驴胶补血颗粒升高白细胞作用及机制研究进展
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摘要
白细胞减少症是临床常见疾病,发病原因具有多样化,最常见为药物引起,且以抗肿瘤药物引起的白细胞减少症最为广泛。对于白细胞减少症的治疗,中药能够从多角度、多层面、多靶点发挥综合调控能力。驴胶补血颗粒作为补血益气中药,具有疗效好、使用方便,易被患者接受等特点,临床已有报道其在升高白细胞方面的应用。对驴胶补血颗粒全方、药对及单味药的升高白细胞的作用及机制进行综述,为扩大该药物的临床适应症及合理使用提供参考依据。
Leukopenia is a common clinical disease with diverse pathogenesis. Leukopenia is mostly caused by drugs, especially anti-tumor drugs. For the treatment of leukopenia, Chinese materia medica can play an ability of comprehensive adjusting control from multi-angle, multi-dimension, and multi-target. As a good Chinese medicine for tonifying blood and replenishing qi, Lvjiao Buxue Granules has the advantages of high curative effect, convenient to use, and easy to be accepted by patients. It has been reported in clinical application for elevating leukocytes. This present review will focus on the research progress on the elevating leukocytes effects and mechanisms of Lvjiao Buxue Granules based on complicated Chinese herbal formula, herb-pair, and single herb, so as to provide a reference for expanding the clinical indications and rational use of the drug.
Leukopenia is a common clinical disease with diverse pathogenesis. Leukopenia is mostly caused by drugs, especially anti-tumor drugs. For the treatment of leukopenia, Chinese materia medica can play an ability of comprehensive adjusting control from multi-angle, multi-dimension, and multi-target. As a good Chinese medicine for tonifying blood and replenishing qi, Lvjiao Buxue Granules has the advantages of high curative effect, convenient to use, and easy to be accepted by patients. It has been reported in clinical application for elevating leukocytes. This present review will focus on the research progress on the elevating leukocytes effects and mechanisms of Lvjiao Buxue Granules based on complicated Chinese herbal formula, herb-pair, and single herb, so as to provide a reference for expanding the clinical indications and rational use of the drug.
引文
[1]Ing V W.The etiology and management of leukopenia[J].Can Fam Physician,1984,30(9):1835-1839.
[2]Dai J,Lu Y,Yu C,et al.Reversal of chemotherapyinduced leukopenia using GM-CSF promotes bone metastasis that can be blocked with osteoclast inhibitors[J].Cancer Res,2010,70(12):5014-5023.
[3]刘彩春,刘欢,谷陟欣,等.基于1H-NMR代谢组学的驴胶补血颗粒补血作用机制研究[J].中草药,2016,47(7):1142-1148.
[4]Green D E,Rubin C T.Consequences of irradiation on bone and marrow phenotypes,and its relation to disruption of hematopoietic precursors[J].Bone,2014,63(6):87-94.
[5]Dwivedi P,Greis K D.Granulocyte colony stimulating factor receptor(G-CSFR)signaling in severe congenital neutropenia,chronic neutrophilic leukemia and related malignancies[J].Exp Hematol,2017,46(3):9-20.
[6]Nayak R C,Trump L R,Aronow B J,et al.Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells[J].J Clin Invest,2015,125(8):3103-3116.
[7]Morishima T,Watanabe K,Niwa A,et al.Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis[J].Haematologica,2014,99(1):19-27.
[8]Grayson P C,Sloan J M,Niles J L,et al.Antineutrophil cytoplasmic antibodies,autoimmune neutropenia,and vasculitis[J].Semin Arthritis Rheu,2011,41(3):424-433.
[9]Newburger P E.Autoimmune and other acquired neutropenias[J].Hematol-Am Soc Hemat,2016,2016(1):38-42.
[10]Ciufu C,Arama V,Bumbea H,et al.Correlations of hematological parameters with bone marrow findings in chronic lymphoproliferative disorders associated with hepatitis viruses[J].J Med Life,2013,6(4):464-471.
[11]李妤蓉,张文菊,程瑞彩,等.细菌感染兔发热时相白细胞计数、中性粒细胞及其直径的变化[J].中国老年学杂志,2015,35(13):3540-3542.
[12]何小燕,颜磊,徐向平,等.驴胶补血颗粒对环磷酰胺致小鼠白细胞减少症的作用及代谢组学机制研究[J].中草药,2018,49(10):2282-2290.
[13]彭宇.两种不同工艺的驴胶补血冲剂改善动物血虚的实验对比研究[D].长沙:湖南中医药大学,2007.
[14]颜磊,何小燕,高耀,等.基于网络药理学的驴胶补血颗粒升高白细胞作用机制研究[J].药学学报,2018,53(10):1660-1669.
[15]曾渊华.驴胶补血冲剂治疗白细胞减少症70例临床观察[J].湖南中医杂志,1996(6):15-16.
[16]易凡.驴胶补血冲剂治疗176例恶性肿瘤放疗所致白细胞减少及消化道症状的临床观察[J].湖南中医杂志,1996(6):17-18.
