抗反流手术在治疗胃食管反流疾病中的应用
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摘要
胃食管反流疾病(GERD)是指胃内容物反流到食管而引起不适症状和(或)并发症的上消化道疾病。质子泵抑制剂是治疗GERD的首选药物,但对难治性GERD的患者疗效欠佳,而抗反流手术能有效地治疗这部分患者。内镜下抗反流手术包括经口无切口折叠术(TIF)、射频消融疗法(Stretta术)、抗反流黏膜切除术(ARMS)和内镜下注射或植入技术。外科抗反流手术包括胃底折叠术、磁控括约肌增强技术(MSA)、LES电刺激术及减肥手术。文章重点阐述抗反流手术应用于胃食管反流疾病的治疗。
Gastroesophageal reflux disease(GERD)is defined as refluxing of gastric contents to the esophagus,causing gastrointestinal tract symptoms and/or complications. Proton pump inhibitors are the first choice for the treatment of GERD,but have no such good effect as anti-reflux surgery on refractory GERD. Endoscopic anti-reflux procedures include transoral incisionless fundoplication(TIF),Stretta radiofrequency ablation,anti-reflux mucosectomy(ARMS),and endoscopic injection or implantation. Anti-reflux surgery involves laproscopic Nissen fundoplication(LNF),magnetic sphincter augmentation(MSA),electrical stimulation on the lower esophageal sphincter(LES),and bariatric surgery. This article introduces the progress in anti-reflux surgery for GERD.
Gastroesophageal reflux disease(GERD)is defined as refluxing of gastric contents to the esophagus,causing gastrointestinal tract symptoms and/or complications. Proton pump inhibitors are the first choice for the treatment of GERD,but have no such good effect as anti-reflux surgery on refractory GERD. Endoscopic anti-reflux procedures include transoral incisionless fundoplication(TIF),Stretta radiofrequency ablation,anti-reflux mucosectomy(ARMS),and endoscopic injection or implantation. Anti-reflux surgery involves laproscopic Nissen fundoplication(LNF),magnetic sphincter augmentation(MSA),electrical stimulation on the lower esophageal sphincter(LES),and bariatric surgery. This article introduces the progress in anti-reflux surgery for GERD.
引文
[1]Vakil N,van Zanten SV,Kahrilas P,et al.The Montreal definition and classification of gastroesophageal reflux disease:a global evidencebased consensus[J].Am J Gastroenterol,2006,101(8):1900-1920;quiz 1943.
[2]Internal Clinical Guidelines T.National Institute for Health and Care Excellence:Clinical Guidelines[A].In:Dyspepsia and Gastro-Oesophageal Reflux Disease:Investigation and Management of Dyspepsia,Symptoms Suggestive of Gastro-Oesophageal Reflux Disease,or Both.London:National Institute for Health and Care Excellence(UK)Copyright(c)National Institute for Health and Care Excellence,2014,2014.
[3]Richter JE,Rubenstein JH.Presentation and Epidemiology of Gastroesophageal Reflux Disease[J].Gastroenterology,2018,154(2):267-276.
[4]Hershcovici T,Fass R.Step-by-step management of refractory gastresophageal reflux disease[J].Dis Esophagus,2013,26(1):27-36.
[5]Sifrim D,Zerbib F.Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors[J].Gut,2012,61(9):1340-1354.
[6]Scarpellini E,Ang D,Pauwels A,et al.Management of refractory typical GERD symptoms[J].Nat Rev Gastroenterol Hepatol,2016,13(5):281-294.
[7]Cheung KS,Chan EW,Wong AYS,et al.Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori:a population-based study[J].Gut,2018,67(1):28-35.
[8]Vaezi MF,Yang YX,Howden CW.Complications of Proton Pump Inhibitor Therapy[J].Gastroenterology,2017,153(1):35-48.
[9]Fock KM,Talley N,Goh KL,et al.Asia-Pacific consensus on the management of gastro-oesophageal reflux disease:an update focusing on refractory reflux disease and Barrett's oesophagus[J].Gut,2016,65(9):1402-1415.
[10]Kahrilas PJ.Transoral Incisionless Fundoplication for the Treatment of Gastroesophageal Reflux Disease[J].Gastroenterol Hepatol(NY),2016,12(6):400-402.
[11]Witteman BP,Conchillo JM,Rinsma NF,et al.Randomized controlled trial of transoral incisionless fundoplication vs.proton pump inhibitors for treatment of gastroesophageal reflux disease[J].Am J Gastroenterol,2015,110(4):531-542.
