藏药柳茶化学成分及药理活性研究进展
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摘要
藏药柳茶系蔷薇科鲜卑花属植物窄叶鲜卑花(Sibraea angustata (Rech.) Hand.-Mazz.)的俗称,主要生长于中国青海、四川、甘肃、云南、西藏等高海拔地区。柳茶为藏族民间常用药,具有清胃热、助消化、调节脂代谢、抗氧化、抗肝损伤、提高免疫力、抗肿瘤、抑菌等药用功能。本综述对藏药柳茶的生物学特征、化学成分、药理作用等方面进行了系统综述,并针对其研究过程中存在的问题和发展前景等进行了分析讨论,并进一步阐述了植物分子育种手段在藏药柳茶野生资源保护及开发中的应用,以期为藏药柳茶的种质资源保护、生态环境建设及药用价值的进一步开发利用提升提供理论参考。
Liu tea of folk medicine in the Tibetan is a common name for Sibiraea angustata(Rech.) Hand.-Mazz.of Sibiraea Maxim plants in Rosaceae family, it was mainly produced at high altitude areas, such asin Tibet, Sichuan,Qinghai, Gansu and Yunnan. Liu tea is a common Tibetan folk medicine with the functions of clearing stomach heat, aiding digestion, regulating lipid metabolism, antioxidant, anti-liver injury, immune regulation, anti-tumor,anti-bacterial and so on. The objective of this review was to summarize the biological characteristics, chemical composition and pharmacological research, analyze and discuss the existing problems and development prospects in the course of research. The application of plant molecular breeding in the protection and development of Sibraea angustata was further expounded in order to provide a theoretical reference for the protection of germplasm resources,the construction of ecological environment and the further development and utilization of medicinal value.
Liu tea of folk medicine in the Tibetan is a common name for Sibiraea angustata(Rech.) Hand.-Mazz.of Sibiraea Maxim plants in Rosaceae family, it was mainly produced at high altitude areas, such asin Tibet, Sichuan,Qinghai, Gansu and Yunnan. Liu tea is a common Tibetan folk medicine with the functions of clearing stomach heat, aiding digestion, regulating lipid metabolism, antioxidant, anti-liver injury, immune regulation, anti-tumor,anti-bacterial and so on. The objective of this review was to summarize the biological characteristics, chemical composition and pharmacological research, analyze and discuss the existing problems and development prospects in the course of research. The application of plant molecular breeding in the protection and development of Sibraea angustata was further expounded in order to provide a theoretical reference for the protection of germplasm resources,the construction of ecological environment and the further development and utilization of medicinal value.
引文
An X.Y.,2015,Pharmacodynamics study and component analysis of two plants in Gansu Province,Thesis for M.S.,Lanzhou University,Supervisor:Yang Y.J.,pp.4-5(安小勇,2015,甘肃两种植物部分药效研究及成分分析,硕士学位论文,兰州大学,导师:杨永健,pp.4-5)
Chen L.,Tao T.T.,and Wang T.Z.,2006,Determination of ferulic acid and isoferulic acid in Sibiraea angustata by RP-H-PLC,Huaxi Yaoxue Zazhi(West China Journal of Pharmaceutical Sciences),21(2):196-197(陈璐,陶婷婷,王天志,2006,RP-HPLC测定藏药柳茶中阿魏酸和异阿魏酸的含量,华西药学杂志,21(2):196-197)
