视疲劳防治中药专利的研究概况及其用药规律分析
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摘要
目的:通过分析中药防治视疲劳领域近20年的专利状况,探讨中药在视疲劳防治过程中的用药规律。方法:在Inco Pat科技创新情报平台中,对中药防治视疲劳的全球专利进行系统检索,分析专利的申请趋势、类别和法律状态等指标,采用IBM SPSS Modeler 18. 0进行关联度分析,比较口服方与外用方的配伍规律与用药差异。结果:全球专利申请量逐渐增大,中国占全球中药视疲劳专利申请量的99%以上,在专利申请中常用的类别为药物组合物、口服制剂、外用眼贴和眼罩等,但授权专利占总量比例偏低。在用药规律方面,口服方偏重于滋补肝肾类中药,外用方则偏重于清热明目、芳香开窍类中药。结论:国内中药防治视疲劳领域的专利申请数量庞大,但授权率偏低;基于中医理论的中药配伍有规可循,可为防治视疲劳中药产品的研发与推广提供参考。
Objective: To explore drug utilizing regularity of traditional Chinese medicine( TCM) in treating and preventing asthenopia by analyzing the patent status of TCM in the field of asthenopia control for nearly20 years. Method: Global patents about TCM in treating and preventing asthenopia were systematic searched in IncoPat platform. The application trend,legal status and categories of patents were analyzed. Meanwhile,the oral prescriptions and external prescriptions were performed correlation index analysis by IBM SPSS Modeler 18. 0,respectively; the difference of compatibility rules between them was compared. Result: The number of global patents in treating and preventing asthenopia gradually increased,and the proportion of patents from China was more than 99%. The main patent applications were pharmaceutical composition,oral preparation,external eye patch and so on,but the ratio of licensed patents in total patents was low. In term of drug utilizing regularity,the oral prescriptions paid much attention to using TCM for nourishing the liver and kidney, while external prescriptions highlighted relieving sickness heat and detoxification. Conclusion: Patents of TCM in treating and preventing asthenopia has been kept increasing in recent years,but the authorization rate is low. Formulation based on TCM theory can be statistically summarized,which can be helpful for the development of anti-asthenopia products.
Objective: To explore drug utilizing regularity of traditional Chinese medicine( TCM) in treating and preventing asthenopia by analyzing the patent status of TCM in the field of asthenopia control for nearly20 years. Method: Global patents about TCM in treating and preventing asthenopia were systematic searched in IncoPat platform. The application trend,legal status and categories of patents were analyzed. Meanwhile,the oral prescriptions and external prescriptions were performed correlation index analysis by IBM SPSS Modeler 18. 0,respectively; the difference of compatibility rules between them was compared. Result: The number of global patents in treating and preventing asthenopia gradually increased,and the proportion of patents from China was more than 99%. The main patent applications were pharmaceutical composition,oral preparation,external eye patch and so on,but the ratio of licensed patents in total patents was low. In term of drug utilizing regularity,the oral prescriptions paid much attention to using TCM for nourishing the liver and kidney, while external prescriptions highlighted relieving sickness heat and detoxification. Conclusion: Patents of TCM in treating and preventing asthenopia has been kept increasing in recent years,but the authorization rate is low. Formulation based on TCM theory can be statistically summarized,which can be helpful for the development of anti-asthenopia products.
引文
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[3]杨来庆.视疲劳病因病机研究[D].济南:山东中医药大学,2011.
[4]亓祥顺,周广英,王艳.关于视疲劳诊断、病因及其治疗方法的探讨[J].临床医药文献电子杂志,2017,4(29):5733-5736.
[5]唐琼.缓解视疲劳功能性饮料的研发及其功效评价[D].杭州:浙江大学,2015.
[6]刘娟.中药复方治疗呼吸系统疾病的专利文献分析[J].四川图书馆学报,2017(3):86-88.
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[9]易振威.基于关联规则的物流运输数据挖掘算法的研究[D].北京:北京邮电大学,2017.
[10]覃峰,朱林平,吴静,等.视频终端视疲劳的中医治疗研究进展[J].山东中医杂志,2017,36(12):1078-1080.
[11]朱晓林,张云松.角膜炎治疗方药聚类分析[J].中国实验方剂学杂志,2014,20(2):204-206.
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