骨肽结合种植牙治疗粉碎性牙槽骨骨折疗效观察
|
摘要
目的观察骨肽注射液结合种植牙修复治疗粉碎性牙槽骨骨折的临床疗效。方法选取佛山市高明区人民医院口腔科2014年5月至2017年2月收治的80例粉碎性牙槽骨骨折患者,采用随机数表法分为对照组和观察组,每组40例,对照组单纯采用种植牙修复治疗,观察组则采用骨肽注射液结合种植牙修复治疗,比较两组修复后3、6、12个月的种植体骨吸收量及牙龈指数(GI指数)差异,并评价两组患者修复1年后牙齿松动情况及整体修复效果。结果观察组患者修复后3、6、12个月GI指数分别为(0.83±0.25)、(0.61±0.29)和(0.43±0.21),植体骨吸收量分别为(1.61±0.34) mm、(0.53±0.23) mm和(0.59±0.29) mm,对照组修复后3、6、12个月GI指数分别为(1.03±0.24)、(0.78±0.27)和(0.62±0.23),植体骨吸收量分别为(1.38±0.36) mm、(0.78±0.28) mm和(0.83±0.28) mm,观察组优于对照组,差异均有统计学意义(P<0.05);修复1年后,观察组和对照组患者的牙齿Ⅰ度(15.0%vs 20.0%)、Ⅱ度(2.5%vs17.5%)、Ⅲ度(0 vs 7.5%)松动度比较,观察组明显低于对照组,差异均有统计学意义(P<0.05);修复1年后,观察组患者的修复总合格率为95.0%,明显高于对照组的80.0%,差异有统计学意义(P<0.05)。结论种植牙修复联合骨肽注射液治疗粉碎性牙槽骨骨折可快速促进骨折愈合,恢复牙颌功能,其疗效确切,值得临床推广。
Objective To observe the curative effect of bone peptide injection combined with dental implant in the treatment of comminuted alveolar fracture. Methods A total of 80 patients with comminuted alveolar fracture treated in the Department of Stomatology at Gaoming District People's Hospital from May 2014 to February 2017 were selected and randomly divided into a control group and an observation group, with 40 cases in each group. The control group was treated with dental implants only, and the observation group was treated with bone peptide injection combined with dental implant. The differences of implant bone resorption and gingival index(GI index) at 3, 6 and 12 months after repair were compared between the two groups. The tooth loosening and the overall restoration effect after 1 year of repair in both groups were evaluated. Results Of the observation group, the GI index at 3, 6 and 12 months after repair were respectively 0.83±0.25, 0.61±0.29 and 0.43±0.21; and the bone absorptive capacity of the implant were respectively(1.61±0.34) mm,(0.53±0.23) mm and(0.53±0.25) mm. Of the control group, the GI index at the 3, 6 and 12 months after repair were respectively 1.03±0.24, 0.78±0.27 and 0.62±0.23; the bone resorption of the implant were respectively(1.38±0.36) mm,(0.78±0.28) mm and(0.83±0.28) mm. The observation group was better than the control group, and the difference was statistically significant(P<0.05). After 1 year of repair, the looseness degree of the teeth Ⅰdegree(15.0%vs 20.0%), Ⅱ degree(2.5% vs 17.5%) and Ⅲ degree(0 vs 7.5%) in the observation group was significantly lower than those in the control group, and the differences were statistically significant(P<0.05). After 1 year of repair, the total qualified rate of the observation group(95.0%) was significantly higher than that of the control group(80.0%), and the difference was statistically significant(P<0.05). Conclusion Dental implant prosthesis combined with bone peptide injection for the treatment of comminuted alveolar fracture can quickly promote fracture healing and restore dental function.It can promote fracture healing quickly and restore the function of tooth and jaw. Its curative effect is definite and worthy of clinical popularization.
Objective To observe the curative effect of bone peptide injection combined with dental implant in the treatment of comminuted alveolar fracture. Methods A total of 80 patients with comminuted alveolar fracture treated in the Department of Stomatology at Gaoming District People's Hospital from May 2014 to February 2017 were selected and randomly divided into a control group and an observation group, with 40 cases in each group. The control group was treated with dental implants only, and the observation group was treated with bone peptide injection combined with dental implant. The differences of implant bone resorption and gingival index(GI index) at 3, 6 and 12 months after repair were compared between the two groups. The tooth loosening and the overall restoration effect after 1 year of repair in both groups were evaluated. Results Of the observation group, the GI index at 3, 6 and 12 months after repair were respectively 0.83±0.25, 0.61±0.29 and 0.43±0.21; and the bone absorptive capacity of the implant were respectively(1.61±0.34) mm,(0.53±0.23) mm and(0.53±0.25) mm. Of the control group, the GI index at the 3, 6 and 12 months after repair were respectively 1.03±0.24, 0.78±0.27 and 0.62±0.23; the bone resorption of the implant were respectively(1.38±0.36) mm,(0.78±0.28) mm and(0.83±0.28) mm. The observation group was better than the control group, and the difference was statistically significant(P<0.05). After 1 year of repair, the looseness degree of the teeth Ⅰdegree(15.0%vs 20.0%), Ⅱ degree(2.5% vs 17.5%) and Ⅲ degree(0 vs 7.5%) in the observation group was significantly lower than those in the control group, and the differences were statistically significant(P<0.05). After 1 year of repair, the total qualified rate of the observation group(95.0%) was significantly higher than that of the control group(80.0%), and the difference was statistically significant(P<0.05). Conclusion Dental implant prosthesis combined with bone peptide injection for the treatment of comminuted alveolar fracture can quickly promote fracture healing and restore dental function.It can promote fracture healing quickly and restore the function of tooth and jaw. Its curative effect is definite and worthy of clinical popularization.
