针灸联合天麻素注射液对后循环缺血性眩晕病人血液流变学及日常生活能力的影响
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摘要
目的探讨针灸联合天麻素注射液对后循环缺血性眩晕病人血液流变学及日常生活能力的影响。方法选取郑州市中医院2016年4月—2018年1月后循环缺血性眩晕病人60例,按随机数字表法分为对照组与研究组,每组30例。常规干预基础上对照组采取针灸治疗,研究组于对照组基础上采用天麻素注射液治疗,两组均治疗14 d。比较两组临床疗效,观察两组治疗前及治疗后血液流变学指标(血浆黏度、全血高切黏度、全血低切黏度、纤维蛋白原)水平、日常生活能力量表(ADL)评分。结果研究组总有效率为93.33%,高于对照组的73.33%(P<0.05);治疗后两组血浆黏度、全血高切黏度、全血低切黏度、纤维蛋白原水平较治疗前降低,且研究组低于对照组(P<0.05);治疗后两组ADL评分较治疗前增高,且研究组高于对照组(P<0.05)。结论联合采取针灸及天麻素注射液治疗后循环缺血性眩晕,可有效调节血液流变学状态,改善病人日常生活能力,提高临床疗效。
Objective To explore the effect of acupuncture and Gastrodin injection on hemorheology and activities of daily living(ADL) in patients with posterior circulation ischemic vertigo(PCIV).Methods Sixty patients with PCIV in our hospital from April 2016 to January 2018 were randomly divided into two groups:control group(n=30) treated with acupuncture,and treatment group(n=30) treated with acupuncture and Gastrodin injection in the basis of routine treatment for 14 days.The clinical efficacy was compared between two groups.The hemorheological indexes(plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,and fibrinogen) and the ADL score were compared before and after treatment.Results The total effective rate in treatment group was 93.33%,which was higher after treatment than that in control group(73.33%,P<0.05).After treatment,the levels of plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,and fibrinogen were lower than that in two groups before treatment,which were lower in treatment group than that in control group(P<0.05).The ADL scores were higher than those in two groups before treatment,which were higher in treatment group than that in control group(P<0.05).Conclusion Acupuncture and Gastrodin injection can effectively regulate blood rheology,improve patients′ daily living ability and clinical efficacy in patients with PCIV.
Objective To explore the effect of acupuncture and Gastrodin injection on hemorheology and activities of daily living(ADL) in patients with posterior circulation ischemic vertigo(PCIV).Methods Sixty patients with PCIV in our hospital from April 2016 to January 2018 were randomly divided into two groups:control group(n=30) treated with acupuncture,and treatment group(n=30) treated with acupuncture and Gastrodin injection in the basis of routine treatment for 14 days.The clinical efficacy was compared between two groups.The hemorheological indexes(plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,and fibrinogen) and the ADL score were compared before and after treatment.Results The total effective rate in treatment group was 93.33%,which was higher after treatment than that in control group(73.33%,P<0.05).After treatment,the levels of plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,and fibrinogen were lower than that in two groups before treatment,which were lower in treatment group than that in control group(P<0.05).The ADL scores were higher than those in two groups before treatment,which were higher in treatment group than that in control group(P<0.05).Conclusion Acupuncture and Gastrodin injection can effectively regulate blood rheology,improve patients′ daily living ability and clinical efficacy in patients with PCIV.
引文
[1] 张丽梅.楂葛夏陈汤联合天麻素注射液对后循环缺血性眩晕的临床疗效分析[J].中国中医基础医学杂志,2014,20(2):202-203.
[2] PURRUCKER J C,HERRMANN O,LUTSCH J K,et al.Serum protein S100β is a diagnostic biomarker for distinguishing posterior circulation stroke from vertigo of nonvascular causes[J].Eur Neurol,2014,72(5/6):278-284.
[3] 蒋盈盈.针灸配合穴位贴敷中药治疗后循环缺血性眩晕[J].中医临床研究,2017,9(7):33-34.
[4] 封臻,廉全荣.天麻素联合苦碟子注射液治疗后循环缺血性眩晕40例[J].陕西中医,2014,35(2):161-162.
[5] 孟祥东,侯沛红,孙启钊.疏血通联合天麻素治疗后循环缺血性眩晕的疗效观察[J].实用中西医结合临床,2015,15(3):67-68.
