罗库溴铵与维库溴铵在胃癌患者全麻气管插管期间的药效对比
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摘要
目的观察并比较罗库溴铵和维库溴铵在胃癌患者全麻气管插管期间的药效。方法选取全麻下行胃癌根治术患者98例,随机分为罗库溴铵组和维库溴铵组,各49例。比较两组气管插管状态,肌松药起效时间、作用时间和恢复指数,比较两组不良反应的发生情况。结果全麻诱导后,罗库溴铵组气管插管状态优良率(100.00%)显著高于维库溴铵组(81.63%)(P<0.05)。罗库溴铵组肌松效应的平均起效时间显著短于维库溴铵组(P<0.05),而两组临床作用时间、恢复指数无显著差异(P>0.05)。两组术中术后均未出现严重的不良反应。罗库溴铵组不良反应的发生率显著低于维库溴铵组(P<0.05)。结论与维库溴铵相比,罗库溴铵起效快,不良反应发生少,是快速气管插管期间肌松药的理想选择。
Objective To observe and compare the efficacy of rocuronium and vecuronium in the general anesthesia tracheal intubation in patients with gastric cancer. Methods Selected 98 patients with gastric cancer during endotracheal intubation. All patients were randomly divided into rocuronium group and vecuronium group,each group of 49 cases. Tracheal intubation state,muscle relaxant onset time,recovery index and the incidence of adverse reactions were compared between the 2 groups. Results The excellent rate of tracheal intubation in rocuronium group was significantly higher than that of vecuronium group( 81. 63%)( P < 0. 05) after induction of general anesthesia. The mean onset time of muscle relaxation was significantly lower in rocuronium group than vecuronium group( P < 0. 05). There was no significant difference between the 2 groups in clinical time and recovery index( P > 0. 05). There were no serious adverse reactions after operation in both groups. The incidence of adverse reactions was significantly lower in the rocuronium group than in vecuronium( P < 0. 05). Conclusion Rocuronium is quicker in onset without side effects,and it is ideal choice of relaxants for endotracheal intubation.
Objective To observe and compare the efficacy of rocuronium and vecuronium in the general anesthesia tracheal intubation in patients with gastric cancer. Methods Selected 98 patients with gastric cancer during endotracheal intubation. All patients were randomly divided into rocuronium group and vecuronium group,each group of 49 cases. Tracheal intubation state,muscle relaxant onset time,recovery index and the incidence of adverse reactions were compared between the 2 groups. Results The excellent rate of tracheal intubation in rocuronium group was significantly higher than that of vecuronium group( 81. 63%)( P < 0. 05) after induction of general anesthesia. The mean onset time of muscle relaxation was significantly lower in rocuronium group than vecuronium group( P < 0. 05). There was no significant difference between the 2 groups in clinical time and recovery index( P > 0. 05). There were no serious adverse reactions after operation in both groups. The incidence of adverse reactions was significantly lower in the rocuronium group than in vecuronium( P < 0. 05). Conclusion Rocuronium is quicker in onset without side effects,and it is ideal choice of relaxants for endotracheal intubation.
引文
[1]李鑫,宣燕,王江,等.非去极化肌松药对琥珀胆碱术后肌痛预防效果的系统评价[J].中国循证医学杂志,2015,15(1):62-68.
[2]来伟,丁国友,帅君,等.表面麻醉下无肌松药气管插管在会厌声带手术麻醉中的应用[J].东南国防医药,2015,17(5):474-477.
[3]蒋丰智,刘伟东,邓皓辉.肌松药在PICU诱导快速顺序气管插管中的应用[J].儿科药学杂志,2017,23(7):29-31.
[4]周加倩,陈锡明,徐辉.不同剂量新斯的明拮抗小儿罗库溴铵和维库溴铵的轻度残余肌松效应的比较[J].实用医学杂志,2015,31(24):4123-4126.
[5]Ji HL,Kim Y,Lee KH,et al.The effects of nicardipine or esmolol on the onset time of rocuronium and intubation conditions during rapid sequence induction:a randomized double-blind trial[J].J Anesth,2015,29(3):403-408.
[6]戴体俊.麻醉药理学的研究进展及发展前景[J].中国药理学与毒理学杂志,2015,29(5):716-719.
[7]陈岱莉,黄绍农,王亮,等.罗库溴铵应用于产科全麻快速诱导气管插管最佳剂量的研究[J].实用医院临床杂志,2015,12(4):24-27.
