前列舒通胶囊联合坦索罗辛治疗慢性前列腺炎伴早泄的临床疗效观察
|
摘要
目的:探讨前列舒通胶囊联合坦索罗辛治疗慢性前列腺炎(chronic prostatitis,CP)伴早泄(premature ejaculation,PE)症状的临床疗效。方法:收集2017-09～2018-03在我院泌尿外科门诊被诊断为CP并PE的患者87例,随机分为对照组(n=43,服用前列舒通胶囊)和实验组(n=44,服用前列舒通胶囊联合坦索罗辛)。记录并比较两组治疗前后前列腺炎症状指数(national institute of health-chronic prostatitis symptom index,NIH-CPSI)评分、阴道内射精潜伏时间(intravaginal ejaculation latency time,IELT)、早泄诊断工具(premature ejaculation diagnostic tool,PEDT)评分、焦虑自评量表(self-rating anxiety scale,SAS)评分和性生活满意度(sexual life satisfaction,SLS)评分。结果:对照组治疗后NIH-CPSI、PEDT、SAS评分与治疗前比较明显好转,差异有统计学意义(P<0.05),而IELT和SLS评分与治疗前比较差异无统计学意义(P>0.05);实验组治疗后NIH-CPSI、PEDT、SAS、SLS评分和IELT与治疗前比较均有明显改善,差异有统计学意义(P<0.05),且与对照组比较,效果更明显,差异有统计学意义(P<0.05)。结论:前列舒通胶囊联合坦索罗辛治疗慢性前列腺炎伴早泄在改善会阴部、后尿道、阴囊胀痛及尿路刺激症状的同时可延长阴道内射精潜伏时间,提高性生活满意度,具有良好的疗效及安全性。
Objective:To investigate the clinical efficacy of Qianlie Shutong capsule combined with tamsulosin in treatment of chronic prostatitis(CP)with premature ejaculation(PE).Methods:Eighty-seven patients with CP and PE in our outpatient department were randomly divided into the control group(n=43)and the experimental group(n=44).The control group took Qianlie Shutong capsule and the experimental group took Qianlie Shutong capsule combined with tamsulosin.The national institute of health-chronic prostatitis symptom index(NIH-CPSI)score,intravaginal ejaculation latency time(IELT),premature ejaculation diagnostic tool(PEDT)score,self-rating anxiety scale(SAS)and sexual life satisfaction(SLS)score were observed before and after treatment.Results:The NIH-CPSI,PEDT and SAS scores of control group before and after treatment were significantly improved,the differences were statistically significant(P <0.05),while IELT and SLS scores has no significant difference(P>0.05).The NIH-CPSI,PEDT,SAS,SLS scores and IELT of the experimental group were significantly improved before and after treatment,and the differences were statistically significant(P<0.05),and compared with the control group,the difference was also statistically significant(P<0.05).Conclusion:Qianlie Shutong capsule joint tamsulosin in treatment of CP with PE can improve the perineum,the urethra,scrotal pain,urinary tract irritation of the vagina at the same time can extend the ejaculation latency,improve sexual satisfaction,it has good effect and security.
Objective:To investigate the clinical efficacy of Qianlie Shutong capsule combined with tamsulosin in treatment of chronic prostatitis(CP)with premature ejaculation(PE).Methods:Eighty-seven patients with CP and PE in our outpatient department were randomly divided into the control group(n=43)and the experimental group(n=44).The control group took Qianlie Shutong capsule and the experimental group took Qianlie Shutong capsule combined with tamsulosin.The national institute of health-chronic prostatitis symptom index(NIH-CPSI)score,intravaginal ejaculation latency time(IELT),premature ejaculation diagnostic tool(PEDT)score,self-rating anxiety scale(SAS)and sexual life satisfaction(SLS)score were observed before and after treatment.Results:The NIH-CPSI,PEDT and SAS scores of control group before and after treatment were significantly improved,the differences were statistically significant(P <0.05),while IELT and SLS scores has no significant difference(P>0.05).The NIH-CPSI,PEDT,SAS,SLS scores and IELT of the experimental group were significantly improved before and after treatment,and the differences were statistically significant(P<0.05),and compared with the control group,the difference was also statistically significant(P<0.05).Conclusion:Qianlie Shutong capsule joint tamsulosin in treatment of CP with PE can improve the perineum,the urethra,scrotal pain,urinary tract irritation of the vagina at the same time can extend the ejaculation latency,improve sexual satisfaction,it has good effect and security.
引文
[1]向彬,雷光辉,张旭,等.复方玄驹胶囊辅助西医治疗对慢性前列腺炎患者免疫功能及生活质量的影响[J].陕西中医,2016,37(10):1297-1298.