Chen Y.,Shi X.Y.,Li H.L.,and Luo G.H.,2017,The analysis of chemical composition of volatile oil from leaves of Sibiraea angustata by GS-MS,Shipin Gongye Keji(Science and Technology of Food Industry),38(12):31-33(陈叶,石秀云,李海亮,罗光宏,2017,窄叶鲜卑花叶挥发油成分分析,食品工业科技,38(12):31-33)
Cheng Y.,Ha S.Q.M.G.,Qin X.Z.,Tang X.Y.,Chen J.N.,Wang H.Y.,and Gao A.,2016,Effects of traditional Tibetan drug Liu Tea on proliferation and chemotherapeutic sensitivity of drug-resistant human gastric cancer cell BGC823/5-FU,Zhongguo Zhongyao Zazhi(China Journal of Chinese Materia Medica),41(4):603-608(程燕,哈斯其美格,覃小珍,唐祥友,陈健楠,王慧莹,高傲,2016,藏药柳茶水提物对胃癌耐药细胞bgc823/5-fu增殖及药物敏感性的影响,中国中药杂志,41(4):603-608)
Dong Y.,Zhang Y.M.,Zhou L.,and Wang P.X.,2009,Application of transgenic technology in medicinal plants,Zhongcaoyao(Chinese Traditional and Herbal Drugs),40(3):489-492(董燕,张雅明,周联,王培训,2009,转基因技术在药用植物中的应用,中草药,40(3):489-492)
Duan B.W.,Li Y.,Liu X.,and Yang Y.J.,2010,Effect of polysaccharides in processed Sibiraea on immunologic function of immunosuppression mice,Zhongguo Zhongyao Zazhi(China Journal of Chinese Materia Medica),35(11):1466-1469(段博文,李运,刘昕,杨永建,2010,柳茶多糖对小鼠免疫功能的影响,中国中药杂志,35(11):1466-1469)
Lei S.Y.,Yan Z.H.,Zhu T.F.,and Yang Y.J.,2010,Determination of trace elements in Sibirae by atomic absorption spectrometry,Xiandai Yiyao Weisheng(Journal of Modern Medicine&Health),26(4):497-498(雷世庸,闫志慧,朱仝飞,杨永建,2010,火焰原子吸收光谱法测定甘肃省鲜卑花属植物叶中的微量元素,现代医药卫生,26(4):497-498)
Li B.,Lee J.B.,Hayashi K.,Ito Y.,Sun W.J.,Wang X.,Kano Y.,and Hayashi T.,2010,Two new monoterpenes from Sibiraea angustata,J.Nat.Med.,64:89-92
Liu J.F.,Cheng Y.Q.,and Chen Z.W.,2009,Protoplast isolation and plant regeneration from leaves of Rhodiola sachalinensis,Zhongcaoyao(Chinese Traditional and Herbal Drugs),40(7):1127-1131(刘剑锋,程云清,陈智文,2009,高山红景天叶肉原生质体分离培养与植株再生,中草药,40(7):1127-1131)
Liu J.X.,Wu S.J.,Wei X.Y.,and Yang R.Z.,1999,Studies on the chemical constituents of Sibiraea angustata,Redai Yaredai Zhiwu Xuebao(Journal of Tropical and Subtropical Botany),(3):248-251(刘建祥,吴淑君,魏孝义,杨仁洲,1999,窄叶鲜卑花的化学成分研究,热带亚热带植物学报,(3):248-251)
Shi L.,Zhang D.M.,Qi J.,Li J.Y.,and Yang Y.J.,2009,Isolation and purification of and polysaccharide from Liucha and analysis of its chemical composition by gas chromatography-mass spectrometry,Shizhen Guoyi Guoyao(Lishizhen Medicine and Materia Medica Research),20(9):2191-2192(石磊,张冬梅,齐洁,李建银,杨永建,2009,柳茶多糖的分离纯化及气相色谱-质谱分析,时珍国医国药,20(9):2191-2192)
Sun W.W.,Xie B.F.,Liu H.,and Liu X.,2012,The role of hypercholesterolemia in the outbreak of Alzheimer's disease and the treatment effect of Sibraea angustata extract,Zhongyaocai(Journal of Chinese Medicinal Materials),35(4):596-602(孙雯雯,颉宾芳,刘卉,刘昕,2012,高胆固醇血症在阿尔兹海默病发生中的作用及藏药柳茶提取物的治疗效应,中药材,35(4):596-602)
Tao T.T.,Sei Y.,Wang T.Z.,Bai C.,and Chang Y.B.,2006,Chemical constituents of Sibiraea angustata,Zhongguo Tianran Yaowu(Chinese Journal of Natural Medicines),4(4):257-259(陶婷婷,濑井康雄,王天志,柏川,常艳波,2006,窄叶鲜卑花的化学成分,中国天然药物,4(4):257-259)
