妊娠期高血压疾病患者血清尿酸和乳酸脱氢酶水平的分析
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摘要
目的:探讨妊娠期高血压疾病(HDCP)患者尿酸(UA)和乳酸脱氢酶(LDH)的血清水平及其意义。方法:选取2016年10月—2018年4月于华北理工大学附属医院产科住院的80例子痫前期患者为研究对象(病例组),根据病情不同程度分为轻度子痫前期组(n=25)和重度子痫前期组(n=55);根据发病不同时间分为早发重度子痫前期组(n=23)和晚发重度子痫前期组(n=32)。随机选取同期正常妊娠孕妇80例为对照组。比较病例组和对照组孕妇血清UA和LDH水平,以及不同类型子痫前期患者血清UA和LDH水平。结果:病例组血清UA和LDH水平均显著高于对照组(P<0.05);与轻度子痫前期患者比较,重度子痫前期患者血清UA和LDH水平显著升高(P<0.05);与早发重度子痫前期患者比较,晚发重度子痫前期患者血清UA水平升高(P<0.05);随着病情的进展,围产儿不良结局对照组、轻度子痫前期组和重度子痫前期组3组比较,差异有统计学意义(P<0.05)。结论:血清UA和LDH水平随着HDCP病情的进展逐渐升高;血清UA和LDH水平可以为HDCP病情变化的监测指标。
Objective:To investigate the levels of serum uric acid(UA)and lactate dehydrogenase(LDH)of women with hypertensive disorder complicating pregnancy(HDCP),and to analyze their significances.Methods:80 women with pre-eclampsia who had been hospitalized in the affiliated hospital of north China university of science and technology from October 2016 to April 2018 were selected into observation group,which were divided into mild pre-eclampsia group(n=25)and severe pre-eclampsia group(n=55)according to the severity of pre-eclampsia.And the women with severe pre-eclampsia were also divided into early onset severe pre-eclampsia group(n=23)and late onset severe pre-eclampsia group(n=32).Another 80 normal pregnant women were selected in control group.The serum levels of UA and LDH of women were compared between observation group and control group,and the serum levels of UA and LDH of women with different types of pre-eclampsia were also compared.Results:Serum UA and LDH levels of women in observation group were significant higher than those of women in control group(P<0.05).Compared with those of women with mild pre-eclampsia,the levels of serum UA and LDH of women with severe pre-eclampsia were significant higher(P<0.05).Compared with those of women with early onset severe preeclampsia,the levels of serum UA and LDH of women with late onset of severe pre-eclampsia were significant higher(P<0.05).Furthermore,with the pre-eclampsia aggravated,the incidence of perinatal adverse outcomes had increased,and there was a significant difference in perinatal adverse outcomes among normal pregnant women,women with mild pre-eclampsia,and women with severe pre-eclampsia(P < 0.05).Conclusion:Serum levels of UA and LDH will increase following the preeclampsia aggravating,so serum levels of UA and LDH maybe monitoring indicators of the changes in condition of women with HDCP.
Objective:To investigate the levels of serum uric acid(UA)and lactate dehydrogenase(LDH)of women with hypertensive disorder complicating pregnancy(HDCP),and to analyze their significances.Methods:80 women with pre-eclampsia who had been hospitalized in the affiliated hospital of north China university of science and technology from October 2016 to April 2018 were selected into observation group,which were divided into mild pre-eclampsia group(n=25)and severe pre-eclampsia group(n=55)according to the severity of pre-eclampsia.And the women with severe pre-eclampsia were also divided into early onset severe pre-eclampsia group(n=23)and late onset severe pre-eclampsia group(n=32).Another 80 normal pregnant women were selected in control group.The serum levels of UA and LDH of women were compared between observation group and control group,and the serum levels of UA and LDH of women with different types of pre-eclampsia were also compared.Results:Serum UA and LDH levels of women in observation group were significant higher than those of women in control group(P<0.05).Compared with those of women with mild pre-eclampsia,the levels of serum UA and LDH of women with severe pre-eclampsia were significant higher(P<0.05).Compared with those of women with early onset severe preeclampsia,the levels of serum UA and LDH of women with late onset of severe pre-eclampsia were significant higher(P<0.05).Furthermore,with the pre-eclampsia aggravated,the incidence of perinatal adverse outcomes had increased,and there was a significant difference in perinatal adverse outcomes among normal pregnant women,women with mild pre-eclampsia,and women with severe pre-eclampsia(P < 0.05).Conclusion:Serum levels of UA and LDH will increase following the preeclampsia aggravating,so serum levels of UA and LDH maybe monitoring indicators of the changes in condition of women with HDCP.