[12]Huang X,Chen S,Zhao H,et al.Efficacy of transoral incisionless fundoplication(TIF)for the treatment of GERD:a systematic review with meta-analysis[J].Surg Endosc,2017,31(3):1032-1044.
[13]Zacherl J,Roy-Shapira A,Bonavina L,et al.Endoscopic anterior fundoplication with the Medigus Ultrasonic Surgical Endostapler(MUSE)for gastroesophageal reflux disease:6-month results from a multi-center prospective trial[J].Surg Endosc,2015,29(1):220-229.
[14]Kim HJ,Kwon CI,Kessler WR,et al.Long-term follow-up results of endoscopic treatment of gastroesophageal reflux disease with the MUSEendoscopic stapling device[J].Surg Endosc,2016,30(8):3402-3408.
[15]Weitzendorfer M,Spaun GO,Antoniou SA,et al.Interim Report of a Prospective Trial on the Clinical Efficiency of a New Full-thickness Endoscopic Plication Device for Patients With GERD:Impact of Changed Suture Material[J].Surg Laparosc Endosc Percutan Tech,2017,27(3):163-169.
[16]Weitzendorfer M,Spaun GO,Antoniou SA,et al.Clinical feasibility of a new full-thickness endoscopic plication device(GERDx)for patients with GERD:results of a prospective trial[J].Surg Endosc,2018,32(5):2541-2549.
[17]Liang WT,Wang ZG,Wang F,et al.Long-term outcomes of patients with refractory gastroesophageal reflux disease following a minimally invasive endoscopic procedure:a prospective observational study[J].BMC Gastroenterol,2014,14:178.
[18]Lipka S,Kumar A,Richter JE.No evidence for efficacy of radiofrequency ablation for treatment of gastroesophageal reflux disease:a systematic review and meta-analysis[J].Clin Gastroenterol Hepatol,2015,13(6):1058-1067.e1051.
[19]Fass R,Cahn F,Scotti DJ,et al.Systematic review and meta-analysis of controlled and prospective cohort efficacy studies of endoscopic radiofrequency for treatment of gastroesophageal reflux disease[J].Surg Endosc,2017,31(12):4865-4882.
[20]Inoue H,Ito H,Ikeda H,et al.Anti-reflux mucosectomy for gastroesophageal reflux disease in the absence of hiatus hernia:a pilot study[J].Ann Gastroenterol,2014,27(4):346-351.
[21]Benias PC,D'Souza L,Lan G,et al.Initial experience with a novel resection and plication(RAP)method for acid reflux:a pilot study[J].Endosc Int Open,2018,6(4):E443-e449.
[22]Lo WK,Mashimo H.Critical Assessment of Endoscopic Techniques for Gastroesophageal Reflux Disease[J].J Clin Gastroenterol,2015,49(9):720-724.
[23]Mikami DJ,Murayama KM.Physiology and pathogenesis of gastroesophageal reflux disease[J].Surg Clin North Am,2015,95(3):515-525.
[24]Fass R.An Overview of Transoral Incisionless Fundoplication and Magnetic Sphincter Augmentation for GERD[J].Gastroenterol Hepatol(NY),2017,13(1):50-52.
[25]Gyawali CP,Fass R.Management of Gastroesophageal Reflux Disease[J].Gastroenterology,2018,154(2):302-318.
[26]Alpers DA.Laparoscopic Nissen fundoplication[J].Semin Perioper Nurs,1995,4(3):162-167.
[27]Katz PO,Gerson LB,Vela MF.Guidelines for the diagnosis and management of gastroesophageal reflux disease[J].Am J Gastroenterol,2013,108(3):308-328,quiz 329.
[28]Richter JE,Kumar A,Lipka S,et al.Efficacy of Laparoscopic Nissen Fundoplication vs Transoral Incisionless Fundoplication or Proton Pump Inhibitors in Patients With Gastroesophageal Reflux Disease:A Systematic Review and Network Meta-analysis[J].Gastroenterology,2018,154(5):1298-1308.e1297.
[29]Glen P,Chasse M,Doyle MA,et al.Partial versus complete fundoplication for the correction of pediatric GERD:a systematic review and metaanalysis[J].PLoS One,2014,9(11):e112417.
[30]Wileman SM,McCann S,Grant AM,et al.Medical versus surgical management for gastro-oesophageal reflux disease(GORD)in adults[J].Cochrane Database Syst Rev,2010,(3):Cd003243.
