基于双掩模和3D区域迭代矢量选择的双回波Dixon水脂分离方法
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摘要
目的:提出一种基于双掩模和3D区域迭代矢量选择(DM-3DRIPE)的水脂分离方法,使其在包含低信噪比(SNR)区域和强不均匀磁场情况下更可靠.方法:两点水脂分离的关键在于确定正确的场矢量.低SNR体素场矢量受噪声影响较大,为了降低噪声的影响,通过双掩模方法进行图像质量控制,先计算高质量体素点场矢量,然后再用于辅助计算低质量体素点场矢量.为了降低主磁场不均匀的影响,联合区域迭代矢量选择(RIPE)方法和三维信息辅助确定场矢量.结果:仿真实验结果表明,即使低SNR区域(r_(SN)=0.8)或场不均匀性是常规场图的4倍,水图和脂肪图依然能够成功分离.413层人体图像实验结果显示,与传统的RIPE方法相比,DM-3DRIPE方法可将错误率从28.33%降到0.73%.结论:在低SNR区域和强不均匀主磁场存在时,DM-3DRIPE方法鲁棒性更高.
Objective:To develop a double masks and 3D regional iterative phasor extraction(DM-3DRIPE)method for robust water-fat separation in the presence of low signal-to-noise ratio(SNR) region and strong inhomogeneous field map. Methods: Determination of field phasor was the key of two-point water-fat separation. The field phasor of low SNR was affected by noise easily. To minimize the effect of noise, double masks were proposed to control the quality of image. Field phasor of high quality was firstly determined, and then was assisted to calculate field phasor of low quality.To reduce the effect of inhomogeneous field map, 3D information was combined with regional iterative phasor extraction(RIPE) to reliably calculate phasor.Results: Results of simulation data showed water and fat maps were successfully achieved in the image containing low SNR region(r_(SN)=0.8) and 4 times inhomogeneous field map than usual.Compared with traditional RIPE method, the DM-3DRIPE method decreased the error ratio from 28.33% to 0.73% for 413 in vivo images.Conclusion:The DM-3DRIPE method was shown more robust when applied to low SNR regionand strong inhomogeneous field map.
Objective:To develop a double masks and 3D regional iterative phasor extraction(DM-3DRIPE)method for robust water-fat separation in the presence of low signal-to-noise ratio(SNR) region and strong inhomogeneous field map. Methods: Determination of field phasor was the key of two-point water-fat separation. The field phasor of low SNR was affected by noise easily. To minimize the effect of noise, double masks were proposed to control the quality of image. Field phasor of high quality was firstly determined, and then was assisted to calculate field phasor of low quality.To reduce the effect of inhomogeneous field map, 3D information was combined with regional iterative phasor extraction(RIPE) to reliably calculate phasor.Results: Results of simulation data showed water and fat maps were successfully achieved in the image containing low SNR region(r_(SN)=0.8) and 4 times inhomogeneous field map than usual.Compared with traditional RIPE method, the DM-3DRIPE method decreased the error ratio from 28.33% to 0.73% for 413 in vivo images.Conclusion:The DM-3DRIPE method was shown more robust when applied to low SNR regionand strong inhomogeneous field map.
引文
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[14] CHENG J,MEI Y,LIU B,et al.A novel phase-unwrapping method based on pixel clustering and local surface fitting with application to Dixon water-fat MRI[J].Magn Reson Med,2018,79(1):515-528.
[15] CHENG J,GUAN J,MEI Y,et al.A novel phase-unwrapping method by using phase-jump detection and local surface fitting:application to Dixon water-fat MRI[J].Magn Reson Med,2018,80(6):2630-2640.
[16] STINSON E G,TRZASKO J D,FLETCHER J G,et al.Dual echo Dixon imaging with a constrained phase signal model and graph cuts reconstruction[J].Magn Reson Med,2017,78(6):2203-2215.