Wang H.G.,Wu Y.,and Yue H.P.,2016,The effect of extracts Sibraea angustata on the expression of Mrp2 and Mrp6 of INH-induced hepatotoxicity in mice,Shizhen Guoyi Guoyao(Lishizhen Medicine and Materia Medica Research),27(11):2594-2595(王汉国,武燕,岳汉萍,2016,藏药柳茶提取物对异烟肼引起的肝损伤小鼠膜转运体Mrp2和Mrp6表达影响,时珍国医国药,27(11):2594-2595
Wang X.L.,and Yang B.X.,1995,Protective effect and mechanism of Sibiraea angustata on CCl4 liver injury,Zhongguo Zhongyao Zazhi(China Journal of Chinese Materia Medica),20(12):746-748(汪晓立,杨兵勋,1995,柳茶对CCl4肝损伤的保护作用及机理初探,中国中药杂志,20(12):746-748)
Wang Z.H.,Zhu D.L.,and Yu C.,2010,Application in germplasm improvement of medical plants via biotechnology,Keji Tongbao(Bulletin of Science and Technology),26(1):88-92,119(王忠华,朱东亮,俞超,2010,现代育种技术在药用植物品种改良中的应用,科技通报,26(1):88-92,119)
Wang Z.W.,Li B.,Yu S.S.,Lai X.W.,Liu B.,and Hayashi T.,2013,Eight new monoterpene acylglucosides from Sibiraea angustata,Phytochem.Lett.,6(3):461-466
Wei Y.F.,Yang Y.J.,Li J.Y.,Duan W.B.,and Li Y.,2011,Preliminary study of Liucha on diabetic mice induced by Alloxan,Shizhen Guoyi Guoyao(Lishizhen Medicine and M-ateria Medica Research),22(10):2460-2461(卫阳飞,杨永建,李建银,段博文,李运,2011,藏药柳茶提取物对四氧嘧啶糖尿病小鼠降糖作用的研究,时珍国医国药,22(10):2460-2461)
Wei Y.F.,2012,Preliminary study of Liucha on diabetic mice induced by Alloxan and free fatty acids in rats with hyperlipidemia,Thesis for M.S.,Lanzhou University,Supervisor Yang Y.J.,pp.9-10(卫阳飞,2012,柳茶对四氧嘧啶糖尿病小鼠降糖作用和对高脂血症大鼠游离脂肪酸影响的实验研究,硕士学位论文,兰州大学,导师:杨永健,pp.9-10)
Wu L.R.,He H.,and Lin X.H.,2006,Application and prospect o artificial mutation technology in medicinal plant breeding Zhongcaoyao(Chinese Traditional and Herbal Drugs),(7)1107-1109(吴立蓉,贺红,林小桦,2006,人工诱变技术在药用植物育种中的应用与展望,中草药,(7):1107-1109)
Wu N.,1998,The community types and biomass of Sibiraea ang ustata scrub and their relationship with environmental fac tors in northwestern Sichuan,Zhiwu Xuebao(Acta Botani ca Sinica),40(9):860-870(吴宁,1998,川西北窄叶鲜卑花灌丛的类型和生物量及其与环境因子的关系,植物学报,40(9):860-870)
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Yan Z.H.,Chen L.S.,Zhu T.F.,Chen Z.,Yang Y.J.,Wang D.C.2014,Determination of the chemical constituents in aqueo us alcohol extract of Sibiraea angustata(Rehd.)leaf Hand.Mazz.,Yingyong Huaxue(Chinese Journal of Applied Che mistry),31(2):237-241(闫志慧,陈立书,朱仝飞,姜珂,陈竹,杨永建,王大成,2014,藏药柳茶叶乙醇水提取物中化学成分的鉴定,应用化学,31(2):237-241)
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Yang M.X.,Tian Y.X.,Liu J.D.,Zhang S.Y.,Ji X.,Gao H.Q.Gao G.J.,Wang B.Y.,and Wang S.X.,2003,Effect of Zhi tiaokang capsule on SOD activity and MDA content in ser um of patients with hyperlipidemia,Hebei Zhongyi(Hebe Journal of Traditional Chinese Medicine),25(12):889-891(杨牧祥,田元祥,刘建东,张素英,冀绪,高焕强,高功军王秉岳,王少贤,2003,脂调康胶囊对高脂血症患者血清超氧化物歧化酶、丙二醛的影响,河北中医,25(12):889891)
Yao L.,Jiao H.S.,and Li X.Q.,2010a,Effect of Sibiraea augusta ta on blood lipid,superoxide dismutase and malondialde hyde in experimental hyperlipidemia rats,Lanzhou Daxu Xuebao(Journal of Lanzhou University(Medical Sciences))36(2):68-70(姚莉,焦海胜,李晓强,2010a,柳茶对高脂血症大鼠血脂、超氧化物歧化酶及丙二醛的影响,兰州大学学报(医学版),36(2):68-70)
