BDNF信号通路调节学习记忆的研究进展
摘要
<正>神经营养因子是一类内源性、小型的分泌蛋白,具有促进神经元存活和分化及调节突触生长和发育的功能~([1,2])。哺乳动物脑区的神经营养因子主要有以下几类:脑源性神经营养因子(BDNF)、神经生长因子(NGF)、神经营养素(NT)-3及NT-4/5[3]等。BDNF在中枢神经系统内表达,在哺乳动物脑内含量最多,主要分布于海马和皮质组织等关键脑区,其中以海马CA3区最为富集~([4～6])。BDNF在基因转录翻译过程中,首先形成32 kD的前体蛋白p
引文
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4 Rivera-Olvera A,Rodríguez-Durán LF,Escobar ML.Conditioned taste aversion prevents the long-lasting BDNF-induced enhancement of synaptic transmission in the insular cortex:a metaplastic effect[J].Neurobiol Learn Mem,2016;130:71-6.
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7 Cattaneo A,Bocchio-Chiavetto L,Zanardini R,et al.BDNF Val66Met polymorphism and protein levels in amniotic fluid[J].BMC Neurosci,2010;11(1):16.
8 Nemcsik J,László A,Lénárt L,et al.Hyperthymic affective temperament and hypertension are independent determinants of serum brain-derived neurotrophic factor level[J].Ann Gen Psychiatry,2016;15(1):17.
9 Levada OA,Cherednichenko NV.Brain-derived neurotrophic factor (BDNF):neurobiology and marker value in neuropsychiatry[J].Lik Sprava,2015;(3-4):15-25.
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3 Aid T,Kazantseva A,Piirsoo M,et al.Mouse and rat BDNF gene structure and expression revisited[J].J Neurosci Res,2007;85(3):525-35.
4 Rivera-Olvera A,Rodríguez-Durán LF,Escobar ML.Conditioned taste aversion prevents the long-lasting BDNF-induced enhancement of synaptic transmission in the insular cortex:a metaplastic effect[J].Neurobiol Learn Mem,2016;130:71-6.
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6 Gratacos M,Soria V,Urretavizcaya M,et al.A brain-derived neurotrophic factor (BDNF) haplotype isassociated with antidepressant treatment outcome in mood disorders[J].Pharmacogenomics J,2008;8(2):101-12.
7 Cattaneo A,Bocchio-Chiavetto L,Zanardini R,et al.BDNF Val66Met polymorphism and protein levels in amniotic fluid[J].BMC Neurosci,2010;11(1):16.
8 Nemcsik J,László A,Lénárt L,et al.Hyperthymic affective temperament and hypertension are independent determinants of serum brain-derived neurotrophic factor level[J].Ann Gen Psychiatry,2016;15(1):17.
9 Levada OA,Cherednichenko NV.Brain-derived neurotrophic factor (BDNF):neurobiology and marker value in neuropsychiatry[J].Lik Sprava,2015;(3-4):15-25.
10 Matusica D,Alfonsi F,Turner BJ,et al.Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domainfragment[J].J Cell Sci,2016;129(3):517-30.
11 潘妹霞,李卓能,肖本熙.大豆异黄酮对去势大鼠学习记忆能力改善作用[J].中国公共卫生,2010;(10):1265-7.
12 Rostami E,Krueger F,Plantman S,et al.Alteration in BDNF and its receptors,full-length and truncated TrkB and p75NTR following penetrating traumatic brain injury[J].Brain Res,2014;1542:195-205.
13 Plotkin JL,Day M,Peterson JD,et al.Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington′s disease[J].Neuron,2014;83(1):178-88.
14 Jerónimo-Santos A,Fonseca-Gomes J,Guimar?es DA,et al.Brain-derivedneurotrophic factor mediates neuroprotection against A β-induced toxicity through a mechanism independent on adenosine 2A receptor activation[J].Growth Factors,2015;33(4):298-308.
15 Notaras M,Hill R,Van Den Buuse M.The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility:progress and controversy[J].Mol Psychiatry,2015;20(8):916-30.
16 Biojone C,Casarotto PC,Joca SR,et al.Interplay between nitric oxide and brain-derived neurotrophic factor in neuronal plasticity[J].CNS Neurol Disord Drug Targets,2015;14(8):979-87.
17 Lawn S,Krishna N,Pisklakova A,et al.Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells[J].J Biol Chem,2015;290(6):3814-24.
18 松林,莲花,白龙,等.肉蔻五味丸对慢性应激性抑郁症大鼠学习记忆能力及海马 BDNF,TrkB 蛋白表达的影响[J].中华中医药杂志,2017;34(8):3797-800.
19 Zhang F,Kang Z,Li W,et al.Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer′s disease[J].J Clin Neurosci,2012;19(7):946-9.
20 孙治坤,张杰文,杨红旗,等.脑源性神经生长因子通过调节Bax/Bcl表达抑制β-淀粉样蛋白诱导的细胞凋亡[J].中华神经医学杂志,2011;10(1):19-23.
21 李岩,陈俊逾,伊琦忠.抑郁症大鼠模型海马区及前额叶组织BDNF因子,Trkb蛋白表达的实验研究[J].中国医药导刊,2015;17(1):94-5,98.
