超临界CO_2萃取技术在海洋生物活性物质的应用研究进展
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摘要
海洋生物种类多样,资源丰富,提取和分离纯化其中的生物活性物质在医药和食品等工业应用中有重要意义。超临界CO_2萃取技术是一种新型高效绿色分离技术,被广泛应用于食品、医药和化工等领域。综述国内外超临界CO_2萃取海洋生物油脂、不饱和脂肪酸、色素、酚类、萜类和其他活性物质的研究进展。
Marine life is diverse and rich in resources. Separation and purification of active components from marine life are great significant to the development of medicine and food industry. Supercritical CO_2 extraction technology is a new type of high-efficiency green separation technology, widely used in food, medicine and chemical industries. The principles and technology involved in application of supercritical carbon dioxide extraction using in active components from marine life were summarized. The extraction of oil, unsaturated fatty acid, pigments, phenols, apes and other active substances at home and abroad for research progress was reviewed.
Marine life is diverse and rich in resources. Separation and purification of active components from marine life are great significant to the development of medicine and food industry. Supercritical CO_2 extraction technology is a new type of high-efficiency green separation technology, widely used in food, medicine and chemical industries. The principles and technology involved in application of supercritical carbon dioxide extraction using in active components from marine life were summarized. The extraction of oil, unsaturated fatty acid, pigments, phenols, apes and other active substances at home and abroad for research progress was reviewed.
引文
[1]刘云国,刘艳华.海洋生物活性物质的研究开发现状[J].食品与药品, 2005, 7(10A):66-68.
[2]施丽梅,葛海涛,孔秀芹,等.γ-亚麻酸对实验性大鼠动脉粥样硬化形成初期的影响[J].中国中药杂志, 2008, 33(23):2808-2812.
[3]刘永,周家华,孙福强,等.超临界CO2萃取技术提取生理活性物质的研究进展[J].化工生产与技术, 2002, 9(4):18-21.
[4]李振,李爱芬,张成武.硅藻金色奥杜藻色素的HPLC分析与超临界CO2萃取研究[J].天然产物研究与开发, 2012,24(6):814-818.
[5]胡蓓娟,王雪青,姚领,等.从微藻中分离提取生物活性物质[J].食品科学, 2006, 27(7):264-269.
[6] HARDARDOTTIR I, KINSELLA J E. Extraction of Lipid and Cholesterol from Fish Muscle with Supercritical Fluids[J].Journal of Food Science, 2010, 53(6):1656-1658.
[7] HIROYUKI TSUDA, OZAKI K, UWAGAWA S, et al.Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats[J]. Japanese Journal of Cancer Research Gann, 2010, 83(11):1154-1165.
[8]刘发义,李烈英.超临界流体萃取技术在海洋生物活性物质提取中的应用[J].海洋科学, 1996, 20(4):41-44.
[9]秦昌蓉.富油微藻中油脂的提取及DHA富集纯化的研究[D].天津:天津大学, 2010.
[10]SANTANAA,JESUSS,LARRAYOZMA,etal.Supercritical carbon dioxide extraction of algal lipids for the biodiesel production[J]. Procedia Engineering, 2012, 42(10):1755-1761.
[11] HALIM R, GLADMAN B, DANQUAH M K, et al.Oil extraction from microalgae for biodiesel production[J].Bioresource Technology, 2011, 102(1):178-185.
[12] TANG S, QIN C, WANG H, et al. Study on supercritical extraction of lipids and enrichment of DHA from oil-rich microalgae[J]. Journal of Supercritical Fluids, 2011, 57(1):44-49.
[13]段敏.小球藻油制备生物柴油的试验和优化工艺研究[D].杭州:浙江大学, 2011.
[14] CHENG C H, DU T B, PI H C, et al. Comparative study of lipid extraction from microalgae by organic solvent and supercritical CO2[J]. Bioresource Technology, 2011, 102(21):10151-10153.
[15]周泉诚,吴谋成.超临界CO2萃取技术在油脂工业中的应用[J].中国油脂, 2003, 28(3):17-20.
