苯并吡喃类衍生物的合成及其抑菌活性研究
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摘要
设计合了4种新型的苯并吡喃类衍生物(2a～2d),并通过~1H NMR、~(13)C NMR对其结构进行了表征。此外,我们还选择我国农田发生的9种代表性病原真菌对目标化合物进行了抑菌性测试。抑菌实验结果表明,在50 mg·L~(-1)剂量下,目标化合物2a～2d对9种植物病原真菌均表现出较好的广谱抑菌活性。而且化合物2a～2d对黄瓜灰霉病菌、水稻纹枯病菌的抑菌率,与嘧菌酯的抑菌率相当甚至更高。
4 novel kinds of benzopyran derivatives(2a ～ 2d) were designed,synthesized and characterized by ~1H NMR and ~(13)C NMR. In addition,their anti-fungal activities against the nine representative pathogenic fungi from farmland in China were evaluated. The results of anti-fungal experiments showed that compounds 2a ～ 2d exhibited excellent broad-spectrum anti-fungal activities against the tested nine plant pathogenic fungus at 50 mg·L~(-1). And the fungicidal activities of 2a ～ 2d against Botrytis cinerea and Pellicularia sasakii were as well as Azoxystrobin at 50 mg·L~(-1).
4 novel kinds of benzopyran derivatives(2a ～ 2d) were designed,synthesized and characterized by ~1H NMR and ~(13)C NMR. In addition,their anti-fungal activities against the nine representative pathogenic fungi from farmland in China were evaluated. The results of anti-fungal experiments showed that compounds 2a ～ 2d exhibited excellent broad-spectrum anti-fungal activities against the tested nine plant pathogenic fungus at 50 mg·L~(-1). And the fungicidal activities of 2a ～ 2d against Botrytis cinerea and Pellicularia sasakii were as well as Azoxystrobin at 50 mg·L~(-1).
引文
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[2]郭萍.香豆素和香豆素类的合成方法及研究进展[J].辽宁华工,1998,27(2):76-78.
[3]李靖.4-羟基香豆素及其衍生物的微波合成、光谱及电化学性质研究[D].西安:西安建筑科技大学,2008.
[4]董环文,李科,郑灿辉,等.3-胺基取代苯并吡喃酮类化合物的设计合成及抗肿瘤活性[J].化学学报,2009,67(8):819-824.
[5]胡文姬,李学坚,刘布鸣,等.黄芒果苷苷元研究进展[J].时珍国医国药,2013,24(11):2759-2763.
[6]黄华艺,农朝赞,郭凌霄,等.芒果甙对肝癌细胞增殖的抑制和凋亡的诱导[J].中华消化杂志社,2002,22(6):341-343.
[7]邓晓莉,程龙,刘征,等.新型四氢-β-咔啉类衍生物的合成及其抑菌活性[J].合成化学,2018,26(7):469-473.
[8]Yuan L,Li Z Y,Jia G K,et al.Synthesis and Biological Activity of Perimidine Derivatives[J].Chin.J.Appl.Chem.,2017,34(6):685-691.