[17]孙大威,谢华,孙操.黄芪和当归不同配伍提取物对造模小鼠白细胞的影响[J].黑龙江医药,2010,23(2):199-200.
[18]史旭芹,尚尔鑫,唐于平,等.基于响应曲面分析法对当归-黄芪配伍养血补血功效相互作用研究[J].药学学报,2012,47(10):1375-1383.
[19]蒋立峰,刘怀民.当归补血汤防治肿瘤化疗后骨髓抑制临床观察[J].中医学报,2013,28(4):475-477.
[20]龚晓丽,杨炀,陈娇娇,等.归芪升血颗粒升高白细胞作用的实验研究[J].中药药理与临床,2017,33(3):149-151.
[21]丁荣楣,王平,马丽君,等.芪胶升白胶囊对肺癌放疗患者白细胞减少的疗效及生存质量的影响[J].现代肿瘤医学,2016,24(3):400-403.
[22]邓波,易峰涛.参芪十一味颗粒联合同步放疗治疗鼻咽癌的临床研究[J].中医药导报,2017,23(20):33-35.
[23]刘安琪,毕红霞.八珍汤加减对肺癌化疗所致白细胞减少疗效及血清IL-2变化的临床研究[J].内蒙古中医药,2015,34(5):49-50.
[24]贾磊,张跃强.八珍汤加减对肺癌化疗后骨髓抑制的影响[J].北方药学,2018,15(1):53.
[25]王正引,郭明章,全世建.四物汤对血虚证小鼠肝细胞凋亡以及凋亡相关基因表达的影响[J].中华中医药杂志,2015,30(6):2219-2222.
[26]Tian J S,Zhang X,Liu H,et al.The hematinic effect of Colla Corii Asini(Ejiao)using 1H-NMR metabolomics coupled with correlation analysis in APH-induced anemic rats[J].RSC Adv,2017,7(15):8952-8962.
[27]应军,肖百全,杨威,等.鸡血藤与阿胶升白细胞作用的比较研究[J].中药新药与临床药理,2011,22(2):175-177.
[28]庞萌萌,李敏,田晨颖,等.阿胶酶解液相对分子质量分布及其补血升白作用[J].中国实验方剂学杂志,2017,23(12):13-17.
[29]王二兵,郝津芳,刘锐玲,等.基于代谢组学技术的黄芪根与地上部分醋酸乙酯部位的药效比较[J].中草药,2018,49(10):2240-2247.
[30]曲婷丽,王二兵,李震宇,等.黄芪注射液乙酸乙酯萃取物对小鼠白细胞减少症作用的代谢组学[J].中成药,2017,39(3):455-461.
[31]严辉,段金廒,尚尔鑫,等.当归不同部位入药功效取向差异的化学物质基础与药性关联性研究[J].中草药,2014,45(21):3208-3212.
[32]卢志伟,王磊,许小敏,等.当归及当归多糖对X射线照射致SD大鼠免疫功能损伤的影响[J].中国中医药信息杂志,2017,24(10):44-48.
[33]Xiao H,Xiong L,Song X,et al.Angelica sinensis polysaccharides ameliorate stress-induced premature senescence of hematopoietic cell via protecting bone marrow stromal cells from oxidative injuries caused by5-fluorouracil[J].Int J Mol Sci,2017,18(11):2265-2286.
[34]赵晓梅.分析补益药党参的药理和临床应用[J].中国实用医药,2016,11(32):135-136.
[35]丁采苒.白术及其提取物免疫调节功能和机制研究[D].郑州:河南大学,2016.
[36]冯雪梅,吕艳,祝彼得,等.熟地和制首乌多糖对贫血小鼠骨髓有核细胞数和细胞周期的影响[J].四川中医,2006(6):17-19.
[2]Dai J,Lu Y,Yu C,et al.Reversal of chemotherapyinduced leukopenia using GM-CSF promotes bone metastasis that can be blocked with osteoclast inhibitors[J].Cancer Res,2010,70(12):5014-5023.
[3]刘彩春,刘欢,谷陟欣,等.基于1H-NMR代谢组学的驴胶补血颗粒补血作用机制研究[J].中草药,2016,47(7):1142-1148.
[4]Green D E,Rubin C T.Consequences of irradiation on bone and marrow phenotypes,and its relation to disruption of hematopoietic precursors[J].Bone,2014,63(6):87-94.
[5]Dwivedi P,Greis K D.Granulocyte colony stimulating factor receptor(G-CSFR)signaling in severe congenital neutropenia,chronic neutrophilic leukemia and related malignancies[J].Exp Hematol,2017,46(3):9-20.
[6]Nayak R C,Trump L R,Aronow B J,et al.Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells[J].J Clin Invest,2015,125(8):3103-3116.
[7]Morishima T,Watanabe K,Niwa A,et al.Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis[J].Haematologica,2014,99(1):19-27.
[8]Grayson P C,Sloan J M,Niles J L,et al.Antineutrophil cytoplasmic antibodies,autoimmune neutropenia,and vasculitis[J].Semin Arthritis Rheu,2011,41(3):424-433.