[2]米华,陈凯,莫曾南.中国慢性前列腺炎的流行病学特征[J].中华男科学杂志,2012,18(7):579-582.
[3]朱勇,葛晓东,施勇,等.前列腺炎Ⅰ号经验方治疗难治性Ⅲ型前列腺炎的疗效及安全性[J].中华男科学杂志,2018,24(7):640-644.
[4]冯燕,赵雁,黄亮.前列舒通与左氧氟沙星联用对慢性细菌性前列腺炎患者的临床疗效及其对相关炎症因子水平的影响[J].抗感染药学,2018,15(6):1098-1100.
[5]杜文亮,肖永双,陈跃,等.复方利多卡因乳膏联合盐酸坦索罗辛治疗慢性前列腺炎合并早泄的临床研究[J].中国男科学杂志,2016,30(10):46-48.
[6]李跃辉,郑丽算.曲唑酮联合坦索罗辛治疗早泄的临床观察[J].中国男科学杂志,2009,23(7):60-61.
[7]徐锋,魏志峰,徐晓峰,等.萘哌地尔片联合复方利多卡因乳膏治疗慢性非细菌性前列腺炎合并早泄的疗效观察[J].东南国防医药,2015,17(4):358-361.
[8]邢增术,张冲,刘振湘,等.盐酸达泊西汀联合小剂量他达拉非治疗原发性早泄的前瞻性随机对照临床研究[J].临床泌尿外科杂志,2018,33(8):623-632.
[9]郭军,王福,耿强,等.国际性医学会(ISSM)《早泄诊治指南(2010年版)》解读[J].中国性科学,2011,20(7):5-8.
[10]叶铿,沈利杨,高岑,等.慢性前列腺炎患者性功能及性生活质量影响研究[J].中国性科学,2018,27(2):19-21.
[11]姜辉,刘德风,邓春华,等.早泄诊断量表的汉化研究和信效度评价[J].中华男科学杂志,2015,21(7):598-603.
[12]胡明球,贺利军,李宁忱,等.包皮环切及系带成形术对阴道内射精潜伏时间的影响[J].中外医疗,2015,34(29):11-13.
[13]江敏,李又空.盐酸达泊西汀治疗早泄患者对焦虑抑郁情绪的影响[J].中国性科学,2018,27(1):24-27.
[14]沈建武,高瞻,张林,等.益气活血托毒方改善ⅢB型前列腺炎患者NIH-CPSI评分的临床观察[J].中国性科学,2018,27(6):97-102.
[15]Schaeffer A J,Knauss J S,Landis J R,et al.Leukocyte and bacterial counts do not correlate with severity of symptoms in men with chronic prostatitis:the national institutes of health chronic prostatitis cohort study[J].J Urol,2002,168(3):1048-1053.
[16]Breser M L,Salazar F C,Rivero V E,et al.Immunological mechanisms underlying chronic pelvic pain and prostate inflammation in chronic pelvic pain syndrome[J].Front Immunol,2017,8:898.
[17]叶春红,吴松江,蒋聿瑛,等.慢性前列腺炎患者的心理状况及相关因素分析[J].中国现代医生,2014,52(35):32
[18]王增利,赵卫红,孙伍柒,等.中年慢性前列腺炎患者性生活状况调查[J].中国性科学,2016,25(3):32-34.
[19]Magri V,Wagenlehner F M,Marras E,et al.Influence of infection on the distribution patterns of NIH-chronic prostatitis symptom index scores in patients with chronic prostatitis chronic pelvic pain syndrome(CP/CPPS)[J].Exp Ther Med,2013,6(2):503-508.
[20]万焕真,庄瞞,阙华发,等.慢性前列腺炎所致的早泄的3组药物治疗比较[J].中国性科学,2015,18(2):6-9.
[21]肖飞,陈永华,谷现恩.复方玄驹胶囊联合前列舒通胶囊治疗ⅢB型前列腺炎的疗效评价[J].中国性科学,2018,27(5):13-15.
[22]于淼.前列舒通胶囊联合盐酸莫西沙星治疗慢性前列腺炎的效果观察[J].临床合理用药杂志,2016,9(7):57-58.
[23]李广裕,梁季鸿,蒙志彬,等.不同剂量盐酸坦洛新缓释片治疗早泄的临床疗效[J].中华泌尿外科杂志,2012,33(5):390-392.
[24]汪自力,杨进,陈刚,等.盐酸坦洛新缓释片治疗早泄的分析[J].湖南中医药大学学报,2010,30(10):23-24.
[25]Lepor H,Jones K,Williford W.The mechanism of adverse events associated with terazosin:an analysis of the veterans affairs cooperative study[J].J Urol,2000,163(4):1134-1137.
