药食用真菌灰树花防治肿瘤相关应用的研究进展
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摘要
随着肿瘤发病率的不断上升,寻找针对肿瘤的安全而有效的预防和治疗方法成为肿瘤研究中的迫切关注点,灰树花作为大型的药食用真菌,在近年来的国内外研究中以其显著的抗肿瘤活性引发关注,并引发了全世界对其相关活性和功效机制的深入探索。为了开发一款在防治肿瘤中安全有效的药膳产品,对灰树花肿瘤相关的文献进行了研究,从文献研究中发现,灰树花在抗肿瘤方面具有显著的活性并在肿瘤治疗中有良好的辅助作用,在肿瘤防治有关产品开发方面有巨大的潜力。
With the increasing incidence of cancer,the researchers paid a lot of attention to look for a safe and effective way to prevent and treat cancer. Griflola frondosa is an edible medicinal fungus which attracted great attention of domestic and foreign researchers for the significant anti-tumor activity,and it has led to an in-depth exploration of its related activities and efficacies. This article was a literature study of prevent and treat tumor activity for develop safe and effective medicinal food products.It was found that Griflola frondosa has significant activity in anti-tumor and good instrumental role in tumor therapy,it has great potential in develop product for prevent and treat tumor.
With the increasing incidence of cancer,the researchers paid a lot of attention to look for a safe and effective way to prevent and treat cancer. Griflola frondosa is an edible medicinal fungus which attracted great attention of domestic and foreign researchers for the significant anti-tumor activity,and it has led to an in-depth exploration of its related activities and efficacies. This article was a literature study of prevent and treat tumor activity for develop safe and effective medicinal food products.It was found that Griflola frondosa has significant activity in anti-tumor and good instrumental role in tumor therapy,it has great potential in develop product for prevent and treat tumor.
引文
[1]张媛媛,孟梦,王明飞,等.灰树花多糖的分离纯化及体外抗肝癌作用研究[J].食品研究与开发,2016,37(15):1-5.
[2]乔彦茹.灰树花子实体多糖的分离纯化及免疫活性研究[D].重庆:西南大学,2011.
[3]孙一丹,赖虹宇,肖辉,等.舞茸菌液体发酵富硒培养研究[J].食品安全导刊,2016(11):70.
[4]隆毅.灰树花质量控制关键技术与质量评价体系研究[D].济南:山东中医药大学,2013.
[5]吴彩云.对羟基苯甲醛等天麻成分对灰树花多糖代谢的影响及其机理研究[D].贵阳:贵州大学,2016.
[6]甘长飞.灰树花及其药理作用研究进展[J].食药用菌,2014,22(5):264-267,281.
[7]谢文佳,黄小玲.灰树花多糖的生物活性与研究进展[J].食用菌,2010,32(5):1-3.
[8]李磊,王卫国,郭彦亮,等.灰树花多糖的制备及其生物活性研究进展[J].食品工业科技,2009,30(11):327-331.
[9]Nanba H.Antitumor activity oforal administered“D-Fraction”from maitake mushroom(Grifola frondosa)[J].JNat Med,1993(4):10-15.
[10]胡馨予,胡爽,张峻榕,等.灰树花提取物抗肝癌活性及初步机制研究[J].中国药学杂志,2015,50(24):2 107-2 111.
[11]Zhao F,Zhao J,Song L,et al.The induction of apoptosis and autophagy in human hepatoma SMMC-7721 cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa[J].Programmed Cell Death,2017(11):1 461-1 472.
[12]Lin C,Chang C,Wan L,et al.Cold-water extracts of Grifola frondosa and its purified active fraction inhibit hepatocellular carcinoma in vitro and in vivo[J].Experimental Biology and Medicine,2016(13):1 374-1 385.
[13]Kodama N,Komuta K,Nanba H.Can maitake MD-fractionaid cancerpatients[J].Altern Med,2002(3):236-239.
[14]Zhang Y,Sun D,Meng Q,et al.Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway[J].International Journal of Molecular Medicine,2017(4):1 089-1 095.
[15]李小定,吴谋成,曾晓波,等.灰树花多糖粗品与纯品的抗肿瘤作用和对免疫功能的影响[J].营养学报,2003(1):7-9.
[16]Vetvicka V,Vetvickova J.Immune-enhancing effects of Maitake(Grifola frondosa)and Shiitake(Lentinula edode)s extracts[J].Annals of Translational Medicine,2014(2):14.
[17]刘佳,包海鹰,白日忠,等.灰树花孔菌超微粉体内抗肿瘤作用研究[J].菌物学报,2018(2):226-236.
[18]Chen X D,Liu X W,Wu W T.Separation,purification and antitumor activities of low molecular weight polysaccharide from Grifola frondosa[J].Chinese J.Nat.Med.,2006(11):77-79.
[19]Ting Z,Yina F,Xiangyang W,et al.Purification,characterization and antioxidant activities of enzymolysis polysaccharide from Grifola frondosa[J].Iranian Journal of Pharmaceutical Research,2017(1):347-356.
[20]Konno S.Synergistic potentiation of D-fraction with with vitamin C as possible alternative approach for cancer therapy[J].Int J Gen Med,2009(2):91-108.
[21]颜燕,杨菲,姚文环,等.灰树花多糖免疫调节及抗辐射损伤作用研究[J].中国辐射卫生,2010(1):6-8.
[22]贺长生,房克敏.灰树花多糖对胃黏膜损伤的辅助保护作用试验[J].求医问药(下半月),2011(4):100-101.