[17] REEDER S B,WEN Z,YU H,et al.Multicoil Dixon chemical species separation with an iterative least-squares estimation method[J].Magn Reson Med,2004,51(1):35-45.
[18] CHEBROLU V V,HINES C D,YU H,et al.Independent estimation of T*2 for water and fat for improved accuracy of fat quantification[J].Magn Reson Med,2010,63(4):849-857.
[19] CUI C,WU X,NEWELL J D,et al.Fat water decomposition using globally optimal surface estimation (GOOSE) algorithm[J].Magn Reson Med,2015,73(3):1289-1299.
[20] 蔡秋月,陈智毅,蒋薇,等.基于MRI图像的眼眶脂肪体积定量测定方法[J].南方医科大学学报,2017,37(9):1248-1251.CAI Q Y,CHEN Z Y,JIANG W,et al.A novel method for quantitative measurement of orbital fat volume based on magnetic resonance images[J].Journal of Southern Medical University,2017,37(9):1248-1251.
[21] LEE D H,LEE J Y,LEE K B,et al.Evaluation of hepatic steatosis by using acoustic structure quantification US in a rat model:Comparison with pathologic examination and MR spectroscopy[J].Radiology,2017,285(2):445-453.
[22] 赖水青,洪真真,陈红梅,等.肝脏而不是骨骼肌的脂肪含量与胰岛素抵抗和糖代谢异常密切相关[J].南方医科大学学报,2017,37(11):1461-1466.LAI S Q,HONG Z Z,CHEN H M,et al.Correlation between ectopic fat accumulation and insulin sensitivity in obese individuals with different glucose tolerance levels[J].Journal of Southern Medical University,2017,37(11):1461-1466.
[23] TANG A,DESAI A,HAMILTON G,et al.Accuracy of MR imaging-estimated proton density fat fraction for classification of dichotomized histologic steatosis grades in nonalcoholic fatty liver disease[J].Radiology,2015,274(2):416-425.
[24] YEUNG D K,GRIFFITH J F,ANTONIO G E,et al.Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation:a proton MR spectroscopy study[J].Journal of magnetic resonance imaging :JMRI,2005,22(2):279-285.
[25] 陈芳妮,李绍林,张晓东,等.强直性脊柱炎骨盆骨髓脂肪沉积的磁共振成像分析[J].南方医科大学学报,2014,34(2):256-259.CHEN F N,LI S L,ZHANG X D,et al.Magnetic resonance imaging for pelvic bone marrow fat deposition in patients with ankylosing spondylitis[J].Journal of Southern Medical University,2014,34(2):256-259.
[26] SINGHAL V,BREDELLA M A.Marrow adipose tissue imaging in humans[J].Bone,2018,118:69-76.
[27] PENG X G,BAI Y Y,FANG F,et al.Renal lipids and oxygenation in diabetic mice:noninvasive quantification with MR imaging[J].Radiology,2013,269(3):748-757.
[28] SCHNEIDER M,JANAS G,LUGAUER F,et al.Accurate fatty acid composition estimation of adipose tissue in the abdomen based on bipolar multi-echo MRI[J].Magn Reson Med,2018,81(4):2330-2346.
[29] LEPORQ B,LAMBERT S A,RONOT M,et al.Hepatic fat fraction and visceral adipose tissue fatty acid composition in mice:Quantification with 7.0T MRI[J].Magn Reson Med,2016,76(2):510-518.
[30] HAMILTON G,YOKOO T,BYDDER M,et al.In vivo characterization of the liver fat (1)H MR spectrum[J].NMR Biomed,2011,24(7):784-790.
[31] PETERSON P,MANSSON S.Simultaneous quantification of fat content and fatty acid composition using MR imaging[J].Magn Reson Med,2013,69(3):688-697.
