血清NGAL在糖尿病肾病中的研究进展
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摘要
糖尿病(diabetesmellitus,DM)已成为危害人类健康的主要疾病之一。糖尿病肾病(diabeticnephropathy,DN)是糖尿病最重要的微血管并发症之一,并且是终末期肾病的常见原因。微量白蛋白尿水平的变化长期以来被认为是DN发展的标志,但一些糖尿病患者发生肾脏病理改变,而微量白蛋白尿在正常范围。这表明微量白蛋白尿不是早期发现DN理想的指标。国内外研究表明,血清中性粒细胞明胶酶相关载脂蛋白(serum neutrophil gelatinase-associated apolipoprotein,sNGAL)与DN的发生发展密切相关,在微量白蛋白尿出现之前可以检测到sNGAL水平的增加,比微量白蛋白尿更敏感和特异。因此,sNGAL有望成为诊断早期DN新的生物学标志物。
Diabetes mellitus(DM) has become one of the major diseases that endanger human health. Diabetic nephropathy(DN) is one of the most main microvascular complications of diabetes and is a common cause of end-stage renal disease. Change in microalbuminuria level has long been considered a hallmark of DN development, but some diabetic patients have renal pathological changes, while microalbuminuria is in the normal range. This suggests that microalbuminuria is not an ideal indicator for early detection of DN. Studies at home and abroad have shown that serum neutrophil gelatinase-associated apolipoprotein(sNGAL) is closely related to the development of DN, sNGAL can be detected before the appearance of microalbuminuria and is more sensitive and specific than microalbuminuria. Therefore, sNGAL is expected to become a new biomarker for the diagnosis of early DN.
Diabetes mellitus(DM) has become one of the major diseases that endanger human health. Diabetic nephropathy(DN) is one of the most main microvascular complications of diabetes and is a common cause of end-stage renal disease. Change in microalbuminuria level has long been considered a hallmark of DN development, but some diabetic patients have renal pathological changes, while microalbuminuria is in the normal range. This suggests that microalbuminuria is not an ideal indicator for early detection of DN. Studies at home and abroad have shown that serum neutrophil gelatinase-associated apolipoprotein(sNGAL) is closely related to the development of DN, sNGAL can be detected before the appearance of microalbuminuria and is more sensitive and specific than microalbuminuria. Therefore, sNGAL is expected to become a new biomarker for the diagnosis of early DN.
引文
1.国际糖尿病联合会.全球糖尿病概览(第7版)发布[J].糖尿病文摘,2015(12):7.International Diabetes Federation.Publication of global diabetes overview(7th ed)[J].Diabetes Abstracts,2015(12):5-5.
2.Satirapoj B,Aramsaowapak K,Tangwonglert T,et al.Novel tubular biomarkers predict renal progression in type 2 diabetes mellitus:a prospective cohort study[J].J Diabetes Res,2016,2016:3102962.
3.Fiseha T,Tamir Z.Urinary markers of tubular injury in early diabetic nephropathy[J].Int J Nephrol,2016,2016:4647685.
4.Kern EF,Erhard P,Sun W,et al.Early urinary markers of diabetic kidney disease:a nested case-control study from the Diabetes Control and Complications Trial(DCCT)[J].Am J Kidney Dis,2010,55(5):824-834.
5.Kaul A,Behera MR,Rai MK,et al.Neutrophil gelatinase-associated lipocalin:as a predictor of early diabetic nephropathy in type 2 diabetes mellitus[J].Indian J Nephrol,2018,28(1):53-60.
6.Siddiqi Z,Karoli R,Kaul A,et al.Evaluation of neutrophil gelatinaseassociated lipocalin and cystatin C as early markers of diabetic nephropathy[J].Ann Afr Med,2017,16(3):101-106.
7.Gilbert RE,Cooper ME.The tubulointerstitum in pro-gressive diabetic kidney disease:more than an aftermath of glomerular injury[J].Kidney Int,1999,56(5):1627-1637.
8.张朝云.糖尿病肾病中的近端肾小管损伤机制[J].中华糖尿病杂志,2015,7(11):661-663.ZHANG Chaoyun.Mechanism of proximal tubular injury in diabetic nephropathy[J].Chinese Journal of Diabetes,2015,7(11):661-663.
9.Tonkonogi A,C arlsson AC,Helmersson-karlqvist J,et al.Associations between urinary kidney injury biomarkers and cardiovascular mortality risk in elderly men with diabetes[J].Ups J Med Sci,2016,121(3):174-178.
10.Chen H,Li H.Clinical implication of cystatin C andβ2-microglobulin in early detection of diabetic nephropathy[J].Clin Lab,2017,63(2):241-247.
11.Zhang X,Zhou H,Li Y.Combined detection of urinary micro albumin,α1-microglobulin and N-acetyl-β-D-glucosaminidase in the early diagnosis of diabetic nephropathy[J].Pak J Med Sci,2017,33(6):1324-1327.
