摘要
目的比较药物涂层球囊与普通球囊治疗下肢动脉硬化闭塞症的临床效果。方法回顾性分析2015年9月—2017年12月蚌埠医学院第一附属医院收治的下肢动脉硬化闭塞症患者的临床资料,并分析其病因、临床症状、体征、治疗方式、临床疗效及安全性。共纳入297例患者(315条患肢,334处病变),其中接受药物涂层球囊治疗的54例患者(57条患肢,62处病变)作为药物涂层球囊组(DCB组),接受普通球囊治疗的243例患者(258条患肢,272处病变)作为普通球囊组(SAB组),两组均随访6~33个月。结果药物涂层球囊组的再狭窄发生率、晚期管腔丢失及靶病变血运重建率低于普通球囊组,差异有统计学意义(P<0.05);药物涂层球囊组的卢瑟福分级的改善及踝肱指数的改善优于普通球囊组,差异有统计学意义(P<0.05);两组的手术并发症、血栓形成率及截肢率比较,差异无统计学意义(P>0.05)。结论药物涂层球囊相较于普通球囊在下肢动脉硬化的治疗中具有更优的临床疗效,且不会增加患者的安全性风险。
Objective Comparison of the clinical effects of drug-coated balloons and standard angioplasty balloon in the treatment of lower extremity arteriosclerosis obliterans. Methods Retrospectively analyzed the clinical data of patients with arteriosclerosis obliterans of lower extremities admitted to the first affiliated hospital of Bengbu Medical College from September 2015 to December 2017. Its etiology,clinical symptoms,signs,treatment methods,clinical efficacy and safety were analyzed.A total of 297 patients( 315 limbs,334 lesions) were enrolled,54 patients( 57 limbs,62 lesions) received drug-coated balloon therapy were in drugcoated balloon group( DCB),and 243 patients( 258 limbs,272 lesions) received standard angioplasty balloon were in standard angioplasty balloon group( SAB),followed up for 6 to 33 months. Results The incidence of restenosis,late lumen loss and target lesion revascularization rate in the drug-coated balloon group were lower than those in the standard angioplasty balloon group,the difference was statistically significant( P < 0. 05). The improvement of Rutherford class and the improvement of Ankle Brachial Pressure Index in the drug-coated balloon group were better than those in the standard angioplasty balloon group,and the difference was statistically significant( P < 0. 05). There were no significant differences in surgical complications,thrombosis rate,and amputation rate between the two groups.Conclusions Drug-coated balloons have superior clinical efficacy in the treatment of lower extremity arteriosclerosis compared to ordinary balloons,and do not increase the safety risk of patients.
引文
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