头孢哌酮-他唑巴坦与其他临床常用药物配伍禁忌文献分析
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摘要
目的探讨头孢哌酮-他唑巴坦与其他临床常用药物联合用药的配伍禁忌,为安全用药提供参考。方法以"头孢哌酮钠他唑巴坦钠"、"配伍禁忌"或"配伍稳定性"为检索词,检索2005年1月1日至2018年3月31日中国知网、万方、维普等数据库收载的头孢哌酮-他唑巴坦与其他临床常用药物配伍禁忌相关的文献,并进行分析。结果共筛选出有效文献85篇,涉及药物包括抗菌药类、镇痛镇静类、糖皮质激素类、中药类及其他类,共39种药物与头孢哌酮-他唑巴坦存在配伍禁忌。头孢哌酮-他唑巴坦的溶媒大多采用氯化钠注射液(80/96), pH值为4.5～7.0;部分采用5%葡萄糖注射液(7/96), pH值为3.2～6.5;与其有配伍禁忌的药物采用的溶媒大部分为氯化钠注射液(39/96),其次是5%葡萄糖注射液(11/96)。配伍方式以序贯输入为主,发生位置主要在输液管及莫非滴管中,发生时间各文献表述不一,发生现象主要有浑浊、絮状物等。结论头孢哌酮-他唑巴坦与多种临床常用药物存在配伍禁忌,主要与pH值改变、溶媒选择不适宜有关,与配伍方式、发生位置无关。
AIM To explore the incompatibility of cefoperazone-tazobactam combined with other commonly used drugs,and provide reference for safe and rational drug use.METHODS "Cefoperazone sodium tazobactam sodium","incompatibility" or "compatibility" were selected as the keywords.The case reports of cefoperazone-tazobactam was incompatible with other commonly used drugs were collected and analyzed statistically from CNKI,Wanfang and VIP database from January 1,2005 to March 31,2018.RESULTS A total of 85 effective literatures were selected,involving antibacterial,analgesic sedative,glucocorticoids,traditional Chinese medicine and other types.A total of 39 drugs were contraindicated with cefoperazone-tazobactam.Most of the solvents for cefoperazone-tazobactam were sodium chloride injection(80/96),which pH value was 4.5-7.0.And some used 5% glucose injection(7/96),which pH value was 3.2-6.5.Most of the solvents used in combination with the contraindications were sodium chloride injection(39/96),followed by 5%glucose injection(11/96).The compatibility mode was mainly sequential input,and the occurrence position was mainly in the infusion tube and the Mohs dropper.The occurrence time was different in each literature,and the occurrence phenomenon mainly included turbidity,floc,etc.CONCLUSION The cefoperazone-tazobactam is incompatibility with various commonly used drugs,which is mainly related to the change of pH value,the inappropriate choice of solvent and has nothing to do with the compatibility mode and the location of occurrence.
AIM To explore the incompatibility of cefoperazone-tazobactam combined with other commonly used drugs,and provide reference for safe and rational drug use.METHODS "Cefoperazone sodium tazobactam sodium","incompatibility" or "compatibility" were selected as the keywords.The case reports of cefoperazone-tazobactam was incompatible with other commonly used drugs were collected and analyzed statistically from CNKI,Wanfang and VIP database from January 1,2005 to March 31,2018.RESULTS A total of 85 effective literatures were selected,involving antibacterial,analgesic sedative,glucocorticoids,traditional Chinese medicine and other types.A total of 39 drugs were contraindicated with cefoperazone-tazobactam.Most of the solvents for cefoperazone-tazobactam were sodium chloride injection(80/96),which pH value was 4.5-7.0.And some used 5% glucose injection(7/96),which pH value was 3.2-6.5.Most of the solvents used in combination with the contraindications were sodium chloride injection(39/96),followed by 5%glucose injection(11/96).The compatibility mode was mainly sequential input,and the occurrence position was mainly in the infusion tube and the Mohs dropper.The occurrence time was different in each literature,and the occurrence phenomenon mainly included turbidity,floc,etc.CONCLUSION The cefoperazone-tazobactam is incompatibility with various commonly used drugs,which is mainly related to the change of pH value,the inappropriate choice of solvent and has nothing to do with the compatibility mode and the location of occurrence.
引文
[1]金晶.头孢哌酮钠他唑巴坦钠不良反应集中监测[D].太原:山西医科大学, 2016:1.
[2]付滢舟,杨立平,谌赟,等.我院铜绿假单胞菌耐药性与抗菌药物使用强度相关性分析[J].中国药房, 2017, 28(5):607-610.
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[4]任立新,梅少奇.舒利迭联合复方甲氧那明对COPD患者稳定期临床疗效观察[J].临床肺科杂志, 2012, 17(4):622-623.