[31]Ganz RA.A Modern Magnetic Implant for Gastroesophageal Reflux Disease[J].Clin Gastroenterol Hepatol,2017,15(9):1326-1337.
[32]Lipham JC,Taiganides PA,Louie BE,et al.Safety analysis of first 1000 patients treated with magnetic sphincter augmentation for gastroesophageal reflux disease[J].Dis Esophagus,2015,28(4):305-311.
[33]Ganz RA,Edmundowicz SA,Taiganides PA,et al.Long-term Outcomes of Patients Receiving a Magnetic Sphincter Augmentation Device for Gastroesophageal Reflux[J].Clin Gastroenterol Hepatol,2016,14(5):671-677.
[34]Skubleny D,Switzer NJ,Dang J,et al.LINX((R))magnetic esophageal sphincter augmentation versus Nissen fundoplication for gastroesophageal reflux disease:a systematic review and meta-analysis[J].Surg Endosc,2017,31(8):3078-3084.
[35]Rodriguez L,Rodriguez P,Gomez B,et al.Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD:final results of open-label prospective trial[J].Surg Endosc,2013,27(4):1083-1092.
[36]Rodriguez L,Rodriguez P,Neto MG,et al.Short-term electrical stimulation of the lower esophageal sphincter increases sphincter pressure in patients with gastroesophageal reflux disease[J].Neurogastroenterol Motil,2012,24(5):446-450,e213.
[37]Rodriguez L,Rodriguez PA,Gomez B,et al.Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD:long-term 3-year results[J].Surg Endosc,2016,30(7):2666-2672.
[38]Khan A,Kim A,Sanossian C,et al.Impact of obesity treatment on gastroesophageal reflux disease[J].World J Gastroenterol,2016,22(4):1627-1638.
[39]Roman S,Pandolfino JE.Environmental-lifestyle related factors[J].Best Pract Res Clin Gastroenterol,2010,24(6):847-859.
[40]Wilson LJ,Ma W,Hirschowitz BI.Association of obesity with hiatal hernia and esophagitis[J].Am J Gastroenterol,1999,94(10):2840-2844.
[41]Thereaux J,Lesuffleur T,Czernichow S,et al.Do sleeve gastrectomy and gastric bypass influence treatment with proton pump inhibitors 4years after surgery?A nationwide cohort[J].Surg Obes Relat Dis,2017,13(6):951-959.
[42]Braghetto I,Csendes A,Korn O,et al.Gastroesophageal reflux disease after sleeve gastrectomy[J].Surg Laparosc Endosc Percutan Tech,2010,20(3):148-153.
[43]Madalosso CA,Gurski RR,Callegari-Jacques SM,et al.The Impact of Gastric Bypass on Gastroesophageal Reflux Disease in Morbidly Obese Patients[J].Ann Surg,2016,263(1):110-116.
[44]Parmar CD,Mahawar KK,Boyle M,et al.Conversion of Sleeve Gastrectomy to Roux-en-Y Gastric Bypass is Effective for Gastro-Oesophageal Reflux Disease but not for Further Weight Loss[J].Obes Surg,2017,27(7):1651-1658.
[45]Borbely Y,Kroll D,Nett PC,et al.Radiologic,endoscopic,and functional patterns in patients with symptomatic gastroesophageal reflux disease after Roux-en-Y gastric bypass[J].Surg Obes Relat Dis,2018,14(6):764-768.
[2]Internal Clinical Guidelines T.National Institute for Health and Care Excellence:Clinical Guidelines[A].In:Dyspepsia and Gastro-Oesophageal Reflux Disease:Investigation and Management of Dyspepsia,Symptoms Suggestive of Gastro-Oesophageal Reflux Disease,or Both.London:National Institute for Health and Care Excellence(UK)Copyright(c)National Institute for Health and Care Excellence,2014,2014.
[3]Richter JE,Rubenstein JH.Presentation and Epidemiology of Gastroesophageal Reflux Disease[J].Gastroenterology,2018,154(2):267-276.
[4]Hershcovici T,Fass R.Step-by-step management of refractory gastresophageal reflux disease[J].Dis Esophagus,2013,26(1):27-36.
[5]Sifrim D,Zerbib F.Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors[J].Gut,2012,61(9):1340-1354.
[6]Scarpellini E,Ang D,Pauwels A,et al.Management of refractory typical GERD symptoms[J].Nat Rev Gastroenterol Hepatol,2016,13(5):281-294.
