芎红活血外洗方预防卡培他滨相关手足综合征效果观察
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摘要
【目的】探讨芎红活血外洗方手足浸泡方法对卡培他滨化疗后手足综合征(hand-foot syndrome,HFS)的预防作用。【方法】随机将67例接受含卡培他滨化疗的胃肠道恶性肿瘤患者分为2组,实验组(34人)采用基础护理及芎红活血外洗方手足浸泡治疗,对照组(33人)予以基础护理及温水浸泡。使用卡培他滨化疗的同时开始对两组人群予以相应治疗。【结果】实验组HFS发生率显著低于对照组(17.6%与42.4%,P=0.027),且发生时间显著晚于对照组(P=0.032)。对照组患者的手足疼痛症状较实验组患者明显(P=0.002)。是否使用中药浸泡(OR=3.280,P=0.040)是HFS发生的独立危险因素。对照组中,卡培他滨联合紫杉醇患者的HFS发生率,高于卡培他滨联合奥沙利铂的患者(P=0.047)。【结论】芎红活血外洗方手足浸泡对卡培他滨相关性HFS具有很好的预防作用。
[Objective] To investigate the curative effect of early application of the herbal fumigation on hand-foot syndrome(HFS) induced by capecitabine. [Methods] A series of 67 patients with gastrointestinal malignancies receiving capecitabine chemotherapy were randomly divided into two groups.The treatment group(34 patients) was treated with herbal immersion and basic care,while the control group(33 patients) with warm water immersion and basic care.The corresponding treatment was adopted as soon as the chemotherapy with capecitabine was started. [Results] The incidence and occurrence time of HFS in the treatment group were significantly lower(17.6% vs 42.4%,P=0.027) and later(P=0.032) than that in the control group.The symptoms of pain in the control group were more significant than those in the treatment group(P=0.002).Treatment without herbal immersion(OR=3.280,P=0.040) were independently related to HFS.In the control group,the incidence of HFS in patient taking capecitabine and paclitaxel were significantly higher than those taking capecitabine and oxaliplatine(P=0.047). [Conclusion] Herbal immersion has preventive and therapeutic effect on hand-foot syndrome caused by capecitabine.
[Objective] To investigate the curative effect of early application of the herbal fumigation on hand-foot syndrome(HFS) induced by capecitabine. [Methods] A series of 67 patients with gastrointestinal malignancies receiving capecitabine chemotherapy were randomly divided into two groups.The treatment group(34 patients) was treated with herbal immersion and basic care,while the control group(33 patients) with warm water immersion and basic care.The corresponding treatment was adopted as soon as the chemotherapy with capecitabine was started. [Results] The incidence and occurrence time of HFS in the treatment group were significantly lower(17.6% vs 42.4%,P=0.027) and later(P=0.032) than that in the control group.The symptoms of pain in the control group were more significant than those in the treatment group(P=0.002).Treatment without herbal immersion(OR=3.280,P=0.040) were independently related to HFS.In the control group,the incidence of HFS in patient taking capecitabine and paclitaxel were significantly higher than those taking capecitabine and oxaliplatine(P=0.047). [Conclusion] Herbal immersion has preventive and therapeutic effect on hand-foot syndrome caused by capecitabine.
引文
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[17]杨丽侠,陈迎,井桂莲,等.芎红乌草桂枝汤治疗卡培他滨致手足综合征的临床护理研究[J].中国保健营养,2016,26(4):33-34.
[2]ILYAS S,WASIF K,SAIF M W.Topical henna ameliorated capecitabine-induced hand-foot syndrome[J].Cutan Ocul Toxicol,2014,33(3):253-255.
[3]ELYASI S,SHOJAEE F S R,ALLAHYARI A,et al.Topical silymarin administration for prevention of capecitabine-induced hand-foot syndrome:a randomized,double-blinded,placebo-controlled clinical trial[J].Phytother Res,2017,31(9):1323-1329.
[4]GRESSETT S M,SHAH S R.Intricacies of bevacizumab-induced toxicities and their management[J].Ann Pharmacother,2009,43(3):490-501.
[5]HEO Y S,CHANG H M,KIM T W,et al.Hand-foot syndrome in patients treated with capecitabine-containing combination chemotherapy[J].J Clin Pharmacol,2004,44(10):1166-1172.
[6]GRESSETT S M,STANFORD B L,HARDWICKE F.Management of hand-foot syndrome induced by capecitabine[J].J Oncol Pharm Pract,2006,12(3):131-141.
[7]YAP Y S,KWOK L L,SYN N,et al.Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome:a randomized clinical trial[J].JAMA Oncol,2017,3(11):1538-1545.
[8]郭梦如,何东仪.经皮给药治疗类风湿关节炎动物实验的中药复方制剂概况[J].上海预防医学,2014,26(4):176-179.
[9]梁小珍,梁耀君.紫草油外涂防治希罗达所致手足综合征25例疗效观察[J].新中医,2013(5):108-109.
[10]陈州华,周胜涟.芪归通络汤浸泡治疗化疗后手足综合征30例[J].陕西中医,2012,33(1):32-34.
[11]娄彦妮,陈信义,田爱平,等.通络活血法外用治疗化疗性手足综合征临床研究[J].辽宁中医药大学学报,2013,15(4):68-70.
[12]魏征,张俊萍,蔡小平.四妙活血散外洗防治卡培他滨化疗后手足综合征[J].中国民康医学,2013,25(10):57,76.
[13]陈青青.加味桂枝汤熏洗防治卡培他滨所致手足综合征观察[J].浙江中医杂志,2012,47(1):39.
[14]王阳,陈浩暘.炎敌油用于希罗达治疗乳腺癌所致手足综合征的疗效观察[J].实用药物与临床,2013,16(7):650-651.
[15]黄春英.京万红软膏可治疗希罗达所致手足综合征[J].护理学报,2009,16(16):42.
[16]匡卫华.湿润烧伤膏治疗希罗达所致手足综合征的疗效观察[J].实用癌症杂志,2008,23(6):655.
[17]杨丽侠,陈迎,井桂莲,等.芎红乌草桂枝汤治疗卡培他滨致手足综合征的临床护理研究[J].中国保健营养,2016,26(4):33-34.