黄芪桂枝五物汤治疗气血两虚型类风湿关节炎的效果
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摘要
目的探讨黄芪桂枝五物汤治疗类风湿关节炎气血两虚型的疗效。方法将40例我科收治的气血两虚型类风湿关节炎患者按照随机数字表法分为观察组及对照组。对照组患者接受再造生血胶囊治疗,观察组患者接受黄芪桂枝五物汤加味治疗。比较两组患者治疗前后关节肿胀数、关节压痛数、晨僵时间、类风湿关节炎患者病情评价(DAS28评分)、中医症候积分、类风湿因子(RF)、红细胞沉降率(ESR)及C反应蛋白(CRP)水平,比较两组患者治疗后的疗效。结果治疗3个疗程后,观察组患者关节肿胀数、关节压痛数、晨僵时间、DAS28评分及中医证候积分均低于对照组患者(P <0.05);观察组患者的RF、ESR及CRP水平均低于对照组患者(P <0.05);观察组患者总有效率(95.0%)高于对照组患者(70.0%),两组疗效资料差异有统计学意义(P <0.05)。结论黄芪桂枝五物汤治疗类风湿关节炎气血两虚型的疗效显著,能够减轻患者的疾病症状,降低RF、ESR及CRP水平。
Objective To explore the effect of Huangqi Guizhi Wuwu Decoction on rheumatoid arthritis.Methods 40 patients of rheumatoid arthritis with qi-blood deficiency were randomly divided into the observation group and the control group.Patients in the control group were treated with Zaizao Shengxue Capsule,while patients in the observation group were treated with Huangqi Guizhi Wuwu Decoction.The number of joint swelling,number of joint tenderness,morning stiffness time,DAS28 score,TCM syndrome score,RF,ESR and CRP before and after treatment were compared between the two groups.Results After 3 treatment courses,the number of joint swelling,joint tenderness,morning stiffness time,DAS28 score and TCM syndrome score in the observation group were all lower than those in the control group(P < 0.05).RF,ESR and CRP levels in the observation group were lower than those in the control group(P < 0.05).The total effective rate in the observation group(95.0%) was higher than that in the control group(70.0%),There was significant difference between the two groups in curative effect data(P < 0.05).Conclusion Huangqi Guizhi Wuwu Decoction has a significant curative effect on rheumatoid arthritis with qi-blood deficiency,which can alleviate the disease symptoms of patients and reduce the levels of RF,ESR and CRP.
Objective To explore the effect of Huangqi Guizhi Wuwu Decoction on rheumatoid arthritis.Methods 40 patients of rheumatoid arthritis with qi-blood deficiency were randomly divided into the observation group and the control group.Patients in the control group were treated with Zaizao Shengxue Capsule,while patients in the observation group were treated with Huangqi Guizhi Wuwu Decoction.The number of joint swelling,number of joint tenderness,morning stiffness time,DAS28 score,TCM syndrome score,RF,ESR and CRP before and after treatment were compared between the two groups.Results After 3 treatment courses,the number of joint swelling,joint tenderness,morning stiffness time,DAS28 score and TCM syndrome score in the observation group were all lower than those in the control group(P < 0.05).RF,ESR and CRP levels in the observation group were lower than those in the control group(P < 0.05).The total effective rate in the observation group(95.0%) was higher than that in the control group(70.0%),There was significant difference between the two groups in curative effect data(P < 0.05).Conclusion Huangqi Guizhi Wuwu Decoction has a significant curative effect on rheumatoid arthritis with qi-blood deficiency,which can alleviate the disease symptoms of patients and reduce the levels of RF,ESR and CRP.
引文
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[11]朱洁宜,吴鑫宇,周海纯,等.中医药治疗类风湿关节炎的研究进展[J].中医药信息,2015,32(1):115-117.
[12]刘雪辉,谢淑玲,伍文彬,等.加味黄芪桂枝五物汤治疗老年2型糖尿病周围神经病变疗效观察[J].山东医药,2015,55(34):60-61.
[13]卢军,陈燕芬.林昌松从阴血亏虚论治类风湿关节炎经验[J].广州中医药大学学报,2015,32(6):1111-1113.
[2]马武开,周静,姚血明,等.中医药对类风湿关节炎滑膜作用机制探讨[J].贵阳中医学院学报,2016,38(2):5-7.
[3]王宝新,李鑫,谷捷,等.正清风痛宁治疗类风湿关节炎有效性及安全性的系统评价[J].湖南中医药大学学报,2015,35(3):67-71.
[4]刘佳维,王永辉,李艳彦,等.黄芪桂枝五物汤对CIA模型大鼠关节滑膜细胞凋亡的影响[J].中国实验方剂学杂志,2017,23(14):171-176.
[5]ALETAHA D,NEOGI T,SILMAN A J,et al.2010 Rheumatoid arthritis classification criteria:An American College of Rheumatology/European League Against Rheumatism collaborative initiative[J].Arthritis Rheum,2010,62(9):2569-2581.
[6]中华中医药学会风湿病分会.类风湿关节炎病证结合诊疗指南[J].中医杂志,2018,59(20):1794-1800.
[7]郑筱萸.中药新药临床研究指导原则(试行)[M].中国医药科技出版社,2002:230.
[8]姜一真,唐若余,潘娇娇,等.泼尼松联合甲氨蝶呤或来氟米特治疗老年类风湿关节炎的疗效比较[J].中国老年学杂志,2015,35(21):6199-6201.
[9]魏蕾,姜林娣.类风湿关节炎病因和发病机制研究进展[J].医学综述,2015,21(9):1548-1551.
[10]刘雪涛,李庆.类风湿关节炎治疗药物进展[J].现代生物医学进展,2015,15(6):1171-1173.
[11]朱洁宜,吴鑫宇,周海纯,等.中医药治疗类风湿关节炎的研究进展[J].中医药信息,2015,32(1):115-117.
[12]刘雪辉,谢淑玲,伍文彬,等.加味黄芪桂枝五物汤治疗老年2型糖尿病周围神经病变疗效观察[J].山东医药,2015,55(34):60-61.
[13]卢军,陈燕芬.林昌松从阴血亏虚论治类风湿关节炎经验[J].广州中医药大学学报,2015,32(6):1111-1113.