STAT3在固有免疫中的研究进展
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摘要
信号转导与转录活化因子3(signal transduction and activator of transcription 3,STAT3)是STATs家族的重要成员,参与多种细胞因子的信号转导过程,对细胞的生长和存活发挥重要的调控作用。近年来,多数研究证明,STAT3在致免疫耐受中亦发挥重要作用,尤其在固有免疫中,对粒细胞、巨噬细胞、树突状细胞(dendritic cells,DC)等都有重要的调节功能。
引文
[1] Johnson DE, O'Keefe RA. Targeting the IL-6/JAK/STAT3 signalling axis in cancer[J]. Nat Rev Clin Oncol, 2018,15(4):234-248.
[2] Eid RA, Alkhateeb MA, Eleawa S, et al. Cardioprotective effect of ghrelin against myocardial infarction-induced left ventricular injury via inhibition of SOCS3 and activation of JAK2/STAT3 signaling[J].Basic Res Cardiol, 2018,113(2):13.
[3] Dasgupta M, Dermawan JK, Willard B. STAT3-driven transcription depends upon the dimethylation of K49by EZH2[J]. Proc Natl Acad Sci U S A, 2015,112(13):3985-3990.
[4] Boettcher S, Gerosa RC, Radpour R, et al. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis[J]. Blood, 2014, 124(9):1393-1403.
[5] Nguyen-Jackson H, Panopoulos AD, Zhang H, et al.STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction[J]. Blood, 2010,115(16):3354-3363.
[6] Zhang H, Nguyen-Jackson H, Panopoulos AD, et al. STAT3controls myeloid progenitor growth during emergency granulopoiesis[J]. Blood, 2010,116(14):2462-2471.
[7] Shah CA, Broglie L, Hu L, et al. Stat3 and CCAAT enhancer-binding proteinβ(C/ebpβ)activate Fanconi C gene transcription during emergency granulopoiesis[J]. J Biol Chem, 2018,293(11):3937-3948.
[8] Nguyen-Jackson HT, Li HS, Zhang H, et al.G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils[J]. J Leukoc Biol,2012,92(6):1215-1225.
[9] Chen YY, Ma ZB, Xu HY, et al. IL-6/STAT3/SOCS3 signaling pathway playing a regulatory role in ulcerative colitis carcinogenesis[J]. Int J Clin Exp Med, 2015,8(8):12009-12017.
[10] Santillán-Benítez JG, Mendieta-Zerón H, Gómez-Oliván LM, et al. JAK2, STAT3 and SOCS3 gene expression in women with and without breast cancer[J].Gene, 2014,547(1):70-76.
[11] Yu T, Zuo Y, Cai R, et al. SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop[J]. J Mol Cell Biol, 2017,9(2):144-153.
[12] Gardner JC, Noel JG, Nikolaidis NM, et al. G-CSF drives a posttraumatic immune program that protects the host from infection[J]. J Immunol, 2014,192(5):2405-2417.
[13] Laouar Y, Welte T, Fu XY. STAT3 is required for Flt3L-dependent dendritic cell differentiation[J].Immunity, 2003,19(6):903-912.
[14] Li HS, Yang CY, Nallaparaju KC, et al. The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development[J].Blood, 2012,120(22):4363-4373.
[15] Esashi E, Wang YH, Perng O, et al. The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8[J].Immunity, 2008,28(4):509-520.
[16] Singh P, Hoggatt J, Hu P, et al. Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells[J]. Blood,2012,119(7):1671-1682.
[17] Al-Jamal HA, Mat Jusoh SA, Hassan R. Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3activation and confer sensitivity in lestaurtinib(CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia[J]. BMC Cancer, 2015(15):869.
[18] Carotta S, Dakic A, D'Amico A, et al. The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner[J]. Immunity, 2010,32(5):628-641.
[19] Stickel N, Hanke K, Marschner D, et al. MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation[J]. Leukemia, 2017,31(12):2732-2741.
[20] Liu YF, Chen YY, He YY, et al. Expansion and activation of granulocytic, myeloid-derived suppressor cells in childhood precursor B cell acute lymphoblastic leukemia[J]. J Leukoc Biol, 2017,102(2):449-458.
[21] Zhong L, Yang Q, Xie W. Liver X receptor regulates mouse GM-CSF-derived dendritic cell differentiation in vitro[J]. Mol Immunol, 2014,60(1):32-43.
[22] Tang D, Zhao D, Wu Y, et al. The miR-3127-5p/pSTAT3 axis up-regulates PD-L1 inducing chemoresistance in non-small-cell lung cancer[J]. J Cell Mol Med, 2018,22(8):3847-3856.
[23] Cai Z, Li J, Zhuang Q, et al. MiR-125a-5p ameliorates monocrotaline-induced pulmonary arterial hypertension by targeting the TGF-β1 and IL-6/STAT3signaling pathways[J]. Exp Mol Med, 2018,50(4):45.
[24] Melillo JA, Song L, Bhagat G, et al. Dendritic cell(DC)-specific targeting reveals Stat3 as a negative regulator of DC function[J]. J Immunol, 2010,184(5):2638-2645.
[25] Liang S, Ristich V, Arase H, et al. Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway[J]. Proc Natl Acad Sci U S A, 2008,105(24):8357-8362.
[26] Hutchins AP, Diez D. The IL-10/STAT3-mediated antiinflammatory response:recent developments and future challenges[J]. Brief Funct Genomics, 2013, 12(6):489-498.
