潜伏性结核感染诊断抗原研究进展
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摘要
潜伏性结核感染患者是结核病防治的关键人群,但目前缺乏诊断潜伏性结核感染的金标准。现有的诊断方法无法鉴别潜伏性结核和活动性结核,因此,需要建立更高效准确的方法来提高潜伏性结核的诊断准确性。近年来,一些潜伏性结核感染相关抗原被用于建立新的潜伏性结核诊断方法,本文就潜伏性结核诊断抗原的研究进展进行综述。
Patients with latent tuberculosis infection are a key group for TB prevention and control. However, there is still lack of gold standard for the diagnosis of latent tuberculosis infection. The existing diagnostic methods are unable to distinguish between identify latent tuberculosis and active tuberculosis, and therefore more efficient and accurate methods are required to improve the diagnostic accuracy of latent tuberculosis. In recent years, some latent tuberculosis infection-related antigens have been used to establish new methods for the diagnosis of latent tuberculosis. Therefore, this article reviewed and summarized the progress in diagnostic antigens for latent tuberculosis.
Patients with latent tuberculosis infection are a key group for TB prevention and control. However, there is still lack of gold standard for the diagnosis of latent tuberculosis infection. The existing diagnostic methods are unable to distinguish between identify latent tuberculosis and active tuberculosis, and therefore more efficient and accurate methods are required to improve the diagnostic accuracy of latent tuberculosis. In recent years, some latent tuberculosis infection-related antigens have been used to establish new methods for the diagnosis of latent tuberculosis. Therefore, this article reviewed and summarized the progress in diagnostic antigens for latent tuberculosis.
引文
[1]刘宇红.浅读世界卫生组织《潜伏结核感染管理指南》[J].临床肺科杂志,2015,20(10):1915-1916.
[2]World Health Organization.Guidelines on the management of latent tuberculosis infection[Z].Geneva:World Health Organization,2015.
[3]Diel R,Goletti D,Ferrara G,et al.Interferon-γrelease assays for the diagnosis of latent Mycobacterium tuberculosis infection:a systematic review and meta-analysis[J].The European respiratory journal,2011,37(1):88-99.
[4]Oxlade O,Pinto M,Trajman A,et al.How methodologic differences affect results of economic analyses:a systematic review of interferon gamma release assays for the diagnosis of LTBI[J].PLOS One,2013,8(3):e56044.
[5]Koufopoulou M,Sutton AJ,Breheny K,et al.Methods used in economic evaluations of tuberculin skin tests and interferon gamma release assays for the screening of latent tuberculosis infection:a systematic review[J].Value in health:the journal of the International Society for Pharmacoeconomics and Outcomes Research,2016,19(2):267-276.
[6]Reither K,Katsoulis L,Beattie T,et al.Safety and immunogenicity of H1/IC31?,an adjuvanted TB subunit vaccine,in HIV-infected adults with CD4+lymphocyte counts greater than 350 cells/mm3:a phase II,multi-centre,double-blind,randomized,placebo-controlle d tria l[J].PLOS O ne,2014,9(12):e114602.
[7]Van Dissel JT,Soonawala D,Joosten SA,et al.Ag85B-ESAT-6adjuvanted with IC31?promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection[J].Vaccine,2011,29(11):2100-2109.
[8]Kana BD,Mizrahi V.Resuscitation-promoting factors as lytic enzymes for bacterial growth and signaling[J].FEMS Immunology and Medical Microbiology,2010,58(1):39-50.
[9]Mukamolova GV,Turapov OA,Young DI,et al.A family of autocrine growth factors in Mycobacterium tuberculosis[J].Molecular Microbiology,2002,46(3):623-635.
[10]Betts JC,Lukey PT,Robb LC,et al.Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling[J].Molecular Microbiology,2002,43(3):717-731.
[11]Bai XJ,Liang Y,Yang YR,et al.Potential novel markers to discriminate between active and latent tuberculosis infection in Chinese individua ls[J].C ompa ra tive Immunology Mic robiology and Infectious Diseases,2016,44:8-13.
[12]Rian軌o F,Arroyo L,París S,et al.T cell responses to Dos R and Rpf proteins in actively and latently infected individuals from Colombia[J].Tuberculosis(Edinburgh,Scotland),2012,92(2):148-159.
[13]Goletti D,Butera O,Vanini V,et al.Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection[J].The European respiratory journal,2010,36(1):135-142.
[14]Hozumi H,Tsujimura K,Yamamura Y,et al.Immunogenicity of dormancy-related antigens in individuals infected with Mycobacterium tuberculosis in Japan[J].International Journal of Tuberculosis and Lung Disease,2013,17(6):818-824.
[15]Arroyo L,Rojas M,Franken KL,et al.Multifunctional T cell response to Dos R and Rpf antigens is associated with protection in Long-Term mycobacterium tuberculosis-Infected individuals in Colombia[J].Clinical and vaccine immunology:CVI,2016,23(10):813-824.
[16]Pen軌a D,Rovetta AI,Hernández Del Pino RE,et al.A mycobacterium tuberculosis dormancy antigen differentiates latently infected bacillus Calmette-Guérin-vaccinated individuals[J].EBio Medicine,2015,2(8):884-890.
[17]Prabhavathi M,Pathakumari B,Raja A.IFN-γ/TNF-αratio in response to immuno proteomically identified human T-cell antigens of Mycobacterium tuberculosis-The most suitable surrogate biomarker for latent TB infection[J].The Journal of infection,2015,71(2):238-249.
[18]Huang W,Qi Y,Ren C,et al.Interferon-γresponses to Mycobacterium tuberculosis Rpf proteins in contact investigation[J].Tuberculosis(Edinburgh,Scotland),2013,93(6):612-617.
