深层过滤在非达霉素粗品提炼工艺中的改进应用
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摘要
非达霉素等超级抗生素产品在生产工艺中往往经由发酵、提炼、制备、合成、结晶工艺得到,工艺的关键步骤是提炼。提炼经常由活性炭吸附实现,但是在工业化生产时缺陷明显。我们采用3M公司的深层过滤新技术,进行了非达霉素的粗品处理,发现该技术具有操作简单、除杂效果明显的优点,值得进一步研究使用。
Super antibiotics such as Fidaxomicin are commonly prepared through fermentation, refining, preparation, synthesis, and crystallization.Among them, refining is the critical process.Activated carbon adsorption is usually used for refining which has many disadvantages.Thus we treated crude Fidaxomicin with deep filtration technology by 3 M company products and we find a quick & easy maneuverability way to lower the impurities which worth further research and application.
Super antibiotics such as Fidaxomicin are commonly prepared through fermentation, refining, preparation, synthesis, and crystallization.Among them, refining is the critical process.Activated carbon adsorption is usually used for refining which has many disadvantages.Thus we treated crude Fidaxomicin with deep filtration technology by 3 M company products and we find a quick & easy maneuverability way to lower the impurities which worth further research and application.
引文
[1] 姜春梅,刘洋,王京晶,等.抗感染新药非达霉素的药理作用与临床评价[J].中国新药杂志,2011(23):2283-2285.
[2] 张萌萌,顾觉奋.新型大环内酯类抗菌药物非达霉素的临床研究进展[J]抗感染药学,2012(3):161-165.
[3] 霍培元,可爱兵,路新华.非达霉素的研究进展[J].河北化工,2012(5):20-21.
[4] 高月麒,任风芝,王海燕,等.非达霉素粗品中杂质的分离与鉴定[J].中国抗生素杂志,2015(11):828-830.
[5] 张月.浅析深层过滤技术在生物制药工艺中的运用[J].医药卫生(引用版),2018,7(1):124.
[2] 张萌萌,顾觉奋.新型大环内酯类抗菌药物非达霉素的临床研究进展[J]抗感染药学,2012(3):161-165.
[3] 霍培元,可爱兵,路新华.非达霉素的研究进展[J].河北化工,2012(5):20-21.
[4] 高月麒,任风芝,王海燕,等.非达霉素粗品中杂质的分离与鉴定[J].中国抗生素杂志,2015(11):828-830.
[5] 张月.浅析深层过滤技术在生物制药工艺中的运用[J].医药卫生(引用版),2018,7(1):124.