[2]米华,陈凯,莫曾南.中国慢性前列腺炎的流行病学特征[J].中华男科学杂志,2012,18(7):579-582.
[3]朱勇,葛晓东,施勇,等.前列腺炎Ⅰ号经验方治疗难治性Ⅲ型前列腺炎的疗效及安全性[J].中华男科学杂志,2018,24(7):640-644.
[4]冯燕,赵雁,黄亮.前列舒通与左氧氟沙星联用对慢性细菌性前列腺炎患者的临床疗效及其对相关炎症因子水平的影响[J].抗感染药学,2018,15(6):1098-1100.
[5]杜文亮,肖永双,陈跃,等.复方利多卡因乳膏联合盐酸坦索罗辛治疗慢性前列腺炎合并早泄的临床研究[J].中国男科学杂志,2016,30(10):46-48.
[6]李跃辉,郑丽算.曲唑酮联合坦索罗辛治疗早泄的临床观察[J].中国男科学杂志,2009,23(7):60-61.
[7]徐锋,魏志峰,徐晓峰,等.萘哌地尔片联合复方利多卡因乳膏治疗慢性非细菌性前列腺炎合并早泄的疗效观察[J].东南国防医药,2015,17(4):358-361.
[8]邢增术,张冲,刘振湘,等.盐酸达泊西汀联合小剂量他达拉非治疗原发性早泄的前瞻性随机对照临床研究[J].临床泌尿外科杂志,2018,33(8):623-632.
[9]郭军,王福,耿强,等.国际性医学会(ISSM)《早泄诊治指南(2010年版)》解读[J].中国性科学,2011,20(7):5-8.
[10]叶铿,沈利杨,高岑,等.慢性前列腺炎患者性功能及性生活质量影响研究[J].中国性科学,2018,27(2):19-21.
[11]姜辉,刘德风,邓春华,等.早泄诊断量表的汉化研究和信效度评价[J].中华男科学杂志,2015,21(7):598-603.
[12]胡明球,贺利军,李宁忱,等.包皮环切及系带成形术对阴道内射精潜伏时间的影响[J].中外医疗,2015,34(29):11-13.
[13]江敏,李又空.盐酸达泊西汀治疗早泄患者对焦虑抑郁情绪的影响[J].中国性科学,2018,27(1):24-27.
[14]沈建武,高瞻,张林,等.益气活血托毒方改善ⅢB型前列腺炎患者NIH-CPSI评分的临床观察[J].中国性科学,2018,27(6):97-102.
[15]Schaeffer A J,Knauss J S,Landis J R,et al.Leukocyte and bacterial counts do not correlate with severity of symptoms in men with chronic prostatitis:the national institutes of health chronic prostatitis cohort study[J].J Urol,2002,168(3):1048-1053.
[16]Breser M L,Salazar F C,Rivero V E,et al.Immunological mechanisms underlying chronic pelvic pain and prostate inflammation in chronic pelvic pain syndrome[J].Front Immunol,2017,8:898.
[17]叶春红,吴松江,蒋聿瑛,等.慢性前列腺炎患者的心理状况及相关因素分析[J].中国现代医生,2014,52(35):32
[18]王增利,赵卫红,孙伍柒,等.中年慢性前列腺炎患者性生活状况调查[J].中国性科学,2016,25(3):32-34.
[19]Magri V,Wagenlehner F M,Marras E,et al.Influence of infection on the distribution patterns of NIH-chronic prostatitis symptom index scores in patients with chronic prostatitis chronic pelvic pain syndrome(CP/CPPS)[J].Exp Ther Med,2013,6(2):503-508.
[20]万焕真,庄瞞,阙华发,等.慢性前列腺炎所致的早泄的3组药物治疗比较[J].中国性科学,2015,18(2):6-9.
[21]肖飞,陈永华,谷现恩.复方玄驹胶囊联合前列舒通胶囊治疗ⅢB型前列腺炎的疗效评价[J].中国性科学,2018,27(5):13-15.
[22]于淼.前列舒通胶囊联合盐酸莫西沙星治疗慢性前列腺炎的效果观察[J].临床合理用药杂志,2016,9(7):57-58.
[23]李广裕,梁季鸿,蒙志彬,等.不同剂量盐酸坦洛新缓释片治疗早泄的临床疗效[J].中华泌尿外科杂志,2012,33(5):390-392.
[24]汪自力,杨进,陈刚,等.盐酸坦洛新缓释片治疗早泄的分析[J].湖南中医药大学学报,2010,30(10):23-24.
[25]Lepor H,Jones K,Williford W.The mechanism of adverse events associated with terazosin:an analysis of the veterans affairs cooperative study[J].J Urol,2000,163(4):1134-1137.