中药延缓类风湿关节炎骨破坏的研究进展
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摘要
类风湿关节炎(RA)的骨破坏是导致RA患者生活质量下降的重要病理因素,几乎伴随着RA的始末,发病隐秘,预后较差。常规的免疫抑制剂、激素等疗效有限,患者经济负担重,且伴有较明显的副作用。近年来的研究报道表明,中医中药对延缓类风湿关节炎骨破坏有着较好疗效。本文对中药延缓类风湿关节炎骨破坏的研究进展进行综述,为临床和科研提供一定的参考。
The bone destruction of rheumatoid arthritis(RA) is an important pathological factor leading to the decline of quality of life in RA patients,almost accompanied by the beginning and end of RA, the pathogenesis is secret, and the prognosis is poor. Conventional immunosuppressive agents,hormones, etc. have limited efficacy, and the patient has a heavy economic burden with obvious side effects. Recent studies have shown that traditional Chinese medicine has a good effect on delaying bone destruction of rheumatoid arthritis. This article reviews the research progress of Chinese medicine in delaying bone destruction of rheumatoid arthritis, and provides some reference for clinical and scientific research.
The bone destruction of rheumatoid arthritis(RA) is an important pathological factor leading to the decline of quality of life in RA patients,almost accompanied by the beginning and end of RA, the pathogenesis is secret, and the prognosis is poor. Conventional immunosuppressive agents,hormones, etc. have limited efficacy, and the patient has a heavy economic burden with obvious side effects. Recent studies have shown that traditional Chinese medicine has a good effect on delaying bone destruction of rheumatoid arthritis. This article reviews the research progress of Chinese medicine in delaying bone destruction of rheumatoid arthritis, and provides some reference for clinical and scientific research.
引文
[1]冯佳,龚书识,夏燕,等.艾拉莫德对类风湿关节炎外周血破骨细胞分化及破骨细胞相关基因表达的影响[J].中国骨质疏松杂志,2019,25(1):97-102.
[2]王凛介,李永红,孙建,等.甲氨蝶呤对类风湿关节炎患者骨破坏抑制及血清IL-1β和TNF-α的影响[J].河北医药,2019,41(1):58-61.
[3]任春贞,骆亚莉,李玲,等.焦树德教授治疗类风湿关节炎经验小结[J].甘肃科技,2016,32(5):120-121.
[4]姜泉.路志正调理脾胃治疗风湿病学术思想传承及临床应用研究[D].中国中医科学院,2012.
[5]孟庆良,周子朋,谷慧敏,等.朱良春国医大师治痹经验临床运用体会[J].辽宁中医杂志,2012,39(5):791-792.
[6]朱俊岭.阎小萍教授治疗类风湿关节炎经验撷菁[J].实用中医内科杂志,2008,22(5):12-13.
[7]王义军.关于中医药阻止类风湿性关节炎骨侵蚀的几点思考[J].中国中医基础医学杂志,2005,11(5):365-366.
[8]方胜林.吴秋玲治疗类风湿性关节炎的经验[J].江苏中医药,2008,40(4):17-18.
[9]Corrado A,Maruotti N,Cantatore FP.Osteoblast Role in Rheumatic Diseases[J].International Journal of Molecular Sciences,2017,18(6):1272.
[10]Lacey DL,Timms E,Tan HL,et al Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation[J].Cell,1998,93(2):165-176.
[11]陶黎.基于EphB4/ephrinB2探讨益肾蠲痹丸改善去势CIA大鼠骨破坏的作用机制[D].中国中医科学院,2018.
[12]Remuzgo-Martínez S,Genre F,López-Mejías R,et al.Expression of osteoprotegerin and its ligands,RANKL and TRAIL,in rheumatoid arthritis[J].Scientific reports,2016(6):29713.
[13]杨林,吕丹,沈小芳,等.细胞因子对类风湿性关节炎骨平衡的调节作用[J].生命科学,2019,31(1):1-9.
[14]Quinn JMW,Elliott J,Gillespie MT,et al.A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro[J].Endocrinology,1998,139(10):4424-4427.
[15]Lubberts E.The IL-23-IL-17 axis in inflammatory arthritis[J].Nature Reviews Rheumatology,2015,11(7):415.