12.?y?ka A,Gala-B??dzińska A,Dumnicka P,et al.Is urinary NGALdetermination useful for monitoring kidney function and assessment of cardiovascular disease?A 12-month observation of patients with type 2diabetes[J].Dis Markers,2016,2016:8489543.
13.沈东惠,杨贤明,杨毅华.NGAL:糖尿病肾病的早期标志物[J].国际检验医学杂志,2010,31(11):1289-1291.SHEN Donghui,YANG Xianming,YANG Yihua.NGAL:an early marker of diabetic nephropathy[J].International Journal of Laboratory Medicine,2010,31(11):1289-1291.
14.Malyszko J,Tesar V,Macdougall IC.Neutrophil gelatinase-associated lipocalin and hepcidin:what do they have in common and is there a potential interaction?[J].Kidney Blood Press Res,2010,33(2):157-165.
15.Katagiri D,Doi K,Matsubara T,et al.New biomarker panel of plasma neutrophil gelatinase-associated lipocalin and endotoxin activity assay for detecting sepsis in acute kidney injury[J].J Crit Care,2013,28(5):564-570.
16.Mori K,Nakao K.Neutrophil gelatinase-associated lipocalin as the realtime indicator of active kidney damage[J].Kidney Int,2007,71(10):967-970.
17.Bennett M,Dent CL,Ma Q,et al.Urine NGAL predicts severity of acute kidney injury after cardiac surgery:a prospective study[J].Clin JAm Soc Nephrol,2008,3(3):665-673.
18.Sivalingam Z,Larsen SB,Grove EL,et al.Neutrophil gelatinaseassociated lipocalin as a risk marker in cardiovascular disease[J].Clin Chem Lab Med,2017,56(1):5-18.
19.Yun BA,Yang EM,Kim CJ.Plasma neutrophil gelatinase-associated lipocalin as a predictor of renal parenchymal involvement in infants with febrile urinary tract infection:a preliminary study[J].Ann Lab Med,2018,38(5):425-430.
20.Xu H,Sun X,Sun WJ.Expression and clinical correlation of NGALand VEGF in endometrial carcinoma[J].Eur Rev Med Pharmacol Sci,2018,22(3):632-636.
21.Wang Y,Lam KS,Kraegen EW,et al.Lipocalin-2is an inflammatory marker closely associated with obesity,in-sulin resistance,and hyperglycemia in humans[J].Clin Chem,2007,53(1):134-141.
22.Bacci MR,Chehter EZ,Azzalis LA,et al.Serum NGAL and cystatin Ccomparison with urinary albumin-to-creatinine ratio and inflammatory biomarkers as early predictors of renal dysfunction in patients with type2 diabetes[J].Kidney Int Rep,2017,2(2):152-158.
23.Mahfouz MH,Assiri AM,Mukhtar MH.Assessment of neutrophil gelatinase-associated lipocalin(NGAL)and retinol-binding protein4(RBP4)in type 2 diabetic patients with nephropathy[J].Biomark Insights,2016,11(11):31-40.
24.孙丽,牛国平.血浆NGAL和血清CysC在糖尿病肾病早期诊断中的临床价值[J].国际检验医学杂志,2015,36(9):1182-1184.SUN Li,NIU Guoping.Clinical value of plasma NGAL and serum CysC in early diagnosis of diabetic nephropathy[J].International Journal of Laboratory Medicine,2015,36(9):1182-1184.
25.Lacquaniti A,Donato V,Pintaudi B,et al.“Normoalbuminuric”diabetic nephropathy:Tubular damage and NGAL[J].Acta Diabetol,2013,50(6):935-942.
26.Zachwieja J,Soltysiak J,Fichna P,et al.Normal-range albuminuria does not exclude nephropathy in diabetic children[J].Pediatr Nephrol,2010,25(8):1445-1451.
2.Satirapoj B,Aramsaowapak K,Tangwonglert T,et al.Novel tubular biomarkers predict renal progression in type 2 diabetes mellitus:a prospective cohort study[J].J Diabetes Res,2016,2016:3102962.
3.Fiseha T,Tamir Z.Urinary markers of tubular injury in early diabetic nephropathy[J].Int J Nephrol,2016,2016:4647685.
4.Kern EF,Erhard P,Sun W,et al.Early urinary markers of diabetic kidney disease:a nested case-control study from the Diabetes Control and Complications Trial(DCCT)[J].Am J Kidney Dis,2010,55(5):824-834.
5.Kaul A,Behera MR,Rai MK,et al.Neutrophil gelatinase-associated lipocalin:as a predictor of early diabetic nephropathy in type 2 diabetes mellitus[J].Indian J Nephrol,2018,28(1):53-60.
6.Siddiqi Z,Karoli R,Kaul A,et al.Evaluation of neutrophil gelatinaseassociated lipocalin and cystatin C as early markers of diabetic nephropathy[J].Ann Afr Med,2017,16(3):101-106.