[32] 程军营,王常青,冯衍秋,等.相位分区和局部多项式曲面拟合的相位解缠绕[J].中国图象图形学报,2018,23(6):906-916.CHENG J Y,WANG C Q,FENG Y Q,et al.New phase-unwrapping method based on phase partition and local polynomial surface fitting[J].Journal of Image and Graphics,2018,23(6):0906-0916.
[2] 刘亚涛,俎栋林,包尚联.水、脂分离磁共振成像Dixon方法[J].中国医学物理学杂志,2012,29(6):3759-3768+92.LIU Y T,ZU D L,BAO S L,et al.Separation of water and fat with Dixon methods in MRI[J].Chinese Journal of Medical Physics,2012,29(6):3759-3768,3792.
[3] LU W,YU H,SHIMAKAWA A,et al.Water-fat separation with bipolar multiecho sequences[J].Magn Reson Med,2008,60(1):198-209.
[4] KELLER P J,HUNTER W W,SCHMALBROCK P.Multisection fat-water imaging with chemical shift selective presaturation[J].Radiology,1987,164(2):539-541.
[5] BYDDER G M,YOUNG I R.MR imaging:clinical use of the inversion recovery sequence[J].Journal of computer assisted tomography,1985,9(4):659-675.
[6] DIXON W T.Simple proton spectroscopic imaging[J].Radiology,1984,153(1):189-194.
[7] YU H,REEDER S B,MCKENZIE C A,et al.Single acquisition water-fat separation:feasibility study for dynamic imaging[J].Magn Reson Med,2006,55(2):413-422.
[8] XIANG Q S.Two-point water-fat imaging with partially-opposed-phase (POP) acquisition:an asymmetric Dixon method[J].Magn Reson Med,2006,56(3):572-584.
[9] EGGERS H,BRENDEL B,DUIJNDAM A,et al.Dual-echo Dixon imaging with flexible choice of echo times[J].Magn Reson Med,2011,65(1):96-107.
[10] MA J.Breath-hold water and fat imaging using a dual-echo two-point Dixon technique with an efficient and robust phase-correction algorithm[J].Magn Reson Med,2004,52(2):415-419.
[11] MA J,SON J B,HAZLE J D.An improved region growing algorithm for phase correction in MRI[J].Magn Reson Med,2016,76(2):519-529.
[12] 张晶,刁文超,程军营,等.基于3D区域增长的磁共振水脂分离方法[J].中国医学物理学杂志,2017,34(10):1013-1017.ZHANG J,DIAO W C,CHENG J Y,et al.Three-dimensional region growing method-based water-fat separation in magnetic resonance image[J].Chinese Journal of Medical Physics,2017,34(10):1013-1017.
[13] 刘镖水,张晶,程军营,等.基于多分辨率和区域增长的两点Dixon水脂分离技术[J].南方医科大学学报,2017,37(2):245-250.LIU B S,ZHANG J,CHENG J Y,et al.A two-point Dixon technique for water-fat separation using multiresolution and regiongrowing algorithm[J].Journal of Southern Medical University,2017,37(2):245-250.
[14] CHENG J,MEI Y,LIU B,et al.A novel phase-unwrapping method based on pixel clustering and local surface fitting with application to Dixon water-fat MRI[J].Magn Reson Med,2018,79(1):515-528.
[15] CHENG J,GUAN J,MEI Y,et al.A novel phase-unwrapping method by using phase-jump detection and local surface fitting:application to Dixon water-fat MRI[J].Magn Reson Med,2018,80(6):2630-2640.
[16] STINSON E G,TRZASKO J D,FLETCHER J G,et al.Dual echo Dixon imaging with a constrained phase signal model and graph cuts reconstruction[J].Magn Reson Med,2017,78(6):2203-2215.
[17] REEDER S B,WEN Z,YU H,et al.Multicoil Dixon chemical species separation with an iterative least-squares estimation method[J].Magn Reson Med,2004,51(1):35-45.