[16] LUCIEN F P, LIONG K K, COTTON N J, et al. Separation of biomolecules using supercritical fluid extraction[J].Australasian Biotechnology, 1993, 3(3):143.
[17] ANDRICH G, NESTI U, VENTURI F, et al. Supercritical fluid extraction of bioactive lipids from the microalga Nannochloropsis sp[J]. European Journal of Lipid Science&Technology, 2005, 107(6):381-386.
[18] COUTO R M, SIM?ES P C, REIS A, et al. Supercritical fluid extraction of lipids from the heterotrophic microalga Crypthecodiniumcohnii[J]. Engineering in Life Sciences,2010, 10(2):158-164.
[19]张穗,宋启煌.海洋微藻中EPA和DHA的超临界CO2提取方法研究[J].热带海洋学报, 1999, 18(2):33-38.
[20]SAJILATAMG,SINGHALRS,KAMATMY.Supercritical CO2 extraction ofγ-linolenic acid(GLA)from SpirulinaplatensisARM740usingresponsesurface methodology[J]. Journal of Food Engineering, 2008, 84(2):321-326.
[21] MENDES R L, REIS A D, PALAVRA A F. Supercritical CO2 extraction ofγ-linolenic acid and other lipids from Arthrospira(Spirulina)maxima:Comparison with organic solvent extraction[J]. Food Chemistry, 2006, 99(1):57-63.
[22] NOBRE B, MARCELO F, PASSOS R, et al. Supercritical carbon dioxide extraction of astaxanthin and other carotenoids from the microalga Haematococcus pluvialis[J]. European Food Research and Technology, 2006, 223(6):787-790.
[23] MACI?AS-SáNCHEZ M D, MANTELL C, RODRI?GUEZ M, et al. Supercritical fluid extraction of carotenoids and chlorophyll a, from Nannochloropsis gaditana[J]. Journal of Food Engineering, 2005, 66(2):245-251.
[24]隋晓.盐藻中β-胡萝卜素及多糖的研究[D].青岛:中国海洋大学, 2005.
[25]厉剑剑,张文焕,黄惠华.超临界CO2萃取小球藻精油及其抗氧化分析[J].现代食品科技, 2011, 27(8):938-941.
[26] LIM G B, LEE S Y, LEE E K, et al. Separation of astaxanthin from red yeast Phaffia rhodozyma, by supercritical carbon dioxide extraction[J]. Biochemical Engineering Journal, 2002,11(3):181-187.
[27]张昆,邵晨,黄慧民,等.用超临界CO2从螺旋藻中萃取食用黄色素的研究[J].食品与机械, 1995(3):29.
[28]梁叶星,熊家艳.超临界CO2技术应用于天然色素萃取的研究进展[J].饮料工业, 2013, 16(7):1-7.
[29] KLEJDUS B, KOPECKyJ, BENE?OVáL, et al. Solidphase/supercritical-fluid extraction for liquid chromatography of phenolic compounds in freshwater microalgae and selected cyanobacterial species[J]. Journal of Chromatography A,2009, 1216(5):763-771.
[30]李娜,邓永智,李文权.蜈蚣藻中萜类化合物的超临界CO2流体萃取及GC-MS分析[J].食品科学, 2009, 30(12):131-134.
[31]RUILM,NOBREBP,CARDOSOMT,etal.Supercritical carbon dioxide extraction of compounds with pharmaceutical importance from microalgae[J]. Inorganica Chimica Acta, 2003, 356(3):328-334.
[32] PALAVRA A M F, COELHO J P, BARROSO J G, et al.Supercritical carbon dioxide extraction of bioactive compounds from microalgae and volatile oils from aromatic plants[J].Journal of Supercritical Fluids, 2011, 60(2):21-27.
[33]李民贤,蔡伊婷,游宜屏,等.海洋褐藻功能性成分之萃取与有效性评估[A]. 2009年健康与管理学术讨论会论文集[C]. 2009年.
[34]刘淑集,吴成业,苏永昌,等.超临界萃取技术在海洋水产的应用研究进展[J].渔业研究, 2013, 35(5):402-406.
