丁苯酞治疗急性脑梗死患者hs-CRP及神经炎症变化
摘要
目的通过观察急性脑梗死(acute cerebral infarction,ACI)患者在丁苯酞注射液治疗不同时期血液中hs-CRP及神经炎症因子白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)的含量变化及通过NIHSS评分评估ACI的临床疗效。方法我院收治的120例ACI患者,对照组为接受脑梗死基础治疗患者,试验组为接受丁苯酞注射液联合脑梗死基础治疗患者。2组均于治疗前(≤48h)和治疗后(≥14d)采外周血,采用酶联免疫吸附实验(ELISA)检测ACI患者血液中hs-CRP及神经炎症因子(IL-1β、IL-6和TNF-α)的含量,采用NIHSS评分评估其临床疗效。结果 (1) 2组患者hsCRP及神经炎症细胞因子(IL-1β、IL-6和TNF-α)的含量较治疗前明显降低,NIHSS评分优于治疗前。(2)治疗后,联合组较对照组hs-CRP及神经炎症细胞因子(IL-1β、IL-6和TNF-α)的含量低,NIHSS评分优于对照组。结论丁苯酞注射液治疗急性缺血性脑卒中可明显降低hs-CRP及神经炎症反应提高临床疗效,改善患者神经功能缺损。
引文
[1]徐东升,黄伟,陈炜,等.同型半胱氨酸、超敏C反应蛋白、尿酸、D-二聚体和纤维蛋白原与急性脑梗死关系的研究[J].药物生物技术,2015(6):515-518.
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[4]刘顺达,郝万庆,高娟,等.依达拉奉联合丁苯酞软胶囊治疗急性脑梗死的疗效研究[J].宁夏医学杂志,2016,38(12):1196-1197.
[5]杨阳.急性脑梗死患者血清CRP水平测定及与病情、预后的关系[J].山东医药,2011,51(23):82-83.
[6]林久座,缪克强,张海霞,等.急性脑梗死早期血清TNF-α和IL-6水平的变化及其意义[J].浙江大学学报(医学版),2010,39(4):415-418.
[7]SPARKMAN N L,BUCHANAN J B,HEYEN J R,et al.Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers.Journal of Neuroscience,2006.26(42):10709-10716.
[8]SAPKOTA A,GAIRE B P,CHO K S,et a l.Eupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation.Plos One,2017.12(2):171479.
[9]FAHMI R M,ELSAID A F.Infarction S,Interleukin-6,and Their Interaction Are Predictors of Short-Term Stroke Outcome in Young Egyptian Adults.Journal of Stroke Cerebrovascular Diseases,2016,25(10):2475-2481.
[10]TERRANDO N,MONACO C,MA D,et al.Tumor necrosis factor-αtriggers a cytokine cascade yielding postoperative cognitive decline.Proceedings of the National Academy of Sciences of the United States of America,2010,107(47):20518-20522.
[2]中华医学会神经病学分会,中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[3]伊恋,李星达,王建秀,等.依达拉奉联合丁苯酞治疗急性缺血性脑卒中的临床观察[J].中国药房,2016,27(29):4130-4132.
[4]刘顺达,郝万庆,高娟,等.依达拉奉联合丁苯酞软胶囊治疗急性脑梗死的疗效研究[J].宁夏医学杂志,2016,38(12):1196-1197.
[5]杨阳.急性脑梗死患者血清CRP水平测定及与病情、预后的关系[J].山东医药,2011,51(23):82-83.
[6]林久座,缪克强,张海霞,等.急性脑梗死早期血清TNF-α和IL-6水平的变化及其意义[J].浙江大学学报(医学版),2010,39(4):415-418.
[7]SPARKMAN N L,BUCHANAN J B,HEYEN J R,et al.Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers.Journal of Neuroscience,2006.26(42):10709-10716.
[8]SAPKOTA A,GAIRE B P,CHO K S,et a l.Eupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation.Plos One,2017.12(2):171479.
[9]FAHMI R M,ELSAID A F.Infarction S,Interleukin-6,and Their Interaction Are Predictors of Short-Term Stroke Outcome in Young Egyptian Adults.Journal of Stroke Cerebrovascular Diseases,2016,25(10):2475-2481.
[10]TERRANDO N,MONACO C,MA D,et al.Tumor necrosis factor-αtriggers a cytokine cascade yielding postoperative cognitive decline.Proceedings of the National Academy of Sciences of the United States of America,2010,107(47):20518-20522.