缺血性脑中风的发病机制及其常用治疗中药研究进展
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摘要
脑中风目前已成为世界上第二大致死疾病,其中以缺血性脑中风发病占主导地位。因其具有发病迅速、病情复杂等特点,故缺血性脑中风也是造成残疾的主要神经系统疾病。缺血性脑中风主要起源于动脉粥样硬化,进而引发脑组织能量代谢障碍、兴奋性氨基酸毒性作用、氧化/硝化应激、炎症反应、细胞凋亡、细胞自噬等一系列病理过程。传统单味中药、复方及制剂因其具有多成分、多靶点的组成和治疗特点,可作用于缺血性脑中风不同的发病阶段。该文对近年来缺血性脑中风的发病机制及常用治疗中药最新研究进展进行两方面总结,以期对缺血性脑中风的进一步研究及临床治疗提供参考。
Stroke has become the second leading cause of death in the world, and the most common type is the ischemic stroke. Due to its rapid onset and complex conditions, ischemic stroke is a major neurological disorder that causes disability. Ischemic stroke mainly results from atherosclerosis, and the pathogenesis of ischemic stroke mainly includes energy metabolism disorders in the brain, the toxicity of excitatory amino acids, oxidative/nitrification stress, inflammatory response, apoptosis, and autophagy. With the characteristics of multi-component and multi-target, traditional Chinese medicine could be used to treat ischemic stroke at different stages. This article summarized the latest research progress on the pathogenesis of ischemic stroke and commonly used traditional Chinese medicine for treatment of ischemic stroke in order to provide references for the further research and clinical treatment of ischemic stroke.
Stroke has become the second leading cause of death in the world, and the most common type is the ischemic stroke. Due to its rapid onset and complex conditions, ischemic stroke is a major neurological disorder that causes disability. Ischemic stroke mainly results from atherosclerosis, and the pathogenesis of ischemic stroke mainly includes energy metabolism disorders in the brain, the toxicity of excitatory amino acids, oxidative/nitrification stress, inflammatory response, apoptosis, and autophagy. With the characteristics of multi-component and multi-target, traditional Chinese medicine could be used to treat ischemic stroke at different stages. This article summarized the latest research progress on the pathogenesis of ischemic stroke and commonly used traditional Chinese medicine for treatment of ischemic stroke in order to provide references for the further research and clinical treatment of ischemic stroke.
引文
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