糖皮质激素雾化吸入治疗支气管哮喘所致不良反应及干预措施研究进展
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摘要
从全身和局部不良反应2个方面对近20年来关于糖皮质激素雾化吸入治疗支气管哮喘过程中出现的不良反应及其干预措施进行分析和概述,从而为糖皮质激素雾化吸入治疗支气管哮喘的基础研究及临床合理用药提供参考。
This paper analyses and summarizes from two aspects of systemic and topical adverse reactions and intervention measures on aerosol inhalation of glucocorticoids in the treatment of bronchial asthma in recent 20 years,thus provides a reference for the basic research and rational administration in clinical practice of aerosol inhalation of glucocorticoids in the treatment of bronchial asthma.
This paper analyses and summarizes from two aspects of systemic and topical adverse reactions and intervention measures on aerosol inhalation of glucocorticoids in the treatment of bronchial asthma in recent 20 years,thus provides a reference for the basic research and rational administration in clinical practice of aerosol inhalation of glucocorticoids in the treatment of bronchial asthma.
引文
[1]中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗及教育和管理方案)[J].中华结核和呼吸杂志,2003,26(3):132-138.
[2]刘国梁,林江涛,陈萍,等.支气管哮喘对中国患者生活、情感影响及相关因素的调查分析[J].中国呼吸与危重监护杂志,2016,15(3):232-235.
[3]刘畅,周向东,李华,等.支气管哮喘合并肺结核患者脑源性神经营养因子和神经激肽A表达对预后的影响分析[J].中华医院感染学杂志,2017,27(4):785-787.
[4]王雯,刘继贤.儿童支气管哮喘影响因素分析[J].中国实用儿科杂志,2015,30(6):441-445.
[5]崔家玉,谢晓慧.新指南中支气管哮喘和慢性阻塞性肺疾病的药物治疗比较[J].中国医院药学杂志,2016,36(21):1897-1900.
[6]夏正坤.糖皮质激素临床应用再认识[J].医学研究生学报,2018,31(2):113-117.
[7]叶涛,詹珊珊.吸入糖皮质激素治疗支气管哮喘的不良反应[J].医学综述,2012,18(10):1511-1514.
[8]宋梅,陈妙爱,谢晓鹏,等.吸入丙酸氟替卡松对支气管哮喘患者肾上腺功能影响的Meta分析[J/CD].中华哮喘杂志(电子版),2009,3(6):418-422.
[9]Clark D J,Grove A,Cargill R I,et al.Comparative adrenal suppression with inhaled budesonide and fluticasone propionate in adult asthmatic patients[J]. Thorax,1996,51(3):262-266.
[10]Kamada A K,Szefler S J,Martin R J,et al.Issues in the use of inhaled glucocorticoids:the asthma clinical research network[J].Am J Respir Crit Care Med,1996,153(6 Pt 1):1739-1748.
[11]陈清霞,余晓霞.糖皮质激素隔日疗法的临床调查与分析[J].临床合理用药杂志,2013,6(6B):175-177.
[12]王培,许利平,金喜宏,等.糖皮质激素对哮喘模型大鼠肾阴阳虚证候演变的影响[J].中西医结合学报,2010,8(1):80-85.
[13]丘余良,郑健,吴竞,等.糖皮质激素治疗对原发性肾病综合征患者中医证候影响的规律探讨[J].中华中医药杂志,2013,28(5):1535-1537.
[14]刘春香.持续性糖皮质激素吸入治疗儿童支气管哮喘的疗效及对患儿骨密度及骨代谢的影响[J].中国妇幼保健,2017,32(5):982-984.
[15]韩春玲,邱艳玲,刘丽.小剂量吸入糖皮质激素对儿童生长发育的影响研究[J].中国全科医学,2017,20(增刊1):113-115.
[16]曲蓓蕾,贾博.长期应用小剂量激素对哮喘婴幼儿发育及血清钙磷影响的研究[J].中国医药科学,2017,7(9):59-61.
[17]张敏,阎德文,沈观乐,等.吸入激素对男性哮喘患者骨代谢的影响[J].华中科技大学学报(医学版),2005,34(2):196-198.
