百令胶囊联合二甲双胍治疗对多囊卵巢综合征患者代谢指标及性激素的影响
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摘要
目的:探讨百令胶囊联合二甲双胍治疗对多囊卵巢综合征患者代谢指标及性激素的影响。方法:将多囊卵巢综合征患者107例按随机双盲法分为联合组55例与对照组52例,2组均接受炔雌醇环丙孕酮治疗,对照组加用二甲双胍治疗,联合组同时予百令胶囊联合二甲双胍治疗,连续治疗3个月后检测2组患者脂代谢指标含量变化及性激素水平变化,并对比其临床疗效。结果:治疗后,2组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)含量较治疗前显著改善(P <0.05),且联合组TG、TC、LDL-C、HDL-C含量改善幅度显著大于对照组(P <0.05)。治疗后,2组睾酮(T)、雌二醇(E_2)、黄体生成素(LH)、卵泡刺激素(FSH)水平较治疗前降低,差异有统计学意义(P <0.05),联合组E_2水平降低幅度与对照组比较,差异无统计学意义(P> 0.05),联合组T、LH、FSH水平降低幅度大于对照组(P <0.05)。结论:百令胶囊联合二甲双胍治疗多囊卵巢综合征有利于有效调节改善其脂代谢指标含量和性激素水平,提高临床疗效。
Objective:To explore the effect of Bailing capsules combined with metformin on metabolism indexes and sex hormone of polycystic ovary syndrome. Methods:Divided 107 cases of patients with polycystic ovary syndrome into the combination group and the control group by randomized double blind method,55 cases in the combination group and 52 cases in the control group.The two groups were treated with ethinylestradiol and cyproterone acetate tablets. The control group was additionally received metformin for treatment, while the combination group was additionally received Bailing capsules combined with metformin. After three months of continuous treatment, detected the changes in contents of lipid metabolism indexes and level of sex hormone in the two groups and compared the clinical effect. Results: After treatment, contents of triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) in the two groups were significantly improved when compared with those before treatment,the difference being significant(P < 0.05),and the contents of TG,TC,LDL-C and HDL-C in the combination group was significantly improved than that in the control group,the difference being significant(P < 0.05). After treatment, levels of testosterone(T), estradiol(E_2), luteinizing hormone(LH) and follicle-stimulating hormone(FSH) in the two groups were significantly decreased when compared with those before treatment,the difference being significant(P < 0.05). Compared the decrease of level of E_2 between the two groups, there was no significance in the difference(P > 0.05). The decrease of levels of T, LH and FSH in the combination group was significantly greater than that in the control group(P < 0.05). Conclusion: The therapy of Bailing capsules combined with metformin for polycystic ovary syndrome can effectively regulate and improve the contents of lipid metabolism indexes and level of sex hormone as well as improve the clinical effect.
Objective:To explore the effect of Bailing capsules combined with metformin on metabolism indexes and sex hormone of polycystic ovary syndrome. Methods:Divided 107 cases of patients with polycystic ovary syndrome into the combination group and the control group by randomized double blind method,55 cases in the combination group and 52 cases in the control group.The two groups were treated with ethinylestradiol and cyproterone acetate tablets. The control group was additionally received metformin for treatment, while the combination group was additionally received Bailing capsules combined with metformin. After three months of continuous treatment, detected the changes in contents of lipid metabolism indexes and level of sex hormone in the two groups and compared the clinical effect. Results: After treatment, contents of triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) in the two groups were significantly improved when compared with those before treatment,the difference being significant(P < 0.05),and the contents of TG,TC,LDL-C and HDL-C in the combination group was significantly improved than that in the control group,the difference being significant(P < 0.05). After treatment, levels of testosterone(T), estradiol(E_2), luteinizing hormone(LH) and follicle-stimulating hormone(FSH) in the two groups were significantly decreased when compared with those before treatment,the difference being significant(P < 0.05). Compared the decrease of level of E_2 between the two groups, there was no significance in the difference(P > 0.05). The decrease of levels of T, LH and FSH in the combination group was significantly greater than that in the control group(P < 0.05). Conclusion: The therapy of Bailing capsules combined with metformin for polycystic ovary syndrome can effectively regulate and improve the contents of lipid metabolism indexes and level of sex hormone as well as improve the clinical effect.
引文
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[3]张玉珍.中医妇科学[M].7版.北京:中国中医药出版社,2005:178-179.
[4]王盾.桃红四物汤联合克罗米芬治疗多囊卵巢综合征患者疗效观察[J].新中医,2015,47(11):146-147.
[5]漆伟,雷伟,严亚波,等.冬虫夏草药理学作用的研究进展[J].环球中医药,2014,7(3):227-232.
[6]赵成元,王丽,喻琳麟,等.中药促排汤联合炔雌醇环丙孕酮和二甲双胍治疗多囊卵巢综合征不孕的临床探讨[J].中国妇幼保健,2014,29(19):3109-3112.
[7]杨志平.达英-35联合二甲双胍治疗多囊卵巢综合征对激素、胰岛素抵抗的影响[J].中国妇幼保健,2016,31(5):1015-1017.
[8]李向红,薛翔,哈灵侠,等.百令胶囊对多囊卵巢综合征患者卵泡液骨形态蛋白、生长分化因子-9及胰岛素样生长因子的影响[J].现代生物医学进展,2017,17(19):3668-3671.