基于近似熵及关联维度对浅针疗法干预失眠患者脑电数据的提取及分析
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摘要
目的:使用非线性动力学手段评估浅针疗法对失眠患者脑电信号的影响。方法:对6名原发性失眠患者进行山根穴浅针干预15min。获取浅针干预前和浅针干预时的脑电信号,将各脑区的脑电信号转换成关联维度(D 2)和近似熵(ApEn),利用SPSS 22.0统计软件对各个脑区的脑电信号特征进行聚类分析和因子分析。结果:浅针干预前较干预时Fp 2、O 1、F 8脑区的脑电信号ApEn存在显著性差异(P<0.05),而D 2则在Fp 2、F 7、F 8脑区存在显著性差异(P<0.05)。通过聚类分析及因子分析发现Fp 2、F 8、O 1、O 2脑区的ApEn下降趋势较为突出,而Fp 2、F 4、F 8脑区D 2的变化较为突出。结论:通过采用多元统计方式对脑电非线性数据的二次分析能有效提取浅针治疗失眠患者额颞枕区脑电信号,并初步发现其潜在的正向作用。
Objective To evaluate the influence of superficial needling on electroencephalogram(EEG)in patients with insomnia by using nonlinear kinetics measure.Methods Six patients(3 male and 3 female)suffering from insomnia for more than a month were recruited in the present study.EEG data before and during superficial acupuncture stimulation of Shangen point(the midpoint between the bilateral inner canthus)was recorded using an electroencephalograph for analyzing the correlation dimensionality(D 2)and approximate entropy(ApEn)of different cerebral regions.Results During superficial needling,the D 2 data of the right-forehead(Fp 2),anterior area of the left temple(F 7)and the anterior region of the right temple(F 8)were significantly increased(P<0.05),and ApEn data at the right anterior forehead(Fp 2),left occipital region(O 1),and F 8 region markedly decreased relevant to pre-acupuncture(P<0.05).Both paring test and trend analysis of D 2 data showed no significant changes.Only an obvious increase of D 2 was found in the Fp 2 region,suggesting a coherence of EEG activities in stability and synchronization during acupuncture treatment.Clustering analysis of D 2 data of various cerebral regions displayed a relatively concentrated tendency,particularly in the Fp 2,the right forehead(F 4)and F 8 regions.Factor analysis of ApEn data showed a significant change in Fp 2,F 8,O 1 and right occipital(O 2)regions.It suggests that during superficial needling stimulation of Shangen point,the EEG signals were lowered in complexity,and improved in synchronization,stabilization and ordering,favoring sleep at last.Conclusion Superficial needling of Shangen point can make the EEG signals synchronized in insomnia patients,suggesting an improvement of sleeping.
Objective To evaluate the influence of superficial needling on electroencephalogram(EEG)in patients with insomnia by using nonlinear kinetics measure.Methods Six patients(3 male and 3 female)suffering from insomnia for more than a month were recruited in the present study.EEG data before and during superficial acupuncture stimulation of Shangen point(the midpoint between the bilateral inner canthus)was recorded using an electroencephalograph for analyzing the correlation dimensionality(D 2)and approximate entropy(ApEn)of different cerebral regions.Results During superficial needling,the D 2 data of the right-forehead(Fp 2),anterior area of the left temple(F 7)and the anterior region of the right temple(F 8)were significantly increased(P<0.05),and ApEn data at the right anterior forehead(Fp 2),left occipital region(O 1),and F 8 region markedly decreased relevant to pre-acupuncture(P<0.05).Both paring test and trend analysis of D 2 data showed no significant changes.Only an obvious increase of D 2 was found in the Fp 2 region,suggesting a coherence of EEG activities in stability and synchronization during acupuncture treatment.Clustering analysis of D 2 data of various cerebral regions displayed a relatively concentrated tendency,particularly in the Fp 2,the right forehead(F 4)and F 8 regions.Factor analysis of ApEn data showed a significant change in Fp 2,F 8,O 1 and right occipital(O 2)regions.It suggests that during superficial needling stimulation of Shangen point,the EEG signals were lowered in complexity,and improved in synchronization,stabilization and ordering,favoring sleep at last.Conclusion Superficial needling of Shangen point can make the EEG signals synchronized in insomnia patients,suggesting an improvement of sleeping.