22 Sun Y,Kaneko S,Li XK,et al.The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway[J].Oncogene,2015;34(19):2527-37.
23 Engelman JA.Targeting PI3K signalling in cancer:opportunities,challenges and limitations[J].Nat Rev Cancer,2009;9(8):550-62.
24 Zhang J,Yu XH,Yan YG,et al.PI3K/Akt signaling in osteosarcoma[J].Clin Chim Acta,2015;444:182-92.
25 Bu Y,Jia QA,Ren ZG,et al.The herbal compound Songyou Yin (SYY) inhibits hepatocellular carcinoma growth and improves survival in models of chronic fibrosis via paracrine inhibition of activated hepatic stellate cells[J].Oncotarget,2015;6(37):40068-80.
26 王暖,耿德勤,黄红莉,等.老年大鼠海马细胞凋亡和神经元信号转导通路的变化与学习记忆的关系[J].中国老年学杂志,2013;33(7):1573-6.
27 Poulin B,Butcher A,McWilliams P,et al.The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner[J].Proc Natl Acad Sci U S A,2010;107(20):9440-5.
28 Callaghan CK,Kelly áM.Differential BDNF signaling in dentate gyrusand perirhinal cortex during consolidation of recognition memory in the rat[J].Hippocampus,2012;22(11):2127-35.
29 李万里,王侠,高原,等.合欢花黄酮对慢性应激模型大鼠抗抑郁作用[J].中国公共卫生,2013;29(4):515-7.
30 Beaulieu JM,Sotnikova TD,Yao WD,et al.Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3signaling cascade[J].Proc Natl Acad Sci U S A,2004;101(14):5099-104.
31 Weichhart T.Mammalian target of rapamycin:a signaling kinase for every aspect of cellular life[J].Methods Mol Biol,2012;821:1-14.
32 Inoki K,Kim J,Guan KL.AMPK and mTOR in cellular energy homeostasis and drug targets[J].Annu Rev Pharmacol Toxicol,2012;52:381-400.
33 Voleti B,Navarria A,Liu RJ,et al.Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling,synaptogenesis,and antidepressant behavioral responses[J].Biol Psychiatry,2013;74(10):742-9.
34 Hoeffer CA,Klann E.mTOR signaling:at the crossroads of plasticity,memory and disease[J].Trends Neurosci,2010;33(2):67-75.
35 Briz V,Hsu YT,Li Y,et al.Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis[J].J Neurosci,2013;33(10):4317-28.
36 Dwyer JM,Lepack AE,Duman RS.mTOR activation is required for the antidepressant effects of mGluR2/3 blockade[J].Int J Neuropsychopharmacol,2012;15(4):429-34.
37 Laplante M,Sabatini DM.mTOR signaling in growth control and disease[J].Cell,2012;149(2):274-93.
38 Magnuson B,Ekim B,Fingar DC.Regulation and function of ribosomalprotein S6 kinase (S6K) within mTOR signalling networks[J].Biochem J,2012;441(1):1-21.
39 Chen KT,Tsai MH,Wu CH,et al.AMPA receptor-mTOR activation is required for the antidepressant-like effects of sarcosine during the forcedswim test in rats:insertion of AMPA receptor may play a role[J].Front Behav Neurosci,2015;9:162.
40 Nakai T,Nagai T,Tanaka M,et al.Girdin phosphorylation is crucial for synaptic plasticity and memory:a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor[J].J Neurosci,2014;34(45):14995-5008.
41 Fortin DA,Srivastava T,Dwarakanath D,et al.Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors[J].J Neurosci,2012;32(24):8127-37.
42 Nosyreva E,Szabla K,Autry AE,et al.Acute suppression of spontaneous neurotransmission drives synaptic potentiation[J].J Neurosci,2013;33(16):6990-7002.
43 Siu MKY,Wong OGW,Cheung ANY.TrkB as a therapeutic target for ovarian cancer[J].Exp Opin Therapeutic Targets,2009;13(10):1169-78.
44 Luikart BW,Zhang W,Wayman GA,et al.Neurotrophin-dependent dendritic filopodial motility:a convergence on PI3K signaling[J].J Neurosci,2008;28(27):7006-12.
45 Kong X,Pan J,Zhang D,et al.Identification of mitogen-activated proteinkinase kinase gene family and MKK-MAPK interaction network in maize[J].Biochem Biophys Res Commun,2013;441(4):964-9.
46 刘甜甜,赵海峰.植物化学物对阿尔茨海默病保护作用研究进展[J].中国公共卫生,2013;29(5):772-5.
47 张晓东,金戈.水飞蓟宾改善学习记忆作用研究进展[J].中国老年学杂志,2017;37(23):6002-4.
48 李娜,程雪娇,王茜,等.白藜芦醇抑制海马 β-APP 表达改善大鼠学习记忆[J].中国公共卫生,2015;31(3):327-9.
49 刘静,杨遥,徐江涛.Tau 蛋白过度磷酸化与阿尔茨海默病[J].医学综述,2013;19(3):423-5.
50 Ma N,Wang X,Gao P,et al.Effects of DiBP on the cAMP/PKA-CREB-BDNF signaling pathway of hippocampus in mice[J].J Hygiene Res,2013;42(3):405-9.
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