机械灌注技术引领器官捐献与移植模式的变革——器官ICU时代即将到来?
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摘要
机械灌注(MP)技术是器官移植领域的全球研究热点之一,近年的探索成果显示出其在器官保存、器官活力评估、修复受损器官中的优异性,将引领器官捐献与移植模式的变革。本文就近期MP技术在提升器官保存效果、评估器官活力、修复器官以及进行干预性治疗等方面的研究进展进行综述,并讨论未来临床应用的潜在模式。
引文
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[11]MICHEL SG,LA MURAGLIA GM 2ND,MADARIAGA ML,et al.Twelve-hour hypothermic machine perfusion for donor heart preservation leads to improved ultrastructural characteristics compared to conventional cold storage[J].Ann Transplant,2015,20:461-468.DOI:10.12659/AOT.893784.
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[13]KOX J,MOERS C,MONBALIU D,et al.The benefits of hypothermic machine preservation and short cold ischemia times in deceased donor kidneys[J].Transplantation,2018,102(8):1344-1350.DOI:10.1097/TP.0000000000002188.
[14]VAN RIJN R,VAN LEEUWEN OB,MATTON APM,et al.Hypothermic oxygenated machine perfusion reduces bile duct reperfusion injury after transplantation of donation after circulatory death livers[J].Liver Transpl,2018,24(5):655-664.DOI:10.1002/lt.25023.
[15]DONDOSSOLA D,LONATI C,ZANELLA A,et al.Preliminary experience with hypothermic oxygenated machine perfusion in an Italian liver transplant center[J].Transplant Proc,2019,51(1):111-116.DOI:10.1016/j.transproceed.2018.04.070.
[16]LEEMKUIL M,LIER G,ENGELSE MA,et al.Hypothermic oxygenated machine perfusion of the human donor pancreas[J].Transplant Direct,2018,4(10):e388.DOI:10.1097/TXD.0000000000000829.
[17]BUTLER AJ,REES MA,WIGHT DG,et al.Successful extracorporeal porcine liver perfusion for 72 hr[J].Transplantation,2002,73(8):1212-1218.
[18]VOGEL T,BROCKMANN JG,QUAGLIA A,et al.The 24-hour normothermic machine perfusion of discarded human liver grafts[J].Liver Transpl,2017,23(2):207-220.DOI:10.1002/lt.24672.
[19]VAN LEEUWEN OB,UBBINK R,DE MEIJER VE,et al.The first case of ischemia-free organ transplantation in humans:a proof of concept[J].Am J Transplant,2018,18(8):2091.DOI:10.1111/ajt.14869.
[20]ZHAO Q,HUANG S,WANG D,et al.Does ischemia free liver procurement under normothermic perfusion benefit the outcome of liver transplantation?[J].Ann Transplant,2018,23:258-267.
[21]BLUM MF,LIU Q,SOLIMAN B,et al.Comparison of normothermic and hypothermic perfusion in porcine kidneys donated after cardiac death[J].J Surg Res,2017,216:35-45.DOI:10.1016/j.jss.2017.04.008.
[22]HOSGOOD SA,BARLOW AD,HUNTER JP,et al.Ex vivo normothermic perfusion for quality assessment of marginal donor kidney transplants[J].Br J Surg,2015,102(11):1433-1440.DOI:10.1002/bjs.9894.
[23]HOSGOOD SA,SAEB-PARSY K,HAMED MO,et al.Successful transplantation of human kidneys deemed untransplantable but resuscitated by ex vivo normothermic machine perfusion[J].Am JTransplant,2016,16(11):3282-3285.DOI:10.1111/ajt.13906.
[24]HOSGOOD SA,NICHOLSON ML.An assessment of urinary biomarkers in a series of declined human kidneys measured during ex vivo normothermic kidney perfusion[J].Transplantation,2017,101(9):2120-2125.DOI:10.1097/TP.0000000000001504.
[25]WATSON CJE,KOSMOLIAPTSIS V,PLEY C,et al.Observations on the ex situ perfusion of livers for transplantation[J].Am J Transplant,2018,18(8):2005-2020.DOI:10.1111/ajt.14687.
[26]SUTTON ME,OP DEN DRIES S,KARIMIAN N,et al.Criteria for viability assessment of discarded human donor livers during ex vivo normothermic machine perfusion[J].PLoS One,2014,9(11):e110642.DOI:10.1371/journal.pone.0110642.
[27]NASRALLA D,COUSSIOS CC,MERGENTAL H,et al.A randomized trial of normothermic preservation in liver transplantation[J].Nature,2018,557(7703):50-56.DOI:10.1038/s41586-018-0047-9.
[28]SLAMA A,SCHILLAB L,BARTA M,et al.Standard donor lung procurement with normothermic ex vivo lung perfusion:a prospective randomized clinical trial[J].J Heart Lung Transplant,2017,36(7):744-753.DOI:10.1016/j.healun.2017.02.011.
[29]BARLOW AD,HAMED MO,MALLON DH,et al.Use of ex vivo normothermic perfusion for quality assessment of discarded human donor pancreases[J].Am J Transplant,2015,15(9):2475-2482.DOI:10.1111/ajt.13303.
[30]CERESA CDL,NASRALLA D,COUSSIOS CC,et al.The case for normothermic machine perfusion in liver transplantation[J].Liver Transpl,2018,24(2):269-275.DOI:10.1002/lt.25000.
[31]DIRITO JR,HOSGOOD SA,TIETJEN GT,et al.The future of marginal kidney repair in the context of normothermic machine perfusion[J].Am JTransplant,2018,18(10):2400-2408.DOI:10.1111/ajt.14963.
[32]VAN RAEMDONCK D,REGA F,REX S,et al.Machine perfusion of thoracic organs[J].J Thorac Dis,2018,10(Suppl 8):S910-S923.DOI:10.21037/jtd.2018.02.85.
[33]KARIMIAN N,YEH H.Opportunities for therapeutic intervention during machine perfusion[J].Curr Transplant Rep,2017,4(2):141-148.DOI:10.1007/s40472-017-0144-y.
[34]ATHANASOPOULOS PG,HADJITTOFI C,DHARMAPALA AD,et al.Successful outflow reconstruction to salvage traumatic hepatic veincaval avulsion of a normothermic machine ex-situ perfused liver graft:case report and management of organ pool challenges[J].Medicine(Baltimore),2016,95(15):e3119.DOI:10.1097/MD.0000000000003119.
[35]GOLDARACENA N,SPETZLER VN,ECHEVERRI J,et al.Inducing hepatitis C virus resistance after pig liver transplantation-a proof of concept of liver graft modification using warm ex vivo perfusion[J].Am J Transplant,2017,17(4):970-978.DOI:10.1111/ajt.14100.
[36]GHINOLFI D,CAPONI L,MARSELLI L,et al.Anti-inflammatory signaling during ex vivo liver perfusion improves the preservation of pig liver grafts before transplantation[J].Liver Transpl,2017,23(5):707-708.DOI:10.1002/lt.24683.
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