三伏三九贴止咳、祛痰、平喘作用实验研究
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摘要
目的探讨三伏三九贴对实验动物的止咳、祛痰、平喘作用。方法采用小鼠浓氨水喷雾法、大鼠毛细玻管法观察三伏三九贴的止咳、祛痰作用;采用组胺致豚鼠哮喘和卵清蛋白引发豚鼠过敏性哮喘试验观察三伏三九贴的平喘作用。结果三伏三九贴能明显延长小鼠的咳嗽潜伏期,并可减少咳嗽次数,增加大鼠痰液分泌量,延长豚鼠引喘潜伏期和哮喘潜伏期并减轻哮喘症状。结论三伏三九贴具有明显的止咳、祛痰、平喘作用。
Objective To investigate the antitussive,expectorant and anti-asthmatic effects of Sanfusanjiu Paste on the experimental animals.Methods Through concentrated ammonia water spray method in mice and capillary sputum excretion method in rats,the antitussive and expectorant effects of Sanfusanjiu Paste were observed.Through the experiments of asthma induced by histamine and allergic asthma induced by ovalbumin in guinea pigs,the asthmatic effect of Sanfusanjiu Paste was observed.Results Sanfusanjiu Paste could significantly prolong the incubation period of cough and reduce the frequency of cough in mice,increase the secretion of sputum in rats,prolong the latency of asthma induction and asthma in guinea pigs,and alleviate the symptoms of asthma.Conclusion Sanfusanjiu Paste has obvious antitussive,expectorant and anti-asthmatic effects.
Objective To investigate the antitussive,expectorant and anti-asthmatic effects of Sanfusanjiu Paste on the experimental animals.Methods Through concentrated ammonia water spray method in mice and capillary sputum excretion method in rats,the antitussive and expectorant effects of Sanfusanjiu Paste were observed.Through the experiments of asthma induced by histamine and allergic asthma induced by ovalbumin in guinea pigs,the asthmatic effect of Sanfusanjiu Paste was observed.Results Sanfusanjiu Paste could significantly prolong the incubation period of cough and reduce the frequency of cough in mice,increase the secretion of sputum in rats,prolong the latency of asthma induction and asthma in guinea pigs,and alleviate the symptoms of asthma.Conclusion Sanfusanjiu Paste has obvious antitussive,expectorant and anti-asthmatic effects.
引文
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[2]陈淑彦,司小兵,关东升,等.穴位贴敷“咳喘宁”贴膏对实验动物止咳、祛痰、平喘作用的实验研究[J].甘肃中医学院学报,2006,23(5):9-12.
[3]张玉昆,李金凤,刘涛,等.止咳平喘贴的药效学研究[J].中医药学报,2012,40(3):47-50.
[4]毕敏.镇咳平喘颗粒镇咳、祛痰作用的实验研究[J].安徽医药,2006,10(7):486-487.
[5]陈奇.中药药理研究方法学[M].第2版.北京:人民卫生出版社,2006:625-626,631-632.
[6]廖峻,曾南.咳喘灵巴布剂止咳化痰平喘药效学研究[J].成都中医药大学学报,2011,34(4):73-74.
[7]丁永芳,彭蕴茹,沈明勤,等.小儿咳喘宁颗粒对豚鼠过敏性哮喘模型的影响[J].中国中医药信息杂志,2006,13(5):40-41.
[8]徐叔云,卞如濂,陈修.药理实验方法学[M].第3版.北京:人民卫生出版社,2002:1380.
[9]李显华,宋达夫,甘雨,等.固本清肺贴膏对豚鼠过敏性哮喘模型的影响[J].实验动物科学,2010,27(1):25-26.