[9]Newburger P E.Autoimmune and other acquired neutropenias[J].Hematol-Am Soc Hemat,2016,2016(1):38-42.
[10]Ciufu C,Arama V,Bumbea H,et al.Correlations of hematological parameters with bone marrow findings in chronic lymphoproliferative disorders associated with hepatitis viruses[J].J Med Life,2013,6(4):464-471.
[11]李妤蓉,张文菊,程瑞彩,等.细菌感染兔发热时相白细胞计数、中性粒细胞及其直径的变化[J].中国老年学杂志,2015,35(13):3540-3542.
[12]何小燕,颜磊,徐向平,等.驴胶补血颗粒对环磷酰胺致小鼠白细胞减少症的作用及代谢组学机制研究[J].中草药,2018,49(10):2282-2290.
[13]彭宇.两种不同工艺的驴胶补血冲剂改善动物血虚的实验对比研究[D].长沙:湖南中医药大学,2007.
[14]颜磊,何小燕,高耀,等.基于网络药理学的驴胶补血颗粒升高白细胞作用机制研究[J].药学学报,2018,53(10):1660-1669.
[15]曾渊华.驴胶补血冲剂治疗白细胞减少症70例临床观察[J].湖南中医杂志,1996(6):15-16.
[16]易凡.驴胶补血冲剂治疗176例恶性肿瘤放疗所致白细胞减少及消化道症状的临床观察[J].湖南中医杂志,1996(6):17-18.
[17]孙大威,谢华,孙操.黄芪和当归不同配伍提取物对造模小鼠白细胞的影响[J].黑龙江医药,2010,23(2):199-200.
[18]史旭芹,尚尔鑫,唐于平,等.基于响应曲面分析法对当归-黄芪配伍养血补血功效相互作用研究[J].药学学报,2012,47(10):1375-1383.
[19]蒋立峰,刘怀民.当归补血汤防治肿瘤化疗后骨髓抑制临床观察[J].中医学报,2013,28(4):475-477.
[20]龚晓丽,杨炀,陈娇娇,等.归芪升血颗粒升高白细胞作用的实验研究[J].中药药理与临床,2017,33(3):149-151.
[21]丁荣楣,王平,马丽君,等.芪胶升白胶囊对肺癌放疗患者白细胞减少的疗效及生存质量的影响[J].现代肿瘤医学,2016,24(3):400-403.
[22]邓波,易峰涛.参芪十一味颗粒联合同步放疗治疗鼻咽癌的临床研究[J].中医药导报,2017,23(20):33-35.
[23]刘安琪,毕红霞.八珍汤加减对肺癌化疗所致白细胞减少疗效及血清IL-2变化的临床研究[J].内蒙古中医药,2015,34(5):49-50.
[24]贾磊,张跃强.八珍汤加减对肺癌化疗后骨髓抑制的影响[J].北方药学,2018,15(1):53.
[25]王正引,郭明章,全世建.四物汤对血虚证小鼠肝细胞凋亡以及凋亡相关基因表达的影响[J].中华中医药杂志,2015,30(6):2219-2222.
[26]Tian J S,Zhang X,Liu H,et al.The hematinic effect of Colla Corii Asini(Ejiao)using 1H-NMR metabolomics coupled with correlation analysis in APH-induced anemic rats[J].RSC Adv,2017,7(15):8952-8962.
[27]应军,肖百全,杨威,等.鸡血藤与阿胶升白细胞作用的比较研究[J].中药新药与临床药理,2011,22(2):175-177.
[28]庞萌萌,李敏,田晨颖,等.阿胶酶解液相对分子质量分布及其补血升白作用[J].中国实验方剂学杂志,2017,23(12):13-17.
[29]王二兵,郝津芳,刘锐玲,等.基于代谢组学技术的黄芪根与地上部分醋酸乙酯部位的药效比较[J].中草药,2018,49(10):2240-2247.
[30]曲婷丽,王二兵,李震宇,等.黄芪注射液乙酸乙酯萃取物对小鼠白细胞减少症作用的代谢组学[J].中成药,2017,39(3):455-461.
[31]严辉,段金廒,尚尔鑫,等.当归不同部位入药功效取向差异的化学物质基础与药性关联性研究[J].中草药,2014,45(21):3208-3212.
[32]卢志伟,王磊,许小敏,等.当归及当归多糖对X射线照射致SD大鼠免疫功能损伤的影响[J].中国中医药信息杂志,2017,24(10):44-48.
[33]Xiao H,Xiong L,Song X,et al.Angelica sinensis polysaccharides ameliorate stress-induced premature senescence of hematopoietic cell via protecting bone marrow stromal cells from oxidative injuries caused by5-fluorouracil[J].Int J Mol Sci,2017,18(11):2265-2286.
[34]赵晓梅.分析补益药党参的药理和临床应用[J].中国实用医药,2016,11(32):135-136.
[35]丁采苒.白术及其提取物免疫调节功能和机制研究[D].郑州:河南大学,2016.
[36]冯雪梅,吕艳,祝彼得,等.熟地和制首乌多糖对贫血小鼠骨髓有核细胞数和细胞周期的影响[J].四川中医,2006(6):17-19.