引文
[1]黄会杰,陈贵丰.口腔种植修复与常规修复治疗牙列缺失的效果比较[J].广东医学, 2016, 37(4):583-584.
[2]罗新宇,倪峰,柏全民,等. 10例牙齿重度磨损伴牙列缺损种植修复与咬合重建[J].牙体牙髓牙周病学杂志, 2015, 25(1):41-44.
[3]陈志方,张薇.牙-牙槽骨联合移植修复牙列缺损的临床应用研究[J].华西口腔医学杂志, 2016, 34(4):364-368.
[4]李勇伟,谢莉莉,罗仁惠.平台转移种植体和传统基台连接种植体边缘骨吸收比较[J].海南医学, 2017, 28(15):2546-2547.
[5]释栋,孟焕新,张立,等.因牙周炎缺失上前牙种植修复后短期软组织美学效果评价[J].北京大学学报(医学版), 2014, 46(6):950-953.
[6] PISANI L, BONACCORSO L, FASTUCA R, et al. Systematic review for orthodontic and orthopedic treatments for anterior open bite in the mixed dentition[J]. Prog Orthod, 2016, 17(1):28.
[7]郑巧仪,陈觉尧,陈俊兰.环状植骨结合牙种植技术的近期临床效果观察[J].中国口腔颌面外科杂志, 2016, 14(1):57-61.
[8]汪皖,吴海珍. RGD肽在种植体表面涂层的成骨作用[J].中国口腔种植学杂志, 2011, 16(3):183-187.
[9]杨玉鹏,赵海静,谷建琦,等.钛芯与骨形成蛋白复合材料修复即刻种植牙槽骨缺陷的评价[J].中国组织工程研究, 2017, 21(22):3536-3540.
[10] CHEN ZX, CHANG M, PENG YL, et al. Osteogenic growth peptide Cterminal pentapeptide[OGP(10-14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes[J]. Regul Pept, 2007, 142(1-2):16-23.
[11]庄艳琴,陈慧敏,吴齐越,等.β-磷酸三钙复合成骨细胞特异性多肽植入拔牙窝位点保存牙槽骨[J].中国组织工程研究, 2018, 22(10):1517-1522.
[12]高艳,王青山.神经肽类物质与牙周支持组织及口腔骨修复[J].中国组织工程研究, 2014, 18(11):1780-1786.
[13]钱建国,吴秋丽.骨肽注射液对新生大鼠的成骨细胞增殖和碱性磷酸酶活性的影响[J].中国生化药物杂志, 2012, 33(3):254-256.
[14]王兴,刘洪臣.自体骨移植修复种植位点骨缺损的研究进展[J].口腔颌面修复学杂志, 2016, 17(1):49-52.
[15]杨隆震,成美好,邢俊,等.骨肽结合种植牙在牙槽骨粉碎性骨折损伤治疗中的应用[J].中国现代药物应用, 2016, 10(7):78-79.
[2]罗新宇,倪峰,柏全民,等. 10例牙齿重度磨损伴牙列缺损种植修复与咬合重建[J].牙体牙髓牙周病学杂志, 2015, 25(1):41-44.
[3]陈志方,张薇.牙-牙槽骨联合移植修复牙列缺损的临床应用研究[J].华西口腔医学杂志, 2016, 34(4):364-368.
[4]李勇伟,谢莉莉,罗仁惠.平台转移种植体和传统基台连接种植体边缘骨吸收比较[J].海南医学, 2017, 28(15):2546-2547.
[5]释栋,孟焕新,张立,等.因牙周炎缺失上前牙种植修复后短期软组织美学效果评价[J].北京大学学报(医学版), 2014, 46(6):950-953.
[6] PISANI L, BONACCORSO L, FASTUCA R, et al. Systematic review for orthodontic and orthopedic treatments for anterior open bite in the mixed dentition[J]. Prog Orthod, 2016, 17(1):28.
[7]郑巧仪,陈觉尧,陈俊兰.环状植骨结合牙种植技术的近期临床效果观察[J].中国口腔颌面外科杂志, 2016, 14(1):57-61.
[8]汪皖,吴海珍. RGD肽在种植体表面涂层的成骨作用[J].中国口腔种植学杂志, 2011, 16(3):183-187.
[9]杨玉鹏,赵海静,谷建琦,等.钛芯与骨形成蛋白复合材料修复即刻种植牙槽骨缺陷的评价[J].中国组织工程研究, 2017, 21(22):3536-3540.
[10] CHEN ZX, CHANG M, PENG YL, et al. Osteogenic growth peptide Cterminal pentapeptide[OGP(10-14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes[J]. Regul Pept, 2007, 142(1-2):16-23.
[11]庄艳琴,陈慧敏,吴齐越,等.β-磷酸三钙复合成骨细胞特异性多肽植入拔牙窝位点保存牙槽骨[J].中国组织工程研究, 2018, 22(10):1517-1522.
[12]高艳,王青山.神经肽类物质与牙周支持组织及口腔骨修复[J].中国组织工程研究, 2014, 18(11):1780-1786.
[13]钱建国,吴秋丽.骨肽注射液对新生大鼠的成骨细胞增殖和碱性磷酸酶活性的影响[J].中国生化药物杂志, 2012, 33(3):254-256.
[14]王兴,刘洪臣.自体骨移植修复种植位点骨缺损的研究进展[J].口腔颌面修复学杂志, 2016, 17(1):49-52.
[15]杨隆震,成美好,邢俊,等.骨肽结合种植牙在牙槽骨粉碎性骨折损伤治疗中的应用[J].中国现代药物应用, 2016, 10(7):78-79.