育龄期妇女人乳头状瘤病毒感染与宫颈柱状上皮异位的相关性分析
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摘要
目的探讨育龄期妇女人乳头状瘤病毒(HPV)感染与宫颈柱状上皮异位的相关性。方法选取200例宫颈柱状上皮异位患者为观察组,选择同期200例非宫颈柱状上皮异位育龄期妇女为对照组,两组患者均接受了13种HPV检测,以探求育龄期妇女HPV感染与宫颈柱状上皮异位的关系。结果观察组患者HPV感染率明显高于对照组患者(χ~2=4.22,P<0.05),其中观察组患者HPV感染以58亚型最为常见,对照组患者HPV感染以18亚型最为常见;III度宫颈柱状上皮异位患者HPV感染率明显高于II度宫颈柱状上皮异位与I度宫颈柱状上皮异位患者(χ~2=4.29、4.78,均P<0.05);乳突型宫颈柱状上皮异位患者HPV感染率明显高于单纯型宫颈柱状上皮异位与颗粒型宫颈柱状上皮异位患者(χ~2=4.60、4.02,均P<0.05)。结论育龄期妇女HPV感染与宫颈柱状上皮异位发生密切相关,HPV感染妇女一旦发生宫颈柱状上皮异位,经常是程度重、分型差,因此,HPV感染的检测对宫颈柱状上皮异位的预防与治疗具有重要的临床价值。
Objective To discuss the correlation of human papilloma virus(HPV) infection and cervical ectopic columnar epithelium in women of child-bearing age. Methods 200 patients with cervical ectopic columnar epithelium were selected as observation group, and 200 women without cervical ectopic columnar epithelium at the same time were selected as control group. All the women in the two groups received the detection of13 kinds of HPV to study the relation between HPV infection and cervical ectopic columnar epithelium of women of child-bearing age. Results The HPV infection rate of women in the observation group was much higher than that in control group(χ~2=4.22, P<0.05), where 58-subtype of HPV infection was the most common in observation group and 18-subtype of HPV infection was the most common in control group. The HPV infection rate of patients with III-cervical ectopic columnar epithelium was much higher than those of patients with II and I-cervical ectopic columnar epithelium(χ~2=4.29 and 4.78, all P<0.05). The HPV infection rate of patients with mastoid-type cervical ectopic columnar epithelium was much higher than those of patients with simple-type and granular-type cervical ectopic columnar epithelium(χ~2=4.60 and 4.02, all P<0.05). Conclusions The HPV infection of women of child-bearing age has close relation with the occurrence of cervical ectopic columnar epithelium, and once cervical ectopic columnar epithelium occurs on women with HPV infection, the outcomes are serious with bad types. Therefore, the detection of HPV infection has significant clinical value on the prevention and medical treatment of cervical ectopic columnar epithelium.
Objective To discuss the correlation of human papilloma virus(HPV) infection and cervical ectopic columnar epithelium in women of child-bearing age. Methods 200 patients with cervical ectopic columnar epithelium were selected as observation group, and 200 women without cervical ectopic columnar epithelium at the same time were selected as control group. All the women in the two groups received the detection of13 kinds of HPV to study the relation between HPV infection and cervical ectopic columnar epithelium of women of child-bearing age. Results The HPV infection rate of women in the observation group was much higher than that in control group(χ~2=4.22, P<0.05), where 58-subtype of HPV infection was the most common in observation group and 18-subtype of HPV infection was the most common in control group. The HPV infection rate of patients with III-cervical ectopic columnar epithelium was much higher than those of patients with II and I-cervical ectopic columnar epithelium(χ~2=4.29 and 4.78, all P<0.05). The HPV infection rate of patients with mastoid-type cervical ectopic columnar epithelium was much higher than those of patients with simple-type and granular-type cervical ectopic columnar epithelium(χ~2=4.60 and 4.02, all P<0.05). Conclusions The HPV infection of women of child-bearing age has close relation with the occurrence of cervical ectopic columnar epithelium, and once cervical ectopic columnar epithelium occurs on women with HPV infection, the outcomes are serious with bad types. Therefore, the detection of HPV infection has significant clinical value on the prevention and medical treatment of cervical ectopic columnar epithelium.