Yao L.,Luo Q.,Li H.W.,and Ju Y.,2010b,Proteetive actions o Liu Tea on D-galactosamine induced acute liver injury in rats and its mechanism of action,Zhongguo Yiyuan Yaox ue Zazhi(Chinese Journal of Hospital Pharmacy),30(6)483-484(姚莉,骆勤,李红卫,鞠洋,2010b,柳茶对D-半乳糖胺肝损伤的保护作用及机制,中国医院药学杂志30(6):483-484)
Yao L.,and Ju Y.,2009,Effects of Sibiraea augustata on digestiv system,Zhongguo Zhongxiyi Jiehe Xiaohua Zazhi(Chines Journal of Integrated Traditional and Western Medicine on Digestion),17(6):376-378(姚莉,鞠洋,2009,窄叶鲜卑花促消化作用的实验研究,中国中西医结合消化杂志,17(6):376-378)
Zhao K.H.,Wang J.,Lv X.M.,Liu Y.,Wei Z.C.,Tang C.,Nie J.Zhang Y.,and De L.,2018,Pharmacological study of Ti betan medicine emblica in the prevention and treatment o high altitude polycythemia,Zhonghua Zhongyiyao Zazh(China Journal of Traditional Chinese Medicine and Phar macy),33(3):934-939(赵可惠,王静,吕秀梅,刘悦,魏志成,唐策,聂佳,张艺,德洛,2018,藏药余甘子防治高原红细胞增多症的网络药理学研究,中华中医药杂志,33(3):934-939)
Chen L.,Tao T.T.,and Wang T.Z.,2006,Determination of ferulic acid and isoferulic acid in Sibiraea angustata by RP-H-PLC,Huaxi Yaoxue Zazhi(West China Journal of Pharmaceutical Sciences),21(2):196-197(陈璐,陶婷婷,王天志,2006,RP-HPLC测定藏药柳茶中阿魏酸和异阿魏酸的含量,华西药学杂志,21(2):196-197)
Chen Y.,Shi X.Y.,Li H.L.,and Luo G.H.,2017,The analysis of chemical composition of volatile oil from leaves of Sibiraea angustata by GS-MS,Shipin Gongye Keji(Science and Technology of Food Industry),38(12):31-33(陈叶,石秀云,李海亮,罗光宏,2017,窄叶鲜卑花叶挥发油成分分析,食品工业科技,38(12):31-33)
Cheng Y.,Ha S.Q.M.G.,Qin X.Z.,Tang X.Y.,Chen J.N.,Wang H.Y.,and Gao A.,2016,Effects of traditional Tibetan drug Liu Tea on proliferation and chemotherapeutic sensitivity of drug-resistant human gastric cancer cell BGC823/5-FU,Zhongguo Zhongyao Zazhi(China Journal of Chinese Materia Medica),41(4):603-608(程燕,哈斯其美格,覃小珍,唐祥友,陈健楠,王慧莹,高傲,2016,藏药柳茶水提物对胃癌耐药细胞bgc823/5-fu增殖及药物敏感性的影响,中国中药杂志,41(4):603-608)
Dong Y.,Zhang Y.M.,Zhou L.,and Wang P.X.,2009,Application of transgenic technology in medicinal plants,Zhongcaoyao(Chinese Traditional and Herbal Drugs),40(3):489-492(董燕,张雅明,周联,王培训,2009,转基因技术在药用植物中的应用,中草药,40(3):489-492)
Duan B.W.,Li Y.,Liu X.,and Yang Y.J.,2010,Effect of polysaccharides in processed Sibiraea on immunologic function of immunosuppression mice,Zhongguo Zhongyao Zazhi(China Journal of Chinese Materia Medica),35(11):1466-1469(段博文,李运,刘昕,杨永建,2010,柳茶多糖对小鼠免疫功能的影响,中国中药杂志,35(11):1466-1469)
Lei S.Y.,Yan Z.H.,Zhu T.F.,and Yang Y.J.,2010,Determination of trace elements in Sibirae by atomic absorption spectrometry,Xiandai Yiyao Weisheng(Journal of Modern Medicine&Health),26(4):497-498(雷世庸,闫志慧,朱仝飞,杨永建,2010,火焰原子吸收光谱法测定甘肃省鲜卑花属植物叶中的微量元素,现代医药卫生,26(4):497-498)
Li B.,Lee J.B.,Hayashi K.,Ito Y.,Sun W.J.,Wang X.,Kano Y.,and Hayashi T.,2010,Two new monoterpenes from Sibiraea angustata,J.Nat.Med.,64:89-92
Liu J.F.,Cheng Y.Q.,and Chen Z.W.,2009,Protoplast isolation and plant regeneration from leaves of Rhodiola sachalinensis,Zhongcaoyao(Chinese Traditional and Herbal Drugs),40(7):1127-1131(刘剑锋,程云清,陈智文,2009,高山红景天叶肉原生质体分离培养与植株再生,中草药,40(7):1127-1131)
