抗环瓜氨酸肽抗体、类风湿性因子联合检测在类风湿性关节炎诊断中的应用价值
|
摘要
目的探讨抗环瓜氨酸肽(抗-CCP)抗体、类风湿因子(RF)联合检测对类风湿关节炎(RA)的临床应用价值。方法选取类风湿性关节炎患者117例为类风湿关节炎组,另选取其他自身免疫病患者86例和正常健康体检者120例为对照组。检测抗-CCP、RF均采用免疫比浊法。结果 RA组的抗-CCP和RF的阳性率均高于非RA组和对照组,差异有统计学意义(P<0.05)。RA组抗-CCP和RF二者联合检测的阳性率明显高于其余2组,差异有统计学意义(P<0.05),抗-CCP灵敏度为82.4%、特异度为93.5%,RF灵敏度为84.8%、特异度为76.4%;二者联合检测,灵敏度为82.4%、特异度为94.5%。结论 RF与抗-CCP抗体联合检测有利于提高RA检测的阳性率,对RA诊断及早期诊断具有重要的临床意义。
Objective To investigate the combined detection value of anti cycliccitrullinated peptide(CCP) antibody and rheumatoid factor(RF) in the diagnosis of rheumatoid arthritis(RA). Methods A total of 117 patients with rheumatoid arthritis(RA) were selected as the control group, and patients with other autoimmune diseases(n=86) and normal healthy subjects(n=120) were selected as control group. The anti-CCP and rheumatoid factors were detected by immune turbidimetry. Results The positive rates of anti CCP and RF in RA group were higher than those of autoimmune group and control group(P<0.05). The positive rate of combined detection in the RA group was significantly higher than the other two groups, with the differences statistically significant(P<0.05); The sensitivity of anti CCP antibody was 82.4%, specificity was 93.5%; The sensitivity of RA was 84.8%, the specificity was 76.4%; The sensitivity of combined detection was 82.4%, specificity was 94.5%. Conclusion RF combined with anti-CCP antibody is helpful to improve the positive rate of RA detection, and has important clinical significance for the early diagnosis of RA.
Objective To investigate the combined detection value of anti cycliccitrullinated peptide(CCP) antibody and rheumatoid factor(RF) in the diagnosis of rheumatoid arthritis(RA). Methods A total of 117 patients with rheumatoid arthritis(RA) were selected as the control group, and patients with other autoimmune diseases(n=86) and normal healthy subjects(n=120) were selected as control group. The anti-CCP and rheumatoid factors were detected by immune turbidimetry. Results The positive rates of anti CCP and RF in RA group were higher than those of autoimmune group and control group(P<0.05). The positive rate of combined detection in the RA group was significantly higher than the other two groups, with the differences statistically significant(P<0.05); The sensitivity of anti CCP antibody was 82.4%, specificity was 93.5%; The sensitivity of RA was 84.8%, the specificity was 76.4%; The sensitivity of combined detection was 82.4%, specificity was 94.5%. Conclusion RF combined with anti-CCP antibody is helpful to improve the positive rate of RA detection, and has important clinical significance for the early diagnosis of RA.
引文
[1] 叶松,方湖军,谭婧.类风湿关节炎的诊断与鉴别诊断[J].海军医学杂志,2013,34(1):51-53.
[2] 童丹红,王永丽,朱丽,等.抗环瓜氨酸肽抗体(抗-CCP)与类风湿(RF)联合检测对类风湿性关节炎的诊断价值[J].中国现代医生,2012,50(34):59-60.
[3] 郑静,袁兆林,郑玉芬,等.血清中葡萄糖-6-磷酸异构酶抗原的检测在类风湿性关节炎中的意义[J].中国卫生检验杂志,2012,22(10):2398-2400.
[4] Bas S,Pemeger TV,Seitz M,et al.Diagmostic tests for rhcuma Toidarthritis:comparison of anti-cyclic citrullinated peptide antibodies,anti-keratin antibodies and IgM rheums toid factor[J].Rheumatology(Oxford),2002,41(7):809-814.
[5] 李玉刚,李兴达,李磊.血清抗环瓜氨酸肽抗体检测在类风湿关节炎诊断中的价值[J].检验医学与临床,2011,8(23):2868-2869.
[6] 陈平,樊卫.CCP抗体、AKA和RF检测对类风湿关节炎早期诊断的临床价值[J].检验医学与临床,2012,9(20):2584-2585.
[7] 胡壮彬.研究抗CCP抗体在诊断类风湿关节炎中的临床应用[J].中外医学研究,2014,12(2):57-57,58.