引文
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[6]曹雯,张荔,刘超,等.正常妊娠与妊娠高血压患者血清尿酸水平的变化[J].江苏医药,2014,40(16):1913-1914.
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[10]熊俊,吴振恭.不同年龄妊娠期高血压疾病患者的围生期结局.中国妇产科临床杂志[J],2014,15(4):349-351.
[11]宋健,黄亚娟,陆继红.子痫前期孕妇的血清尿酸水平对母胎妊娠结局的预测作用[J],国际妇产科学杂志,2017,44(2):219-221.
[12]张立军,钟利若,梁训宏.妊娠期高血压疾病患者血清尿素氮、肌酐和尿酸水平变化的探讨[J].临床和实验医学杂志,2016,15(7):682-685.
[13]周晓珍,娄甜平,周桂月.妊娠期高血压疾病患者血清肌酐、尿素氮、尿酸联合检测的临床意义[J].生殖医学杂志,2013,22(11):855-859.
[14]陈自力,杨莉莉.重度子痫前期患者血清尿素氮、肌酐、尿酸水平变化[J].山东医药,2017,57(19):66-68.
[2]杨孜.多因素、多通路、多机制致病解子痫前期综合征制胜真实世界临床实践[J].中国实用妇科与产科杂志,2017,33(1):45-51.
[3]Sundstrom J,Sullivan L,D'agostino R B,et al.Relations of serum uric acid to longitudinal blood press tracking and hypertension incidence[J].Hypertension,2005,45(1):28-33.
[4]梁丽荣,杨天时,王璐,等.妊娠期高血压孕妇血清微量元素、乳酸脱氢酶和尿酸测定的临床应用[J].中国妇幼保健,2012,27(22):3415-3417.
[5]陈大立,柴利强,彭兰,等.血清乳酸脱氢酶与子痫前期及妊娠不良结局的关系[J].国际妇产科学杂志,2016,43(4):393-398.
[6]曹雯,张荔,刘超,等.正常妊娠与妊娠高血压患者血清尿酸水平的变化[J].江苏医药,2014,40(16):1913-1914.
[7]Peralta Pedrero ML,Basavilvazo Rodriguez MA,Cruz Avelar A,et al.Clinical significance of the laboratory determinations in preeclamptic patients[J].Ginecologiay obstetricia de Mexico,2004,72:57-62.
[8]Moreno Santillan AA,Briones Garduno JC,Diaz de Leon Ponce MA.Uric Acid in Pregnancy:New Concepts[J].Contributions to nephrology,2018,192:110-115.
[9]苏平平,包怡荣,黄一颖,等.妊娠期高血压619例临床分析[J].同济大学学报(医学版)[J],2016,37(3):76-79.
[10]熊俊,吴振恭.不同年龄妊娠期高血压疾病患者的围生期结局.中国妇产科临床杂志[J],2014,15(4):349-351.
[11]宋健,黄亚娟,陆继红.子痫前期孕妇的血清尿酸水平对母胎妊娠结局的预测作用[J],国际妇产科学杂志,2017,44(2):219-221.
[12]张立军,钟利若,梁训宏.妊娠期高血压疾病患者血清尿素氮、肌酐和尿酸水平变化的探讨[J].临床和实验医学杂志,2016,15(7):682-685.
[13]周晓珍,娄甜平,周桂月.妊娠期高血压疾病患者血清肌酐、尿素氮、尿酸联合检测的临床意义[J].生殖医学杂志,2013,22(11):855-859.
[14]陈自力,杨莉莉.重度子痫前期患者血清尿素氮、肌酐、尿酸水平变化[J].山东医药,2017,57(19):66-68.