引文
[1]何芙蓉,郑美凤,王鹏,等.浅针山根穴治疗原发性失眠症的疗效观察[J].甘肃中医学院学报,2012,29(5):45-48.
[2]王志福,龚德贵,俞向梅,等.浅析吴炳煌针灸调节免疫功能的学术思想与临床经验[J].中国针灸,2016,36(8):861-863.
[3]郑美凤,何芙蓉,林煜芬,等.浅针山根穴治疗原发性失眠的疗效观察及其对血清褪黑素的影响[J].浙江中医药大学学报,2014,38(7):902-905.
[4]黄燕熙,郑樱.浅针疗法对精神分裂症睡眠障碍干预:随机对照研究[J].中国针灸,2015,35(9):869-873.
[5]王健,姚斌,张英谦.非线性理论和脑电的非线性[J].神经疾病与精神卫生,2007,7(3):239-241.
[6]张成,赵志付.中医心身医学研究新手段:脑电非线性分析[J].环球中医药,2013,6(3):218-221.
[7]孙玉.基于脑电非线性动力学分析的中医针刺疗法和经皮穴位电刺激疗法研究[D].杭州:浙江大学,2007.
[8]耿跃华,徐桂芝,杨硕,等.磁刺激神门穴脑电信号的非线性动力学分析[J].中国组织工程研究与临床康复,2009,13(4):675-679.
[9]沈花,王宝俊,唐孝威.电刺足三里穴脑电信号的非线性动力学方法初探[J].中国医学物理学杂志,2006,23(3):216-219.
[10]周涛,王江,韩春晓,等.不同频率针刺手法诱发脊髓背角广动力范围神经元放电模式的非线性分析[J].中国中西医结合杂志,2012,32(10):1403-1406.
[11]中华医学会精神病学分会.中国精神障碍分类与诊断标准第三版(精神障碍分类)[J].中华精神科杂志,2001,34(3):59-63.
[12]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:30-31.
[13]吴炳煌,陈跃,董卫国,等.浅针治疗面神经功能异常症及其与解剖学的关系[J].中国针灸,2004,24(8):70-72.
[14]王金权,贺连平,任小花,等.单向有序分类资料的常见统计误用及R软件和SPSS软件正确实现过程[J].中国临床药理学与治疗学,2014,19(7):824-827.
[15]周权,李卉,罗美玲,等.剂量反应关系Meta分析在R软件中的实现[J].现代预防医学,2015,42(5):789-794.
[16]ACHARYA U R,FAUST O,KANNATHAL N,et al.Non-linear analysis of EEG signals at various sleep stages[J].Comput Methods Programs Biomed,2005,80(1):37-45.
[17]ASHWIN P.Nonlinear dynamics:synchronization from chaos[J].Nature,2003,422(6930):384-385.
[18]吴东宇,董为伟.非线性动力学分析在脑电图中的应用[J].临床神经电生理学杂志,2003,12(1):46-51.
[19]马婷婷,梁繁荣.针灸效应复杂性的讨论[J].世界科学技术-中医药现代化,2008,10(2):42-45.
[20]王频,杨华元,王忆勤.中风病及其虚实证候的耳穴电阻抗非线性特征[J].中西医结合学报,2010,8(6):525-529.
[21]袁英,刘玲,屈亚萍,等.应用脑电非线性动力学分析法研究针刺穴位对不同意识障碍患者的作用[J].中国脑血管病杂志,2009,6(9):461-465.
[22]李晓琴.基于针刺神经电信号的适应性分析与特征提取[D].天津:天津职业技术师范大学,2014.
[23]郑雪峰,龚德贵,李沛.吴炳煌教授运用浅针疗法临床经验举隅[J].现代中西医结合杂志,2005,14(6):724-725.
[24]董国亚,吴祈耀.应用近似熵对睡眠脑电进行分期的研究[J].北京生物医学工程,1999,18(4):197-202.
[25]和卫星,陈晓平,邵珺婷.基于样本熵的睡眠脑电分期[J].江苏大学学报(自然科学版),2009,30(5):501-504.