[16]何俊洲,赵骞,效伟,等.淫羊藿苷对RANKL+M-CSF诱导脐带血单核细胞为破骨样细胞的影响[J].中药材,2016,39(6):1399-1402.
[17]李伟娟,谢保平,石丽颖,等.从ERα/RANK通路探讨淫羊藿苷抑制破骨细胞分化作用[J].中国实验方剂学杂志,2017,23(7):121-126.
[18]黄慧,陈健,何剑全,等.巴戟天含药血清对成骨-破骨细胞共育体系OPGmRNA、RANKLmRNA表达的影响[J].中国骨质疏松杂志,2015,21(1):67-71.
[19]鲍蕾蕾,秦路平,卞俊,等.巴戟天甲基异茜草素对破骨细胞性骨吸收的影响[J].解放军药学学报,2009,25(6):505-509.
[20]刘金文,黄永明,许少健,等.中药骨碎补对大鼠骨髓破骨细胞体外培养的影响[J].中医研究,2005(7):5-7.
[21]贾朝娟,鞠大宏,刘梅洁,等.山药对卵巢切除大鼠骨质疏松症的治疗作用及其机理探讨[J].中国中医基础医学杂志,2009,15(4):268-271.
[22]程仕萍,贾冬梅,吕爱平,等.核心配伍药改善类风湿性关节炎骨破坏的分子机制预测[J].时珍国医国药,2017,28(10):2309-2313.
[23]姜玉宝,林昌松,李楠,等.断藤益母汤对类风湿关节炎患者血清骨代谢指标的影响[J].中华中医药学刊,2018,36(1):114-117.
[24]Terpos E,Dimopoulos MA,Sezer O,et al.The use of biochemical markers of bone remodeling in multiple myeloma:a report of the International Myeloma Working Group[J].Leukemia,2010,24(10):1700-1712.
[25]Arrabal-Polo MA,Girón-Prieto MS,Cano-García Mdel C,et al.Retrospective Review of Serum and Urinary Lithogenic Risk Factors in Patients With Osteoporosis and Osteopenia[J].Urology,2015,85(4):782-785.
[26]朱俊.护骨胶囊对类风湿关节炎患者骨破坏的影响[J].河南医学高等专科学校学报,2018,30(3):276-278.
[27]刘冬梅.补肾化瘀法对去卵巢骨质疏松症模型大鼠骨生化代谢影响的机制探讨[D].湖北民族学院,2012.
[28]冯佳,袁林,苏林冲,等.强骨康疏胶囊对去卵巢骨质疏松大鼠骨细微结构及骨代谢的影响[J].中国免疫学杂志,2012,28(9):797-801.
[29]赵小丹.补肾活血法对去卵巢大鼠骨组织中TGF-β1、Smad2、Smad4信号传导通路的研究[D].湖北民族学院,2014.
[30]谭珂.强骨康疏方治疗绝经后骨质疏松症的临床观察[D].湖北民族学院,2018.
[31]康勤龙,荣晓凤.复方大黄散对类风湿关节炎NF-κB受体活化因子配体、骨保护素的影响[J].现代中西医结合杂志,2019,28(1):6-9,14.
[2]王凛介,李永红,孙建,等.甲氨蝶呤对类风湿关节炎患者骨破坏抑制及血清IL-1β和TNF-α的影响[J].河北医药,2019,41(1):58-61.
[3]任春贞,骆亚莉,李玲,等.焦树德教授治疗类风湿关节炎经验小结[J].甘肃科技,2016,32(5):120-121.
[4]姜泉.路志正调理脾胃治疗风湿病学术思想传承及临床应用研究[D].中国中医科学院,2012.
[5]孟庆良,周子朋,谷慧敏,等.朱良春国医大师治痹经验临床运用体会[J].辽宁中医杂志,2012,39(5):791-792.
[6]朱俊岭.阎小萍教授治疗类风湿关节炎经验撷菁[J].实用中医内科杂志,2008,22(5):12-13.
[7]王义军.关于中医药阻止类风湿性关节炎骨侵蚀的几点思考[J].中国中医基础医学杂志,2005,11(5):365-366.
[8]方胜林.吴秋玲治疗类风湿性关节炎的经验[J].江苏中医药,2008,40(4):17-18.
