CD14启动子-159位点基因多态性与中国朝鲜族2型糖尿病患者下肢动脉硬化的相关性
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摘要
目的:研究CD14启动子-159位点基因多态性与中国朝鲜族2型糖尿病(T2DM)患者下肢动脉硬化(LLAS)之间的关联性。方法:选取诊断为T2DM的中国朝鲜族患者268例,彩色多普勒超声观察患者LLAS情况,将存在LLAS的患者分为无斑块和有斑块组,记录全部T2DM患者血液生化指标。采用聚合酶链反应-限制性片段长度多态性技术分析T2DM患者CD14启动子159位点的基因型。结果:比较无斑块和有斑块两组,CD14启动子-159位点上CC基因与CT及TT基因基因频率相比较存在统计学差异(P<0.05);Logistic回归分析显示CD14启动子-159位点基因多态性与病程及吸烟同为下肢动脉硬化斑块(LLASP)形成的危险因素;CC纯合子基因型发生LLASP的风险高于CT杂合子及TT纯合子基因型患者。结论:CD14启动子-159位点基因多态性与中国朝鲜族T2DM患者并发LLAS存在相关性,其中CC纯合子基因是中国朝鲜族T2DM患者并发LLASP的遗传学风险因素。
引文
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[11]Jalkanen J, Maksimow M, Jalkanen S, et al. Cardiovascular risk factors differ in inflammation pathology in patients with clinically symptomatic lower limb atherosclerosis[J]. Atherosclerosis,2016, 252(10):221.
[12]Koshkin VM, Nastavsheva OD, Kalashov PB, et al. Efficacy of walking training in patients with obliterating atherosclerosis of lower limb arteries[J]. Angiol Sosud Khir, 2017, 23(2):25-31.
[13]张彬号,王瑞琼.吸烟对2型糖尿病患者动脉硬化的影响[J].深圳中西医结合杂志,2016,26(19):142-143.
[2]周辰光.下肢动脉硬化闭塞症合并糖尿病足的介入治疗及其研究进展[J].医学综述,2015,21(1):109-111.
[3]金光明,金成子,郑寿焕. CD14启动子-159位点基因多态性与糖尿病患者颈动脉粥样硬化相关性研究[J].中国超声医学杂志,2010,26(10):872-875.
[4]金光明,郑寿焕. CD14启动子-159位点基因多态性与糖尿病肾病患者肾动脉血流动力学的相关性研究[J].中国现代医学杂志,2013,23(36):52-55.
[5]金光明,郑寿焕,田莲姬. CD14启动子-159位点基因多态性与糖尿病视网膜病变视网膜中央动脉血流动力学变化关系[J].实用医学杂志,2014,30(4):583-585.
[6]艾则孜,玉素甫.彩色多普勒超声与DSA在下肢动脉硬化闭塞症中的诊断价值[J].临床超声医学杂志,2015,3(1):72-73.
[7]Sun P, Xiao L, Gong KM, et al. Microarray-based miRNAs profiling in lower limb arteriosclerosis of diabetic rats[J]. Chin J Pathophysiol, 2016, 32(5):917-922.
[8]Yang WX, Chen B, Wang RF, et al. Serum and bronchial lavage fluid concentrations of IL-8, SLPI, s CD14 and s ICAM-1 in patients with COPD and asthma[J]. J Hunan Nor Uni, 2016, 101(9):1947-1953.
[9]Lonchakova IY, Makarov SA, Artamonova GV, et al. Organizational aspects of managing patients with atherosclerosis obliterans of lower-limb vessels at an ambulatory stage[J]. Angiol Sosud Khir, 2015, 21(3):38.
[10]Klein DC, Skjesol A, Kers-Rebel ED, et al. CD14, TLR4 and TRAM show different trafficking dynamics during LPS stimulation[J]. Traffic, 2015, 16(7):677-690.
[11]Jalkanen J, Maksimow M, Jalkanen S, et al. Cardiovascular risk factors differ in inflammation pathology in patients with clinically symptomatic lower limb atherosclerosis[J]. Atherosclerosis,2016, 252(10):221.
[12]Koshkin VM, Nastavsheva OD, Kalashov PB, et al. Efficacy of walking training in patients with obliterating atherosclerosis of lower limb arteries[J]. Angiol Sosud Khir, 2017, 23(2):25-31.
[13]张彬号,王瑞琼.吸烟对2型糖尿病患者动脉硬化的影响[J].深圳中西医结合杂志,2016,26(19):142-143.