[7]Cheung KS,Chan EW,Wong AYS,et al.Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori:a population-based study[J].Gut,2018,67(1):28-35.
[8]Vaezi MF,Yang YX,Howden CW.Complications of Proton Pump Inhibitor Therapy[J].Gastroenterology,2017,153(1):35-48.
[9]Fock KM,Talley N,Goh KL,et al.Asia-Pacific consensus on the management of gastro-oesophageal reflux disease:an update focusing on refractory reflux disease and Barrett's oesophagus[J].Gut,2016,65(9):1402-1415.
[10]Kahrilas PJ.Transoral Incisionless Fundoplication for the Treatment of Gastroesophageal Reflux Disease[J].Gastroenterol Hepatol(NY),2016,12(6):400-402.
[11]Witteman BP,Conchillo JM,Rinsma NF,et al.Randomized controlled trial of transoral incisionless fundoplication vs.proton pump inhibitors for treatment of gastroesophageal reflux disease[J].Am J Gastroenterol,2015,110(4):531-542.
[12]Huang X,Chen S,Zhao H,et al.Efficacy of transoral incisionless fundoplication(TIF)for the treatment of GERD:a systematic review with meta-analysis[J].Surg Endosc,2017,31(3):1032-1044.
[13]Zacherl J,Roy-Shapira A,Bonavina L,et al.Endoscopic anterior fundoplication with the Medigus Ultrasonic Surgical Endostapler(MUSE)for gastroesophageal reflux disease:6-month results from a multi-center prospective trial[J].Surg Endosc,2015,29(1):220-229.
[14]Kim HJ,Kwon CI,Kessler WR,et al.Long-term follow-up results of endoscopic treatment of gastroesophageal reflux disease with the MUSEendoscopic stapling device[J].Surg Endosc,2016,30(8):3402-3408.
[15]Weitzendorfer M,Spaun GO,Antoniou SA,et al.Interim Report of a Prospective Trial on the Clinical Efficiency of a New Full-thickness Endoscopic Plication Device for Patients With GERD:Impact of Changed Suture Material[J].Surg Laparosc Endosc Percutan Tech,2017,27(3):163-169.
[16]Weitzendorfer M,Spaun GO,Antoniou SA,et al.Clinical feasibility of a new full-thickness endoscopic plication device(GERDx)for patients with GERD:results of a prospective trial[J].Surg Endosc,2018,32(5):2541-2549.
[17]Liang WT,Wang ZG,Wang F,et al.Long-term outcomes of patients with refractory gastroesophageal reflux disease following a minimally invasive endoscopic procedure:a prospective observational study[J].BMC Gastroenterol,2014,14:178.
[18]Lipka S,Kumar A,Richter JE.No evidence for efficacy of radiofrequency ablation for treatment of gastroesophageal reflux disease:a systematic review and meta-analysis[J].Clin Gastroenterol Hepatol,2015,13(6):1058-1067.e1051.
[19]Fass R,Cahn F,Scotti DJ,et al.Systematic review and meta-analysis of controlled and prospective cohort efficacy studies of endoscopic radiofrequency for treatment of gastroesophageal reflux disease[J].Surg Endosc,2017,31(12):4865-4882.
[20]Inoue H,Ito H,Ikeda H,et al.Anti-reflux mucosectomy for gastroesophageal reflux disease in the absence of hiatus hernia:a pilot study[J].Ann Gastroenterol,2014,27(4):346-351.
[21]Benias PC,D'Souza L,Lan G,et al.Initial experience with a novel resection and plication(RAP)method for acid reflux:a pilot study[J].Endosc Int Open,2018,6(4):E443-e449.
[22]Lo WK,Mashimo H.Critical Assessment of Endoscopic Techniques for Gastroesophageal Reflux Disease[J].J Clin Gastroenterol,2015,49(9):720-724.
[23]Mikami DJ,Murayama KM.Physiology and pathogenesis of gastroesophageal reflux disease[J].Surg Clin North Am,2015,95(3):515-525.
[24]Fass R.An Overview of Transoral Incisionless Fundoplication and Magnetic Sphincter Augmentation for GERD[J].Gastroenterol Hepatol(NY),2017,13(1):50-52.
[25]Gyawali CP,Fass R.Management of Gastroesophageal Reflux Disease[J].Gastroenterology,2018,154(2):302-318.
