基于数据挖掘分析丘和明治疗免疫性血小板减少症的用药规律
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摘要
目的:分析丘和明教授治疗免疫性血小板减少症(ITP)的用药规律。方法:收集丘教授临床运用中医药治疗ITP的处方,建立数据库,通过"中医传承辅助平台"(V2.5)软件对数据进行关联规则、复杂系统熵聚类、层次聚类等数据挖掘以分析其治疗ITP的用药规律。结果:共筛选并统计分析了188首处方,明确了丘教授治疗ITP高频药物的使用情况以及药物的组合规律,并挖掘出核心药物组合24个及候选新方12首。结论:丘教授认为ITP的病机以肾阴虚、脾气虚为本,火热、风热之邪为标,临证多处以滋阴补肾、健脾摄血、祛风清热之品,并随证加减,体现了其"扶正祛邪,标本同治"的学术思想。
Objective: To analyze Professor QIU He-ming's medical experience for primary immune thrombocytopenia(ITP). Methods: QIU He-ming's prescription for ITP patients in the clinic was collected and logged into a database which was analyzed by the Traditional Chinese Medicine Inheritance Support Platform(V2. 5). And data mining methods such as revised mutual information, complex system entropy cluster and unsupervised hierarchical cluster were used. Results: Based on analysis of 188 prescriptions, the frequency and combinational patterns of the herbals was exposed. Furthermore, 24 core combination and 12 new prescriptions were deduced.Conclusion: Professor QIU He-ming believed that the TIP take kidney Yin deficiency and spleen Qi weakness as original cause and fire-heat or wind-heat evil is the superficial cause. So while treating ITP patients, herbals that could enrich yin and nourish kidney, strengthen the spleen and stop bleeding, expel pathogenic wind and clear pathogenic heat were most used. Thus his academic thought that "strengthening body resistance and eliminating evil, treating both cause and symptoms" was reflected.
Objective: To analyze Professor QIU He-ming's medical experience for primary immune thrombocytopenia(ITP). Methods: QIU He-ming's prescription for ITP patients in the clinic was collected and logged into a database which was analyzed by the Traditional Chinese Medicine Inheritance Support Platform(V2. 5). And data mining methods such as revised mutual information, complex system entropy cluster and unsupervised hierarchical cluster were used. Results: Based on analysis of 188 prescriptions, the frequency and combinational patterns of the herbals was exposed. Furthermore, 24 core combination and 12 new prescriptions were deduced.Conclusion: Professor QIU He-ming believed that the TIP take kidney Yin deficiency and spleen Qi weakness as original cause and fire-heat or wind-heat evil is the superficial cause. So while treating ITP patients, herbals that could enrich yin and nourish kidney, strengthen the spleen and stop bleeding, expel pathogenic wind and clear pathogenic heat were most used. Thus his academic thought that "strengthening body resistance and eliminating evil, treating both cause and symptoms" was reflected.
引文
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[12]康林之,袁敏,邵峰,等.仙鹤草不同提取物抗疲劳抗氧化及免疫调节作用研究[J].时珍国医国药,2016,27(5):1079-1081.
[13]傅力明,李华峰,姚杰,等.中药蒲公英花提取物的抑菌性能研究[J].山西医药杂志,2015,44(8):947-949.
[14]田维毅,张智伟,蔡琨,等.蒲公英含药血清对巨噬细胞功能干预作用的初步研究[J].中华中医药杂志,2014,29(5):1604-1607.
[15]郑国庆.风药是治疗血证新的切入口[J].中医药导报,2000,6(1):8-10.
[2] Cines D B, Blanchette V S. Immune thrombocytopenic purpura[J].New England Journal of Medicine,2002,346(13):995.
[3]杨宝峰.药理学[M].8版.北京:人民卫生出版社,2013:338.
[4]中华医学会血液学分会血栓与止血学组.成人原发免疫性血小板减少症诊断与治疗中国专家共识(2016年版)[J].中华血液学杂志,2016,37(2):89-93.
[5] Mülfay V, Popa D P. International consensus report on the investigation and management of primary immune thrombocytopenia[J].Blood,2010,115(2):168-186.
[6]国家中医药管理局.中医病证诊断疗效标准(2012版)[M].北京:中国医药科技出版社,2012:1-94.
[7]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2010.
[8]国家中医药管理局《中华本草》编委会.中华本草(精选本)[M].上海:上海科学技术出版社,1998.
[9]杨洪军.中医传承辅助平台的开发与应用[M].福州:福建科学技术出版社,2013:45-49.
[10]夏丽娜,袁世清,雍小嘉.肝脾在血证中止血协同性理论探讨[J].中医药导报,2010,16(12):11-12.
[11]黄兴,王哲,王保和.仙鹤草药理作用及临床应用研究进展[J].山东中医杂志,2017,36(2):172-176.
[12]康林之,袁敏,邵峰,等.仙鹤草不同提取物抗疲劳抗氧化及免疫调节作用研究[J].时珍国医国药,2016,27(5):1079-1081.
[13]傅力明,李华峰,姚杰,等.中药蒲公英花提取物的抑菌性能研究[J].山西医药杂志,2015,44(8):947-949.
[14]田维毅,张智伟,蔡琨,等.蒲公英含药血清对巨噬细胞功能干预作用的初步研究[J].中华中医药杂志,2014,29(5):1604-1607.
[15]郑国庆.风药是治疗血证新的切入口[J].中医药导报,2000,6(1):8-10.