中药复方治疗糖尿病合并脑梗死机制的研究进展
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摘要
糖尿病合并脑梗死是糖尿病最常见、最严重的血管并发症,致残、致死率高,严重威胁着人类健康,因发病机制尚不明确,越来越多国内外学者把目光关注到糖尿病脑梗死的基础和临床研究上。中医药治疗临床疗效显著,多靶点起效,副作用小,药物依赖性低,患者认可度高,社会需求量大,临床应用广泛。目前关于中药治疗糖尿病合并脑梗死的相关研究越来越多,但主要集中在疗效观察和单一作用机制等方面,缺乏对中药复方作用机制的深入研究和归纳总结。本文通过系统地查阅和整理国内外相关文献资料,对近5年来经临床观察与动物实验证实对糖尿病脑梗死确有疗效的中药复方的作用机制的研究进展进行分析,研究发现其作用机制主要涉及降压、降糖、降脂、促进血管再生、改善血管内皮功能、抗凝血、抗血栓、改善神经功能缺损、缩小梗死体积、改善血液流变性、抑制炎症反应、抑制血小板聚集、促进侧枝循环建立等方面,深入总结起效的作用机制及靶点,以期为进一步的临床治疗提供参考。
Diabetes mellitus complicated with cerebral infarction is the commonest and most serious vascular complication of diabetes mellitus. With a high disability and mortality rate,it seriously threatens human health. Because the pathogenesis is still unclear,more and more scholars have focused on the research of diabetic cerebral infarction at home and abroad. Traditional Chinese medicine( TCM) compounds have a remarkable curative effect in the treatment of diabetic cerebral infarction. Its mechanisms of action mainly include antihypertension,reduction of blood sugar and lipid,promotion of vascular regeneration and vascular endothelial function,anticoagulation,anti-thrombosis,improvement of nerve function defect,reduction of infarct volume,improvement of hemorheological,inhibition of inflammation and platelet aggregation,and promotion of collateral circulation. Through literature search,this paper summarizes the research progress of the mechanisms of TCM compounds in treating diabetic cerebral infarction in recent five years at home and abroad,in order to provide reference for clinical treatment.
Diabetes mellitus complicated with cerebral infarction is the commonest and most serious vascular complication of diabetes mellitus. With a high disability and mortality rate,it seriously threatens human health. Because the pathogenesis is still unclear,more and more scholars have focused on the research of diabetic cerebral infarction at home and abroad. Traditional Chinese medicine( TCM) compounds have a remarkable curative effect in the treatment of diabetic cerebral infarction. Its mechanisms of action mainly include antihypertension,reduction of blood sugar and lipid,promotion of vascular regeneration and vascular endothelial function,anticoagulation,anti-thrombosis,improvement of nerve function defect,reduction of infarct volume,improvement of hemorheological,inhibition of inflammation and platelet aggregation,and promotion of collateral circulation. Through literature search,this paper summarizes the research progress of the mechanisms of TCM compounds in treating diabetic cerebral infarction in recent five years at home and abroad,in order to provide reference for clinical treatment.
引文
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