[27] Zhang H, Hu H, Greeley N, et al. STAT3 restrains RANK-and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13[J]. Nat Commun, 2014(5):5798.
[28] Siegel AM, Stone KD, Cruse G, et al. Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation[J]. J Allergy Clin Immunol, 2013,132(6):1388-1396.
[2] Eid RA, Alkhateeb MA, Eleawa S, et al. Cardioprotective effect of ghrelin against myocardial infarction-induced left ventricular injury via inhibition of SOCS3 and activation of JAK2/STAT3 signaling[J].Basic Res Cardiol, 2018,113(2):13.
[3] Dasgupta M, Dermawan JK, Willard B. STAT3-driven transcription depends upon the dimethylation of K49by EZH2[J]. Proc Natl Acad Sci U S A, 2015,112(13):3985-3990.
[4] Boettcher S, Gerosa RC, Radpour R, et al. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis[J]. Blood, 2014, 124(9):1393-1403.
[5] Nguyen-Jackson H, Panopoulos AD, Zhang H, et al.STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction[J]. Blood, 2010,115(16):3354-3363.
[6] Zhang H, Nguyen-Jackson H, Panopoulos AD, et al. STAT3controls myeloid progenitor growth during emergency granulopoiesis[J]. Blood, 2010,116(14):2462-2471.
[7] Shah CA, Broglie L, Hu L, et al. Stat3 and CCAAT enhancer-binding proteinβ(C/ebpβ)activate Fanconi C gene transcription during emergency granulopoiesis[J]. J Biol Chem, 2018,293(11):3937-3948.
[8] Nguyen-Jackson HT, Li HS, Zhang H, et al.G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils[J]. J Leukoc Biol,2012,92(6):1215-1225.
[9] Chen YY, Ma ZB, Xu HY, et al. IL-6/STAT3/SOCS3 signaling pathway playing a regulatory role in ulcerative colitis carcinogenesis[J]. Int J Clin Exp Med, 2015,8(8):12009-12017.
[10] Santillán-Benítez JG, Mendieta-Zerón H, Gómez-Oliván LM, et al. JAK2, STAT3 and SOCS3 gene expression in women with and without breast cancer[J].Gene, 2014,547(1):70-76.
[11] Yu T, Zuo Y, Cai R, et al. SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop[J]. J Mol Cell Biol, 2017,9(2):144-153.
[12] Gardner JC, Noel JG, Nikolaidis NM, et al. G-CSF drives a posttraumatic immune program that protects the host from infection[J]. J Immunol, 2014,192(5):2405-2417.
[13] Laouar Y, Welte T, Fu XY. STAT3 is required for Flt3L-dependent dendritic cell differentiation[J].Immunity, 2003,19(6):903-912.
[14] Li HS, Yang CY, Nallaparaju KC, et al. The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development[J].Blood, 2012,120(22):4363-4373.
[15] Esashi E, Wang YH, Perng O, et al. The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8[J].Immunity, 2008,28(4):509-520.
[16] Singh P, Hoggatt J, Hu P, et al. Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells[J]. Blood,2012,119(7):1671-1682.
[17] Al-Jamal HA, Mat Jusoh SA, Hassan R. Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3activation and confer sensitivity in lestaurtinib(CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia[J]. BMC Cancer, 2015(15):869.
[18] Carotta S, Dakic A, D'Amico A, et al. The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner[J]. Immunity, 2010,32(5):628-641.
[19] Stickel N, Hanke K, Marschner D, et al. MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation[J]. Leukemia, 2017,31(12):2732-2741.
[20] Liu YF, Chen YY, He YY, et al. Expansion and activation of granulocytic, myeloid-derived suppressor cells in childhood precursor B cell acute lymphoblastic leukemia[J]. J Leukoc Biol, 2017,102(2):449-458.
[21] Zhong L, Yang Q, Xie W. Liver X receptor regulates mouse GM-CSF-derived dendritic cell differentiation in vitro[J]. Mol Immunol, 2014,60(1):32-43.
[22] Tang D, Zhao D, Wu Y, et al. The miR-3127-5p/pSTAT3 axis up-regulates PD-L1 inducing chemoresistance in non-small-cell lung cancer[J]. J Cell Mol Med, 2018,22(8):3847-3856.
[23] Cai Z, Li J, Zhuang Q, et al. MiR-125a-5p ameliorates monocrotaline-induced pulmonary arterial hypertension by targeting the TGF-β1 and IL-6/STAT3signaling pathways[J]. Exp Mol Med, 2018,50(4):45.
[24] Melillo JA, Song L, Bhagat G, et al. Dendritic cell(DC)-specific targeting reveals Stat3 as a negative regulator of DC function[J]. J Immunol, 2010,184(5):2638-2645.
[25] Liang S, Ristich V, Arase H, et al. Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway[J]. Proc Natl Acad Sci U S A, 2008,105(24):8357-8362.
[26] Hutchins AP, Diez D. The IL-10/STAT3-mediated antiinflammatory response:recent developments and future challenges[J]. Brief Funct Genomics, 2013, 12(6):489-498.
[27] Zhang H, Hu H, Greeley N, et al. STAT3 restrains RANK-and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13[J]. Nat Commun, 2014(5):5798.
[28] Siegel AM, Stone KD, Cruse G, et al. Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation[J]. J Allergy Clin Immunol, 2013,132(6):1388-1396.