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[6]梁河,钟丽球,韦凤华.醋酸卡泊芬净与多种药物配伍禁忌的研究进展[J].临床合理用药杂志, 2016, 9(30):180-181.
[7]马色各.头孢哌酮钠他唑巴坦钠与甲磺酸加贝酯的配伍禁忌分析[J].临床合理用药杂志, 2015, 8(28):98.
[8]唐晓萍.注射用头孢哌酮钠他唑巴坦钠与30种注射液配伍稳定性分析[J].临床合理用药杂志, 2017, 10(6):82-84.
[9]万正兰,梁嘉碧,田琳.头孢哌酮钠他唑巴坦钠与甲磺酸帕珠沙星存在配伍禁忌[J].中国实用医药, 2009, 4(3):166.
[10]江腊梅,田月洁.盐酸氨溴索注射剂配伍禁忌的文献研究[J].中国药物警戒, 2011, 8(11):672-674.
[11]费元巧.静脉配置药物稳定性的影响因素[J].内蒙古中医药,2012, 31(7):87-88.
[12]刘兵,杜智丽,邢沈超,等.注射用头孢哌酮钠他唑巴坦钠的溶解方法及注意事项[J].中国药房, 2007, 18(22):1726.
[13]朱莉,王真,王雪飞.注射用头孢哌酮钠、他唑巴坦钠与葡萄糖酸依诺沙星存在配伍禁忌[J].中国伤残医学, 2008, 16(4):32.
[14]柯丹纯,文安笑,甘艳军.不同冲洗输液管方法对残留药物的影响[J].华北理工大学学报:医学版, 2010, 12(4):500-501.
[15]王茜,赖碧艳.呋塞米注射液配伍禁忌的文献分析[J].中国药业, 2015, 24(21):253-255.
[16]谢治丽.脂肪乳注射液与头孢哌酮他唑巴坦钠存在配伍禁忌[J].实用医药杂志, 2014, 31(3):278.
[17] SWEETMAN SC.马丁代尔药物大典(35版)[M].李大魁,金有豫,汤光,译.北京:化学工业出版社, 2008:179.
[2]付滢舟,杨立平,谌赟,等.我院铜绿假单胞菌耐药性与抗菌药物使用强度相关性分析[J].中国药房, 2017, 28(5):607-610.
[3]郑松柏,刘菲.重视老年人用药的安全性研究[J].中国新药与临床杂志, 2015, 34(9):649-652.
[4]任立新,梅少奇.舒利迭联合复方甲氧那明对COPD患者稳定期临床疗效观察[J].临床肺科杂志, 2012, 17(4):622-623.
[5]司继刚.药物配伍禁忌致2例热原样反应[J].中国医院药学杂志, 2014, 34(20):1785-1786.
[6]梁河,钟丽球,韦凤华.醋酸卡泊芬净与多种药物配伍禁忌的研究进展[J].临床合理用药杂志, 2016, 9(30):180-181.
[7]马色各.头孢哌酮钠他唑巴坦钠与甲磺酸加贝酯的配伍禁忌分析[J].临床合理用药杂志, 2015, 8(28):98.
[8]唐晓萍.注射用头孢哌酮钠他唑巴坦钠与30种注射液配伍稳定性分析[J].临床合理用药杂志, 2017, 10(6):82-84.
[9]万正兰,梁嘉碧,田琳.头孢哌酮钠他唑巴坦钠与甲磺酸帕珠沙星存在配伍禁忌[J].中国实用医药, 2009, 4(3):166.
[10]江腊梅,田月洁.盐酸氨溴索注射剂配伍禁忌的文献研究[J].中国药物警戒, 2011, 8(11):672-674.
[11]费元巧.静脉配置药物稳定性的影响因素[J].内蒙古中医药,2012, 31(7):87-88.
[12]刘兵,杜智丽,邢沈超,等.注射用头孢哌酮钠他唑巴坦钠的溶解方法及注意事项[J].中国药房, 2007, 18(22):1726.
[13]朱莉,王真,王雪飞.注射用头孢哌酮钠、他唑巴坦钠与葡萄糖酸依诺沙星存在配伍禁忌[J].中国伤残医学, 2008, 16(4):32.
[14]柯丹纯,文安笑,甘艳军.不同冲洗输液管方法对残留药物的影响[J].华北理工大学学报:医学版, 2010, 12(4):500-501.
[15]王茜,赖碧艳.呋塞米注射液配伍禁忌的文献分析[J].中国药业, 2015, 24(21):253-255.
[16]谢治丽.脂肪乳注射液与头孢哌酮他唑巴坦钠存在配伍禁忌[J].实用医药杂志, 2014, 31(3):278.
[17] SWEETMAN SC.马丁代尔药物大典(35版)[M].李大魁,金有豫,汤光,译.北京:化学工业出版社, 2008:179.