[18] CHEBROLU V V,HINES C D,YU H,et al.Independent estimation of T*2 for water and fat for improved accuracy of fat quantification[J].Magn Reson Med,2010,63(4):849-857.
[19] CUI C,WU X,NEWELL J D,et al.Fat water decomposition using globally optimal surface estimation (GOOSE) algorithm[J].Magn Reson Med,2015,73(3):1289-1299.
[20] 蔡秋月,陈智毅,蒋薇,等.基于MRI图像的眼眶脂肪体积定量测定方法[J].南方医科大学学报,2017,37(9):1248-1251.CAI Q Y,CHEN Z Y,JIANG W,et al.A novel method for quantitative measurement of orbital fat volume based on magnetic resonance images[J].Journal of Southern Medical University,2017,37(9):1248-1251.
[21] LEE D H,LEE J Y,LEE K B,et al.Evaluation of hepatic steatosis by using acoustic structure quantification US in a rat model:Comparison with pathologic examination and MR spectroscopy[J].Radiology,2017,285(2):445-453.
[22] 赖水青,洪真真,陈红梅,等.肝脏而不是骨骼肌的脂肪含量与胰岛素抵抗和糖代谢异常密切相关[J].南方医科大学学报,2017,37(11):1461-1466.LAI S Q,HONG Z Z,CHEN H M,et al.Correlation between ectopic fat accumulation and insulin sensitivity in obese individuals with different glucose tolerance levels[J].Journal of Southern Medical University,2017,37(11):1461-1466.
[23] TANG A,DESAI A,HAMILTON G,et al.Accuracy of MR imaging-estimated proton density fat fraction for classification of dichotomized histologic steatosis grades in nonalcoholic fatty liver disease[J].Radiology,2015,274(2):416-425.
[24] YEUNG D K,GRIFFITH J F,ANTONIO G E,et al.Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation:a proton MR spectroscopy study[J].Journal of magnetic resonance imaging :JMRI,2005,22(2):279-285.
[25] 陈芳妮,李绍林,张晓东,等.强直性脊柱炎骨盆骨髓脂肪沉积的磁共振成像分析[J].南方医科大学学报,2014,34(2):256-259.CHEN F N,LI S L,ZHANG X D,et al.Magnetic resonance imaging for pelvic bone marrow fat deposition in patients with ankylosing spondylitis[J].Journal of Southern Medical University,2014,34(2):256-259.
[26] SINGHAL V,BREDELLA M A.Marrow adipose tissue imaging in humans[J].Bone,2018,118:69-76.
[27] PENG X G,BAI Y Y,FANG F,et al.Renal lipids and oxygenation in diabetic mice:noninvasive quantification with MR imaging[J].Radiology,2013,269(3):748-757.
[28] SCHNEIDER M,JANAS G,LUGAUER F,et al.Accurate fatty acid composition estimation of adipose tissue in the abdomen based on bipolar multi-echo MRI[J].Magn Reson Med,2018,81(4):2330-2346.
[29] LEPORQ B,LAMBERT S A,RONOT M,et al.Hepatic fat fraction and visceral adipose tissue fatty acid composition in mice:Quantification with 7.0T MRI[J].Magn Reson Med,2016,76(2):510-518.
[30] HAMILTON G,YOKOO T,BYDDER M,et al.In vivo characterization of the liver fat (1)H MR spectrum[J].NMR Biomed,2011,24(7):784-790.
[31] PETERSON P,MANSSON S.Simultaneous quantification of fat content and fatty acid composition using MR imaging[J].Magn Reson Med,2013,69(3):688-697.
[32] 程军营,王常青,冯衍秋,等.相位分区和局部多项式曲面拟合的相位解缠绕[J].中国图象图形学报,2018,23(6):906-916.CHENG J Y,WANG C Q,FENG Y Q,et al.New phase-unwrapping method based on phase partition and local polynomial surface fitting[J].Journal of Image and Graphics,2018,23(6):0906-0916.