[26]Alpers DA.Laparoscopic Nissen fundoplication[J].Semin Perioper Nurs,1995,4(3):162-167.
[27]Katz PO,Gerson LB,Vela MF.Guidelines for the diagnosis and management of gastroesophageal reflux disease[J].Am J Gastroenterol,2013,108(3):308-328,quiz 329.
[28]Richter JE,Kumar A,Lipka S,et al.Efficacy of Laparoscopic Nissen Fundoplication vs Transoral Incisionless Fundoplication or Proton Pump Inhibitors in Patients With Gastroesophageal Reflux Disease:A Systematic Review and Network Meta-analysis[J].Gastroenterology,2018,154(5):1298-1308.e1297.
[29]Glen P,Chasse M,Doyle MA,et al.Partial versus complete fundoplication for the correction of pediatric GERD:a systematic review and metaanalysis[J].PLoS One,2014,9(11):e112417.
[30]Wileman SM,McCann S,Grant AM,et al.Medical versus surgical management for gastro-oesophageal reflux disease(GORD)in adults[J].Cochrane Database Syst Rev,2010,(3):Cd003243.
[31]Ganz RA.A Modern Magnetic Implant for Gastroesophageal Reflux Disease[J].Clin Gastroenterol Hepatol,2017,15(9):1326-1337.
[32]Lipham JC,Taiganides PA,Louie BE,et al.Safety analysis of first 1000 patients treated with magnetic sphincter augmentation for gastroesophageal reflux disease[J].Dis Esophagus,2015,28(4):305-311.
[33]Ganz RA,Edmundowicz SA,Taiganides PA,et al.Long-term Outcomes of Patients Receiving a Magnetic Sphincter Augmentation Device for Gastroesophageal Reflux[J].Clin Gastroenterol Hepatol,2016,14(5):671-677.
[34]Skubleny D,Switzer NJ,Dang J,et al.LINX((R))magnetic esophageal sphincter augmentation versus Nissen fundoplication for gastroesophageal reflux disease:a systematic review and meta-analysis[J].Surg Endosc,2017,31(8):3078-3084.
[35]Rodriguez L,Rodriguez P,Gomez B,et al.Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD:final results of open-label prospective trial[J].Surg Endosc,2013,27(4):1083-1092.
[36]Rodriguez L,Rodriguez P,Neto MG,et al.Short-term electrical stimulation of the lower esophageal sphincter increases sphincter pressure in patients with gastroesophageal reflux disease[J].Neurogastroenterol Motil,2012,24(5):446-450,e213.
[37]Rodriguez L,Rodriguez PA,Gomez B,et al.Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD:long-term 3-year results[J].Surg Endosc,2016,30(7):2666-2672.
[38]Khan A,Kim A,Sanossian C,et al.Impact of obesity treatment on gastroesophageal reflux disease[J].World J Gastroenterol,2016,22(4):1627-1638.
[39]Roman S,Pandolfino JE.Environmental-lifestyle related factors[J].Best Pract Res Clin Gastroenterol,2010,24(6):847-859.
[40]Wilson LJ,Ma W,Hirschowitz BI.Association of obesity with hiatal hernia and esophagitis[J].Am J Gastroenterol,1999,94(10):2840-2844.
[41]Thereaux J,Lesuffleur T,Czernichow S,et al.Do sleeve gastrectomy and gastric bypass influence treatment with proton pump inhibitors 4years after surgery?A nationwide cohort[J].Surg Obes Relat Dis,2017,13(6):951-959.
[42]Braghetto I,Csendes A,Korn O,et al.Gastroesophageal reflux disease after sleeve gastrectomy[J].Surg Laparosc Endosc Percutan Tech,2010,20(3):148-153.
[43]Madalosso CA,Gurski RR,Callegari-Jacques SM,et al.The Impact of Gastric Bypass on Gastroesophageal Reflux Disease in Morbidly Obese Patients[J].Ann Surg,2016,263(1):110-116.
[44]Parmar CD,Mahawar KK,Boyle M,et al.Conversion of Sleeve Gastrectomy to Roux-en-Y Gastric Bypass is Effective for Gastro-Oesophageal Reflux Disease but not for Further Weight Loss[J].Obes Surg,2017,27(7):1651-1658.
[45]Borbely Y,Kroll D,Nett PC,et al.Radiologic,endoscopic,and functional patterns in patients with symptomatic gastroesophageal reflux disease after Roux-en-Y gastric bypass[J].Surg Obes Relat Dis,2018,14(6):764-768.