五虎汤加减时辰给药对热性哮喘患儿血清TGF-β_1、IL-13的影响
|
摘要
目的:观察从时辰给药法应用五虎汤加减对热性哮喘患儿血清TGF-β_1、IL-13的影响。方法:选取热性哮喘患儿60例,分为对照组和治疗组,每组各30例。在常规治疗的基础上,治疗组予戌时(21∶00∶00)一次性给药,对照组按常规时间分别于09∶00∶00和18∶00∶00等量给药,连续5 d后,比较两组临床疗效,测定治疗前后肺功能以及血清中TGF-β_1、IL-13水平变化。结果:治疗组总有效率显著高于对照组(P<0.05);经治疗后,两组肺功能指标均较前升高,而两组患儿血清中TGF-β_1、IL-13水平均较前下降,且治疗组肺功能指标显著高于对照组(P<0.05),TGF-β_1、IL-13水平明显低于对照组(P<0.05)。结论:从时辰给药法应用五虎汤加减治疗热性哮喘患儿临床疗效显著,可明显改善患儿哮喘症状。
Objective: To observe the effects of five-tiger decoction on TGF-β_1 and IL-13 in serum of children with hot asthma. Methods: 60 patients with thermal asthma treated in our hospital from March 2017 to March 2018 were selected, and 30 patients were randomly divided into control group and treatment group. On the premise of conventional treatment, the treatment group to Xushi one-time dose(21∶00∶00), respectively, control group,according to the normal time, on 09 ∶00 ∶00 and 18 ∶00 ∶00 when the amount of drug delivery, for five days later, compare two groups of clinical curative effect, the determination of pulmonary function before and after the treatment, and TGF-β_1, IL-13 level changes in serum. Results: The total effective rate of treatment group was significantly higher than that in the control group(P<0.05). After treatment, two groups of FEV1, PEF and FEV1/FVC% higher than before, and two groups of children with TGF-β_1, IL-13 in serum levels are compared with the previous declined, and the FEV1, PEF, FEV1/FVC% of treatment group is significantly higher than control group(P<0.05), TGF-β_1, IL-13 levels significantly lower than the control group(P<0.05). Conclusion:The application of five-tiger decoction from the hour dosing method in the treatment of children with heat asthma has a significant clinical effect and can significantly improve the symptoms of children with asthma.
Objective: To observe the effects of five-tiger decoction on TGF-β_1 and IL-13 in serum of children with hot asthma. Methods: 60 patients with thermal asthma treated in our hospital from March 2017 to March 2018 were selected, and 30 patients were randomly divided into control group and treatment group. On the premise of conventional treatment, the treatment group to Xushi one-time dose(21∶00∶00), respectively, control group,according to the normal time, on 09 ∶00 ∶00 and 18 ∶00 ∶00 when the amount of drug delivery, for five days later, compare two groups of clinical curative effect, the determination of pulmonary function before and after the treatment, and TGF-β_1, IL-13 level changes in serum. Results: The total effective rate of treatment group was significantly higher than that in the control group(P<0.05). After treatment, two groups of FEV1, PEF and FEV1/FVC% higher than before, and two groups of children with TGF-β_1, IL-13 in serum levels are compared with the previous declined, and the FEV1, PEF, FEV1/FVC% of treatment group is significantly higher than control group(P<0.05), TGF-β_1, IL-13 levels significantly lower than the control group(P<0.05). Conclusion:The application of five-tiger decoction from the hour dosing method in the treatment of children with heat asthma has a significant clinical effect and can significantly improve the symptoms of children with asthma.
引文
[1] Basedovsky Ho,Sorkin E. Network of immune-neuro-endocrine interations[J].Chin Exp Immunol,1977,27(1):1-12.
[2] Chesnokova V,Melmed S. Minireview:Neuro-immunoendocrine modulation of the hypothalamic-pituitary-adrenal(HPA)axis by gp130 signaling molecules[J].Endocrinology,2002,143(5):1571-1574.
[3]史锁芳,闽婕,李彤.支气管哮喘发作期中医辨证回顾性调查报告[J].南京中医药大学学报,2003,19(1):18-20.
[4]中华医学会儿科学分会呼吸学组.儿童支气管哮喘诊断与防治指南(2016年版)[J].中华儿科杂志,2016,54(3):167-181.
[5]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版署,1994.
[6]马融,胡思源.儿科疾病中医药临床研究技术要点[M].北京:中国医药科技出版社,2012:174.