[35]周泉诚,吴谋成.超临界CO2萃取技术在油脂工业中的应用[J].中国油脂, 2003, 28(3):17-20.
[36]田文杰,郝小红,王锦秀,等.超临界CO2萃取微藻生物活性物质的研究进展[J].应用化工, 2013, 42(8):1524-1526
[37]SANTANAA,JESUSS,LARRAYOZMA,etal.Supercritical carbon dioxide extraction of algal lipids for the biodiesel production[J]. Procedia Engineering, 2012, 42(10):1755-1761.
[38]段敏.小球藻油制备生物柴油的试验和优化工艺研究[D].杭州:浙江大学, 2011.
[39] HALIM R, GLADMAN B, DANQUAH M K, et al.Oil extraction from microalgae for biodiesel production[J].Bioresource Technology, 2011, 102(1):178-185.
[2]施丽梅,葛海涛,孔秀芹,等.γ-亚麻酸对实验性大鼠动脉粥样硬化形成初期的影响[J].中国中药杂志, 2008, 33(23):2808-2812.
[3]刘永,周家华,孙福强,等.超临界CO2萃取技术提取生理活性物质的研究进展[J].化工生产与技术, 2002, 9(4):18-21.
[4]李振,李爱芬,张成武.硅藻金色奥杜藻色素的HPLC分析与超临界CO2萃取研究[J].天然产物研究与开发, 2012,24(6):814-818.
[5]胡蓓娟,王雪青,姚领,等.从微藻中分离提取生物活性物质[J].食品科学, 2006, 27(7):264-269.
[6] HARDARDOTTIR I, KINSELLA J E. Extraction of Lipid and Cholesterol from Fish Muscle with Supercritical Fluids[J].Journal of Food Science, 2010, 53(6):1656-1658.
[7] HIROYUKI TSUDA, OZAKI K, UWAGAWA S, et al.Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats[J]. Japanese Journal of Cancer Research Gann, 2010, 83(11):1154-1165.
[8]刘发义,李烈英.超临界流体萃取技术在海洋生物活性物质提取中的应用[J].海洋科学, 1996, 20(4):41-44.
[9]秦昌蓉.富油微藻中油脂的提取及DHA富集纯化的研究[D].天津:天津大学, 2010.
[10]SANTANAA,JESUSS,LARRAYOZMA,etal.Supercritical carbon dioxide extraction of algal lipids for the biodiesel production[J]. Procedia Engineering, 2012, 42(10):1755-1761.
[11] HALIM R, GLADMAN B, DANQUAH M K, et al.Oil extraction from microalgae for biodiesel production[J].Bioresource Technology, 2011, 102(1):178-185.
[12] TANG S, QIN C, WANG H, et al. Study on supercritical extraction of lipids and enrichment of DHA from oil-rich microalgae[J]. Journal of Supercritical Fluids, 2011, 57(1):44-49.
[13]段敏.小球藻油制备生物柴油的试验和优化工艺研究[D].杭州:浙江大学, 2011.
[14] CHENG C H, DU T B, PI H C, et al. Comparative study of lipid extraction from microalgae by organic solvent and supercritical CO2[J]. Bioresource Technology, 2011, 102(21):10151-10153.
[15]周泉诚,吴谋成.超临界CO2萃取技术在油脂工业中的应用[J].中国油脂, 2003, 28(3):17-20.
[16] LUCIEN F P, LIONG K K, COTTON N J, et al. Separation of biomolecules using supercritical fluid extraction[J].Australasian Biotechnology, 1993, 3(3):143.
[17] ANDRICH G, NESTI U, VENTURI F, et al. Supercritical fluid extraction of bioactive lipids from the microalga Nannochloropsis sp[J]. European Journal of Lipid Science&Technology, 2005, 107(6):381-386.
[18] COUTO R M, SIM?ES P C, REIS A, et al. Supercritical fluid extraction of lipids from the heterotrophic microalga Crypthecodiniumcohnii[J]. Engineering in Life Sciences,2010, 10(2):158-164.
[19]张穗,宋启煌.海洋微藻中EPA和DHA的超临界CO2提取方法研究[J].热带海洋学报, 1999, 18(2):33-38.