Liu J.X.,Wu S.J.,Wei X.Y.,and Yang R.Z.,1999,Studies on the chemical constituents of Sibiraea angustata,Redai Yaredai Zhiwu Xuebao(Journal of Tropical and Subtropical Botany),(3):248-251(刘建祥,吴淑君,魏孝义,杨仁洲,1999,窄叶鲜卑花的化学成分研究,热带亚热带植物学报,(3):248-251)
Shi L.,Zhang D.M.,Qi J.,Li J.Y.,and Yang Y.J.,2009,Isolation and purification of and polysaccharide from Liucha and analysis of its chemical composition by gas chromatography-mass spectrometry,Shizhen Guoyi Guoyao(Lishizhen Medicine and Materia Medica Research),20(9):2191-2192(石磊,张冬梅,齐洁,李建银,杨永建,2009,柳茶多糖的分离纯化及气相色谱-质谱分析,时珍国医国药,20(9):2191-2192)
Sun W.W.,Xie B.F.,Liu H.,and Liu X.,2012,The role of hypercholesterolemia in the outbreak of Alzheimer's disease and the treatment effect of Sibraea angustata extract,Zhongyaocai(Journal of Chinese Medicinal Materials),35(4):596-602(孙雯雯,颉宾芳,刘卉,刘昕,2012,高胆固醇血症在阿尔兹海默病发生中的作用及藏药柳茶提取物的治疗效应,中药材,35(4):596-602)
Tao T.T.,Sei Y.,Wang T.Z.,Bai C.,and Chang Y.B.,2006,Chemical constituents of Sibiraea angustata,Zhongguo Tianran Yaowu(Chinese Journal of Natural Medicines),4(4):257-259(陶婷婷,濑井康雄,王天志,柏川,常艳波,2006,窄叶鲜卑花的化学成分,中国天然药物,4(4):257-259)
Wang H.G.,Wu Y.,and Yue H.P.,2016,The effect of extracts Sibraea angustata on the expression of Mrp2 and Mrp6 of INH-induced hepatotoxicity in mice,Shizhen Guoyi Guoyao(Lishizhen Medicine and Materia Medica Research),27(11):2594-2595(王汉国,武燕,岳汉萍,2016,藏药柳茶提取物对异烟肼引起的肝损伤小鼠膜转运体Mrp2和Mrp6表达影响,时珍国医国药,27(11):2594-2595
Wang X.L.,and Yang B.X.,1995,Protective effect and mechanism of Sibiraea angustata on CCl4 liver injury,Zhongguo Zhongyao Zazhi(China Journal of Chinese Materia Medica),20(12):746-748(汪晓立,杨兵勋,1995,柳茶对CCl4肝损伤的保护作用及机理初探,中国中药杂志,20(12):746-748)
Wang Z.H.,Zhu D.L.,and Yu C.,2010,Application in germplasm improvement of medical plants via biotechnology,Keji Tongbao(Bulletin of Science and Technology),26(1):88-92,119(王忠华,朱东亮,俞超,2010,现代育种技术在药用植物品种改良中的应用,科技通报,26(1):88-92,119)
Wang Z.W.,Li B.,Yu S.S.,Lai X.W.,Liu B.,and Hayashi T.,2013,Eight new monoterpene acylglucosides from Sibiraea angustata,Phytochem.Lett.,6(3):461-466
Wei Y.F.,Yang Y.J.,Li J.Y.,Duan W.B.,and Li Y.,2011,Preliminary study of Liucha on diabetic mice induced by Alloxan,Shizhen Guoyi Guoyao(Lishizhen Medicine and M-ateria Medica Research),22(10):2460-2461(卫阳飞,杨永建,李建银,段博文,李运,2011,藏药柳茶提取物对四氧嘧啶糖尿病小鼠降糖作用的研究,时珍国医国药,22(10):2460-2461)
Wei Y.F.,2012,Preliminary study of Liucha on diabetic mice induced by Alloxan and free fatty acids in rats with hyperlipidemia,Thesis for M.S.,Lanzhou University,Supervisor Yang Y.J.,pp.9-10(卫阳飞,2012,柳茶对四氧嘧啶糖尿病小鼠降糖作用和对高脂血症大鼠游离脂肪酸影响的实验研究,硕士学位论文,兰州大学,导师:杨永健,pp.9-10)
Wu L.R.,He H.,and Lin X.H.,2006,Application and prospect o artificial mutation technology in medicinal plant breeding Zhongcaoyao(Chinese Traditional and Herbal Drugs),(7)1107-1109(吴立蓉,贺红,林小桦,2006,人工诱变技术在药用植物育种中的应用与展望,中草药,(7):1107-1109)
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