联合黄芪颗粒治疗小儿咳嗽变异性哮喘的临床疗效观察[J].湖南师范大学学报(医学版),2015,12(5):101-103
[10] 黄圣荣,夏镭,何英,等.儿童咳嗽变异性哮喘发作诱因及预防[J].浙江预防医学,2014,9(6):615-617
[11] 陈建川,潘凤,余思捷,等.孟鲁司特钠联合丙酸氟替卡松治疗儿童咳嗽变异性哮喘的临床研究[J].中华全科医师杂志,2016,15(8):608-613
[12] 易小青,刘明云.孟鲁司特联合丙酸氟替卡松治疗儿童支气管哮喘合并变应性鼻炎临床疗效观察[J].中南医学科学杂志,2016,44(6):674 -676
[13] 查琳,董质冰,马井国.匹多莫德联合丙酸氟替卡松吸入治疗儿童哮喘的临床效果及对血清白细胞介素16和T淋巴细胞亚群水平的影响[J].中国医药,2018,13(1):44-47
[14] 曹俏春.小儿咳喘灵颗粒联合孟鲁司特钠治疗咳嗽变异性哮喘患儿的疗效观察[J].医疗装备,2015,7(3):250-251
[15] 曹凤.小儿咳喘灵颗粒联合氨溴索口服液治疗儿童支气管肺炎临床观察[J].新中医,2018,50(5):134-137
[16] 姚义忠,白晓红.宣肺活血法治疗小儿咳嗽变异性哮喘疗效探析[J].辽宁中医药大学学报,2012,14(7):225-226
[2] 伍亚辉,杨晓鸥,刘翠梅,等.小儿咳嗽变异性哮喘与肺炎支原体感染相关性研究[J].中国医药导报,2013,8(21):54-56
[3] 贺务实,燕旭东,吴本清,等.孟鲁司特治疗小儿咳嗽变异性哮喘60 例疗效观察[J].中国中西医结合儿科学,2013,5 (3):235-236
[4] 吴贵员,周黎平,徐军,等.开瑞坦联合顺尔宁治疗小儿咳嗽变异性哮喘150例临床分析[J].海南医学,2013,21(4):41-42
[5] 中华医学会儿科学分会呼吸学组.儿童支气管哮喘诊断与防治指南(2016 年版)[J].中华儿科杂志,2016,54(3):167-181
[6] 国家中医药管理局.中药新药临床研究指导原则[S].南京:南京大学出版社,1994:30
[7] 吴艳.孟鲁司特钠联合麻杏石甘汤治疗小儿咳嗽变异性哮喘的疗效分析[J].海峡药学,2014,26(11):185-186
[8] 胡锦丽.养阴祛风法治疗小儿肺阴亏虚型咳嗽变异性哮喘临床疗效观察[J].世界中医药,2017,12(3):582-586
[9] 李胜红,蔡宝珍,胡汉楚,等.酮替芬联合黄芪颗粒治疗小儿咳嗽变异性哮喘的临床疗效观察[J].湖南师范大学学报(医学版),2015,12(5):101-103
[10] 黄圣荣,夏镭,何英,等.儿童咳嗽变异性哮喘发作诱因及预防[J].浙江预防医学,2014,9(6):615-617
[11] 陈建川,潘凤,余思捷,等.孟鲁司特钠联合丙酸氟替卡松治疗儿童咳嗽变异性哮喘的临床研究[J].中华全科医师杂志,2016,15(8):608-613
[12] 易小青,刘明云.孟鲁司特联合丙酸氟替卡松治疗儿童支气管哮喘合并变应性鼻炎临床疗效观察[J].中南医学科学杂志,2016,44(6):674 -676
[13] 查琳,董质冰,马井国.匹多莫德联合丙酸氟替卡松吸入治疗儿童哮喘的临床效果及对血清白细胞介素16和T淋巴细胞亚群水平的影响[J].中国医药,2018,13(1):44-47
[14] 曹俏春.小儿咳喘灵颗粒联合孟鲁司特钠治疗咳嗽变异性哮喘患儿的疗效观察[J].医疗装备,2015,7(3):250-251
[15] 曹凤.小儿咳喘灵颗粒联合氨溴索口服液治疗儿童支气管肺炎临床观察[J].新中医,2018,50(5):134-137
[16] 姚义忠,白晓红.宣肺活血法治疗小儿咳嗽变异性哮喘疗效探析[J].辽宁中医药大学学报,2012,14(7):225-226