[20]SAJILATAMG,SINGHALRS,KAMATMY.Supercritical CO2 extraction ofγ-linolenic acid(GLA)from SpirulinaplatensisARM740usingresponsesurface methodology[J]. Journal of Food Engineering, 2008, 84(2):321-326.
[21] MENDES R L, REIS A D, PALAVRA A F. Supercritical CO2 extraction ofγ-linolenic acid and other lipids from Arthrospira(Spirulina)maxima:Comparison with organic solvent extraction[J]. Food Chemistry, 2006, 99(1):57-63.
[22] NOBRE B, MARCELO F, PASSOS R, et al. Supercritical carbon dioxide extraction of astaxanthin and other carotenoids from the microalga Haematococcus pluvialis[J]. European Food Research and Technology, 2006, 223(6):787-790.
[23] MACI?AS-SáNCHEZ M D, MANTELL C, RODRI?GUEZ M, et al. Supercritical fluid extraction of carotenoids and chlorophyll a, from Nannochloropsis gaditana[J]. Journal of Food Engineering, 2005, 66(2):245-251.
[24]隋晓.盐藻中β-胡萝卜素及多糖的研究[D].青岛:中国海洋大学, 2005.
[25]厉剑剑,张文焕,黄惠华.超临界CO2萃取小球藻精油及其抗氧化分析[J].现代食品科技, 2011, 27(8):938-941.
[26] LIM G B, LEE S Y, LEE E K, et al. Separation of astaxanthin from red yeast Phaffia rhodozyma, by supercritical carbon dioxide extraction[J]. Biochemical Engineering Journal, 2002,11(3):181-187.
[27]张昆,邵晨,黄慧民,等.用超临界CO2从螺旋藻中萃取食用黄色素的研究[J].食品与机械, 1995(3):29.
[28]梁叶星,熊家艳.超临界CO2技术应用于天然色素萃取的研究进展[J].饮料工业, 2013, 16(7):1-7.
[29] KLEJDUS B, KOPECKyJ, BENE?OVáL, et al. Solidphase/supercritical-fluid extraction for liquid chromatography of phenolic compounds in freshwater microalgae and selected cyanobacterial species[J]. Journal of Chromatography A,2009, 1216(5):763-771.
[30]李娜,邓永智,李文权.蜈蚣藻中萜类化合物的超临界CO2流体萃取及GC-MS分析[J].食品科学, 2009, 30(12):131-134.
[31]RUILM,NOBREBP,CARDOSOMT,etal.Supercritical carbon dioxide extraction of compounds with pharmaceutical importance from microalgae[J]. Inorganica Chimica Acta, 2003, 356(3):328-334.
[32] PALAVRA A M F, COELHO J P, BARROSO J G, et al.Supercritical carbon dioxide extraction of bioactive compounds from microalgae and volatile oils from aromatic plants[J].Journal of Supercritical Fluids, 2011, 60(2):21-27.
[33]李民贤,蔡伊婷,游宜屏,等.海洋褐藻功能性成分之萃取与有效性评估[A]. 2009年健康与管理学术讨论会论文集[C]. 2009年.
[34]刘淑集,吴成业,苏永昌,等.超临界萃取技术在海洋水产的应用研究进展[J].渔业研究, 2013, 35(5):402-406.
[35]周泉诚,吴谋成.超临界CO2萃取技术在油脂工业中的应用[J].中国油脂, 2003, 28(3):17-20.
[36]田文杰,郝小红,王锦秀,等.超临界CO2萃取微藻生物活性物质的研究进展[J].应用化工, 2013, 42(8):1524-1526
[37]SANTANAA,JESUSS,LARRAYOZMA,etal.Supercritical carbon dioxide extraction of algal lipids for the biodiesel production[J]. Procedia Engineering, 2012, 42(10):1755-1761.
[38]段敏.小球藻油制备生物柴油的试验和优化工艺研究[D].杭州:浙江大学, 2011.
[39] HALIM R, GLADMAN B, DANQUAH M K, et al.Oil extraction from microalgae for biodiesel production[J].Bioresource Technology, 2011, 102(1):178-185.