[18]王彤,殷凯生,包丽华,等.吸入激素对女性哮喘患者骨密度和骨代谢的影响[J].中国临床康复,2005,43(9):175-177.
[19]顾有守.全身应用糖皮质激素的不良反应及防治对策[J].皮肤病与性病,2016,38(1):16-18.
[20]张志强,闫立平,韦英华,等.温肾逐瘀壮骨汤治疗原发性肾虚瘀滞型骨质疏松症84例疗效观察[J].河北中医,2013,35(5):683-684.
[21]杜旭召,邓素玲,杨豪.补肾活血通络汤治疗糖皮质激素致骨质疏松症临床观察[J].中国实验方剂学杂志,2017,23(4):193-197.
[22]徐进,丁任,石晓兵,等.中药复骨方对激素致骨质疏松骨折大鼠骨代谢及骨密度的影响[J].中国老年学杂志,2016,36(1):21-23.
[23]王剑,郑洪新,刘瑞辉,等.补肾中药复方对糖皮质激素性骨质疏松症大鼠骨和肾组织Dlx5 mRNA及蛋白表达的影响[J].中华中医药杂志,2012,27(4):951-956.
[24]王剑,郑洪新,宗志宏,等.补肾、健脾、活血中药对糖皮质激素性骨质疏松症大鼠骨组织Osterix mRNA及蛋白表达的影响[J].中华中医药杂志,2011,26(4):801-805.
[25]严曼榕,符州,田代印.长期吸入糖皮质激素对支气管哮喘患儿身高的影响[J].实用儿科临床杂志,2012,27(9):709-711.
[26]田红燕.支气管哮喘及吸入糖皮质激素对儿童生长发育影响的研究[J].中国医学工程,2014,22(7):179.
[27]李志瑶,舒敏.支气管哮喘儿童吸入糖皮质激素的安全性评价[J].四川医学,2014,35(9):1139-1143.
[28]El-Sayed Z A,Hamza R T,Sayed Nel-D,et al.Effect of inhaled corticosteroids on growth and puberty in Egyptian asthmatic children and adolescents[J]. Pak J Biol Sci,2010,13(20):977-984.
[29]Stelmach I,Olszowiec-Chlebna M,Jerzynska J,et al. Inhaled corticosteroids may have a beneficial effect on bone metabolism in newly diagnosed asthmatic children[J].Pulm Pharmacol Ther,2011,24(4):414-420.
[30]Kelly H W,Sternberg A L,Lescher R,et al. Effect of inhaled glucocorticoids in childhood on adult height[J]. N Engl J Med,2012,367(10):904-912.
[31]Roland N J,Bhalla R K,Earis J.The local side effects of inhaled corticosteroids:current understanding and review of the literature[J].Chest,2004,126(1):213-219.
[32]林士军,王桂杰,刘玉春.哮喘患者吸入糖皮质激素的不良反应[J].医学综述,2006,12(21):1336-1338.
[33]刘永强,尹娟.布地奈德混悬液对支气管哮喘慢性持续期患者骨密度的影响[J].临床和实验医学杂志,2013,12(2):101-102.
[34]Kurt E,Yildirim H,Kiraz N,et al.Oropharyngeal candidiasis with dry-powdered fluticasone propionate:500 microg/day versus 200 microg/day[J]. Allergol Immunopathol:Madr,2008,36(1):17-20.
[35]许瑞香,谭少屏,梁亚连.吸入糖皮质激素引致口腔念珠菌病的护理[J].全科护理,2013,11(1C):198-199.
[36]孙龙凤,陈晓平,李宝杰,等.哮喘患者长期吸入糖皮质激素的相关问题与护理对策[J].护士进修杂志,2006,21(12):1113-1114.
[37]Dubus J C,Marguet C,Deschildre A,et al. Local sideeffects of inhaled corticosteroids in asthmatic children:influence of drug,dose,age and device[J]. Allergy,2001,56(10):944-948.
