酿酒酵母氧化胁迫应答反应机制
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摘要
氧化胁迫是生物体面对逆境时的重要反应。在与逆境和活性氧做斗争的过程中,细胞进化出一套完整的应答调控机制,通过调节体内活性氧的代谢平衡,来保护DNA、脂质和蛋白质等免受氧化攻击。本文以酿酒酵母为例,根据近年来国内外研究的进展,围绕其在氧化胁迫应答过程中的三道保护屏障,即抗氧化物质和防御酶系统、转录调节和氧化物降解以及细胞器自噬,综述了其抗氧化代谢机理,为深入认识细胞的抗氧化应答机制奠定基础。
Oxidative stress is an important response of organisms to adversity. In fighting against adversity and reactive oxygen,cells have evolved a complete set of response regulation mechanism to protect DNA,lipid and protein from oxidative attack by regulating the metabolic balance of reactive oxygen in vivo. Here,based on the research progress in response to oxidative stress at home and abroad in recent years,we review the mechanisms of antioxidant metabolism in the model of Saccharomyces cerevisiae,and summarize the three protective barriers:antioxidant substances and defensive enzymes,transcriptional regulation,together with oxidant degradation and organelle autophagy,which lays a foundation for further understanding the antioxidant response mechanism of cells.
Oxidative stress is an important response of organisms to adversity. In fighting against adversity and reactive oxygen,cells have evolved a complete set of response regulation mechanism to protect DNA,lipid and protein from oxidative attack by regulating the metabolic balance of reactive oxygen in vivo. Here,based on the research progress in response to oxidative stress at home and abroad in recent years,we review the mechanisms of antioxidant metabolism in the model of Saccharomyces cerevisiae,and summarize the three protective barriers:antioxidant substances and defensive enzymes,transcriptional regulation,together with oxidant degradation and organelle autophagy,which lays a foundation for further understanding the antioxidant response mechanism of cells.
引文
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