[26]江朝晖,冯焕清,刘大路,等.睡眠脑电的关联维数和近似熵分析[J].生物医学工程学杂志,2005,22(4):649-653.
[2]王志福,龚德贵,俞向梅,等.浅析吴炳煌针灸调节免疫功能的学术思想与临床经验[J].中国针灸,2016,36(8):861-863.
[3]郑美凤,何芙蓉,林煜芬,等.浅针山根穴治疗原发性失眠的疗效观察及其对血清褪黑素的影响[J].浙江中医药大学学报,2014,38(7):902-905.
[4]黄燕熙,郑樱.浅针疗法对精神分裂症睡眠障碍干预:随机对照研究[J].中国针灸,2015,35(9):869-873.
[5]王健,姚斌,张英谦.非线性理论和脑电的非线性[J].神经疾病与精神卫生,2007,7(3):239-241.
[6]张成,赵志付.中医心身医学研究新手段:脑电非线性分析[J].环球中医药,2013,6(3):218-221.
[7]孙玉.基于脑电非线性动力学分析的中医针刺疗法和经皮穴位电刺激疗法研究[D].杭州:浙江大学,2007.
[8]耿跃华,徐桂芝,杨硕,等.磁刺激神门穴脑电信号的非线性动力学分析[J].中国组织工程研究与临床康复,2009,13(4):675-679.
[9]沈花,王宝俊,唐孝威.电刺足三里穴脑电信号的非线性动力学方法初探[J].中国医学物理学杂志,2006,23(3):216-219.
[10]周涛,王江,韩春晓,等.不同频率针刺手法诱发脊髓背角广动力范围神经元放电模式的非线性分析[J].中国中西医结合杂志,2012,32(10):1403-1406.
[11]中华医学会精神病学分会.中国精神障碍分类与诊断标准第三版(精神障碍分类)[J].中华精神科杂志,2001,34(3):59-63.
[12]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:30-31.
[13]吴炳煌,陈跃,董卫国,等.浅针治疗面神经功能异常症及其与解剖学的关系[J].中国针灸,2004,24(8):70-72.
[14]王金权,贺连平,任小花,等.单向有序分类资料的常见统计误用及R软件和SPSS软件正确实现过程[J].中国临床药理学与治疗学,2014,19(7):824-827.
[15]周权,李卉,罗美玲,等.剂量反应关系Meta分析在R软件中的实现[J].现代预防医学,2015,42(5):789-794.
[16]ACHARYA U R,FAUST O,KANNATHAL N,et al.Non-linear analysis of EEG signals at various sleep stages[J].Comput Methods Programs Biomed,2005,80(1):37-45.
[17]ASHWIN P.Nonlinear dynamics:synchronization from chaos[J].Nature,2003,422(6930):384-385.
[18]吴东宇,董为伟.非线性动力学分析在脑电图中的应用[J].临床神经电生理学杂志,2003,12(1):46-51.
[19]马婷婷,梁繁荣.针灸效应复杂性的讨论[J].世界科学技术-中医药现代化,2008,10(2):42-45.
[20]王频,杨华元,王忆勤.中风病及其虚实证候的耳穴电阻抗非线性特征[J].中西医结合学报,2010,8(6):525-529.
[21]袁英,刘玲,屈亚萍,等.应用脑电非线性动力学分析法研究针刺穴位对不同意识障碍患者的作用[J].中国脑血管病杂志,2009,6(9):461-465.
[22]李晓琴.基于针刺神经电信号的适应性分析与特征提取[D].天津:天津职业技术师范大学,2014.
[23]郑雪峰,龚德贵,李沛.吴炳煌教授运用浅针疗法临床经验举隅[J].现代中西医结合杂志,2005,14(6):724-725.
[24]董国亚,吴祈耀.应用近似熵对睡眠脑电进行分期的研究[J].北京生物医学工程,1999,18(4):197-202.
[25]和卫星,陈晓平,邵珺婷.基于样本熵的睡眠脑电分期[J].江苏大学学报(自然科学版),2009,30(5):501-504.
[26]江朝晖,冯焕清,刘大路,等.睡眠脑电的关联维数和近似熵分析[J].生物医学工程学杂志,2005,22(4):649-653.