高校男教师良性前列腺增生合并脂肪肝状况及影响因素研究
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摘要
背景高校男教师良性前列腺增生(BHP)和脂肪肝的发病率较高,且两种疾病常伴随出现。目前两种疾病的发病机制及相伴发病的原因尚未明确。目的了解高校男教师BHP合并脂肪肝的患病情况及其影响因素,为有针对性地制定防治策略提供依据。方法收集2016年1月——2017年1月在广州某高校校医院体检中心进行体检的2136例男性教师为研究对象,其中500例单纯BHP者为BHP组,311例BHP合并脂肪肝者为合并组,对比分析两组临床资料。BHP合并脂肪肝的影响因素采用多因素Logistic回归分析。结果高校男教师BHP的患病率为38.0%(811/2136),其BHP合并脂肪肝的患病率为38.4%(311/811)。合并组BMI、尿蛋白、空腹血糖、尿比重、尿酸、低密度脂蛋白胆固醇、三酰甘油、舒张压水平较BHP组明显升高(P<0.05)。多因素Logistic分析显示,体质指数(BMI)[OR=1.447(1.306,1.603),P<0.001]、空腹血糖[OR=1.694(1.365,2.103),P<0.001]、尿酸[OR=1.003(1.000,1.006),P<0.05]、三酰甘油[OR=1.590(1.186,2.132),P<0.05]是高校男教师患BHP合并脂肪肝的危险因素,高密度脂蛋白胆固醇是高校男教师患BHP合并脂肪肝的保护因素[OR=0.389(0.162,0.931),P<0.05]。结论高校男教师BHP合并脂肪肝的患病率较单纯BHP患病率高,BMI、空腹血糖、三酰甘油、尿酸、高密度脂蛋白胆固醇是高校男教师患BHP合并脂肪肝的影响因素。
Background The incidence of benign prostatic hyperplasia(BPH) or fatty liver disease(FLD) in male university teachers is high,and both diseases are often accompanied.At present,the pathogenesis of the two diseases and the causes of their concomitant diseases are not clear yet.Objective To explore the prevalence rate of BPH with FLD and its influencing factors among male university teachers,providing a basis for the formulation of targeted prevention and control strategies.Methods The enrolled 2136 male university teachers were sampled from individuals undergoing physical examination in the physical examination center of a university hospital in Guangzhou between January 2016 and January 2017,including 500 with BHP(BHP group) and 311 with BHP and FLD(combination group).Clinical data of these two groups were analyzed comparatively.Influencing factors of BHP combined with FLD were analyzed by using multivariate Logistic regression.ResultsTotaled 811 cases(38.0%) were found with BHP,311 of whom(38.4%) were identified with FLD.Those with BHP and FLD demonstrated significantly increased mean levels of BMI,urine protein,fasting blood glucose(FBG),urine specific gravity(USG),uric acid(UA),low-density lipoprotein,triacylglycerol(TG),diastolic blood pressure compared with those with BHP(P<0.05).Multivariate Logistic regression analysis showed that increased BMI[OR=1.447(1.306,1.603),P<0.001],FBG[OR=1.694(1.365,2.103),P<0.001],UA[OR=1.003(1.000,1.006),P<0.05]and TG[OR=1.590(1.186,2.132),P<0.05]were risk factors for BHP combined with FLD,while increased high-density lipoprotein was the protective factor for BHP combined with FLD[OR=0.389(0.162,0.931),P<0.05].Conclusion The prevalence rate of BHP combined with FLD is higher than that of BHP among male university teachers.BMI,FBG,TG,UA and high-density lipoprotein are the influencing factors of BHP combined with FLD.
Background The incidence of benign prostatic hyperplasia(BPH) or fatty liver disease(FLD) in male university teachers is high,and both diseases are often accompanied.At present,the pathogenesis of the two diseases and the causes of their concomitant diseases are not clear yet.Objective To explore the prevalence rate of BPH with FLD and its influencing factors among male university teachers,providing a basis for the formulation of targeted prevention and control strategies.Methods The enrolled 2136 male university teachers were sampled from individuals undergoing physical examination in the physical examination center of a university hospital in Guangzhou between January 2016 and January 2017,including 500 with BHP(BHP group) and 311 with BHP and FLD(combination group).Clinical data of these two groups were analyzed comparatively.Influencing factors of BHP combined with FLD were analyzed by using multivariate Logistic regression.ResultsTotaled 811 cases(38.0%) were found with BHP,311 of whom(38.4%) were identified with FLD.Those with BHP and FLD demonstrated significantly increased mean levels of BMI,urine protein,fasting blood glucose(FBG),urine specific gravity(USG),uric acid(UA),low-density lipoprotein,triacylglycerol(TG),diastolic blood pressure compared with those with BHP(P<0.05).Multivariate Logistic regression analysis showed that increased BMI[OR=1.447(1.306,1.603),P<0.001],FBG[OR=1.694(1.365,2.103),P<0.001],UA[OR=1.003(1.000,1.006),P<0.05]and TG[OR=1.590(1.186,2.132),P<0.05]were risk factors for BHP combined with FLD,while increased high-density lipoprotein was the protective factor for BHP combined with FLD[OR=0.389(0.162,0.931),P<0.05].Conclusion The prevalence rate of BHP combined with FLD is higher than that of BHP among male university teachers.BMI,FBG,TG,UA and high-density lipoprotein are the influencing factors of BHP combined with FLD.
引文
[1]刘绍峰.枣庄市某高校教职工健康状况分析及对策研究[D].济南:山东大学,2013.