7.Gilbert RE,Cooper ME.The tubulointerstitum in pro-gressive diabetic kidney disease:more than an aftermath of glomerular injury[J].Kidney Int,1999,56(5):1627-1637.
8.张朝云.糖尿病肾病中的近端肾小管损伤机制[J].中华糖尿病杂志,2015,7(11):661-663.ZHANG Chaoyun.Mechanism of proximal tubular injury in diabetic nephropathy[J].Chinese Journal of Diabetes,2015,7(11):661-663.
9.Tonkonogi A,C arlsson AC,Helmersson-karlqvist J,et al.Associations between urinary kidney injury biomarkers and cardiovascular mortality risk in elderly men with diabetes[J].Ups J Med Sci,2016,121(3):174-178.
10.Chen H,Li H.Clinical implication of cystatin C andβ2-microglobulin in early detection of diabetic nephropathy[J].Clin Lab,2017,63(2):241-247.
11.Zhang X,Zhou H,Li Y.Combined detection of urinary micro albumin,α1-microglobulin and N-acetyl-β-D-glucosaminidase in the early diagnosis of diabetic nephropathy[J].Pak J Med Sci,2017,33(6):1324-1327.
12.?y?ka A,Gala-B??dzińska A,Dumnicka P,et al.Is urinary NGALdetermination useful for monitoring kidney function and assessment of cardiovascular disease?A 12-month observation of patients with type 2diabetes[J].Dis Markers,2016,2016:8489543.
13.沈东惠,杨贤明,杨毅华.NGAL:糖尿病肾病的早期标志物[J].国际检验医学杂志,2010,31(11):1289-1291.SHEN Donghui,YANG Xianming,YANG Yihua.NGAL:an early marker of diabetic nephropathy[J].International Journal of Laboratory Medicine,2010,31(11):1289-1291.
14.Malyszko J,Tesar V,Macdougall IC.Neutrophil gelatinase-associated lipocalin and hepcidin:what do they have in common and is there a potential interaction?[J].Kidney Blood Press Res,2010,33(2):157-165.
15.Katagiri D,Doi K,Matsubara T,et al.New biomarker panel of plasma neutrophil gelatinase-associated lipocalin and endotoxin activity assay for detecting sepsis in acute kidney injury[J].J Crit Care,2013,28(5):564-570.
16.Mori K,Nakao K.Neutrophil gelatinase-associated lipocalin as the realtime indicator of active kidney damage[J].Kidney Int,2007,71(10):967-970.
17.Bennett M,Dent CL,Ma Q,et al.Urine NGAL predicts severity of acute kidney injury after cardiac surgery:a prospective study[J].Clin JAm Soc Nephrol,2008,3(3):665-673.
18.Sivalingam Z,Larsen SB,Grove EL,et al.Neutrophil gelatinaseassociated lipocalin as a risk marker in cardiovascular disease[J].Clin Chem Lab Med,2017,56(1):5-18.
19.Yun BA,Yang EM,Kim CJ.Plasma neutrophil gelatinase-associated lipocalin as a predictor of renal parenchymal involvement in infants with febrile urinary tract infection:a preliminary study[J].Ann Lab Med,2018,38(5):425-430.
20.Xu H,Sun X,Sun WJ.Expression and clinical correlation of NGALand VEGF in endometrial carcinoma[J].Eur Rev Med Pharmacol Sci,2018,22(3):632-636.
21.Wang Y,Lam KS,Kraegen EW,et al.Lipocalin-2is an inflammatory marker closely associated with obesity,in-sulin resistance,and hyperglycemia in humans[J].Clin Chem,2007,53(1):134-141.
22.Bacci MR,Chehter EZ,Azzalis LA,et al.Serum NGAL and cystatin Ccomparison with urinary albumin-to-creatinine ratio and inflammatory biomarkers as early predictors of renal dysfunction in patients with type2 diabetes[J].Kidney Int Rep,2017,2(2):152-158.
23.Mahfouz MH,Assiri AM,Mukhtar MH.Assessment of neutrophil gelatinase-associated lipocalin(NGAL)and retinol-binding protein4(RBP4)in type 2 diabetic patients with nephropathy[J].Biomark Insights,2016,11(11):31-40.
24.孙丽,牛国平.血浆NGAL和血清CysC在糖尿病肾病早期诊断中的临床价值[J].国际检验医学杂志,2015,36(9):1182-1184.SUN Li,NIU Guoping.Clinical value of plasma NGAL and serum CysC in early diagnosis of diabetic nephropathy[J].International Journal of Laboratory Medicine,2015,36(9):1182-1184.
25.Lacquaniti A,Donato V,Pintaudi B,et al.“Normoalbuminuric”diabetic nephropathy:Tubular damage and NGAL[J].Acta Diabetol,2013,50(6):935-942.
26.Zachwieja J,Soltysiak J,Fichna P,et al.Normal-range albuminuria does not exclude nephropathy in diabetic children[J].Pediatr Nephrol,2010,25(8):1445-1451.