炎性细胞因子及代谢综合征在骨性关节炎发病机制中的研究现状
摘要
<正>骨性关节炎(OA)为一种退行性病变,是一种关节软骨退化损伤、关节周缘和软骨下骨反应性增生性疾病。随着老龄化社会的到来,到2025年我国>60岁老年人口达3.33亿,将有大量OA患者~([1])。目前对OA的发病机制尚不完全明确,在研究中发现在病情发展过程中有重要的炎性细胞因子参与,也观察到在代谢综合征患者中OA发病率高,脂肪因子也参与到了OA的发病进程。
引文
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[15]管兴发,董金波,王维山,等.骨关节炎患者血清及关节液中TNF-α与MMP-3含量及临床意义[J].青岛医药卫生,2008,40(1)9-12.
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[20]McNulty AL,Miller MR,O'Connor SK,et al The effects of adipokines on cartilage and meniscus catabolism[J].Connect Tissue Res2011(52):523-533.
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[2]罗玉明,郑维篷,魏合伟.骨关节炎与细胞因子TNF-α、IL-6关系的研究进展[J].现代诊断与治疗,2013,13(2):326-327.
[3]王艳荣,马张稳,田红英,等.炎症细胞因子在膝关节骨性关节炎滑液中的表达及临床意义[J].延安大学学报(医学科学版)2015,13(1):16-18.
[4]Heraud F,Heraud A,Harmand MF,et al Apoptosis in normal and osteoarthritis human articular cartilage[J].J Ann Rheum Dis2000,59(11):959-965.
[5]Maldonado M,Nam J.The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis[J].Biomed Res Int,2013(2013)284873.
[6]卫小春.关节软骨[M].北京:科学出版社2007:42.
[7]Shakibaei M,John T,Seifarth C,et al.Resveratml inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro[J].Ann NY Acad Sci,2007(1095):554563.
[8]Sun JM,Sun LZ.Liu J,et al.Scrum interleukin-15 levels are assoc:iated with severity of pain in patients with knee osteoarlhritis[J]Dis Marjers,2013(35):203-206.
[9]Tao Y,Qiu X,Xu C,et al.Expression and corre-lation of matrix metalloproteinase-7and inter-leukin-15 in human osteoairhritis[J].Int J Clin Exp Pathol,2015,8(8)9772-9778.
[10]胡爱心.细胞因子在骨性关节炎的发生及治疗方面的相关研究[D].武汉:武汉大学2015.
[11]董天华.膝关节骨性关节炎的基础与临床研究[D].河北医科大学,2016.
[12]王凤龙.OA滑膜细胞中IL-18及PGE2含量测定及意义[D].广州:南方医科大学,2016.
[13]李新友,王民,刘淼,等.白细胞介素6在突出的腰椎间盘中的表达及意义[J].中国矫形外科杂志,2001,8(6):581-584.
[14]陈游,孙才江,方建珍,等.不同程度膝骨关节炎患者滑液中几种细胞因子水平变化[J].中国临床康复,2002,6(10):1426-1427.
[15]管兴发,董金波,王维山,等.骨关节炎患者血清及关节液中TNF-α与MMP-3含量及临床意义[J].青岛医药卫生,2008,40(1)9-12.
[16]Conde J,Scotece M,Gomez R,et al.Adipokines and osteoarthritis:novel molecules invoIved in the pathogenesis and progression of disease[J].Arthritis,2011(2011):203901.
[17]Poonpet T,Honsawek S.Adipokines:Biomarkers for osteoarthritis[J].world J Orthop2014,5(3):319-327.
[18]Tong KM,Chen CP,Huang KC,et al.Adiponec:tin in-creases MM P-3 expression in human chondrocytes through adiporl signaling pathway[J].J Cell Biochem,2011(112)1431-1440.
[19]左伟,吴志宏,苏新林,等.脂联素促进OA滑膜细胞PGE2合成及其机制的初步研究[J]中国骨与关节外科,2012(5):425-428.
[20]McNulty AL,Miller MR,O'Connor SK,et al The effects of adipokines on cartilage and meniscus catabolism[J].Connect Tissue Res2011(52):523-533.
[21]Scotece M,Conde J,Gómez R,et al.Beyond fat mass:exploring the role of adipokines in theumatic diseases[J].Sci World J,2011(11)1932-1947.