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[9]宋欢,王金龙,王昌,等.徐州市某普通高校教师健康检查结果分析[J].职业与健康,2016,32(24):3422-3424,3428.SONG H,WANG J L,WANG C,et al.Analysis on physical examination results of teachers in a university of Xuzhou City[J].Occupation and Health,2016,32(24):3422-3424,3428.
[10]王亚军,耿辉,蒿花,等.2011—2015年健康体检人群脂肪肝患病情况分析[C]//2017国际数字医学会数字中医药分会论文集.广州:国际数字医学会,2017:2.
[11]LEE S W H,CHAN E M C,LAI Y K.The global burden of lower urinary tract symptoms suggestive of benign prostatic hyperplasia:A systematic review and meta-analysis[J].Scientific Reports,2017,7(1):7984.DOI:10.1038/s41598-017-06628-8.
[12]BEDOGNI G,NOBILI V,TIRIBELLI C.Epidemiology of fatty liver:an update[J].WJG,2014,20(27):9050-9054.DOI:10.3748/wjg.v20.i27.9050.
[13]范德民.老年人良性前列腺增生与能影响微血管病变因素的相关性研究[D].济南:山东大学,2014.
[14]李瑞峰.高血压住院患者中脂肪肝发生的相关危险因素分析[J].中国冶金工业医学杂志,2017,34(6):711-712.LI R F.Analysis of related risk factors of fatty liver in hospitalized patients with hypertension[J].Chinese Medical Journal of Metallurgical Industry,2017,34(6):711-712.
[15]刘晓玲.体检人群中高尿酸血症与脂肪肝的相关性[J].中华临床医师杂志(电子版),2016,10(4):231-232.
[2]葛梦颍,张程达,侯全亮,等.良性前列腺增生主要影响因素的Meta分析[J].现代预防医学,2017,44(10):1902-1907.GE M Y,ZHANG C D,HOU Q L,et al.Meta-analysis for primary influencing factors of benign prostatic hyperplasia[J].Modern Preventive Medicine,2017,44(10):1902-1907.
[3]曾永威,邓学斌,高婉仪,等.三水区前列腺增生患者的发病现状及健康教育需求[J].广东医学,2014,35(13):2120-2122.ZENGYW,DENGXB,GAOWY,etal.Thestatusof uterine prostatic hyperplasia and health education needs in Sanshui area[J].Guangdong Medical Journal,2014,35(13):2120-2122.DOI:10.13820/j.cnki.gdyx.2014.13.056.
[4]刘多.广西体检人群脂肪肝检出率及其影响因素的研究[D].南宁:广西医科大学,2016.
[5]苗莉,陈哲,高春英,等.代谢综合征对老年良性前列腺增生的影响研究[J].现代医药卫生,2013,29(10):1446-1447,1450.MIAO L,CHEN Z,GAO C Y,et al.Influence of metabolic syndrome on aged patients with benign prostatic hyperplasia[J].Journal of Modern Medicine&Health,2013,29(10):1446-1447,1450.
[6]杜志澎.原发性高血压与脂肪肝及血脂相关性调查[J].中国心血管病研究,2013,11(10):758-759.DOI:10.3969/j.issn.1672-5301.2013.10.007.DU Z P.Relations between essential hypertension and fatty liver and relating parameters of laboratory tests[J].Chinese Journal of Cardiovascular Research,2013,11(10):758-759.DOI:10.3969/j.issn.1672-5301.2013.10.007.
[7]那彦群,叶章群,孙颖浩,等.中国泌尿外科疾病诊断治疗指南[M].北京:人民卫生出版社,2013:245-266.
[8]王光荣,余国芳.社区老年人良性前列腺增生相关影响因素分析[J].中国实用医药,2017,12(28):28-30.DOI:10.3969/j.issn.1672-5301.2013.10.007.WANG G R,YU G F.Analysis of related influential factors of elderly benign prostatic hyperplasia in community[J].China Practical Medicine,2017,12(28):28-30.DOI:10.3969/j.issn.1672-5301.2013.10.007.
[9]宋欢,王金龙,王昌,等.徐州市某普通高校教师健康检查结果分析[J].职业与健康,2016,32(24):3422-3424,3428.SONG H,WANG J L,WANG C,et al.Analysis on physical examination results of teachers in a university of Xuzhou City[J].Occupation and Health,2016,32(24):3422-3424,3428.
[10]王亚军,耿辉,蒿花,等.2011—2015年健康体检人群脂肪肝患病情况分析[C]//2017国际数字医学会数字中医药分会论文集.广州:国际数字医学会,2017:2.
[11]LEE S W H,CHAN E M C,LAI Y K.The global burden of lower urinary tract symptoms suggestive of benign prostatic hyperplasia:A systematic review and meta-analysis[J].Scientific Reports,2017,7(1):7984.DOI:10.1038/s41598-017-06628-8.
[12]BEDOGNI G,NOBILI V,TIRIBELLI C.Epidemiology of fatty liver:an update[J].WJG,2014,20(27):9050-9054.DOI:10.3748/wjg.v20.i27.9050.
[13]范德民.老年人良性前列腺增生与能影响微血管病变因素的相关性研究[D].济南:山东大学,2014.
[14]李瑞峰.高血压住院患者中脂肪肝发生的相关危险因素分析[J].中国冶金工业医学杂志,2017,34(6):711-712.LI R F.Analysis of related risk factors of fatty liver in hospitalized patients with hypertension[J].Chinese Medical Journal of Metallurgical Industry,2017,34(6):711-712.
[15]刘晓玲.体检人群中高尿酸血症与脂肪肝的相关性[J].中华临床医师杂志(电子版),2016,10(4):231-232.