[23]雷萍,韩晓伟,侯殿东,等.灰树花多糖对脾虚小鼠T细胞亚群和Th1/Th2亚群的影响[J].中国中医药信息杂志,2013,20(7):27-29.
[24]Bao H,Ran P,Du J,et al.Griflola frondosa(GF)produces significant antidepressant effects involving AMPA receptor activation in mice[J].Pharmaceutical Biology,2017,55(1):299-305.
[25]Chen Z,Tang Y,Liu A,et al.Oral administration of Grifola frondosa polysaccharides improves memory impairment in aged rats via antioxidant action[J].Molecular Nutrition&Food Research,2017,61(11):1 367-1 372.
[26]曹素芳,王新瑞,陈孝,等.灰树花复方制剂降血糖功能的研究[J].食用菌学报,2009,16(4):47-49.
[27]邓功成,赵洪,高礼安,等.灰树花风味酸奶的研制[J].江苏农业科学,2014,42(10):257-260.
[28]李佳,徐志祥.灰树花保健饮料的研究开发[J].食用菌,2014,36(1):68-70.
[2]乔彦茹.灰树花子实体多糖的分离纯化及免疫活性研究[D].重庆:西南大学,2011.
[3]孙一丹,赖虹宇,肖辉,等.舞茸菌液体发酵富硒培养研究[J].食品安全导刊,2016(11):70.
[4]隆毅.灰树花质量控制关键技术与质量评价体系研究[D].济南:山东中医药大学,2013.
[5]吴彩云.对羟基苯甲醛等天麻成分对灰树花多糖代谢的影响及其机理研究[D].贵阳:贵州大学,2016.
[6]甘长飞.灰树花及其药理作用研究进展[J].食药用菌,2014,22(5):264-267,281.
[7]谢文佳,黄小玲.灰树花多糖的生物活性与研究进展[J].食用菌,2010,32(5):1-3.
[8]李磊,王卫国,郭彦亮,等.灰树花多糖的制备及其生物活性研究进展[J].食品工业科技,2009,30(11):327-331.
[9]Nanba H.Antitumor activity oforal administered“D-Fraction”from maitake mushroom(Grifola frondosa)[J].JNat Med,1993(4):10-15.
[10]胡馨予,胡爽,张峻榕,等.灰树花提取物抗肝癌活性及初步机制研究[J].中国药学杂志,2015,50(24):2 107-2 111.
[11]Zhao F,Zhao J,Song L,et al.The induction of apoptosis and autophagy in human hepatoma SMMC-7721 cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa[J].Programmed Cell Death,2017(11):1 461-1 472.
[12]Lin C,Chang C,Wan L,et al.Cold-water extracts of Grifola frondosa and its purified active fraction inhibit hepatocellular carcinoma in vitro and in vivo[J].Experimental Biology and Medicine,2016(13):1 374-1 385.
[13]Kodama N,Komuta K,Nanba H.Can maitake MD-fractionaid cancerpatients[J].Altern Med,2002(3):236-239.
[14]Zhang Y,Sun D,Meng Q,et al.Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway[J].International Journal of Molecular Medicine,2017(4):1 089-1 095.
[15]李小定,吴谋成,曾晓波,等.灰树花多糖粗品与纯品的抗肿瘤作用和对免疫功能的影响[J].营养学报,2003(1):7-9.
[16]Vetvicka V,Vetvickova J.Immune-enhancing effects of Maitake(Grifola frondosa)and Shiitake(Lentinula edode)s extracts[J].Annals of Translational Medicine,2014(2):14.
[17]刘佳,包海鹰,白日忠,等.灰树花孔菌超微粉体内抗肿瘤作用研究[J].菌物学报,2018(2):226-236.
[18]Chen X D,Liu X W,Wu W T.Separation,purification and antitumor activities of low molecular weight polysaccharide from Grifola frondosa[J].Chinese J.Nat.Med.,2006(11):77-79.
[19]Ting Z,Yina F,Xiangyang W,et al.Purification,characterization and antioxidant activities of enzymolysis polysaccharide from Grifola frondosa[J].Iranian Journal of Pharmaceutical Research,2017(1):347-356.
[20]Konno S.Synergistic potentiation of D-fraction with with vitamin C as possible alternative approach for cancer therapy[J].Int J Gen Med,2009(2):91-108.
[21]颜燕,杨菲,姚文环,等.灰树花多糖免疫调节及抗辐射损伤作用研究[J].中国辐射卫生,2010(1):6-8.
[22]贺长生,房克敏.灰树花多糖对胃黏膜损伤的辅助保护作用试验[J].求医问药(下半月),2011(4):100-101.
[23]雷萍,韩晓伟,侯殿东,等.灰树花多糖对脾虚小鼠T细胞亚群和Th1/Th2亚群的影响[J].中国中医药信息杂志,2013,20(7):27-29.
[24]Bao H,Ran P,Du J,et al.Griflola frondosa(GF)produces significant antidepressant effects involving AMPA receptor activation in mice[J].Pharmaceutical Biology,2017,55(1):299-305.
[25]Chen Z,Tang Y,Liu A,et al.Oral administration of Grifola frondosa polysaccharides improves memory impairment in aged rats via antioxidant action[J].Molecular Nutrition&Food Research,2017,61(11):1 367-1 372.
[26]曹素芳,王新瑞,陈孝,等.灰树花复方制剂降血糖功能的研究[J].食用菌学报,2009,16(4):47-49.
[27]邓功成,赵洪,高礼安,等.灰树花风味酸奶的研制[J].江苏农业科学,2014,42(10):257-260.
[28]李佳,徐志祥.灰树花保健饮料的研究开发[J].食用菌,2014,36(1):68-70.