血管内皮生长因子在白血病中相关作用的机制
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摘要
血管内皮生长因子(VEGF)是血管生成过程中重要的调控因子,与白血病的发生发展密切相关。VEGF可通过自分泌链作用与其自身表面的VEGFR结合,生成微血管甚至形成血管网,对自身生长周期进行调节,对白血病细胞的增殖和迁移起到促进作用。
引文
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[20] AMBATI J,AMBATI B K,YOO S H,et al. Age-related macular degeneration:etiology,pathogenesis,and therapeutic strategies[J]. Surv Ophthalmol,2003,48(3):257-293.
[21] STRAWN L M,MCMAHON G,SCHRECK H,et al. Flk-1as a target for tumor growth inhibition[J]. Cancer Res,1996,56(15):3540-3545.
[22]郭海霞,徐令,陈月琴,等.血管内皮细胞生长因子受体2基因短发夹RNA介导基因沉默对白血病的抑制[J].中国组织工程研究与临床康复,2007,11(37):7503-7508.
[23]王鲁,常艳丽,张青云.血管内皮生长因子在肿瘤血管形成中的作用及其靶向治疗研究进展[J].中华临床实验室管理电子杂志,2015,3(3):146-152.
[24]刘玉琴,赵凤菊,陈万青,等.中国2009年白血病发病和死亡资料分析[J].中国肿瘤,2013,22(7):528-534.
[25]王一浩.血管内皮生长因子反义寡核苷酸对白血病细胞系HL60细胞作用的研究[D].郑州:郑州大学,2005.
[26] FOLKMAN J. Tumor angiogenesis:therapeutic implications[J]. N Engl J Med,1971,285(21):1182-1186.
[27] YA-HERTTUALA S,MARTIN J F. Cardiovascular gene therapy[J]. Lancel,2000,355(9199):213-222.
[28]张金巧.血管新生和血管内皮细胞生长因子在急性髓系白血病中的意义及三氧化二砷的抗血管新生作用[D].石家庄:河北医科大学,2003.
[29]张东梅,卿晨.血管内皮生长因子家族及其受体与肿瘤血管新生[J].医学综述,2017,23(3):417-420.
[30] FAN X J,KRIEG S,KUO C J,et al. VEGF blockade inhibits angiogenesisand reepithelialization of endometrium[J]. FASEB J,2008,22(1):3571-3580.
[31]李丽.血管内皮生长因子在白血病细胞中表达及三氧化二砷对其表达的调控[D].苏州:苏州大学,2002.
[2] KINI A R,PETERSON L A,ATLLMAN M S,et al. Angiogenesis in aeute Promyeloeytic leukemia:induetion by vaseular endohtelial growth faetor and ihnibition by all-trans retinoic aeid[J]. Blood,2001,97(12):3919-3924.
[3] FERRARA N,HENZEL W J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells[J]. Biochem Biophys Res Commun,1989,161(2):851-858.
[4]罗君.胃癌细胞VEGF/NRP-1自分泌途径及临床作用的探讨[D].重庆:重庆医科大学,2007.
[5]李京佳,林相国,许涛,等. VEGF家族及其在肿瘤生长中作用的研究[J].现代生物医学进展,2012,12(4):777-779.
[6]朱晶.人可溶性血管内皮生长因子受体1对白血病细胞生长抑制作用的实验研究[D].长春:吉林大学,2006.
[7]张燕香,魏蓉,吕中伟.恶性血液病患者血清VEGF水平与临床关系的研究[J].同济大学学报(医学版),2005,26(6):42-44.
[8] BELLAMY W T,RICHTER L,SIRJANI D,et al. Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes[J].Blood,2001,97(5):1427-1434.
[9] AGUAYO A,KANTARJIAN H,MANSHOURI T,et al. Angiogenesis in acute and chronic leukemias and myelodys plastic syndromes[J]. Blood,2000,96(6):2240-2245.
