解毒洗药溻渍治疗对下肢静脉性溃疡疮周微循环的影响
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摘要
目的:探讨解毒洗药溻渍治疗对下肢静脉性溃疡疮周微循环的影响。方法:选取下肢静脉性溃疡住院患者54例,随机分为治疗组38例,对照组16例;两组创面均常规消毒后湿敷庆大霉素生理盐水纱布,治疗组在换药前应用解毒洗药溻渍治疗患肢(30±2)min,疗程为4周;对比两组疗效,检测治疗前后疮周血流灌注量和经皮氧分压。结果:治疗组治愈率28.95%,显愈率71.05%,有效率97.37%;对照组治愈率18.75%,显愈率43.75%,有效率75.00%,治疗组效果优于对照组。治疗4周后,治疗组血流灌注量基线值、加热后增加率及经皮氧分压均高于治疗前(P<0.05);治疗组血流灌注量基线值、加热后增加率及经皮氧分压均高于对照组(P<0.01~0.05)。结论:解毒洗药溻渍治疗下肢慢性溃疡可通过提高创面局部血流灌注量和氧分压提高疗效。
ObjectiveTo investigate the clinical efficacy of detoxifying lotion on venous ulcer of lower ex-tremity.MethodsFifty-four hospitalized patients with venous leg ulcers were randomly divided into treat-ment group(38 cases) and control group(16 cases).Both groups had been treated with wet compress gentamicinphysiological saline after clean dressing,but the treatment group were fumigated the affected limbs with detoxify-ing lotion before dressing change.The course of treatment was 4 weeks.The efficacy of treatment were comparedthe amount of detected periwound perfusion and transcutaneous oxygen partial pressure changes between twogroups.ResultsIn the control group,the recovery rate was 18.75%,significant improvement rate was 43.75%and effective rate was 75%;while in the treatment group,the above rates were 28.95%,71.05% and 97.37% re-spectively.Treatment effectiveness of treatment group was much better than that of control group.After 4 weeksof treatment,in treatment group the blood perfusion of the baseline value,the increased rate after heating andtranscutaneous oxygen pressure were all higher than those before treatment.In the treatment group,the bloodperfusion of the baseline value,increased rate after heating and transcutaneous oxygen pressure were all higherthan those in the control group(P < 0.01~0.05).ConclusionDetoxifying lotion can obviously improve micro-circulation around the ulcer and enhance local blood perfusion and oxygen partial pressure.
ObjectiveTo investigate the clinical efficacy of detoxifying lotion on venous ulcer of lower ex-tremity.MethodsFifty-four hospitalized patients with venous leg ulcers were randomly divided into treat-ment group(38 cases) and control group(16 cases).Both groups had been treated with wet compress gentamicinphysiological saline after clean dressing,but the treatment group were fumigated the affected limbs with detoxify-ing lotion before dressing change.The course of treatment was 4 weeks.The efficacy of treatment were comparedthe amount of detected periwound perfusion and transcutaneous oxygen partial pressure changes between twogroups.ResultsIn the control group,the recovery rate was 18.75%,significant improvement rate was 43.75%and effective rate was 75%;while in the treatment group,the above rates were 28.95%,71.05% and 97.37% re-spectively.Treatment effectiveness of treatment group was much better than that of control group.After 4 weeksof treatment,in treatment group the blood perfusion of the baseline value,the increased rate after heating andtranscutaneous oxygen pressure were all higher than those before treatment.In the treatment group,the bloodperfusion of the baseline value,increased rate after heating and transcutaneous oxygen pressure were all higherthan those in the control group(P < 0.01~0.05).ConclusionDetoxifying lotion can obviously improve micro-circulation around the ulcer and enhance local blood perfusion and oxygen partial pressure.
引文
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[17]历建萍.中药溻渍的应用研究[J].长春中医药大学学报,2011,27(6):1058.
[18]邓大一,阙华发.中药熏洗疗法治疗下肢慢性溃疡[J].光明中医,2010,25(3):548-549.
[2]国家中医药管理局科技司.中医外科病证诊断疗效标准[S].北京:人民卫生出版社,1999:48.
[3]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:140.
[4]阙华发,徐杰男,张臻,等.顾氏外科诊治慢性下肢溃疡学术思想及临证经验[J].中医杂志,2014,55(18):1601-1604.
[5]徐杰男.唐汉钧教授治疗慢性下肢溃疡经验撷英[J].四川中医,2014,32(4):7-9.
[6]郎彦波,李义,宋启刚,等.中西医结合治疗下肢静脉性溃疡临床心得[J].黑龙江中医药,2014,43(6):36-37.
[7]孙敏莉,张柏根.下肢慢性静脉功能不全的原因与病理[J].中国中西医结合外科杂志,2009,15(4):347-349.
[8]李建志,刘文丽,王亚贤.9味中草药抗菌作用实验研究[J].中医药学报,2012,40(1):45-46.
[9]林海,龚又明,邓广海.黄柏及其炮制品水提物体内、外抑菌作用研究[J].中国药房,2012,23(31):2900-2902.
[10]马雪梅,马文兵.连翘提取物的抑菌活性研[J].光明中医,2012,27(8):1529-1531.
[11]冯秀丽,徐庆华,赵晓云,等.金银花及其复方的体外抑菌活性与体内抗炎作用[J].沈阳药科大学学报,2013,30(1):35-40.
[12]戴五好,钱利武,杨士友,等.苦参、山豆根生物碱及其总碱的抑菌活性研究[J].中国实验方剂学杂志,2012,18(3):177-180.
[13]刘丽娜,兰燕宇,郑林,等.灯盏细辛、赤芍配伍对血栓形成和凝血时间的交互作用[J].中国实验方剂学杂志,2012,18(21):157-160.
[14]路俊仙,孟蔚,张才波,等.木鳖子制霜前后的体外抑菌作用研究[J].现代中药研究与实践,2009,22(6):33-35.
[15]孙付军,路俊仙,崔璐,等.不同含油量木鳖子霜抗炎镇痛作用比较[J].时珍国医国药,2010,21(5):1084-1085.
[16]樊凯芳,赵建平,冯振宇.论白芷的活血作用[J].中国中医急症,2011,20(12):1928-1929.
[17]历建萍.中药溻渍的应用研究[J].长春中医药大学学报,2011,27(6):1058.
[18]邓大一,阙华发.中药熏洗疗法治疗下肢慢性溃疡[J].光明中医,2010,25(3):548-549.