[38]Williamson I J,Matusiewicz S P,Brown P H,et al. Frequency of voice problems and cough in patients using pressurized aerosol inhaled steroid preparations[J]. Eur Respir J,1995,8(4):590-592.
[39]Molimard M,Le Gros V,Robinson P,et al.Prevalence and associated factors of oropharyngeal side effects in users of inhaled corticosteroids in a real-life setting[J]. J Aerosol Med Pulm Drug Deliv,2010,23(2):91-95.
[40]付晓艳,巩子汉,姚楠,等.糖皮质激素治疗支气管哮喘过程中的中医证型演变及中药防治进展[J].甘肃中医药大学学报,2018,35(3):83-86.
[2]刘国梁,林江涛,陈萍,等.支气管哮喘对中国患者生活、情感影响及相关因素的调查分析[J].中国呼吸与危重监护杂志,2016,15(3):232-235.
[3]刘畅,周向东,李华,等.支气管哮喘合并肺结核患者脑源性神经营养因子和神经激肽A表达对预后的影响分析[J].中华医院感染学杂志,2017,27(4):785-787.
[4]王雯,刘继贤.儿童支气管哮喘影响因素分析[J].中国实用儿科杂志,2015,30(6):441-445.
[5]崔家玉,谢晓慧.新指南中支气管哮喘和慢性阻塞性肺疾病的药物治疗比较[J].中国医院药学杂志,2016,36(21):1897-1900.
[6]夏正坤.糖皮质激素临床应用再认识[J].医学研究生学报,2018,31(2):113-117.
[7]叶涛,詹珊珊.吸入糖皮质激素治疗支气管哮喘的不良反应[J].医学综述,2012,18(10):1511-1514.
[8]宋梅,陈妙爱,谢晓鹏,等.吸入丙酸氟替卡松对支气管哮喘患者肾上腺功能影响的Meta分析[J/CD].中华哮喘杂志(电子版),2009,3(6):418-422.
[9]Clark D J,Grove A,Cargill R I,et al.Comparative adrenal suppression with inhaled budesonide and fluticasone propionate in adult asthmatic patients[J]. Thorax,1996,51(3):262-266.
[10]Kamada A K,Szefler S J,Martin R J,et al.Issues in the use of inhaled glucocorticoids:the asthma clinical research network[J].Am J Respir Crit Care Med,1996,153(6 Pt 1):1739-1748.
[11]陈清霞,余晓霞.糖皮质激素隔日疗法的临床调查与分析[J].临床合理用药杂志,2013,6(6B):175-177.
[12]王培,许利平,金喜宏,等.糖皮质激素对哮喘模型大鼠肾阴阳虚证候演变的影响[J].中西医结合学报,2010,8(1):80-85.
[13]丘余良,郑健,吴竞,等.糖皮质激素治疗对原发性肾病综合征患者中医证候影响的规律探讨[J].中华中医药杂志,2013,28(5):1535-1537.
[14]刘春香.持续性糖皮质激素吸入治疗儿童支气管哮喘的疗效及对患儿骨密度及骨代谢的影响[J].中国妇幼保健,2017,32(5):982-984.
[15]韩春玲,邱艳玲,刘丽.小剂量吸入糖皮质激素对儿童生长发育的影响研究[J].中国全科医学,2017,20(增刊1):113-115.
[16]曲蓓蕾,贾博.长期应用小剂量激素对哮喘婴幼儿发育及血清钙磷影响的研究[J].中国医药科学,2017,7(9):59-61.
[17]张敏,阎德文,沈观乐,等.吸入激素对男性哮喘患者骨代谢的影响[J].华中科技大学学报(医学版),2005,34(2):196-198.
[18]王彤,殷凯生,包丽华,等.吸入激素对女性哮喘患者骨密度和骨代谢的影响[J].中国临床康复,2005,43(9):175-177.
[19]顾有守.全身应用糖皮质激素的不良反应及防治对策[J].皮肤病与性病,2016,38(1):16-18.
[20]张志强,闫立平,韦英华,等.温肾逐瘀壮骨汤治疗原发性肾虚瘀滞型骨质疏松症84例疗效观察[J].河北中医,2013,35(5):683-684.