[7] Machura E, Mazur B, Rusek-Zychma M, et al. Cytokine production by peripheral blood CD4+and CD8+T cells in atopic childhood asthma[J].Clin Immunol,2010,2010(1):606139.
[8]全国儿童哮喘防治协作组.中国城区儿童哮喘患病率调查[J].中华儿科杂志,2003,41(2):123-127.
[9]全国儿科哮喘协作组中国疾病预防控制中心环境与健康相关产品安全所.第三次全国城市儿童哮喘流行病学调查[J].中华儿科杂志,2013,51(10):729-735.
[10]洪建国.中国儿童支气管哮喘防治指南修订要点的探讨[J].临床儿科杂志,2014,32(2):101-103.
[11]张傲凡,李海霞.中医药治疗小儿支气管哮喘的研究进展[J].中医药导报,2018,24(2):113-117.
[12] Qin L, He J, Hanes R N, et al. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanoltreatment[J].Neuroinflammation,2008,5(1):10.
[13]黄婷,王孟清,罗银河,等.五虎汤对婴幼儿哮喘树突细胞共刺激分子表达的影响[J].中国中西医结合杂志,2009,29(10):889-891.
[14]王孟清,罗银河,陈锡军,等.咳喘宁对病毒诱发哮喘患儿Th亚群的调节作用[J].中华中医药杂志,2007,22(7):481-483.
[15]李海霞,罗银河,李英.中医药防治支气管哮喘中气道重塑作用机制的研究进展[J].中医药导报,2014,20(7):91-93.
[16]李海霞,帅云飞,王孟清.五虎汤对哮喘幼年SD大鼠气道重塑及肺组织α-平滑肌肌动蛋白表达的影响[J].中药材,2015,38(3):583-587.
[17]李海霞,王孟清.五虎汤对哮喘幼年大鼠气道重塑影响的实验研究[J].中华中医药杂志,2015,31(2):634-637.
[2] Chesnokova V,Melmed S. Minireview:Neuro-immunoendocrine modulation of the hypothalamic-pituitary-adrenal(HPA)axis by gp130 signaling molecules[J].Endocrinology,2002,143(5):1571-1574.
[3]史锁芳,闽婕,李彤.支气管哮喘发作期中医辨证回顾性调查报告[J].南京中医药大学学报,2003,19(1):18-20.
[4]中华医学会儿科学分会呼吸学组.儿童支气管哮喘诊断与防治指南(2016年版)[J].中华儿科杂志,2016,54(3):167-181.
[5]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版署,1994.
[6]马融,胡思源.儿科疾病中医药临床研究技术要点[M].北京:中国医药科技出版社,2012:174.
[7] Machura E, Mazur B, Rusek-Zychma M, et al. Cytokine production by peripheral blood CD4+and CD8+T cells in atopic childhood asthma[J].Clin Immunol,2010,2010(1):606139.
[8]全国儿童哮喘防治协作组.中国城区儿童哮喘患病率调查[J].中华儿科杂志,2003,41(2):123-127.
[9]全国儿科哮喘协作组中国疾病预防控制中心环境与健康相关产品安全所.第三次全国城市儿童哮喘流行病学调查[J].中华儿科杂志,2013,51(10):729-735.
[10]洪建国.中国儿童支气管哮喘防治指南修订要点的探讨[J].临床儿科杂志,2014,32(2):101-103.
[11]张傲凡,李海霞.中医药治疗小儿支气管哮喘的研究进展[J].中医药导报,2018,24(2):113-117.
[12] Qin L, He J, Hanes R N, et al. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanoltreatment[J].Neuroinflammation,2008,5(1):10.
[13]黄婷,王孟清,罗银河,等.五虎汤对婴幼儿哮喘树突细胞共刺激分子表达的影响[J].中国中西医结合杂志,2009,29(10):889-891.
[14]王孟清,罗银河,陈锡军,等.咳喘宁对病毒诱发哮喘患儿Th亚群的调节作用[J].中华中医药杂志,2007,22(7):481-483.
[15]李海霞,罗银河,李英.中医药防治支气管哮喘中气道重塑作用机制的研究进展[J].中医药导报,2014,20(7):91-93.
[16]李海霞,帅云飞,王孟清.五虎汤对哮喘幼年SD大鼠气道重塑及肺组织α-平滑肌肌动蛋白表达的影响[J].中药材,2015,38(3):583-587.
[17]李海霞,王孟清.五虎汤对哮喘幼年大鼠气道重塑影响的实验研究[J].中华中医药杂志,2015,31(2):634-637.