心房颤动发病机制研究进展
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摘要
心房颤动是最常见的阵发性或持续性心律失常,且随年龄增大其发病率逐渐增加。房颤可诱发栓塞风险,在高原地区更为严重,干扰心室泵血功能,加重心肌损伤。本文就心房解剖、心房肌细胞电生理、心律失常发生机制及心房颤动发生机制等研究进展做一述评。
The atrial fibrillation is the most frequent fibrillation.It's incidence increases with the age.The atrial fibrillation can induce embolism,interfere blood-pumping function of ventricles and aggravate myocardial damage.The present article describes the anatomy of atrium,the electrophysiology of atrial muscle cell and the mechanisms of arrhythmogenesis and atrial fibrillation.
The atrial fibrillation is the most frequent fibrillation.It's incidence increases with the age.The atrial fibrillation can induce embolism,interfere blood-pumping function of ventricles and aggravate myocardial damage.The present article describes the anatomy of atrium,the electrophysiology of atrial muscle cell and the mechanisms of arrhythmogenesis and atrial fibrillation.
引文
[1]Olesen MS,Bentzen BH,Nielsen JB,et al.Mutations in the potassium channel subunit KCNE1are associated with early-onset familial atrial fibrillation[J].BMC Med Genet,2012,13:24.
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[4]Wirka RC,Gore S,Van Wagoner DR,et al.A common connexin-40gene promoter variant affects connexin-40expression in human atria and is associated with atrial fibrillation[J].Circ Arrhythm Electrophysiol,2011,4(1):87-93.
[5]Auerbach DS,Grzda KR,Furspan PB,et al.Structural heterogeneity promotes triggered activity,reflection and arrhythmogenesis in cardiomyocyte monolayers[J].J Physiol,2011,589(Pt 9):2363-2381.
[6]丁绍祥.J波和2相折返形成离子流机制研究进展[J].中国老年学杂志,2012,32(12):2676-2678.
[7]De Lange E,Xie Y,Qu Z.Synchronization of early afterdepolarizations and arrhythmogenesis in heterogeneous cardiac tissue models[J].Biophys J,2012,103(2):365-373.
[8]Pellman J,Lyon RC,Sheikh F.Extracellular matrix remodelingin atrial fibrosis:mechanisms and implications in atrial fibrillation[J].J Mol Cell Cardiol,2010,48(3):461-467.
[9]丁绍祥.早复极发生机制的研究进展[J].天津医药,2012,40(10):1081-1084.
[10]丁绍祥.结间束存在的合理性探讨[J].中国医疗前沿,2009,4(18):9-10.
[11]Terzic A,Alekseev AE,Yamada S,et al.Advances in cardiac ATP-sensitive K+channelopathies from molecules to populations[J].Circ Arrhythm Electrophysiol,2011,4(4):577-585.
[12]Teh AW,Kalman JM,Lee G,et al.Electroanatomic remodelling of the pulmonary veins associated with age[J].Europace,2012,14(1):46-51.
[13]Chan PJ,Osteen JD,Xiong D,et al.Characterization of KCNQ1atrial fibrillation mutations reveals distinct dependence on KCNE1[J].J Gen Physiol,2012,139(2):135-144.
[14]Hatem S.Biology of the substrate of atrial fibrillation[J].Biol Aujourdhui,2012,206(1):5-9.
[15]Sharma D,Li G,Xu G,et al.Atrial remodeling in atrial fibrillation and some related microRNAs[J].Cardiology,2011,120(2):111-121.
[16]Voigt N,Li N,Wang Q,et al.Enhanced sarcoplasmic reticulum Ca2+leak and increased Na+-Ca2+exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation[J].Circulation,2012,125(17):2059-2070.
[17]Trovato GM,Pace P,Cangemi E,et al.Gender,lifestyles,illness perception and stress in stable atrial fibrillation[J].Clin Ter,2012,163(4):281-286.
[2]Bao L,Kefaloyianni E,Lader J,et al.Unique properties of the ATP-sensitive K+channel in the mouse ventricular cardiac conduction system[J].Circ Arrhythm Electrophysiol,2011,4(6):926-935.
[3]Schmidt C,Wiedmann F,Schweizer PA,et al.Cardiac two-poredomain potassium channels(K2P):Physiology,pharmacology,and therapeutic potential[J].Dtsch Med Wochenschr,2012,137(33):1654-1658.
[4]Wirka RC,Gore S,Van Wagoner DR,et al.A common connexin-40gene promoter variant affects connexin-40expression in human atria and is associated with atrial fibrillation[J].Circ Arrhythm Electrophysiol,2011,4(1):87-93.
[5]Auerbach DS,Grzda KR,Furspan PB,et al.Structural heterogeneity promotes triggered activity,reflection and arrhythmogenesis in cardiomyocyte monolayers[J].J Physiol,2011,589(Pt 9):2363-2381.
[6]丁绍祥.J波和2相折返形成离子流机制研究进展[J].中国老年学杂志,2012,32(12):2676-2678.
[7]De Lange E,Xie Y,Qu Z.Synchronization of early afterdepolarizations and arrhythmogenesis in heterogeneous cardiac tissue models[J].Biophys J,2012,103(2):365-373.
[8]Pellman J,Lyon RC,Sheikh F.Extracellular matrix remodelingin atrial fibrosis:mechanisms and implications in atrial fibrillation[J].J Mol Cell Cardiol,2010,48(3):461-467.
[9]丁绍祥.早复极发生机制的研究进展[J].天津医药,2012,40(10):1081-1084.
[10]丁绍祥.结间束存在的合理性探讨[J].中国医疗前沿,2009,4(18):9-10.
[11]Terzic A,Alekseev AE,Yamada S,et al.Advances in cardiac ATP-sensitive K+channelopathies from molecules to populations[J].Circ Arrhythm Electrophysiol,2011,4(4):577-585.
[12]Teh AW,Kalman JM,Lee G,et al.Electroanatomic remodelling of the pulmonary veins associated with age[J].Europace,2012,14(1):46-51.
[13]Chan PJ,Osteen JD,Xiong D,et al.Characterization of KCNQ1atrial fibrillation mutations reveals distinct dependence on KCNE1[J].J Gen Physiol,2012,139(2):135-144.
[14]Hatem S.Biology of the substrate of atrial fibrillation[J].Biol Aujourdhui,2012,206(1):5-9.
[15]Sharma D,Li G,Xu G,et al.Atrial remodeling in atrial fibrillation and some related microRNAs[J].Cardiology,2011,120(2):111-121.
[16]Voigt N,Li N,Wang Q,et al.Enhanced sarcoplasmic reticulum Ca2+leak and increased Na+-Ca2+exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation[J].Circulation,2012,125(17):2059-2070.
[17]Trovato GM,Pace P,Cangemi E,et al.Gender,lifestyles,illness perception and stress in stable atrial fibrillation[J].Clin Ter,2012,163(4):281-286.