摘要
目的探讨多囊卵巢综合征(PCOS)患者血清鸢尾素(Irisin)及连蛋白(Zonulin)水平改变及其临床诊断价值。方法纳入2013年5月-2016年5月就诊的PCOS患者85例为PCOS组,64名健康体检的女性为对照组。使用酶联免疫吸附方法检测两组女性血清Irisin及Zonulin水平,分析与临床指标的相关性及诊断PCOS患者胰岛素抵抗的效能。结果 PCOS组患者血清Irisin(0. 41±0. 14)μg/ml、Zonulin水平(7. 21±2. 96) pg/ml显著高于对照组女性的(0. 26±0. 09)μg/ml、(4. 30±1. 62) pg/ml,差异有统计学意义(P<0. 01)。PCOS组患者Irisin及Zonulin水平分别与BMI、WHA、FPG、FINS、HOMA-IR、TG、T呈显著正相关,与HDL-C呈负相关。Irisn单独诊断PCOS患者是否存在IR的AUC为0. 793 (95%CI:0. 697~0. 889,P<0. 01),Zonulin的AUC为0. 773 (95%CI:0. 668~0. 878,P<0. 01),血清Irisin联合Zonulin诊断的AUC为0. 881 (95%CI为0. 808~0. 953,P <0. 001)。结论 PCOS患者血清Irisin及Zonulin水平存在显著升高,且Irisin联合Zonulin诊断PCOS是否存在胰岛素抵抗的效能较高。
引文
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