[8]竺凌,闻俊,周婷婷,等.琥珀胆碱的体内过程及其法医毒物分析研究[J].药物分析杂志,2015,16(5):849-855.
[9]徐振东,高蕾,李名伟,等.琥珀胆碱导致术后肌痛发生的危险因素[J].中华麻醉学杂志,2015,35(6):660-662.
[10]林宇龙,柯剑娟,姚帆,等.肝功能障碍患者对罗库溴铵药效动力学的影响[J].现代生物医学进展,2016,16(18):3469-3472.
[11]张静,刘鹏飞,胡晓云,等.淋巴水肿患者全身麻醉诱导期按不同体质量使用罗库溴铵的药效动力学比较[J].检验医学与临床,2016,13(2):169-171.
[12]Harvey A,Anderson L,Broome IJ.A comparison of the effect of rocuronium and vecuronium on heart rate during gynaecological laparoscopy[J].Anaesthesia,2015,54(12):1212-1216.
[13]Dobson AP,Mccluskey A,Meakin G,et al.Effective time to satisfactory intubating conditions after administration of rocuronium in adults comparison of propofol and thiopentone for RSI of anaesthesia[J].Anaesthesia,2015,54(2):172-176.
[14]郑永超,黄燕,姜虹.右美托咪定对老年高血压患者全麻诱导气管插管应激反应的影响[J].重庆医学,2016,45(9):1220-1222.
[15]朱敦.罗库溴铵与维库溴铵在全麻诱导期抑制咳嗽反应的效果比较[J].河北医学,2016,22(5):745-747.
[2]来伟,丁国友,帅君,等.表面麻醉下无肌松药气管插管在会厌声带手术麻醉中的应用[J].东南国防医药,2015,17(5):474-477.
[3]蒋丰智,刘伟东,邓皓辉.肌松药在PICU诱导快速顺序气管插管中的应用[J].儿科药学杂志,2017,23(7):29-31.
[4]周加倩,陈锡明,徐辉.不同剂量新斯的明拮抗小儿罗库溴铵和维库溴铵的轻度残余肌松效应的比较[J].实用医学杂志,2015,31(24):4123-4126.
[5]Ji HL,Kim Y,Lee KH,et al.The effects of nicardipine or esmolol on the onset time of rocuronium and intubation conditions during rapid sequence induction:a randomized double-blind trial[J].J Anesth,2015,29(3):403-408.
[6]戴体俊.麻醉药理学的研究进展及发展前景[J].中国药理学与毒理学杂志,2015,29(5):716-719.
[7]陈岱莉,黄绍农,王亮,等.罗库溴铵应用于产科全麻快速诱导气管插管最佳剂量的研究[J].实用医院临床杂志,2015,12(4):24-27.
[8]竺凌,闻俊,周婷婷,等.琥珀胆碱的体内过程及其法医毒物分析研究[J].药物分析杂志,2015,16(5):849-855.
[9]徐振东,高蕾,李名伟,等.琥珀胆碱导致术后肌痛发生的危险因素[J].中华麻醉学杂志,2015,35(6):660-662.
[10]林宇龙,柯剑娟,姚帆,等.肝功能障碍患者对罗库溴铵药效动力学的影响[J].现代生物医学进展,2016,16(18):3469-3472.
[11]张静,刘鹏飞,胡晓云,等.淋巴水肿患者全身麻醉诱导期按不同体质量使用罗库溴铵的药效动力学比较[J].检验医学与临床,2016,13(2):169-171.
[12]Harvey A,Anderson L,Broome IJ.A comparison of the effect of rocuronium and vecuronium on heart rate during gynaecological laparoscopy[J].Anaesthesia,2015,54(12):1212-1216.
[13]Dobson AP,Mccluskey A,Meakin G,et al.Effective time to satisfactory intubating conditions after administration of rocuronium in adults comparison of propofol and thiopentone for RSI of anaesthesia[J].Anaesthesia,2015,54(2):172-176.
[14]郑永超,黄燕,姜虹.右美托咪定对老年高血压患者全麻诱导气管插管应激反应的影响[J].重庆医学,2016,45(9):1220-1222.
[15]朱敦.罗库溴铵与维库溴铵在全麻诱导期抑制咳嗽反应的效果比较[J].河北医学,2016,22(5):745-747.