[9]Corrado A,Maruotti N,Cantatore FP.Osteoblast Role in Rheumatic Diseases[J].International Journal of Molecular Sciences,2017,18(6):1272.
[10]Lacey DL,Timms E,Tan HL,et al Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation[J].Cell,1998,93(2):165-176.
[11]陶黎.基于EphB4/ephrinB2探讨益肾蠲痹丸改善去势CIA大鼠骨破坏的作用机制[D].中国中医科学院,2018.
[12]Remuzgo-Martínez S,Genre F,López-Mejías R,et al.Expression of osteoprotegerin and its ligands,RANKL and TRAIL,in rheumatoid arthritis[J].Scientific reports,2016(6):29713.
[13]杨林,吕丹,沈小芳,等.细胞因子对类风湿性关节炎骨平衡的调节作用[J].生命科学,2019,31(1):1-9.
[14]Quinn JMW,Elliott J,Gillespie MT,et al.A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro[J].Endocrinology,1998,139(10):4424-4427.
[15]Lubberts E.The IL-23-IL-17 axis in inflammatory arthritis[J].Nature Reviews Rheumatology,2015,11(7):415.
[16]何俊洲,赵骞,效伟,等.淫羊藿苷对RANKL+M-CSF诱导脐带血单核细胞为破骨样细胞的影响[J].中药材,2016,39(6):1399-1402.
[17]李伟娟,谢保平,石丽颖,等.从ERα/RANK通路探讨淫羊藿苷抑制破骨细胞分化作用[J].中国实验方剂学杂志,2017,23(7):121-126.
[18]黄慧,陈健,何剑全,等.巴戟天含药血清对成骨-破骨细胞共育体系OPGmRNA、RANKLmRNA表达的影响[J].中国骨质疏松杂志,2015,21(1):67-71.
[19]鲍蕾蕾,秦路平,卞俊,等.巴戟天甲基异茜草素对破骨细胞性骨吸收的影响[J].解放军药学学报,2009,25(6):505-509.
[20]刘金文,黄永明,许少健,等.中药骨碎补对大鼠骨髓破骨细胞体外培养的影响[J].中医研究,2005(7):5-7.
[21]贾朝娟,鞠大宏,刘梅洁,等.山药对卵巢切除大鼠骨质疏松症的治疗作用及其机理探讨[J].中国中医基础医学杂志,2009,15(4):268-271.
[22]程仕萍,贾冬梅,吕爱平,等.核心配伍药改善类风湿性关节炎骨破坏的分子机制预测[J].时珍国医国药,2017,28(10):2309-2313.
[23]姜玉宝,林昌松,李楠,等.断藤益母汤对类风湿关节炎患者血清骨代谢指标的影响[J].中华中医药学刊,2018,36(1):114-117.
[24]Terpos E,Dimopoulos MA,Sezer O,et al.The use of biochemical markers of bone remodeling in multiple myeloma:a report of the International Myeloma Working Group[J].Leukemia,2010,24(10):1700-1712.
[25]Arrabal-Polo MA,Girón-Prieto MS,Cano-García Mdel C,et al.Retrospective Review of Serum and Urinary Lithogenic Risk Factors in Patients With Osteoporosis and Osteopenia[J].Urology,2015,85(4):782-785.
[26]朱俊.护骨胶囊对类风湿关节炎患者骨破坏的影响[J].河南医学高等专科学校学报,2018,30(3):276-278.
[27]刘冬梅.补肾化瘀法对去卵巢骨质疏松症模型大鼠骨生化代谢影响的机制探讨[D].湖北民族学院,2012.
[28]冯佳,袁林,苏林冲,等.强骨康疏胶囊对去卵巢骨质疏松大鼠骨细微结构及骨代谢的影响[J].中国免疫学杂志,2012,28(9):797-801.
[29]赵小丹.补肾活血法对去卵巢大鼠骨组织中TGF-β1、Smad2、Smad4信号传导通路的研究[D].湖北民族学院,2014.
[30]谭珂.强骨康疏方治疗绝经后骨质疏松症的临床观察[D].湖北民族学院,2018.
[31]康勤龙,荣晓凤.复方大黄散对类风湿关节炎NF-κB受体活化因子配体、骨保护素的影响[J].现代中西医结合杂志,2019,28(1):6-9,14.