[19]Serra-Vidal MM,Latorre I,Franken KL,et al.Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis[J].Frontiers in microbiology,2014,5:517.
[20]Bai XJ,Liang Y,Yang YR,et al.Immune responses to latent tuberculosis antigen Rv2659c in Chinese populations[J].Journal of Microbiology,Immunology,and Infection,2015,48(4):381-389.
[21]He H,Yang H,Deng Y.Mycobacterium tuberculosis dormancy-associated antigen of Rv2660c induces stronger immune response in latent Mycobacterium tuberculosis infection than that in active tuberculosis in a Chinese population[J].European journal of clinical microbiology&infectious diseases:official publication of the European Society of Clinical Microbiology,2015,34(6):1103-1109.
[22]Govender L,Abel B,Hughes EJ,et al.Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease[J].Vaccine,2010,29(1):51-57.
[2]World Health Organization.Guidelines on the management of latent tuberculosis infection[Z].Geneva:World Health Organization,2015.
[3]Diel R,Goletti D,Ferrara G,et al.Interferon-γrelease assays for the diagnosis of latent Mycobacterium tuberculosis infection:a systematic review and meta-analysis[J].The European respiratory journal,2011,37(1):88-99.
[4]Oxlade O,Pinto M,Trajman A,et al.How methodologic differences affect results of economic analyses:a systematic review of interferon gamma release assays for the diagnosis of LTBI[J].PLOS One,2013,8(3):e56044.
[5]Koufopoulou M,Sutton AJ,Breheny K,et al.Methods used in economic evaluations of tuberculin skin tests and interferon gamma release assays for the screening of latent tuberculosis infection:a systematic review[J].Value in health:the journal of the International Society for Pharmacoeconomics and Outcomes Research,2016,19(2):267-276.
[6]Reither K,Katsoulis L,Beattie T,et al.Safety and immunogenicity of H1/IC31?,an adjuvanted TB subunit vaccine,in HIV-infected adults with CD4+lymphocyte counts greater than 350 cells/mm3:a phase II,multi-centre,double-blind,randomized,placebo-controlle d tria l[J].PLOS O ne,2014,9(12):e114602.
[7]Van Dissel JT,Soonawala D,Joosten SA,et al.Ag85B-ESAT-6adjuvanted with IC31?promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection[J].Vaccine,2011,29(11):2100-2109.
[8]Kana BD,Mizrahi V.Resuscitation-promoting factors as lytic enzymes for bacterial growth and signaling[J].FEMS Immunology and Medical Microbiology,2010,58(1):39-50.
[9]Mukamolova GV,Turapov OA,Young DI,et al.A family of autocrine growth factors in Mycobacterium tuberculosis[J].Molecular Microbiology,2002,46(3):623-635.
[10]Betts JC,Lukey PT,Robb LC,et al.Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling[J].Molecular Microbiology,2002,43(3):717-731.
[11]Bai XJ,Liang Y,Yang YR,et al.Potential novel markers to discriminate between active and latent tuberculosis infection in Chinese individua ls[J].C ompa ra tive Immunology Mic robiology and Infectious Diseases,2016,44:8-13.
[12]Rian軌o F,Arroyo L,París S,et al.T cell responses to Dos R and Rpf proteins in actively and latently infected individuals from Colombia[J].Tuberculosis(Edinburgh,Scotland),2012,92(2):148-159.
[13]Goletti D,Butera O,Vanini V,et al.Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection[J].The European respiratory journal,2010,36(1):135-142.
[14]Hozumi H,Tsujimura K,Yamamura Y,et al.Immunogenicity of dormancy-related antigens in individuals infected with Mycobacterium tuberculosis in Japan[J].International Journal of Tuberculosis and Lung Disease,2013,17(6):818-824.
[15]Arroyo L,Rojas M,Franken KL,et al.Multifunctional T cell response to Dos R and Rpf antigens is associated with protection in Long-Term mycobacterium tuberculosis-Infected individuals in Colombia[J].Clinical and vaccine immunology:CVI,2016,23(10):813-824.
[16]Pen軌a D,Rovetta AI,Hernández Del Pino RE,et al.A mycobacterium tuberculosis dormancy antigen differentiates latently infected bacillus Calmette-Guérin-vaccinated individuals[J].EBio Medicine,2015,2(8):884-890.
[17]Prabhavathi M,Pathakumari B,Raja A.IFN-γ/TNF-αratio in response to immuno proteomically identified human T-cell antigens of Mycobacterium tuberculosis-The most suitable surrogate biomarker for latent TB infection[J].The Journal of infection,2015,71(2):238-249.
[18]Huang W,Qi Y,Ren C,et al.Interferon-γresponses to Mycobacterium tuberculosis Rpf proteins in contact investigation[J].Tuberculosis(Edinburgh,Scotland),2013,93(6):612-617.
[19]Serra-Vidal MM,Latorre I,Franken KL,et al.Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis[J].Frontiers in microbiology,2014,5:517.
[20]Bai XJ,Liang Y,Yang YR,et al.Immune responses to latent tuberculosis antigen Rv2659c in Chinese populations[J].Journal of Microbiology,Immunology,and Infection,2015,48(4):381-389.
[21]He H,Yang H,Deng Y.Mycobacterium tuberculosis dormancy-associated antigen of Rv2660c induces stronger immune response in latent Mycobacterium tuberculosis infection than that in active tuberculosis in a Chinese population[J].European journal of clinical microbiology&infectious diseases:official publication of the European Society of Clinical Microbiology,2015,34(6):1103-1109.
[22]Govender L,Abel B,Hughes EJ,et al.Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease[J].Vaccine,2010,29(1):51-57.