引文
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[14] 潘凤华,何融泉,韦康来,等.人乳头状病毒E6蛋白与宫颈癌关系的研究进展[J].医学研究生学报,2014,27(11):1229-1232.
[15] 罗平.2010～2013年恩施市事业单位女性职工妇女病体检调查[J].中国妇幼保健,2014,29(33):5466-5467.
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[2] 揭伟霞,薛武进,史志华,等.宫颈上皮内瘤变与宫颈癌患者人乳头状瘤病毒感染的临床分析[J].中华医院感染学杂志,2016,26(6):1380-1381.
[3] Cerda AA,Garcia LY,Gaete FL,et al.Willingness to pay for human papillomavirus vaccine in metropolitan Santiago,Chile[J].Rev Med Chil,2013,141(2):167-172.
[4] 乐杰.妇产科学[M].6版.北京:人民卫生出版社,2003:264-265.
[5] Clad A,Reuschenbach M,Weinschenk J,et al.Performance of the APTIMA high-risk HPV mRNA assay in a referral population in comparison with hybrid capture 2 and cytology[J].Journal of Clinical MicroBiology,2010,49(3):1071-1076.
[6] Rijkaart DC,Coupe VM,Van Kemenade FJ,et al.Comparison of hybrid capture 2 testing at different thresholds with cytology as primary cervical screening test[J].Br J Cancer,2010,103(7):939-946.
[7] 王翔,徐彬,黄筱泓,等.女性型工作者宫颈人乳头状瘤病毒感染特征分析[J].中华临床感染病杂志,2012,5(5):295-297.
[8] 袁飞燕,邱建国,李丽娟,等.保妇康栓治疗宫颈高危型人乳头状病毒感染的疗效观察[J].江西医药,2016,51(3):209-211.
[9] 郭彦蓉,赵广超,李文华,等.人乳头状病毒感染对宫颈局部免疫功能的影响分析[J].中华医院感染学杂志,2014,24(13):3333-3337.
[10] Le Boeuf F,Niknejad N,Wang J,et al.Sensivity of cervical carcinoma cells to vesicular stomatitis virus-induced oncolysis:Potential role of human papilloma virus infection[J].Int J Cancer,2012,131(3):E204-E215.
[11] 郑海燕,马群,张惠.不同亚型人乳头状瘤病毒感染与复发率的研究分析[J].中华医院感染学杂志,2013,23(16):3976-3978.
[12] 魏睿,张振中,程腾,等.37384例妇女宫颈人乳头状瘤病毒感染状况研究[J].中国妇幼保健,2014,29 (24):3885-3888.
[13] 梁海虹,徐旦,吴美飞.2333例35-59岁已婚妇女宫颈疾病分析[J].中国妇幼健康研究,2015,26(2):335-341.
[14] 潘凤华,何融泉,韦康来,等.人乳头状病毒E6蛋白与宫颈癌关系的研究进展[J].医学研究生学报,2014,27(11):1229-1232.
[15] 罗平.2010～2013年恩施市事业单位女性职工妇女病体检调查[J].中国妇幼保健,2014,29(33):5466-5467.
[16] 王云云,龚毅红,苏韵华,等.2011年南通市区妇女病普查结果分析[J].中国妇幼保健,2013,28(2):210-213.
[17] 吴如英.宫颈磨烂患者人乳头状瘤病毒感染状况分析[J].中华医院感染学杂志,2012,22(5):1083-1084.
[18] Gopal Rao G,Jeanes A,Russell H.Effectiveness of short-term,enhaced,infection control support in improving compliance with infection control guidelines and practice in nursing homes:A cluster randomized trial[J].Eidemiology and Infection,2009,137(10):1120-1126.