[6] 中国后循环缺血专家共识组.中国后循环缺血的专家共识[J].中华内科杂志,2006,45(9):786-787.
[7] 中华医学会神经病学分会,中华神经科杂志编辑委员会.眩晕诊治专家共识[J].中华神经外科杂志,2010,43(5):369-374.
[8] 呼建民,王述莲.天麻素联合盐酸氟桂利嗪治疗后循环缺血性眩晕48例分析[J].人民军医,2013,56(6):692-693.
[9] 蒋娟,赵树琴,封爱婷.中医临床护理路径在后循环缺血性眩晕中的应用研究[J].西部中医药,2014,27(3):122-124.
[10] 袁波,谭莉,罗银利,等.天麻素联合前列地尔注射液治疗后循环缺血性眩晕40例疗效观察[J].湖南中医杂志,2015,31(4):45-47.
[11] KATSANOS A H,KOSMIDOU M,KYRITSIS A P,et al.Is vertebral artery hypoplasia a predisposing factor for posterior circulation cerebral ischemic events?A comprehensive review[J].Eur Neurol,2013,70(1/2):78-83.
[12] 刘继刚.天麻素注射液联合血栓通治疗后循环缺血性眩晕疗效观察[J].实用中医药杂志,2014,30(7):651-652.
[13] 魏瑾,程红亮.针灸治疗后循环缺血性眩晕临床研究概况[J].中医药临床杂志,2016,28(11):1508-1510.
[14] 吴婉玉,谢宸宸.天麻素注射液联合血塞通对后循环缺血性眩晕患者临床疗效研究[J].黑龙江医药,2016,29(3):489-491.
[15] 司铁彬.天麻素注射液联合血栓通注射液对后循环缺血性眩晕的治疗效果[J].中国卫生工程学,2017,16(6):825-826.
[2] PURRUCKER J C,HERRMANN O,LUTSCH J K,et al.Serum protein S100β is a diagnostic biomarker for distinguishing posterior circulation stroke from vertigo of nonvascular causes[J].Eur Neurol,2014,72(5/6):278-284.
[3] 蒋盈盈.针灸配合穴位贴敷中药治疗后循环缺血性眩晕[J].中医临床研究,2017,9(7):33-34.
[4] 封臻,廉全荣.天麻素联合苦碟子注射液治疗后循环缺血性眩晕40例[J].陕西中医,2014,35(2):161-162.
[5] 孟祥东,侯沛红,孙启钊.疏血通联合天麻素治疗后循环缺血性眩晕的疗效观察[J].实用中西医结合临床,2015,15(3):67-68.
[6] 中国后循环缺血专家共识组.中国后循环缺血的专家共识[J].中华内科杂志,2006,45(9):786-787.
[7] 中华医学会神经病学分会,中华神经科杂志编辑委员会.眩晕诊治专家共识[J].中华神经外科杂志,2010,43(5):369-374.
[8] 呼建民,王述莲.天麻素联合盐酸氟桂利嗪治疗后循环缺血性眩晕48例分析[J].人民军医,2013,56(6):692-693.
[9] 蒋娟,赵树琴,封爱婷.中医临床护理路径在后循环缺血性眩晕中的应用研究[J].西部中医药,2014,27(3):122-124.
[10] 袁波,谭莉,罗银利,等.天麻素联合前列地尔注射液治疗后循环缺血性眩晕40例疗效观察[J].湖南中医杂志,2015,31(4):45-47.
[11] KATSANOS A H,KOSMIDOU M,KYRITSIS A P,et al.Is vertebral artery hypoplasia a predisposing factor for posterior circulation cerebral ischemic events?A comprehensive review[J].Eur Neurol,2013,70(1/2):78-83.
[12] 刘继刚.天麻素注射液联合血栓通治疗后循环缺血性眩晕疗效观察[J].实用中医药杂志,2014,30(7):651-652.
[13] 魏瑾,程红亮.针灸治疗后循环缺血性眩晕临床研究概况[J].中医药临床杂志,2016,28(11):1508-1510.
[14] 吴婉玉,谢宸宸.天麻素注射液联合血塞通对后循环缺血性眩晕患者临床疗效研究[J].黑龙江医药,2016,29(3):489-491.
[15] 司铁彬.天麻素注射液联合血栓通注射液对后循环缺血性眩晕的治疗效果[J].中国卫生工程学,2017,16(6):825-826.