[10] FERRARA N. Role of vascular endothelial growth factor in the regulation of angiogenesis[J]. Kidney Int,1999,56(3):794-814.
[11] TERMAN B I,DOUGHER-VERMAZEN M,CARRION M E,et al. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor[J]. Biochem Biophys Res Commun,1992,187(3):1579-1586.
[12]王宏光,陈训如,李开宗,等.肝癌细胞中血管内皮生长因子的自分泌及其意义[J].中国癌症杂志,2004,14(2):64-67.
[13]阮国瑞,刘艳荣,陈珊珊,等.自分泌VEGF对人慢性髓性白血病细胞系K562的作用[J].中国实验血液学杂志,2001,9(3):202-206.
[14] VEIGA J P,AFONSO H,SALLAN S E,et al. Acute lymphoblastic leukemia cells and their bone marrow stroma collaborate to induce endothelial cell proliferation thereby promoting leukemia cell survival[J]. Blood,1998,92(10suppl 1):511a.
[15] ROBOZ G J,DIAS S,LAM G,et al. Arsenic trioxide indoces dose and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis[J]. Blood,2000,96(4):1525-1530.
[16]许文林.白血病细胞血管内皮生长因子自分泌链作用的实验研究[D].苏州:苏州大学,2004.
[17]王金良,孔佩艳,徐葳,等.人参皂苷Rg3抑制急性白血病骨髓基质细胞HIF-1α及VEGF的表达及其机制探讨[J].第三军医大学学报,2010,32(7):621-624.
[18]成志勇,潘崚,牛志云,等. PTEN基因转染对白血病细胞VEGF调控作用的影响[J].肿瘤,2010,30(10):815-821.
[19]朱晶,宋艳秋,李薇,等.人可溶性血管内皮生长因子受体1抑制白血病细胞增殖的研究[J].中国实验血液学杂志,2007,15(1):168-174.
[20] AMBATI J,AMBATI B K,YOO S H,et al. Age-related macular degeneration:etiology,pathogenesis,and therapeutic strategies[J]. Surv Ophthalmol,2003,48(3):257-293.
[21] STRAWN L M,MCMAHON G,SCHRECK H,et al. Flk-1as a target for tumor growth inhibition[J]. Cancer Res,1996,56(15):3540-3545.
[22]郭海霞,徐令,陈月琴,等.血管内皮细胞生长因子受体2基因短发夹RNA介导基因沉默对白血病的抑制[J].中国组织工程研究与临床康复,2007,11(37):7503-7508.
[23]王鲁,常艳丽,张青云.血管内皮生长因子在肿瘤血管形成中的作用及其靶向治疗研究进展[J].中华临床实验室管理电子杂志,2015,3(3):146-152.
[24]刘玉琴,赵凤菊,陈万青,等.中国2009年白血病发病和死亡资料分析[J].中国肿瘤,2013,22(7):528-534.
[25]王一浩.血管内皮生长因子反义寡核苷酸对白血病细胞系HL60细胞作用的研究[D].郑州:郑州大学,2005.
[26] FOLKMAN J. Tumor angiogenesis:therapeutic implications[J]. N Engl J Med,1971,285(21):1182-1186.
[27] YA-HERTTUALA S,MARTIN J F. Cardiovascular gene therapy[J]. Lancel,2000,355(9199):213-222.
[28]张金巧.血管新生和血管内皮细胞生长因子在急性髓系白血病中的意义及三氧化二砷的抗血管新生作用[D].石家庄:河北医科大学,2003.
[29]张东梅,卿晨.血管内皮生长因子家族及其受体与肿瘤血管新生[J].医学综述,2017,23(3):417-420.
[30] FAN X J,KRIEG S,KUO C J,et al. VEGF blockade inhibits angiogenesisand reepithelialization of endometrium[J]. FASEB J,2008,22(1):3571-3580.
[31]李丽.血管内皮生长因子在白血病细胞中表达及三氧化二砷对其表达的调控[D].苏州:苏州大学,2002.