[21]杜旭召,邓素玲,杨豪.补肾活血通络汤治疗糖皮质激素致骨质疏松症临床观察[J].中国实验方剂学杂志,2017,23(4):193-197.
[22]徐进,丁任,石晓兵,等.中药复骨方对激素致骨质疏松骨折大鼠骨代谢及骨密度的影响[J].中国老年学杂志,2016,36(1):21-23.
[23]王剑,郑洪新,刘瑞辉,等.补肾中药复方对糖皮质激素性骨质疏松症大鼠骨和肾组织Dlx5 mRNA及蛋白表达的影响[J].中华中医药杂志,2012,27(4):951-956.
[24]王剑,郑洪新,宗志宏,等.补肾、健脾、活血中药对糖皮质激素性骨质疏松症大鼠骨组织Osterix mRNA及蛋白表达的影响[J].中华中医药杂志,2011,26(4):801-805.
[25]严曼榕,符州,田代印.长期吸入糖皮质激素对支气管哮喘患儿身高的影响[J].实用儿科临床杂志,2012,27(9):709-711.
[26]田红燕.支气管哮喘及吸入糖皮质激素对儿童生长发育影响的研究[J].中国医学工程,2014,22(7):179.
[27]李志瑶,舒敏.支气管哮喘儿童吸入糖皮质激素的安全性评价[J].四川医学,2014,35(9):1139-1143.
[28]El-Sayed Z A,Hamza R T,Sayed Nel-D,et al.Effect of inhaled corticosteroids on growth and puberty in Egyptian asthmatic children and adolescents[J]. Pak J Biol Sci,2010,13(20):977-984.
[29]Stelmach I,Olszowiec-Chlebna M,Jerzynska J,et al. Inhaled corticosteroids may have a beneficial effect on bone metabolism in newly diagnosed asthmatic children[J].Pulm Pharmacol Ther,2011,24(4):414-420.
[30]Kelly H W,Sternberg A L,Lescher R,et al. Effect of inhaled glucocorticoids in childhood on adult height[J]. N Engl J Med,2012,367(10):904-912.
[31]Roland N J,Bhalla R K,Earis J.The local side effects of inhaled corticosteroids:current understanding and review of the literature[J].Chest,2004,126(1):213-219.
[32]林士军,王桂杰,刘玉春.哮喘患者吸入糖皮质激素的不良反应[J].医学综述,2006,12(21):1336-1338.
[33]刘永强,尹娟.布地奈德混悬液对支气管哮喘慢性持续期患者骨密度的影响[J].临床和实验医学杂志,2013,12(2):101-102.
[34]Kurt E,Yildirim H,Kiraz N,et al.Oropharyngeal candidiasis with dry-powdered fluticasone propionate:500 microg/day versus 200 microg/day[J]. Allergol Immunopathol:Madr,2008,36(1):17-20.
[35]许瑞香,谭少屏,梁亚连.吸入糖皮质激素引致口腔念珠菌病的护理[J].全科护理,2013,11(1C):198-199.
[36]孙龙凤,陈晓平,李宝杰,等.哮喘患者长期吸入糖皮质激素的相关问题与护理对策[J].护士进修杂志,2006,21(12):1113-1114.
[37]Dubus J C,Marguet C,Deschildre A,et al. Local sideeffects of inhaled corticosteroids in asthmatic children:influence of drug,dose,age and device[J]. Allergy,2001,56(10):944-948.
[38]Williamson I J,Matusiewicz S P,Brown P H,et al. Frequency of voice problems and cough in patients using pressurized aerosol inhaled steroid preparations[J]. Eur Respir J,1995,8(4):590-592.
[39]Molimard M,Le Gros V,Robinson P,et al.Prevalence and associated factors of oropharyngeal side effects in users of inhaled corticosteroids in a real-life setting[J]. J Aerosol Med Pulm Drug Deliv,2010,23(2):91-95.
[40]付晓艳,巩子汉,姚楠,等.糖皮质激素治疗支气管哮喘过程中的中医证型演变及中药防治进展[J].甘肃中医药大学学报,2018,35(3):83-86.