[8] 何穗,毛福青.抗环瓜氨酸肽抗体与类风湿因子联合检测对风湿关节炎的诊断价值[J].现代诊断与治疗,2016,27(2):297-298.
[9] 侯娟,叶红珍.类风湿性关节炎与血清抗-CCP抗体、RF、CRP及ESR的相关性研究[J].当代医药论丛,2016,14(6):30-31.
[10] 黄芳.抗环瓜氨酸多肽抗体在类风湿因子阳性患者及类风湿关节炎不同时期的表达[J].中国误诊学杂志,2012,12(5):1057-1057.
[11] 张静思,陈鑫苹,陈斌.RF、抗-CCP、AKA及GPI联合检测在类风湿关节炎诊断中的价值[J].重庆医学,2015,44(13):1788-1789,1793.
[12] 梁鹏,安宏亮.张劲丰.抗环瓜氨酸肽抗体对类风湿关节炎的诊断及与骨侵蚀相关性研究[J].中国卫生检验杂志,2015,25(1):62-64.
[13] 李鸿斌,铁宁,贾永峰,等.类风湿关节炎患者滑膜抗环瓜氨酸肽表位表达与Th17/调节性T细胞的失衡和滑膜炎症的相关性分析[J].中华风湿病学杂志,2012,16(4):224-228.
[14] 王希平,梁顺容,叶丽燕,等.抗CCP抗体、RF、CRP、ESR在类风湿关节炎诊断中的应用价值[J].国际检验医学杂志,2012,33(17):2067-2068.
[15] 吴庆军,曾小峰,唐福林,等.类风湿关节炎早期诊断的血清学研究和临床应用[J].医学研究杂志,2014,12(5):158-159.
[2] 童丹红,王永丽,朱丽,等.抗环瓜氨酸肽抗体(抗-CCP)与类风湿(RF)联合检测对类风湿性关节炎的诊断价值[J].中国现代医生,2012,50(34):59-60.
[3] 郑静,袁兆林,郑玉芬,等.血清中葡萄糖-6-磷酸异构酶抗原的检测在类风湿性关节炎中的意义[J].中国卫生检验杂志,2012,22(10):2398-2400.
[4] Bas S,Pemeger TV,Seitz M,et al.Diagmostic tests for rhcuma Toidarthritis:comparison of anti-cyclic citrullinated peptide antibodies,anti-keratin antibodies and IgM rheums toid factor[J].Rheumatology(Oxford),2002,41(7):809-814.
[5] 李玉刚,李兴达,李磊.血清抗环瓜氨酸肽抗体检测在类风湿关节炎诊断中的价值[J].检验医学与临床,2011,8(23):2868-2869.
[6] 陈平,樊卫.CCP抗体、AKA和RF检测对类风湿关节炎早期诊断的临床价值[J].检验医学与临床,2012,9(20):2584-2585.
[7] 胡壮彬.研究抗CCP抗体在诊断类风湿关节炎中的临床应用[J].中外医学研究,2014,12(2):57-57,58.
[8] 何穗,毛福青.抗环瓜氨酸肽抗体与类风湿因子联合检测对风湿关节炎的诊断价值[J].现代诊断与治疗,2016,27(2):297-298.
[9] 侯娟,叶红珍.类风湿性关节炎与血清抗-CCP抗体、RF、CRP及ESR的相关性研究[J].当代医药论丛,2016,14(6):30-31.
[10] 黄芳.抗环瓜氨酸多肽抗体在类风湿因子阳性患者及类风湿关节炎不同时期的表达[J].中国误诊学杂志,2012,12(5):1057-1057.
[11] 张静思,陈鑫苹,陈斌.RF、抗-CCP、AKA及GPI联合检测在类风湿关节炎诊断中的价值[J].重庆医学,2015,44(13):1788-1789,1793.
[12] 梁鹏,安宏亮.张劲丰.抗环瓜氨酸肽抗体对类风湿关节炎的诊断及与骨侵蚀相关性研究[J].中国卫生检验杂志,2015,25(1):62-64.
[13] 李鸿斌,铁宁,贾永峰,等.类风湿关节炎患者滑膜抗环瓜氨酸肽表位表达与Th17/调节性T细胞的失衡和滑膜炎症的相关性分析[J].中华风湿病学杂志,2012,16(4):224-228.
[14] 王希平,梁顺容,叶丽燕,等.抗CCP抗体、RF、CRP、ESR在类风湿关节炎诊断中的应用价值[J].国际检验医学杂志,2012,33(17):2067-2068.
[15] 吴庆军,曾小峰,唐福林,等.类风湿关节炎早期诊断的血清学研究和临床应用[J].医学研究杂志,2014,12(5):158-159.